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Effect of chidamide on treating hepatosplenic T-cell lymphoma: A case report

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World Journal of Clinical Cases 2020年第14期8卷 3122-3129页

作者： Xing-Tong Wang Wei Guo Mo Sun Wei Han Zhong-Hua du Xiu-Xiu Wang bei-bei du Ou Bai Department of Hematology The First Hospital of Jilin UniversityJilin Provincial Hematology Research InstituteNational Key DisciplineChangchun 130021Jilin ProvinceChina Department of Pathology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Cardiology The Third Hospital of Jilin UniversityChangchunJilin Province 130031China

BACKGROUND Hepatosplenic T-cell lymphoma(HSTCL)is a rare subtype of non-Hodgkin’s lymphoma,which has an aggressive clinical course and an extremely poor *** is a novel,orally active,benzamide-type histone deacetylase(HDAC)inhibitor that has been used for peripheral T-cell lymphoma(PTCL)***,to date,there has been no report of the treatment and effect of the HDAC inhibitor chidamide in HSTCL,which is a special subtype of *** SUMMARY A 45-year-old male patient was admitted with splenomegaly and slight *** was diagnosed with HSTCL via *** patient was treated with fractionated cyclophosphamide,vincristine,doxorubicin,and dexamethasone alternating with high-dose methotrexate and cytarabine regiment as inductive ***,the disease progressed rapidly during chemotherapy before a suitable allogeneic gene transplant donor was *** chidamide-combined chemotherapy regimen and single-drug oral maintenance regimen achieved complete remission,duration of response of 9 mo,and overall survival of 15 *** The novel agent chidamide can be used in HSTCL to achieve deep remission and improve the duration of response and overall survival.

关键词： Hepatosplenic T-cell lymphoma Gamma-delta T-cell lymphoma Chidamide Novel agent Case report

Rescue treatment and follow-up intervention of a left main acute myocardial infarction with typical carina shift under 3D optical coherence tomography: A case report

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World Journal of Clinical Cases 2020年第4期8卷 848-853页

作者： bei-bei du Ya-Liang Tong Xing-Tong Wang Guo-Hui Liu Kun Liu Ping Yang Yu-Quan He Department of Cardiology China-Japan Union Hospital of Jilin UniversityJilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular DiseaseChangchun 130031Jilin ProvinceChina Department of Hematology and Oncology Cancer CenterThe First Hospital of Jilin UniversityChangchun 130031Jilin ProvinceChina

BACKGROUND Coronary intervention for bifurcation lesions is still challenging for interventional *** main(LM)bifurcation lesions have a higher risk due to the vast blood supply in this area and treatment choice is *** compromise of the side branch decreases patient prognosis,and its management is still an issue despite the different strategies and devices *** SUMMARY A 42-year-old male patient was admitted to hospital due to chest pain and *** angiography showed acute LM *** thrombus aspiration,a LM bifurcation lesion *** angiography was repeated one week later,and at the same time,3D optical coherence tomography(OCT)was carried out to better show the geometry of the bifurcation,which confirmed that the stenosis in the ostial left circumflex artery was caused by a long *** assessment of the plaque characteristics and the minimum lumen area,the cross-over strategy,kissing balloon inflation and proximal optimization technique were chosen to treat the bifurcation lesion.A“moving”carina was found twice during the *** stent apposition and expansion were confirmed by OCT after proximal optimization *** three-month follow-up showed good recovery and normal cardiac *** 3D-OCT can facilitate decision-making for coronary interventions in patients with critical bifurcation lesions.

关键词： 3-Dimensional optical coherence tomography Left main bifurcation Acute myocardial infarction Carina shift Kissing balloon inflation Case report

Treatment of severe upper gastrointestinal bleeding caused by Mallory-Weiss syndrome after primary coronary intervention for acute inferior wall myocardial infarction: A case report

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World Journal of Clinical Cases 2019年第24期7卷 4407-4413页

作者： bei-bei du Xing-Tong Wang Xiang-Dong Li Pei-Pei Li Wei-Wei Chen Si-Ming Li Ping Yang Department of Cardiology China-Japan Union Hospital of Jilin UniversityJilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular DiseaseChangchun 130031Jilin ProvinceChina Department of Hematology and Oncology Cancer CenterThe First Hospital of Jilin UniversityChangchun 130031Jilin ProvinceChina

BACKGROUND Upper gastrointestinal bleeding(UGIB) after an acute myocardial infarction(AMI) is not an uncommon complication. Acute UGIB caused by Mallory-Weiss syndrome(MWS) is usually a dire situation with massive bleeding and hemodynamic instability. Acute UGIB caused by MWS after an AMI has not been previously *** SUMMARY A 57-year-old man with acute inferior wall ST elevation myocardial infarction underwent a primary coronary intervention of the acutely occluded right coronary artery. Six hours after the intervention, the patient had a severe UGIB,followed by vomiting. His hemoglobin level dropped from 15.3 g/d L to 9.7 g/d L. In addition to blood transfusion and a gastric acid inhibition treatment,early endoscopy was employed and MWS was diagnosed. Bleeding was stopped by endoscopic placement of titanium *** Bleeding complications after stent implantation can pose a dilemma. MWS is a rare but severe cause of acute UGIB after an AMI that requires an early endoscopic diagnosis and a hemoclip intervention to stop bleeding.

关键词： Acute upper gastrointestinal bleeding Mallory-Weiss syndrome Primary coronary intervention Acute myocardial infarction Endoscopic treatment Case report

Optical coherence tomography guided treatment avoids stenting in an antiphospholipid syndrome patient:A case report

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World Journal of Clinical Cases 2020年第11期8卷 2399-2405页

作者： bei-bei du Xing-Tong Wang Ya-Liang Tong Kun Liu Pei-Pei Li Xiang-Dong Li Ping Yang Ying Wang Department of Cardiology The Third Hospital of Jilin UniversityJilin Provincial Cardiovascular Research InstituteJilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular DiseaseChangchun 130031Jilin ProvinceChina Department of Hematology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Increasing attention has been paid to acute myocardial infarction(AMI)in young female patients for whom secondary factors should be considered during the diagnostic ***-phospholipid syndrome(APS),a rare autoimmune disease that is most common in young female patients,is reportedly related to *** date,coronary interventions,particularly stenting,remains controversial in this special clinical *** SUMMARY A 26-year-old female patient was admitted to hospital for acute chest pain,palpitations,and *** had a past medical history of APS and pulmonary *** angiography showed acute occlusion of the proximal left anterior descending *** repeated thrombus aspirations,residual thrombus and mild stenosis were found in the proximal left anterior descending *** coherence tomography(OCT)was done,which confirmed the non-atherosclerosis coronary thrombosis and an intact intima in this *** or avoiding stenting based on follow-up intracoronary findings with intensified antithrombotic treatment was *** week later,coronary angiography and OCT confirmed an intact intima with no injury and no residual *** 3-mo telephone follow-up reported a good *** APS can cause acute non-atherosclerosis coronary thrombosis which presents as an AMI in young female *** OCT findings can guide interventional strategies in this special clinical scenario.

关键词： Anti-phospholipid syndrome Myocardial infarction Optical coherence tomography Coronary intervention Coronary thrombosis Case report

Clinical utility of left atrial strain in predicting atrial fibrillation recurrence after catheter ablation: An up-to-date review

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World Journal of Clinical Cases 2022年第23期10卷 8063-8075页

作者： Zhi-Xi Yu Wen Yang Wei-Si Yin Ke-Xin Peng Yi-Lin Pan Wei-Wei Chen bei-bei du Yu-Quan He PingYang Department of Cardiology China-Japan Union Hospital of Jilin UniversityChangchun 130022Jilin ProvinceChina Department of Cardiology China-Japan Union Hospital of Jilin UniversityJilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular DiseaseChangchun 130031Jilin ProvinceChina

Rhythm control is the core part of the integrated management of atrial fibrillation(AF),especially in the early *** advances in catheter ablation(CA),the recurrence rate of AF after CA remains *** a result,stratification and early management of AF recurrence after CA are ***,predictors of recurrence of AF after CA are mostly based on dysfunction caused by structural remodeling,apart from traditional risk *** strain is a recently developed important parameter for detecting the deformability of atrial myocardium during the cardiac cycle prior to atrial *** there is only preliminary evidence,atrial strain is still a promising parameter in predicting the recurrence of AF after CA at an early *** review focuses on the evaluation of atrial strain,the current applications of atrial strain in assessing atrial function,and predicting the recurrence of AF after *** summarize the contents related as follows:(1)CA for rhythm control in AF;(2)Evaluation methods of atrial strain;(3)Atrial strain in the remodeling and reverse remodeling of AF;and(4)Clinical applications of atrial strain in predicting the recurrence of AF after *** there is accumulating evidence on the role of decreased atrial strain in the early prediction of AF recurrence,atrial strain is limited in clinical practice for lacking exact cut-off values and difficulty in distinguishing specific function phases of the *** research is needed in the future to add strength to the early prediction value of atrial strain in AF recurrences.

关键词： Atrial strain Atrial remodeling Speckle tracking image Catheter ablation Atrial fibrillation recurrence

高质量发展是全面建设社会主义现代化国家的首要任务

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新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 43-49,F0002页

作者：金碚中国社会科学院工业经济研究所北京100006

党的二十大报告提出以中国式现代化全面推进中华民族伟大复兴,形成对中国式现代化的系统性认知,强调高质量发展是全面建设社会主义现代化国家的首要任务。改革开放以来,在中国共产党的领导下,我国逐步摆脱观念桎梏和教条约束,坚持一切... 详细信息

党的二十大报告提出以中国式现代化全面推进中华民族伟大复兴,形成对中国式现代化的系统性认知,强调高质量发展是全面建设社会主义现代化国家的首要任务。改革开放以来,在中国共产党的领导下,我国逐步摆脱观念桎梏和教条约束,坚持一切从国情出发,创造了人类文明新形态。经济全球化势不可挡,世界必然是和而不同的全球格局,不同文明形态、不同经济体制、不同行为方式共存形成人类命运共同体。这是中国式现代化的底层逻辑,体现了中国经济高质量发展的世界意义。从中国式现代化视角透视高质量发展的深刻叙事,有助于深刻诠释中国式现代化的核心意涵。

关键词：高质量发展中国式现代化体制机制供需相宜因地制宜新质生产力

Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression

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World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： Juan Liu Yan-Ping Guo Yan-Mei Lu bei-Lin Wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(Pduction in HAMD-17 scores(9.38±3.12 vs 15.45±4.86,P<0.05),higher QLQ-C30 scores,and lower CFS scores(both P<0.05).Additionally,the joint intervention group had a lower incidence of adverse reactions and higher nursing satisfaction(P<0.05).CONCLUSION EPI combined with mindfulness intervention significantly improved clinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

食源性单增李斯特菌LPXTG蛋白基因的检测

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中国兽医杂志 2017年第8期53卷 17-21,25页

作者：丁剑马勋陈朔曹树珠王贝贝杜冬冬张奇文石河子大学动物科技学院新疆石河子832000

单核细胞增多性李斯特菌(Listeria monocytogenes,LM)作为四大重要食源性病原菌之一,对人类及多种畜禽健康威胁极大。LM细胞胞壁表面分布多种毒力蛋白,在感染机体过程中发挥重要作用,其中有一类至关重要的表面蛋白其C末端含有保守基序LP... 详细信息

单核细胞增多性李斯特菌(Listeria monocytogenes,LM)作为四大重要食源性病原菌之一,对人类及多种畜禽健康威胁极大。LM细胞胞壁表面分布多种毒力蛋白,在感染机体过程中发挥重要作用,其中有一类至关重要的表面蛋白其C末端含有保守基序LPXTG,分选酶A能够识别基序LPXTG,共价结合到肽聚糖上,呈现在细胞表面发挥毒力作用。本试验以不同食品中分离得到的24株单增李斯特菌为试验对象,设计合成了41对预测含LPXTG基序表面蛋白的引物,利用PCR技术进行扩增,凝胶电泳成像系统检测扩增产物片段大小,计算24株食品源单增李斯特菌LPXTG基序表面蛋白的携带。结果表明,不同LM分离株LPXTG蛋白基因的携带率不同:其中仅有12.5%(3/24)的分离株携带率在85%以上;不同LPXTG蛋白基因的检出率不同,在41个检测对象中,有8个基因的检出率100%,有3个基因的检出率不足20%,Lmo1115基因在所有分离株中均未检测到。本研究对了解食品源LM分离株的LPXTG蛋白基因的分布以及探明食品源LM的致病性具有重要意义。

关键词：单核细胞增多性李斯特菌 LPXTG基序表面蛋白 PCR

Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang Bin Zhang Haobang Liang bei Hu Longlong Ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li Xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke