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Botulinum toxin type A in treating early-stage patients with small-angle acute acquired comitant esotropia

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1094-1101页

作者： Run-Ting Ma Die-Wen-Jie Hu Lian-Hong Zhou Wen-Ping Li Yuan-Jin Li bei-Xi Yi Department of Ophthalmology Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

AIM:To investigate botulinum toxin A(BTXA)efficacy on small-angle(≤25Δ)acute acquired concomitant esotropia(AACE)in early-stage ***:The electronic medical record data of AACE patients during March 2019 and June 2023 were collected in this retrospective and hospital-based cohort study.A total of 72 small-angle AACE patients received BTXA extraocular muscle *** were grouped by onset-to-treatment time(Group A:≤6mo,Group B:>6mo).Deviation of esotropia,eye alignment and stereopsis were analyzed at the period of pre/post-injection(1wk,1,3,and 6mo).Orthophoria rate at 6mo(horizontal deviation0.05)between two groups except onset-to-treatment time(2mo vs 11mo,P0.05);while in 3 and 6mo Group A was significantly smaller than group B(all P6mo)may reduce BTXA *** BTXA intervention benefits long-term eye alignment and stereopsis recovery.

关键词： acute acquired comitant esotropia botulinum toxin type A stereopsis

Improvement for creep strength of a second-generation single crystal superalloy by design of heat treatments

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Rare Metals 2024年第1期43卷 342-350页

作者： Wan-Shun Xia Xin-Bao Zhao Jia-Chen Xu Quan-Zhao Yue Qing-Qing Ding Huan-Chang Duan Yue-Feng Gu Hong-Bin bei Ze Zhang Institute of Superalloys Science and Technology School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Silicon and Advanced Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

Design of heat treatments is related to the key technology for development of nickel-based single crystal superalloys(Ni-SXs). Based on the full understanding of the solidification characteristics, this work applies optimization design of heat treatments for a second-generation Ni-SX. Microstructure evolution and creep properties are compared in the material under conventional/standard(Std.) and optimized(Opt.) treatments. For the Std. sample,strong dendritic segregations determine inconsistent microstructure evolution in the dendritic(D) and interdendritic region(ID), while the latter serves as weak area to have the prior microcrack initiation, damaging overall performance of the alloy. The Opt. treatment applies higher homogenization temperature, leading to overall reduced segregations, while not inducing incipient melting. A lower temperature of first-step ageing is used to lower the size ofγ'particles. These help to form the more uniform microstructure in dendritic and interdendritic region and relieve the inconsistent microstructure evolution. The balanced local strength makes ID no longer as the weak area,thus restricting microcrack initiation. Great improvement of high temperature and low stress property is obtained by this progress, leading to the pronounced increase of creep rupture life under 1100 °C/140 MPa.

关键词： Single crystal superalloy Heat treatment Segregation Solidification Creep property

Bearing mechanism of roof and rib support structure in automatically formed roadway and its support design method

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Journal of Central South University 2024年第7期31卷 2467-2487页

作者： JIANG bei WANG Ming-zi WANG Qi XIN Zhong-xin XING Xue-yang DENG Yu-song YAO Liang-di State Key Laboratory for Tunnel Engineering China University of Mining and Technology-BeijingBeijing 100083China Research Center of Geotechnical and Structural Engineering Shandong UniversityJi􀆳nan 250061China College of Civil Engineering and Architecture Shandong University of AeronauticsBinzhou 256600China

Non-pillar mining technology with automatically formed roadway is a new mining method without coal pillar reservation and roadway *** stability control of automatically formed roadway is the key to the successful application of the new *** order to realize the stability control of the roadway surrounding rock,the mechanical model of the roof and rib support structure is established,and the influence mechanism of the automatically formed roadway parameters on the compound force is *** this basis,the roof and rib support structure technology of confined lightweight concrete is proposed,and its mechanical tests under different eccentricity are carried *** results show that the bearing capacity of confined lightweight concrete specimens is basically the same as that of ordinary confined concrete *** bearing capacity of confined lightweight concrete specimens under different eccentricities is 1.95 times higher than those of U-shaped steel *** comparing the test results with the theoretical calculated results of the confined concrete,the calculation method of the bearing capacity for the confined lightweight concrete structure is *** design method of confined lightweight concrete support structure is established,and is successfully applied in the extra-large mine,Ningtiaota Coal Mine,China.

关键词： automatically roadway with non-pillar confined lightweight concrete roof and rib support mechanical model bearing behaviour

Linguistic Features of Oral English Corpora and Their Implications for English Teaching in Colleges and Universities

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Journal of Contemporary Educational Research 2024年第2期8卷 208-212页

作者： Yanru Li Yu bei Taishan University Taishan 271000Shandong ProvinceChina

The main goal of English teaching in colleges and universities is to cultivate students’ability to use the language,but many students are still unable to complete oral communication fluently after years of *** this reason,teachers need to deeply analyze and study the linguistic features of oral English corpora and formulate reasonable teaching strategies to improve students’oral expression *** paper outlines the linguistic features of oral English corpora,comparatively analyzes the differences between oral English corpora and written English corpora,and explores effective teaching strategies,hoping to provide guidelines for relevant teachers.

关键词： Oral English corpora Linguistic features Colleges and universities English teaching

The key role of myostatin b in somatic growth in fishes derived from distant hybridization

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Science China(Life Sciences) 2024年第7期67卷 1441-1454页

作者： Qingfeng Liu Lujiao Duan bei Li Xuanyi Zhang Fanglei Liu Jianming Yu Yuqin Shu Fangzhou Hu Jingjing Lin Xiaoxia Xiong Shaojun Liu State Key Laboratory of Developmental Biology of Freshwater Fish Hunan Normal UniversityChangsha 410081China College of Life Sciences Hunan Normal UniversityChangsha 410081China

The basic mechanism of heterosis has not been systematically and completely *** previous studies,we obtained three economically important fishes that exhibit rapid growth,WR(WCC♀×RCC♂),WR-Ⅱ(WR♀×WCC♂),and WR-Ⅲ(WR-Ⅱ♀×4nAU♂),through distant ***,the mechanism underlying this rapid growth remains *** this study,we found that WR,WR-Ⅱ,and WR-Ⅲshowed muscle hypertrophy and higher muscle protein and fat contents compared with their parent species(RCC and WCC).Candidate genes responsible for this rapid growth were then obtained through an analysis of 12 muscle ***,the mRNA level of mstnb(myostatin b),which is a negative regulator of myogenesis,was significantly reduced in WR,WR-Ⅱ,and WR-Ⅲcompared with the parent *** verify the function of mstnb,a mstnb-deficient mutant RCC line was generated using the CRISPR-Cas9 *** average body weight of mstnb-deficient RCC at 12 months of age was significantly increased by 29.57%compared with that in wild-type ***,the area and number of muscle fibers were significantly increased in mstnb-deficient RCC,indicating hypertrophy and ***,the muscle protein and fat contents were significantly increased in mstnb-deficient *** molecular regulatory mechanism of mstnb was then revealed by transcription profiling,which showed that genes related to myogenesis(myod,myog,and myf5),protein synthesis(PI3K-AKT-mTOR),and lipogenesis(pparγand fabp3)were highly activated in hybrid fishes and mstnb-deficient *** study revealed that low expression or deficiency of mstnb regulates somatic growth by promoting myogenesis,protein synthesis,and lipogenesis in hybrid fishes and mstnb-deficient RCC,which provides evidence for the molecular mechanism of heterosis via distant hybridization.

关键词： distant hybridization heterosis somatic growth myostatin b genome editing

METTL5 promotes gastric cancer progression via sphingomyelin metabolism

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1925-1946页

作者： Ya-Qiong Zhang Jian Li Zhe Qin De-Ming Li Fang-Zhou Ye Song-Hua bei Xiao-Hong Zhang Li Feng Endoscopy Center Minhang Hospital Affiliated to Fudan UniversityShanghai 201100China

BACKGROUND The treatment of gastric cancer(GC)has caused an enormous social burden *** studies have reported that N6-methyladenosine(m6A)is closely related to tumor ***5 is a m6A methyltransferase that plays a pivotal role in maintaining the metabolic stability of ***,its aberrant regulation in GC has not been fully *** To excavate the role of METTL5 in the development of *** METTL5 expression and clinicopathological characteristics were analyzed via The Cancer Genome Atlas dataset and further verified via immunohistochemistry,western blotting and real-time quantitative polymerase chain reaction in tissue microarrays and clinical *** tumor-promoting effect of METTL5 on HGC-27 and AGS cells was explored in vitro by Cell Counting Kit-8 assays,colony formation assays,scratch healing assays,transwell assays and flow *** tumor-promoting role of METTL5 in vivo was evaluated in a xenograft tumor *** EpiQuik m6A RNA Methylation Quantification Kit was used for m6A ***,liquid chromatography-mass spectrometry was used to evaluate the association between METTL5 and sphingomyelin metabolism,which was confirmed by Enzyme-linked immunosorbent assay and rescue *** addition,we investigated whether METTL5 affects the sensitivity of GC cells to cisplatin via colony formation and transwell *** Our research revealed substantial upregulation of METTL5,which suggested a poor prognosis of GC *** METTL5 expression indicated distant lymph node metastasis,advanced cancer stage and pathological *** increased level of METTL5 correlated with a high degree of m6A ***5 markedly promotes the proliferation,migration,and invasion of GC cells in ***5 also promotes the growth of GC in animal ***5 knockdown resulted in significant changes in sphingomyelin metabolism,which implies that METTL5 may impact the development of GC via sphin

关键词： Gastric cancer METTL5 Sphingomyelin metabolism Cisplatin

Traditional Chinese medicine Pien-Tze-Huang ameliorates LPS-induced sepsis through bile acid-mediated activation of TGR5-STAT3-A20 signalling

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Journal of Pharmaceutical Analysis 2024年第4期14卷 601-614页

作者： bei Li Yong Zhang Xinyuan Liu Ziyang Zhang Shuqing Zhuang Xiaoli Zhong Wenbo Chen Yilin Hong Pingli Mo Shuhai Lin Shicong Wang Chundong Yu State Key Laboratory of Cellular Stress Biology School of Life SciencesXiamen UniversityXiamen361102China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development ZhangzhouFujian363000China Xiang'an Hospital of Xiamen University School of MedicineXiamen UniversityXiamen361005China Department of Cardiology Xiamen Key Laboratory of Cardiac ElectrophysiologyXiamen Institute of Cardiovascular DiseasesThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361003China

Pien Tze Huang(PZH),a class-1 nationally protected traditional Chinese medicine(TCM),has been used to treat liver diseases such as hepatitis;however,the effect of PZH on the progression of sepsis is ***,we reported that PZH attenuated lipopolysaccharide(LPS)-induced sepsis in mice and reduced LPS-induced production of proinflammatory cytokines in macrophages by inhibiting the activation of mitogen-activated protein kinase(MAPK)and nuclear factor-kappa B(NF-κB)***,PZH stimulated signal transducer and activator of transcription 3(STAT3)phosphorylation to induce the expression of A20,which could inhibit the activation of NF-κB and MAPK *** of the bile acid(BA)receptor G protein-coupled bile acid receptor 1(TGR5)in macrophages abolished the effects of PZH on STAT3 phosphorylation and A20 induction,as well as the LPS-induced inflammatory response,suggesting that BAs in PZH may mediate its anti-inflammatory effects by activating ***,deprivation of BAs in PZH by cholestyramine resin reduced the effects of PZH on the expression of phosphorylated-STAT3 and A20,the activation of NF-κB and MAPK signalling,and the production of proinflammatory cytokines,whereas the addition of BAs to cholestyramine resin-treated PZH partially restored the inhibitory effects on the production of proinflammatory ***,our study identifies BAs as the effective components in PZH that activate TGR5-STAT3-A20 signalling to ameliorate LPS-induced sepsis.

关键词： Pien Tze Huang Bile acids Sepsis Inflammation TGR5 STAT3-A20 signalling

Intelligent diagnostic model for pterygium by combining attention mechanism and MobileNetV2

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1184-1192页

作者： Mao-Nian Wu Kai He Yi-bei Yu Bo Zheng Shao-Jun Zhu Xiang-Qian Hong Wen-Qun Xi Zhe Zhang School of Information Engineering Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina Zhejiang Province Key Laboratory of Smart Management and Application of Modern Agricultural Resources Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina School of Mathematical Information Shaoxing UniversityShaoxing 312000Zhejiang ProvinceChina Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina

AIM:To evaluate the application of an intelligent diagnostic model for ***:For intelligent diagnosis of pterygium,the attention mechanisms—SENet,ECANet,CBAM,and Self-Attention—were fused with the lightweight MobileNetV2 model structure to construct a tri-classification *** study used 1220 images of three types of anterior ocular segments of the pterygium provided by the Eye Hospital of Nanjing Medical *** classification models—VGG16,ResNet50,MobileNetV2,and EfficientNetB7—were trained on the same dataset for *** evaluate model performance in terms of accuracy,Kappa value,test time,sensitivity,specificity,the area under curve(AUC),and visual heat map,470 test images of the anterior segment of the pterygium were ***:The accuracy of the MobileNetV2+Self-Attention model with 281 MB in model size was 92.77%,and the Kappa value of the model was 88.92%.The testing time using the model was 9ms/image in the server and 138ms/image in the local *** sensitivity,specificity,and AUC for the diagnosis of pterygium using normal anterior segment images were 99.47%,100%,and 100%,respectively;using anterior segment images in the observation period were 88.30%,95.32%,and 96.70%,respectively;and using the anterior segment images in the surgery period were 88.18%,94.44%,and 97.30%,***:The developed model is lightweight and can be used not only for detection but also for assessing the severity of pterygium.

关键词： deep learning attention mechanism pterygium intelligent diagnosis

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可能世界理论视域下的跨界叙事

文艺理论研究 2024年第1期44卷 157-164页

作者：邱蓓深圳技术大学外国语学院

跨界是一种特殊的叙事现象,是指文学作品中的人物、情节、场景等从一个叙事空间迁移到另一个叙事空间。借助可能世界理论中的“跨界同一性”(transworld identity)和“客观对应物”(counterpart)这两个核心概念,可以把跨界叙事划分为纵... 详细信息

跨界是一种特殊的叙事现象,是指文学作品中的人物、情节、场景等从一个叙事空间迁移到另一个叙事空间。借助可能世界理论中的“跨界同一性”(transworld identity)和“客观对应物”(counterpart)这两个核心概念,可以把跨界叙事划分为纵向跨界叙事和横向跨界叙事两大类型,其中纵向跨界又可以分为下降跨界叙事和上升跨界叙事,而横向跨界叙事则可以细分为同文本横向跨界叙事和跨文本横向跨界叙事。利用可能世界理论的方法对跨界叙事问题进行系统的分类研究,可以从新的视角审视元小说、平行世界、衍生、戏仿、挪用等后现代文学现象,探讨跨界叙事产生的效果。

关键词：纵向跨界叙事横向跨界叙事可能世界理论跨界叙事同一体客观对应物