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青海地区汉族人群2型糖尿病相关基因多态性与临床特征相关性的研究

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中国糖尿病杂志 2025年第1期33卷 36-42页

作者：李春梅王贝贝达哇卓玛罗玮青海省人民医院急诊科青海省人民医院内分泌科青海省人民医院科教处

目的探讨DM易感位点与青海地区汉族T2DM患者临床特征的相关性。方法选取2021年12月至2023年7月于青海省人民医院住院治疗的T2DM患者286例。通过Illumina测序法对样本DNA进行基因位点测序，运用LASSO回归及Kolmogorov-Smirnov(K-S)检... 详细信息

目的探讨DM易感位点与青海地区汉族T2DM患者临床特征的相关性。方法选取2021年12月至2023年7月于青海省人民医院住院治疗的T2DM患者286例。通过Illumina测序法对样本DNA进行基因位点测序，运用LASSO回归及Kolmogorov-Smirnov(K-S)检验，分析单核苷酸多态性（SNP）与T2DM患者发病年龄的相关性，采用Logistic回归分析DM家族史、FPG、Hb A1c、胰岛素抵抗指数（HOMA-IR）、胰岛β细胞功能指数（HOMA-β）的影响因素。结果男性患者发病年龄、吸烟史、饮酒史、WC高于女性（P<0.05）,HOMA-β、TC、HDL-C、LDL-C低于女性（P<0.05）。LASSO回归及K-S检验分析发现，7个SNP与T2DM发病年龄相关（P<0.05）。Logistic回归分析显示，13个SNP是DM家族史的影响因素（P<0.05）,13个SNP是FPG的影响因素（P<0.05）,11个SNP是Hb A1c的影响因素（P<0.05）,20个SNP是HOMA-IR的影响因素（P<0.05）,16个SNP是HOMA-β的影响因素（P<0.05）。结论青海地区汉族T2DM患者中，多个SNP变异可能通过不同的生物学途径影响T2DM表型，包括发病年龄、血糖指标及胰岛功能等。

关键词：糖尿病,2型单核苷酸多态性基因

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中小学科学教育的理论向度与实践方略

中国电化教育 2025年第2期 51-58页

作者：刘和海谭闵高幸王贝贝安徽师范大学教育科学学院安徽芜湖241000

科学教育关系到国家安全、环境保护、公共健康等领域,是支撑国家战略的重要基石。因此,该文致力于深入剖析科学教育的核心要素,包括其目标、内容、方法和形式,以期对科学教育的本质进行重新解读。同时,探讨了科学教育的理论基础,这一基... 详细信息

科学教育关系到国家安全、环境保护、公共健康等领域,是支撑国家战略的重要基石。因此,该文致力于深入剖析科学教育的核心要素,包括其目标、内容、方法和形式,以期对科学教育的本质进行重新解读。同时,探讨了科学教育的理论基础,这一基础植根于中华民族的科教兴国战略、科学素养的培育、以探究与实践为核心的教学方法,以及科学教育所特有的“加法”理念。在实践策略上,提出持续优化的发展格局、以人为本的教育体系、全面设计的评价框架和多方协同的生态模型,这些措施构成了构建中小学科学教育新体系的行动指南。

关键词：中小学科学教育理论向度实践方略

A detail preserving neural network model for Monte Carlo denoising

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Computational Visual Media 2020年第2期6卷 157-168页

作者： Weiheng Lin beibei wang Lu wang Nicolas Holzschuch School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing210094China School of Computer Science and Technology Shandong UniversityJinan250100China Univ.Grenoble-Alpes InriaCNRSGrenoble INPLJK38000GrenobleFrance

Monte Carlo based methods such as path tracing are widely used in movie production. To achieve low noise, they require many samples per pixel,resulting in long rendering time. To reduce the cost,one solution is Monte Carlo denoising, which renders the image with fewer samples per pixel(as little as128) and then denoises the resulting image. Many Monte Carlo denoising methods rely on deep learning:they use convolutional neural networks to learn the relationship between noisy images and reference images,using auxiliary features such as position and normal together with image color as inputs. The network predicts kernels which are then applied to the noisy input. These methods show powerful denoising ability,but tend to lose geometric or lighting details and to blur sharp features during *** this paper, we solve this issue by proposing a novel network structure, a new input feature—light transport covariance from path space—and an improved loss function. Our network separates feature buffers from the color buffer to enhance detail effects. The features are extracted separately and then integrated into a shallow kernel predictor. Our loss function considers perceptual loss, which also improves detail *** addition, we use a light transport covariance feature in path space as one of the features, which helps to preserve illumination details. Our method denoises Monte Carlo path traced images while preserving details much better than previous methods.

关键词： deep learning light transport covariance perceptual loss Monte Carlo denoising

A practical path guiding method for participating media

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Computational Visual Media 2020年第1期6卷 37-51页

作者： Hong Deng beibei wang Rui wang Nicolas Holzschuch Nanjing University of Science and Technology Nanjing 210094China State Key Lab of CAD&CG Zhejiang UniversityHangzhou 310058China Univ.Grenoble-Alpes InriaCNRSGrenoble INPLJK38000 GrenobleFrance

Rendering translucent materials is costly:light transport algorithms need to simulate a large number of scattering events inside the material before reaching *** cost is especially high for materials with a large albedo or a small mean-freepath,where higher-order scattering effects *** simple terms,the paths get lost in the *** guiding has been proposed for surface rendering to make convergence faster by guiding the sampling *** this paper,we introduce a path guiding solution for translucent *** learn an adaptive approximate representation of the radiance distribution in the volume and use it to sample the scattering direction,combining it with phase function sampling by resampled importance *** proposed method significantly improves the performance of light transport simulation in participating media,especially for small lights and media with refractive *** method can handle any homogeneous participating medium,with high or low scattering,with high or low absorption,and from isotropic to highly anisotropic.

关键词： Monte Carlo ray tracing path guiding volume light transport participating media rendering

A survey on rendering homogeneous participating media

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Computational Visual Media 2022年第2期8卷 177-198页

作者： Wenshi Wu beibei wang Ling-Qi Yan School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjingChina University of California Santa BarbaraUSA

Participating media are frequent in real-world scenes,whether they contain milk,fruit juice,oil,or muddy water in a river or the *** light interacts with these participating media in complex ways:refraction at boundaries and scattering and absorption inside *** radiative transfer equation is the key to solving this *** are several categories of rendering methods which are all based on this equation,but using different *** this paper,we introduce these groups,which include volume density estimation based approaches,virtual point/ray/beam lights,point based approaches,Monte Carlo based approaches,acceleration techniques,accurate single scattering methods,neural network based methods,and spatially-correlated participating media related *** well as discussing these methods,we consider the challenges and open problems in this research area.

关键词： participating media Monte Carlo methods rendering volume density estimation

C反应蛋白与白蛋白比值对急性胰腺炎严重程度早期预测的临床价值

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齐齐哈尔医学院学报 2025年第2期46卷 123-128页

作者：王蓓蓓张帮杰新乡医学院第三附属医院消化内科河南新乡453000

目的探讨C反应蛋白(CRP)与白蛋白(Alb)比值(CAR)对急性胰腺炎(Acute pancreatitis,AP)严重程度早期预测的临床应用价值。方法回顾性分析2019年9月-2022年6月在本院确诊为AP的83例住院患者临床资料,将其分为中重症AP(Moderately severe a... 详细信息

目的探讨C反应蛋白(CRP)与白蛋白(Alb)比值(CAR)对急性胰腺炎(Acute pancreatitis,AP)严重程度早期预测的临床应用价值。方法回顾性分析2019年9月-2022年6月在本院确诊为AP的83例住院患者临床资料,将其分为中重症AP(Moderately severe acute pancreatitis,MSAP)+重症AP(Severe acute pancreatitis,SAP)组(29例)和轻症AP(Mild acute pancreatitis,MAP)组(54例)。比较两组患者一般情况、实验室数据指标,采用单因素分析筛选MSAP+SAP的相关因素,多因素Logistic回归分析早期预测MSAP+SAP的独立危险因素,并绘制受试者工作特征曲线(ROC)评估CAR对MSAP+SAP的早期预测价值。结果单因素分析发现,MSAP+SAP组与MAP组血常规各指标中白细胞绝对计数、中性粒细胞绝对计数(Neutrophil granulocyte,N)比较,差异均有统计学意义(均P<0.05),且与MAP组相比,MSAP+SAP组淀粉酶、脂肪酶、CRP、甘油三酯、NLR、CAR均明显增高,而白蛋白、血清钙离子浓度均明显降低,组间比较,差异均有统计学意义(均P<0.05)。多因素Logistic回归分析提示CAR(OR 1.697,95%CI 1.229~2.344,P=0.001)是预测中、重症急性胰腺炎的独立危险因素(P<0.05)。采用ROC曲线分析,CAR对中、重症急性胰腺炎早期预测具有很好的预测价值,以4.41为cut-off值,其敏感性为72.4%,特异性为98.1%,曲线下面积(AUC)为0.906。结论CAR可作为早期预测中、重症急性胰腺炎的良好标志物之一。

关键词：急性胰腺炎中、重症 C反应蛋白与白蛋白比值预测

Partially known information attack on SM2 key exchange protocol

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Science China(Information Sciences) 2019年第3期62卷 61-74页

作者： Wei WEI Jiazhe CHEN Dan LI beibei wang China Information Technology Security Evaluation Center Institute for Advanced Study Tsinghua University

SM2 key exchange protocol is a part of the SM2 public key cryptographic algorithm based on elliptic curves which has been issued by Chinese State Cryptography Administration since 2010. Under the guide of Chinese government, SM2 has been widely used in Chinese commercial applications. This paper gives the first partially known information attack on SM2 key exchange protocol. Our attack is based on a technique modified from the hidden number problem(HNP) which was introduced originally to study the bit security of Diffie-Hellman and related schemes. We present a polynomial-time algorithm which could recover the user’s secret key when given about half least significant bits of the two unknown intermediate values in each congruence over about 30 to 40 instances. Compared with the standard HNP, our approach deals with congruence involved two independent unknown variables and each of them possesses the same size as the secret key. Moreover, our results almost coincide with the previous best result among the same field considering the extreme case in which one variant is completely revealed.

关键词： SM2 key exchange protocol cryptanalysis information leakage lattice attack extended hidden number problem

Flux mechanism of compound flux on ash and slag of coal with high ash melting temperature

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Chinese Journal of Chemical Engineering 2019年第5期27卷 1200-1206页

作者： Chengli Wu beibei wang Jiuqiang Zheng Hanxu Li School of Chemical Engineering Anhui University of Science and Technology

The melting temperature of Z coal ash was reduced by adding calcium–magnesium compound flux(WCaO/WMgO=1). In the process of simulated coal gasification, the coal ash and slag were prepared. The transformation of minerals in coal ash and slag upon the change of temperature was studied by using X-ray diffraction(XRD). With the increase of temperatures, forsterite in the ash disappears, while the diffraction peak strength of magnesium spinel increases,and the content of the calcium feldspar increases, then the content of the amorphous phase in the ash increases obviously. The species and evolution process of oxygen, silicon, aluminum, calcium, magnesium at different temperatures were analyzed by X-ray photoelectron spectroscopy(XPS). The decrease of the ash melting point mainly affects the structural changes of silicon, aluminum and oxygen. The coordination of aluminum and oxygen in the aluminum element structure, e.g., tetracoordinated aluminum oxide, was changed. Tetrahedral [AlO4] and hexacoordinated aluminoxy octahedral [AlO6] change with the temperature changing. The addition of Ca2+ and Mg2+ destroys silica chain, making bridge oxide silicon change into non-bridge oxysilicon;and bridge oxygen bond was broken and non-bridge oxygen bond was produced in the oxygen element structure. The addition of calcium and magnesium compound flux reacts with aluminum oxide tetrahedron, aluminum oxide octahedron and silicon tetrahedron to promote the breakage of the bridge oxygen bond. Ca2+ and Mg2+ are easily combined with silicon oxide and aluminum oxide tetrahedron and aluminum. Oxygen octahedrons combine with non-oxygen bonds to generate low-melting temperature feldspars and magnesite minerals, thereby reducing the coal ash melting temperatures. The structure of kaolinite and mullite was simulated by quantum chemistry calculation, and kaolinite molecule has a stable structure.

关键词： Coal ash and slag Compound flux X-ray photoelectron spectroscopy Transformation of mineral structure Structure of kaolinite and mullite

Effect of Direct Aging on Corrosion Behavior of AlSi10Mg Alloy Fabricated by Laser Powder Bed Fusion

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 266-282页

作者： Zhen Zhang Zhanyong Zhao Xiaofeng Li beibei wang Peikang Bai Shanxi Key Laboratory of Controlled Metal Solidification and Precision Manufacturing School of Materials Science and EngineeringNorth University of ChinaTaiyuan030051China Technical Center Taiyuan Iron and Steel(Group)Co.LtdTaiyuan030003China School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan030024China

Effect of direct aging of 170℃on corrosion behavior of laser powder bed fused AlSi10Mg(LPBF-AlSi10Mg)was studied by microstructure analysis,electrochemical analysis and X-ray photoelectron *** results show that direct aging of 170℃has little effect on melt pool and Si cellular structure,but promotes the precipitation of nano-Si particles and releases the residual *** increasing aging time from 0 to 4 h to 24 h,the corrosion property of the LPBF-AlSi10Mg is deteriorated,which is evidenced by increased corrosion current density and decreased pitting potential and polarization *** increasing the aging time,the thickness of the oxide film formed on surface of the LPBF-AlSi10Mg *** Si content of the oxide film of the sample aging for 4 h is the lowest,9.42 at.%,and it is the highest,18.62 at.%,for the sample aging for 24 *** electrochemical noise analysis reveals that the middle-frequency contribution of the Hilbert spectrum is responsible for the deteriorated corrosion performance,which corresponds to metastable pitting initiated by nano-Si particles.

关键词： Laser powder bed fusion AlSi10Mg Direct aging Corrosion