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Journal of Contemporary Educational Research 2024年第2期8卷 208-212页

作者： Yanru li Yu bei Taishan University Taishan 271000Shandong ProvinceChina

The main goal of English teaching in colleges and universities is to cultivate students’ability to use the language,but many students are still unable to complete oral communication fluently after years of *** this reason,teachers need to deeply analyze and study the linguistic features of oral English corpora and formulate reasonable teaching strategies to improve students’oral expression *** paper outlines the linguistic features of oral English corpora,comparatively analyzes the differences between oral English corpora and written English corpora,and explores effective teaching strategies,hoping to provide guidelines for relevant teachers.

关键词： Oral English corpora linguistic features Colleges and universities English teaching

The key role of myostatin b in somatic growth in fishes derived from distant hybridization

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Science China(life Sciences) 2024年第7期67卷 1441-1454页

作者： Qingfeng liu Lujiao Duan bei li Xuanyi Zhang Fanglei liu Jianming Yu Yuqin Shu Fangzhou Hu Jingjing lin Xiaoxia Xiong Shaojun liu State Key Laboratory of Developmental Biology of Freshwater Fish Hunan Normal UniversityChangsha 410081China College of life Sciences Hunan Normal UniversityChangsha 410081China

The basic mechanism of heterosis has not been systematically and completely *** previous studies,we obtained three economically important fishes that exhibit rapid growth,WR(WCC♀×RCC♂),WR-Ⅱ(WR♀×WCC♂),and WR-Ⅲ(WR-Ⅱ♀×4nAU♂),through distant ***,the mechanism underlying this rapid growth remains *** this study,we found that WR,WR-Ⅱ,and WR-Ⅲshowed muscle hypertrophy and higher muscle protein and fat contents compared with their parent species(RCC and WCC).Candidate genes responsible for this rapid growth were then obtained through an analysis of 12 muscle ***,the mRNA level of mstnb(myostatin b),which is a negative regulator of myogenesis,was significantly reduced in WR,WR-Ⅱ,and WR-Ⅲcompared with the parent *** verify the function of mstnb,a mstnb-deficient mutant RCC line was generated using the CRISPR-Cas9 *** average body weight of mstnb-deficient RCC at 12 months of age was significantly increased by 29.57%compared with that in wild-type ***,the area and number of muscle fibers were significantly increased in mstnb-deficient RCC,indicating hypertrophy and ***,the muscle protein and fat contents were significantly increased in mstnb-deficient *** molecular regulatory mechanism of mstnb was then revealed by transcription profiling,which showed that genes related to myogenesis(myod,myog,and myf5),protein synthesis(PI3K-AKT-mTOR),and lipogenesis(pparγand fabp3)were highly activated in hybrid fishes and mstnb-deficient *** study revealed that low expression or deficiency of mstnb regulates somatic growth by promoting myogenesis,protein synthesis,and lipogenesis in hybrid fishes and mstnb-deficient RCC,which provides evidence for the molecular mechanism of heterosis via distant hybridization.

关键词： distant hybridization heterosis somatic growth myostatin b genome editing

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Unleashing the Power of Bio-based Thermotropic liquid Crystal Modifiers:Toughening and Reinforcing Petroleum-based Epoxy Resin without Compromising Other Properties

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Chinese Journal of Polymer Science 2024年第8期42卷 1093-1102页

作者： Qing-Yun Lu Hong-Wei Gu Jia-Hui li Qian-Qian Fan bei-Tao liu Yan Kou Xi-Gao Jian Zhi-Huan Weng State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart MaterialsLiaoning Technology Innovation Center of High Performance Resin MaterialsDepartment of Polymer Science&EngineeringDalian University of TechnologyDalian 116024China Thermochemistry Laboratory Liaoning Province Key Laboratory of Thermochemistry for Energy and MaterialsDalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

Toughening the petroleum-based epoxy resin blends with bio-based modifiers without compromising their modulus,mechanical strength,and other properties is still a big challenge in view of the *** this study,a bio-based liquid crystal epoxy resin(THMT-E P)with an s-triazine ring structure was utilized to modify a petroleum-based bisphenol A epoxy resin(E51)with 4,4'-diaminodiphenylsulfone(DDS)as a curing agent,and the blended systems were evaluated for their thermal stability,mechanical properties,and flame *** results showed that the impact strength of the blended system initially increased and then decreased with the increase in THMT-EP content,and it reached the a maximum value of 26.5 kJ/m^(2)when the THMT-EP content was 5%,which was 31.2%higher than that of E51/***,the flexural strength,modulus,and glass transition tem perature of the blended system were all simultaneously improved with the addition of *** the same time,the addition of THMT-EP enhanced the flame retardancy of the system by increasing the char yield at 700℃and decreasing the peak heat release rate and total heat release *** work paves the way for a more sustainable improvement in the comprehensive performance of epoxy resin.

关键词： Epoxy resin Toughening Bio-based Thermotropic liquid crystal

Traditional Chinese medicine Pien-Tze-Huang ameliorates LPS-induced sepsis through bile acid-mediated activation of TGR5-STAT3-A20 signalling

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Journal of Pharmaceutical Analysis 2024年第4期14卷 601-614页

作者： bei li Yong Zhang Xinyuan liu Ziyang Zhang Shuqing Zhuang Xiaoli Zhong Wenbo Chen Yilin Hong Pingli Mo Shuhai lin Shicong Wang Chundong Yu State Key Laboratory of Cellular Stress Biology School of Life SciencesXiamen UniversityXiamen361102China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development ZhangzhouFujian363000China Xiang'an Hospital of Xiamen University School of MedicineXiamen UniversityXiamen361005China Department of Cardiology Xiamen Key Laboratory of Cardiac ElectrophysiologyXiamen Institute of Cardiovascular DiseasesThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361003China

Pien Tze Huang(PZH),a class-1 nationally protected traditional Chinese medicine(TCM),has been used to treat liver diseases such as hepatitis;however,the effect of PZH on the progression of sepsis is ***,we reported that PZH attenuated lipopolysaccharide(LPS)-induced sepsis in mice and reduced LPS-induced production of proinflammatory cytokines in macrophages by inhibiting the activation of mitogen-activated protein kinase(MAPK)and nuclear factor-kappa B(NF-κB)***,PZH stimulated signal transducer and activator of transcription 3(STAT3)phosphorylation to induce the expression of A20,which could inhibit the activation of NF-κB and MAPK *** of the bile acid(BA)receptor G protein-coupled bile acid receptor 1(TGR5)in macrophages abolished the effects of PZH on STAT3 phosphorylation and A20 induction,as well as the LPS-induced inflammatory response,suggesting that BAs in PZH may mediate its anti-inflammatory effects by activating ***,deprivation of BAs in PZH by cholestyramine resin reduced the effects of PZH on the expression of phosphorylated-STAT3 and A20,the activation of NF-κB and MAPK signalling,and the production of proinflammatory cytokines,whereas the addition of BAs to cholestyramine resin-treated PZH partially restored the inhibitory effects on the production of proinflammatory ***,our study identifies BAs as the effective components in PZH that activate TGR5-STAT3-A20 signalling to ameliorate LPS-induced sepsis.

关键词： Pien Tze Huang Bile acids Sepsis Inflammation TGR5 STAT3-A20 signalling

Steric hindrance modulation of hexaazatribenzanthraquinone isomers for high-capacity and wide-temperature-range aqueous proton battery

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National Science Review 2024年第4期11卷 271-282页

作者： Mingsheng Yang Yuxin Hao bei Wang Yan Wang liping Zheng Rui li Huige Ma Xinyu Wang Xiaoming Jing Hongwei li Mengxiao li Zhihui Wang Yujie Dai Guangcun Shan Mingjun Hu Jun Luo Jun Yang School of Materials Science and Engineering Beihang University beijing Institute of Nanoenergy &Nanosystems Chinese Academy of Sciences Center on Nanoenergy Research School of Physical Science & TechnologyGuangxi University School of Chemistry and Chemical Engineering Center on Nanoenergy Research Guangxi University School of Instrumentation Science and Opto-electronics Engineering Beihang University ShenSi Lab Shenzhen Institute for Advanced StudyUniversity of Electronic Science and Technology of China

Organic materials with rich active sites are good candidates of high-capacity anodes in aqueous batteries,but commonly low utilization of active sites limits their ***,two isomers,symmetric and asymmetric hexaazatribenzanthraquinone（s-HATBAQ and a-HATBAQ）,with rich active sites have been synthesized in a controllable *** has been revealed for the first time that a sulfuric acid catalyst can facilitate the stereoselective formation of *** to the reduced steric hindrance in favor of proton insertion as well as the amorphous structure conducive to electrochemical dynamics,s-HATBAQ exhibits 1.5 times larger specific capacity than ***,the electrode of s-HATBAQ with50% reduced graphene oxide（s-HATBAQ-50%rGO） delivers a record high specific capacity of405 mAh g-1in ***,the assembled MnO2//s-HATBAQ-50%rGO aqueous proton full batteries show an exceptional cycling stability at 25℃ and can maintain ～92% capacity after1000 cycles at 0.5 A g-1at-80℃.This work demonstrates the controllable synthesis of isomers,showcases a wide-temperature-range prototype proton battery and highlights the significance of precise mole cular structure modulation in organic energy storage.

关键词： stereoisomers steric effect aqueous battery super cycling stability ultra-low temperature proton battery

CD147 Facilitates the Pathogenesis of Psoriasis through Glycolysis and H3K9me3 Modification in Keratinocytes

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Research 2024年第1期2023卷 509-523页

作者： Chao Chen Xiaoqing Yi Panpan liu Jie li bei Yan Detian Zhang Lei Zhu Pian Yu Lei li Jiaxiong Zhang Yehong Kuang Shuang Zhao Wu Zhu Cong Peng Xiang Chen Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunanChina National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology ChangshaHunanChina Furong Laboratory ChangshaHunanChina Hunan Key Laboratory of Skin Cancer and Psoriasis Hunan Engineering Research Center of Skin Health and DiseaseXiangya HospitalCentral South UniversityChangshaHunanChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunanChina

Psoriasis is a chronic inflammatory skin disease featuring rapid proliferation of epidermal *** elevated glycolysis flux has been reported in psoriasis,the molecular mechanisms underlying its pathogenesis remain *** investigated the role of the integral membrane protein CD147 in psoriasis pathogenesis,observing its high expression in psoriatic skin lesions of humans and imiquimod(IMQ)-induced mouse *** mouse models,genomic deletion of epidermal CD147 markedly attenuated IMQ-induced psoriatic *** found that CD147 interacted with glucose transporter 1(Glut1).Depletion of CD147 in the epidermis blocked glucose uptake and glycolysis in vitro and in *** CD147-knockout mice and keratinocytes,oxidative phosphorylation was increased in the epidermis,indicating CD147's pivotal role in glycolysis reprogramming during pathogenesis of *** non-targeted and targeted metabolic techniques,we found that epidermal deletion of CD147 significantly increased the production of carnitine and α-ketoglutaric acid(α-KG).

关键词： CD147 pathogenesis markedly

Artificial intelligence models based on non-contrast chest CT for measuring bone mineral density

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中国医学影像技术 2024年第8期40卷 1231-1235页

作者： DUAN Wei YANG Guoqing li Yang SHI Feng YANG lian XIONG Xin CHEN bei li Yong FU Quanshui Department of Medical Imaging North Sichuan Medical CollegeNanchong 637000China Department of Radiology Suining Central HospitalSuining 629000China Department of Radiology Suining Hospital of Traditional Chinese MedicineSuining 629000China Shanghai United Imaging Intelligence Co.Ltd. Shanghai 201807China

Objective To observe the value of artificial intelligence(AI)models based on non-contrast chest CT for measuring bone mineral density(BMD).Methods Totally 380 subjects who underwent both non-contrast chest CT and quantitative CT(QCT)BMD examination were retrospectively enrolled and divided into training set(n=304)and test set(n=76)at a ratio of 8∶*** mean BMD of L1—L3 vertebrae were measured based on *** bones of T5—T10 vertebrae were segmented as ROI,radiomics(Rad)features were extracted,and machine learning(ML),Rad and deep learning(DL)models were constructed for classification of osteoporosis(OP)and evaluating BMD,*** operating characteristic curves were drawn,and area under the curves(AUC)were calculated to evaluate the efficacy of each model for classification of ***-Altman analysis and Pearson correlation analysis were performed to explore the consistency and correlation of each model with QCT for measuring *** Among ML and Rad models,ML Bagging-OP and Rad Bagging-OP had the best performances for classification of *** test set,AUC of ML Bagging-OP,Rad Bagging-OP and DL OP for classification of OP was 0.943,0.944 and 0.947,respectively,with no significant difference(all P>0.05).BMD obtained with all the above models had good consistency with those measured with QCT(most of the differences were within the range of Ax-G±1.96 s),which were highly positively correlated(r=0.910—0.974,all P<0.001).Conclusion AI models based on non-contrast chest CT had high efficacy for classification of OP,and good consistency of BMD measurements were found between AI models and QCT.

关键词： osteoporosis bone density tomography,X-ray computed artificial intelligence

Prevalence of Reproductive Tract Infections and Association with Human Papillomavirus Infection Among Reproductive-Age Women—Six Tertiary Hospitals,China,June 2021-December 2022

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China CDC weekly 2024年第10期6卷 189-194,I0002页

作者： Di Gao Jiayue li Gengli Zhao Zhaohui liu Hui Bi Dai Zhang Fengxia Xue Chen liu Hongtao Ma bei lin Xu Wang Xiaosong Zhang linhong Wang Department of Obstetrics and Gynecology Peking University First HospitalBeijingChina School of Medicine University College DublinIreland beijing Obstetrics and Gynecology Hospital BeijingChina Tianjin Medical University General Hospital TianjinChina Northwest Women’s and Children’s Hospital Xi’an CityShaanxi ProvinceChina Third Affiliated Hospital of Zhengzhou University Zhengzhou CityHenan ProvinceChina Shengjing Hospital of China Medical University Shenyang CityLiaoning ProvinceChina National Center for Chronic and Non-Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?Previous studies have indicated a possible association between reproductive tract infections(RTIs)and highrisk human papillomavirus(HPV)infection,but the evidence is still *** is added by this report?This multicenter study found significantly higher positive rates of HPV,including general HPV,highrisk HPV.

关键词： Tertiary infection Reproductive

Cholangiocarcinoma combined with biliary obstruction:an exosomal circRNA signature for diagnosis and early recurrence monitoring

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2642-2654页

作者： Ningyuan Wen Dingzhong Peng Xianze Xiong Geng liu Guilin Nie Yaoqun Wang Jianrong Xu Shaofeng Wang Sishu Yang Yuan Tian bei li Jiong Lu Nansheng Cheng Division of Biliary Surgery Department of General SurgeryWest China HospitalSichuan UniversityChengduSichuanChina Research Center for Biliary Diseases West China HospitalSichuan UniversityChengduSichuanChina

Cholangiocarcinoma(CCA)is a highly malignant biliary tract cancer with currently suboptimal diagnostic and prognostic *** present a novel system to monitor CCA using exosomal circular RNA(circRNA)via serum and biliary liquid biopsies.A pilot cohort consisting of patients with CCA-induced biliary obstruction(CCA-BO,n=5)and benign biliary obstruction(BBO,n=5)was used to identify CCA-derived exosomal circRNAs through microarray *** was followed by a discovery cohort(n=20)to further reveal a CCA-specific circRNA complex(hsa-circ-0000367,hsa-circ-0021647,and hsa-circ-0000288)in both bile and serum *** vitro and in vivo studies revealed the three circRNAs as promoters of CCA *** and prognostic models were established and verified by two independent cohorts(training cohort,n=184;validation cohort,n=105).An interpreter-free diagnostic model disclosed the diagnostic power of biliary exosomal circRNA signature(Bile-DS,AUROC=0.947,RR=6.05)and serum exosomal circRNA signature(Serum-DS,AUROC=0.861,RR=4.04)compared with conventional CA19-9(AUROC=0.759,RR=2.08).A prognostic model of CCA undergoing curative-intent surgery was established by calculating early recurrence score,verified with bile samples(Bile-ERS,C-index=0.783)and serum samples(Serum-ERS,C-index=0.782).These models,combined with other prognostic factors revealed by COX-PH model,enabled the establishment of nomograms for recurrence monitoring of *** study demonstrates that the exosomal triple-circRNA panel identified in both bile and serum samples serves as a novel diagnostic and prognostic tool for the clinical management of CCA.

关键词： biliary diagnosis Serum

链格孢菌毒素能诱导中国月季产生抗蚜活性的细交链孢菌酮酸（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第4期16卷 264-274页

作者： Fa-zhong YANG Bin YANG bei-bei li Chun XIAO School of Plant Protection Yunnan Agricultural University Key Laboratory of Forest Disaster Warning and Control of Yunnan Province Southwest Forestry University

目的:研究链格孢菌毒素能诱导中国月季植株产生对月季长管蚜的抗性,从而证实寄主植物介导的病虫互作关系的存在,并研究其互作机制。创新点:证实了一种对寄主植物和害虫均无毒性的真菌毒素能使寄主植物产生对昆虫的诱导抗性。方法:马铃... 详细信息

目的:研究链格孢菌毒素能诱导中国月季植株产生对月季长管蚜的抗性,从而证实寄主植物介导的病虫互作关系的存在,并研究其互作机制。创新点:证实了一种对寄主植物和害虫均无毒性的真菌毒素能使寄主植物产生对昆虫的诱导抗性。方法:马铃薯葡萄糖琼脂(PDA)培养基培养链格孢菌获得毒素粗品,大孔树脂纯化后配制成不同浓度的溶液,喷施到中国月季植株上。处理结束后接种月季长管蚜,与对照相比,计算毒素处理对蚜虫的抑制百分数。用高效液相色谱法(HPLC)结合标准品分析毒素中是否存在细交链孢菌酮酸(TeA),并测定其含量。TeA同法处理中国月季植株,测定TeA对蚜虫的抑制率,并与毒素粗品比较。再通过HPLC法测定植物体表和体内残留的TeA,以证明TeA能自然降解完全。结论:(1)链格孢菌粗毒素和对照品TeA均能使中国月季植株产生对月季长管蚜的系统诱导抗性,显著降低月季长管蚜对中国月季的危害;(2)链格孢菌粗毒素中的主要抗蚜活性成分是TeA,TeA有望成为中国月季上具有抗蚜活性的先导化合物;(3)粗毒素和对照品TeA对蚜虫和植物均无伤害作用,但能激活植物对虫害的诱导抗性(ISR)和系统获得性抗性(SAR),可直接证实二者间存在着寄主植物介导的间接的病虫互作关系。

关键词：链格孢菌毒素细交链孢菌酮酸病虫互作关系高效液相色谱法(HPLC) 诱导抗性