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Levels of oxidative stress parameters and the protective effects of melatonin in psychosis model rat testis

Asian Journal of Andrology 2008年第2期10卷 259-265页

作者： bekir s. parlaktas Birsen Ozyurt Huseyin Ozyurt Ayten T. Tunc Ali Akbas Department of Urology Gaziosmanpasa University School of Medicine Tokat 60100 Turkey Department of Anatomy Gaziosmanpasa University School of Medicine Tokat 60100 Turkey Department of Biochemistry Gaziosmanpasa University School of Medicine Tokat 60100 Turkey Department of Histology and Embryology Gaziosmanpasa University School of Medicine Tokat 60100 Turkey

Aim： To evaluate the effects of melatonin on antioxidant enzyme levels and histopathologic changes in dizocilpine （MK-801）-induced psychosis model rat testis. Methods： A total of 24 adult male Wistar-Albino rats were divided into three groups with 8 in each. Group I was used as control. Rats in Group II were injected with MK-801 （0.5 mg/kg body weight i.p. for 5 days）. In addition to MK-801, melatonin （50 mg/kg body weight i.p. once a day for 5 days） was injected into the rats in Group Ⅲ. The testes were harvested bilaterally for biochemical and histopathological examinations. Antioxidant enzyme activities, malondialdehyde, protein carbonyl and nitric oxide （NO） levels in testicular tissues were analyzed using spectrophotometric analysis methods. Histopathological examinations of the testes were also performed. Results： MK-801 induced testicular damage, which resulted in significant oxidative stress （Os） by increasing the levels of antioxidant enzymes. The malondialdehyde, protein carbonyl and NO levels were increased in testicular tissues of rats. Treatment with melatonin led to significant decrease in oxidative injury. Administration of melatonin also reduced the detrimental histopathologic effects caused by MK-801. Conclusion： The results of the present study showed that MK-801 cause Os in testicular tissues of rats and treatment with melatonin can reduce the harmful effects＇of MK-801. （Asian JAndro12008 Mar; 10： 259-265）

关键词： testis dizocilpine psychosis oxidative stress melatonin antioxidant enzymes

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The biochemical effects of ischemia-reperfusion injury in the ipsilateral and contralateral testes of rats and the protective role of melatonin

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Asian Journal of Andrology 2014年第2期16卷 314-318,I0012页

作者： bekir s parlaktas Dogan Atilgan Huseyin Ozyurt Yusuf Gencten Ali Akbas Fikret Erdemir Nihat Uluocak Department of Urology Gaziosmanpasa University Faculty of Medicine Tokat Turkey Department of Biochemistry Gaziosmanpasa University Faculty of Medicine Tokat Turkey.

Testicular torsion （TT） is a serious urologic emergency that is observed in adolescent males and that can lead to infertility if left untreated. The ischemia-reperfusion （I/R） injury due to TT has been implicated in the pathogenesis of testicular damage. We investigated the effects of melatonin on oxidative damage in the ipsUateral and contralateral testes of rats induced by unilateral TT. A total of 21 prepubertal male Wistar albino rats were divided into three groups, each consisting of seven rats, In Group 1 （sHAM group）： a sham operation to the left testis and bilateral orchiectomy were performed. In Group 2 （I/R group）： I/R injury was created by rotating the left testis 720° in a clockwise direction for 2 h and detorsing the testis after 2 h. Group 3 （I/R ＋ MEL group）： rats were subjected to I/R injury and one-shot melatonin injection （50mgkg-1, intraperitoneal （i.p.））. The testes of the rats were excised bilaterally in all groups. The testicular tissue activities of antioxidant catalase （CAT）, superoxide dismutase （sOD） and glutathione peroxidase enzymes （GsH-Px）, and the tissue levels of malondialdehyde （MDA）, protein carbonyl （PC） and nitric oxide （NO） were determined. Administration of melatonin caused a significant decrease in lipid peroxidation and enzyme activities in the ipsilateral testis when compared with the control group （P 〈 0.05）. All of the changes in the enzyme activities of the contralateral testis were insignificant （P 〉 0.05）. MDA levels were significantly altered in the contralateral testis （P = 0.009）, Melatonin administration decreased the deleterious effects of I/R injury in the ipsilateral torted testes of the rats. The contralateral testes were slightly affected by unilateral TT.

关键词： antioxidant enzymes ischemia-reperfusion (I/R) lipid peroxidation melatonin testicular torsion {TT)

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Oxidative stress in testicular tissues of rats exposed to cigarette smoke and protective effects of caffeic acid phenethyl ester

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Asian Journal of Andrology 2006年第2期8卷 189-193页

作者： Hüseyin Ozyurt Hidir Pekmez bekir suha parlaktas Ilter Kus Birsen Ozyurt Mustafa saLrsllmaz Departments of Biochemistry Urolog and Tokat 60100Turkey school of Heahh sciences Elaz 23100 Turkey Departments of Urolog Tokat 60100 Turkey Departments of Anatomy School of MedicineGaziosmanpasa UniversityTokat 60100Turkey Department of Anatomy School of MedicineFirat UniversityElaz 23100Turkey

Aim： To show the oxidative stress after cigarette smoke exposure in rat testis and to evaluate the effects of caffeic acid phenethyl ester （CAPE）. Methods： Twenty-one rats were divided into three groups of seven. Animals in Group Ⅰ were used as control. Rats in Group Ⅱ were exposed to cigarette smoke only （4 × 30 min/d） and rats in Group Ⅲ were exposed to cigarette smoke and received daily intraperitoneal injections of CAPE （10 μmol/kg.d）. After 60 days all the rats were killed and the levels of nitric oxide （NO） and anti-oxidant enzymes such as superoxide-dismutase, catalase and glutathione peroxidase （GsH-Px） and the level of malondialdehyde were studied in the testicular tissues of rats with spectrophotometric analysis. Results： There was a significant increase in catalase and superoxide-dismutase activities in Group Ⅱ when compared to the controls, but the levels of both decreased after CAPE administration in Group Ⅲ. GsH-Px activity was decreased in Group Ⅱ but CAPE caused an elevation in GsH-Px activity in Group Ⅲ. The difference between the levels of GsH-Px in Group Ⅰ and Group Ⅱ was significant, but the difference between groups Ⅱ and Ⅲ was not significant. Elevation of malondialdehyde after smoke exposure was significant and CAPE caused a decrease to a level which was not statistically different to the control group. A significantly increased level of NO after exposure to smoke was reversed by CAPE administration and the difference between NO levels in groups Ⅰ and Ⅲ was statistically insignificant. Conclusion： Exposure to cigarette smoke causes changes in the oxidative enzyme levels in rat testis, but CAPE can reverse these harmful effects. （Asian J Andro12006 Mar; 8： 189-193）

关键词： testis cigarette caffeic acid phenetyl ester anti-oxidants nitric oxide

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