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Synthesis and properties of a novel bolaamphiphile surfactant derived from proline

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Chinese Chemical Letters 2016年第3期27卷 447-450页

作者： bei-bei hu Yue Yuan Xiao-Ping Zhou San-Ming Li School of Pharmacy Shenyang Pharmaceutical University Shenyang 110016 China School of Pharmacy Jilin University Changchun 130021 China

A novel bolaamphiphile surfactant N,N0-（octane-1,8-diyl）bis（pyrrolidine-2-carboxamide）（DAOP）, was designed and synthesized from proline and 1,8-diaminooctane, as the hydrophilic part and hydrophobic part, respectively. After separation and purification, the structures of the synthesized bola surfactants were verified by IR, MS and-1 H NMR. The p Kawas measured by a titration experiment, the turbidity was determined using a Shimadzu UV-1750 spectrophotometer, and the critical micelle concentration（CMC）values of the synthesized surfactants in water were obtained using the conductivity and fluorescence probe measurements. The synthesized bolaamphiphile surfactants demonstrate the ability of selfassemble to form vesicles that were confirmed with dynamic light scattering and transmission electron microscopy. The results showed that the novel bolaamphiphile surfactant derived from proline might potentially be an excellent carrier for drug delivery.

关键词： Bolaamphiphile Proline Vesicles Synthesis Physicochemical characterization

Risk Factors Asscociated with Hypokalemia during Postanesthesia Recovery and Its Impact on Outcomes in Gynecological Patients:A Propensity Score Matching Study

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Current Medical Science 2024年第2期44卷 441-449页

作者： bei-bei WANG Li hu Xin-yue hu Dong HAN Jing WU Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Institute of Anesthesia and Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Key Laboratory of Anesthesiology and Resuscitation(huazhong University of Science and Technology) Ministry of EducationWuhan430022China

Objective:This study aimed to explore the risk factors and outcomes of hypokalemia during the recovery period from anesthesia in the gynecological ***:This retrospective cohort study included 208 patients who underwent gynecological surgery at our institution between January 2021 and March *** were collected for each patient,including demographics,disease status,surgical data,and clinical *** bowel preparation,postoperative gastrointestinal function,and electrolyte levels were compared between the two groups using propensity score matching(PSM).Results:The incidence of hypokalemia(serum potassium level<3.5 mmol/L)during the recovery period from anesthesia was approximately 43.75%.After PSM,oral laxative use(96.4%vs.82.4%,P=0.005),the number of general enemas(P=0.014),and the rate of≥2 general enemas(92.9%vs.77.8%,P=0.004)were identified as risk factors for hypokalemia,which was accompanied by decreased PaCO_(2) and *** were no significant differences in postoperative gastrointestinal outcomes,such as the time to first flatus or feces,the I-FEED score(a scoring system was created to evaluate impaired postoperative gastrointestinal function),or postoperative recovery outcomes,between the hypokalemia group and the normal serum potassium ***:Hypokalemia during postanesthesia recovery period occurred in 43.75%of gynecological patients,which resulted from preoperative mechanical bowel preparation;however,it did not directly affect clinical outcomes,including postoperative gastrointestinal function,postoperative complications,and length of hospital stay.

关键词： hypokalemia gynecological surgery postanesthesia recovery perioperative electrolyte disturbances postoperative recovery

Coupling ideality of standing-wave supermode microresonators

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Photonics Research 2024年第8期12卷 1610-1618页

作者： MIN WANG YUECHEN LEI ZHI-GANG hu CHENGHAO LAO YUANLEI WANG XIN ZHOU JINCHENG LI QI-FAN YANG bei-bei LI beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China School of Physics Beihang UniversityBeijing 100191China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Songshan Lake Materials Laboratory Dongguan 523808China

Standing-wave supermode microresonators that are created through the strong coupling between counter-propagating modes have emerged as versatile platforms for sensing and nonlinear *** example,these microresonators have shown potential in nanoparticle sizing and counting,as well as enhancing the single-photon optomechanical coupling rate of stimulated Brillouin ***,it has been observed that the relation between the mode linewidth and on-resonance transmission of the split supermodes differs obviously from that of the non-split *** behavior is typically quantified by the coupling ideality(I),which remains inadequately explored for the standing-wave *** this study,we theoretically and experimentally investigate the coupling ideality of standing-wave supermodes in a commonly employed configuration involving a Si O2microresonator side-coupled to a tapered *** findings demonstrate that,even with a single-mode tapered fiber,the coupling ideality of the standing-wave supermodes is limited to 0.5,due to the strong backscattering-induced energy loss into the counter-propagating direction,resulting in an additional equivalent parasitic *** achieving a coupling ideality of 0.5 presents challenges for reaching over-coupled regimes,it offers a convenient approach for adjusting the total linewidth of the modes while maintaining critically-coupled conditions.

关键词： ideality mode wave

A PET probe targeting polyamine transport system for precise tumor diagnosis and therapy

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 146-159页

作者： Ming Zhou Xiaoqin Yin bei Chen Shuo hu Wenhu Zhou Department of Nuclear Medicine Xiangya HospitalCentral South UniversityChangsha 410008China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China National Clinical Research Center for Geriatric Disorders(Xiangya) Changsha 410008China

Polyamine metabolism dysregulation is a hallmark of many cancers,offering a promising avenue for early tumor *** study presents the development of a nuclear probe derived from spermidine(SPM)for dual-purpose tumor PET imaging and internal radiation *** probe,radiolabeled with either[68Ga]Ga for diagnostic applications or[177Lu]Lu for therapeutic use,was synthesized with exceptional purity,stability,and specific *** testing involving 12 different tumor cell lines revealed remarkable specificity towards B16 melanoma cells,showcasing outstanding tumor localization and target-to-non-target *** investigations employing polyamines,non-labeled precursor,and polyamine transport system(PTS)inhibitor,consistently affirmed the probe?s targetability through recognition of the ***,while previous reports indicated PTS upregulation in various tumor types for targeted therapy,this study observed no positive signals,highlighting a concentration-dependent discrepancy between targeting for therapy and ***,when labeled with[177Lu],the probe demonstrated its therapeutic potential by effectively controlling tumor growth and extending mouse *** into biodistribution,excretion,and biosafety in healthy humans laid a robust foundation for clinical *** study introduces a versatile SPM-based nuclear probe with applications in precise tumor theranostics,offering promising prospects for clinical implementation.

关键词： PET imaging Polyamine metabolism Spermine Radiopharmaceutical Melanoma

Ethanol extract of Abelmoschus manihot suppresses endoplasmic reticulum stress in contrast-induced nephropathy

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Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 17-27,I0002,I0003页

作者： Xin Lin Xin Lu Yun-He Zhao Yi-bei Wang Ru-Ge Niu Xiao-hu Chen Department of Cardiology Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Chinese MedicineNanjingJiangsu 210004China

Objective:To explore the efficacy and potential mechanisms of the ethanol extract of Abelmoschus manihot(L.)Medic in contrast-induced nephropathy(CIN).Methods:CIN rat models and human renal proximal tubular cells(HK-2)with iopromide-induced injury were employed to mimic CIN *** effect of Abelmoschus manihot extract on the rat models and HK-2 cells was *** rat models,kidney function,histology,oxidative stress and apoptosis were *** HK-2 cells,cell viability,apoptosis,mitochondrial membrane potential,and endoplasmic reticulum stress were ***:Abelmoschus manihot extract significantly improved structural and functional impairments in the kidneys of CIN ***,the extract effectively mitigated the decline in cellular viability and reduced iopromide-induced oxidative stress and lipid *** investigations revealed that Abelmoschus manihot extract prominently attenuated acute endoplasmic reticulum stress-mediated apoptosis by downregulating GRP78 and CHOP protein ***:Abelmoschus manihot extract can be used as a promising therapeutic and preventive agent in the treatment of CIN.

关键词： Contrast-induced nephropathy Abelmoschus manihot extract ER stress Apoptosis GRP78 CHOP

Regulating intramolecular hydrogen bonds of p-phenylenediimidazole-based small-molecule compounds towards the enhanced lithium storage capacity

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Journal of Energy Chemistry 2024年第9期96卷 406-413页

作者： Liping Zheng bei Wang Jianze Zhang Wenjie Zhou Jiayi Ren huige Ma Rui Li Chengming Li Mingjun hu Jun Yang Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China College of Chemistry Nankai UniversityTianjin 300071China School of Materials Science and Engineering Beihang UniversityBeijing 100191China ShenSi Lab Shenzhen Institute for Advanced StudyUniversity of Electronic Science and Technology of ChinaShenzhen 518110GuangdongChina

The use of redox-active organic electrode materials in energy storage is restricted due to their inferior solvent resistance,abysmal conductivity,and the resultant low practical *** address these issues,a class of bipolar p-phenylenediimidazole-based small-molecule compounds are designed and ***π-conjugated backbone of these small molecules allows for electron delocalization on a big conjugation plane,endowing them with good conductivity and reaction ***,when the para-positions of phenylene are occupied by hydroxyl groups,as-formed intramolecular hydrogen bonds(N-H...O)between phenolic hydroxyl groups and the–NH groups of imidazole rings further enhance the structural planarity,resulting in higherπ-conjugation degree and better conductivity,and thus higher utilization of active sites and electrode capacity,proved by both experimental results and theoretical *** optimized composite electrode DBNQ@rGO-45 shows a high specific capacity(∼308 mA h g^(−1)at 100 mA g^(−1))and a long cycling stability(112.9 mA h g^(−1)after 6000 cycles at 2000 mA g^(−1)).The significantly better electrochemical properties for hydroxyl group-containing compounds than those without hydroxyl groups attributed to intramolecular hydrogen bond-induced conjugation enhancement will inspire the structure design of organic electrodes for better energy storage.

关键词： Bipolar P-phenylenedimidazole Intramolecular hydrogenbonds Planarity and conjugationd egree High capacity

Optical-Microwave Entanglement Paves the Way for Distributed Quantum Computation

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Chinese Physics Letters 2024年第1期41卷 21-24页

作者：胡志刚许凯张玉祥李贝贝 beijing National Laboratory for Condensed Matter Physics and Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China

Over the past few years,quantum computation based on superconducting circuits has achieved remarkable progress.A milestone occurred in 2019 when Google released Sycamore,a processor with 54 qubits,and claimed quantum supremacy by performing in just 100 s a specific computation which would take a classical supercomputer,as stated by Google’s team,10000 years to complete.[1]In 2021,a strong quantum advantage was demonstrated by Pan and his colleagues from the University of Science and Technology of China,using a quantum processor named Zuchongzhi,which has 66 functional qubits.[2]This year,the record of the number of quantum qubits has been lifted to 127 qubits.[3]Indeed,the number of qubits is limited to a few hundreds due to the finite space of dilution refrigerators,where the superconducting qubits must be placed to be isolated from thermal ***,this number is still several orders of magnitude away from the requirement of quantum error correction,which is essential for general-purpose quantum computers.[4–8].

关键词： quantum stated correction

Introducing electrolytic electrochemical polymerization for constructing protective layers on Ni-rich cathodes of Li-ion batteries

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Rare Metals 2024年第6期43卷 2536-2545页

作者： Lin-Tao Dou bei Li Hao-Long Nie Dong-Dong Xiao Chao-Qun Shang Xiao-Min Wang Zhan-hui Zhang Katerina E.Aifantis Pu hu School of Materials Science and Engineering Wuhan Institute of TechnologyWuhan 430205China huairou Division Institute of PhysicsChinese Academy of SciencesBeijing 101400China Department of Mechanical and Aerospace Engineering University of FloridaGainesvilleFL 32603USA

LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)is the most promising cathode for high-energy Li-ion batteries,despite its poor cycling stability that originates from the reactions that occur with the ***,to solve this interfacial issue,a facile electrolytic electrochemical polymerization process was introduced in this paper,and a uniform conductive electrolyte interface(polyaniline)was successfully constructed on the surface of the NCM811 porous electrode(PANI-NCM),which facilitated the charge transfer during charge/*** side reactions at the interface between the cathode and the electrolyte are suppressed,and thereby,the cycling performance and rate capability are considerably ***-NCM delivers an initial capacity of 157.2 mAh·g^(-1)as well as excellent cyclability(capacity retention of 88%after 500 cycles at 2C),whereas the capacity of the bare NCM811 has dropped to 31.3 mAh·g^(-1).In addition,polypyrrole and polythiophene also can be formed through electrolytic electrochemical polymerization process,which provides a practicable tactic to modify the interfacial stability of cathodes for high-energy Li-ion batteries.

关键词： Lithium-ion battery Ni-rich cathode In-situ polymerization Conductive polymer Electrochemical performance

Botulinum toxin type A in treating early-stage patients with small-angle acute acquired comitant esotropia

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1094-1101页

作者： Run-Ting Ma Die-Wen-Jie hu Lian-Hong Zhou Wen-Ping Li Yuan-Jin Li bei-Xi Yi Department of Ophthalmology Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

AIM:To investigate botulinum toxin A(BTXA)efficacy on small-angle(≤25Δ)acute acquired concomitant esotropia(AACE)in early-stage ***:The electronic medical record data of AACE patients during March 2019 and June 2023 were collected in this retrospective and hospital-based cohort study.A total of 72 small-angle AACE patients received BTXA extraocular muscle *** were grouped by onset-to-treatment time(Group A:≤6mo,Group B:>6mo).Deviation of esotropia,eye alignment and stereopsis were analyzed at the period of pre/post-injection(1wk,1,3,and 6mo).Orthophoria rate at 6mo(horizontal deviation0.05)between two groups except onset-to-treatment time(2mo vs 11mo,P0.05);while in 3 and 6mo Group A was significantly smaller than group B(all P6mo)may reduce BTXA *** BTXA intervention benefits long-term eye alignment and stereopsis recovery.

关键词： acute acquired comitant esotropia botulinum toxin type A stereopsis