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Natural,synthetic and commercially-available biopolymers used to regenerate tendons and ligaments

Bioactive Materials 2023年第1期19卷 179-197页

作者： behzad shiroud heidari Rui Ruan Ebrahim Vahabli Peilin Chen Elena M.De-Juan-Pardo Minghao Zheng Barry Doyle Vascular Engineering Laboratory Harry Perkins Institute of Medical ResearchQEII Medical Centre and the UWA Centre for Medical ResearchThe University of Western AustraliaNedlands6009Australia School of Engineering The University of Western AustraliaPerthAustralia Australian Research Council Centre for Personalised Therapeutics Technologies Australia Division of Surgery(Orthopaedics) Medical SchoolThe University of Western AustraliaPerthAustralia T3mPLATE Harry Perkins Institute of Medical ResearchQEII Medical Centre and the UWA Centre for Medical ResearchThe University of Western AustraliaNedlands6009Australia Science and Engineering Faculty Queensland University of TechnologyBrisbaneQueenslandAustralia Perron Institute for Neurological and Translational Science Nedlands6009Australia BHF Centre for Cardiovascular Science The University of EdinburghUK

Tendon and ligament(TL)injuries affect millions of people *** play a significant role in TL tissue repair,whether the treatment relies on tissue engineering strategies or using artificial tendon *** biopolymer governs the mechanical properties,biocompatibility,degradation,and fabrication method of the TL *** natural,synthetic and hybrid biopolymers have been studied in TL regeneration,often combined with therapeutic agents and minerals to engineer novel scaffold ***,most of the advanced biopolymers have not advanced to clinical use ***,we aim to review recent biopolymers and discuss their features for TL tissue *** introducing the properties of the native tissue,we discuss different types of natural,synthetic and hybrid biopolymers used in TL tissue ***,we review biopolymers used in commercial absorbable and non-absorbable TL ***,we explain the challenges and future directions for the development of novel biopolymers in TL regenerative treatment.

关键词： Synthetic biopolymers Natural biopolymers Hybrid composites Tendon scaffolds Commercial grafts

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Novel hybrid biocomposites for tendon grafts:The addition of silk to polydioxanone and poly(lactide-co-caprolactone)enhances material properties,in vitro and in vivo biocompatibility

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Bioactive Materials 2023年第7期25卷 291-306页

作者： behzad shiroud heidari Emma Muiños Lopez Emma Harrington Rui Ruan Peilin Chen Seyed Mohammad Davachi Benjamin Allardyce Rangam Rajkhowa Rodney Dilley Froilán Granero-Moltó Elena M.De-Juan-Pardo Minghao Zheng Barry Doyle Harry Perkins Institute of Medical Research QEII Medical CentreNedlands and the UWA Centre for Medical ResearchThe University of Western AustraliaPerthAustralia School of Engineering The University of Western AustraliaPerthAustralia Australian Research Council Centre for Personalised Therapeutics Technologies Australia Cell Therapy Area Centro de Investigaci´on M´edica AplicadaIDISNAUniversidad de NavarraPamplonaSpain Centre for Orthopaedic Research Faculty of Health and Medical SciencesThe University of Western AustraliaPerthAustralia Department of Biology and Chemistry Texas A&M International UniversityLaredoTXUSA Institute for Frontier Materials Deakin UniversityGeelongVIC3216Australia Perron Institute for Neurological and Translational Science NedlandsWestern AustraliaAustralia

Biopolymers play a critical role as scaffolds used in tendon and ligament(TL)*** advanced biopolymer materials have been proposed with optimised mechanical properties,biocompatibility,degradation,and processability,it is still challenging to find the right balance between these ***,we aim to develop novel hybrid biocomposites based on poly(p-dioxanone)(PDO),poly(lactide-co-caprolactone)(LCL)and silk to produce high-performance grafts suitable for TL tissue *** containing 1-15%of silk were studied through a range of characterisation *** then explored biocompatibility through in vitro and in vivo studies using a mouse *** found that adding up to 5%silk increases the tensile properties,degradation rate and miscibility between PDO and LCL phases without agglomeration of silk inside the ***,addition of silk increases surface roughness and *** vitro experiments show that the silk improved attachment of tendon-derived stem cells and proliferation over 72 h,while in vivo studies indicate that the silk can reduce the expression of pro-inflammatory cytokines after six weeks of ***,we selected a promising biocomposite and created a prototype TL graft based on extruded *** found that the tensile properties of both individual fibres and braided grafts could be suitable for anterior cruciate ligament(ACL)repair applications.

关键词： Biocomposite Tendon graft Silk Fibre extrusion Biodegradable scaffolds Anterior cruciate ligament

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Warpage and Shrinkage Optimization of Injection-Molded Plastic Spoon Parts for Biodegradable Polymers Using Taguchi, ANOVA and Artificial Neural Network Methods

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Journal of Materials Science & Technology 2016年第8期32卷 710-720页

作者： Erfan Oliaei behzad shiroud heidari Seyed Mohammad Davachi Mozhgan Bahrami Saeed Davoodi Iman Hejazi Javad Seyfi Applied Science Nano Research Group ASNARKA P.C. *** Tehran Iran Macromolecular Science and Engineering University of Michigan Ann Arbor Michigan 48109-2136. United States Department of Chemical Engineering Shahrood Branch Islamic Azad University RO. Box 36155-163 Shahrood lran

In this study, it is attempted to give an insight into the injection processability of three self-prepared polymers from A to Z. This work presents material analysis, injection molding simulation, design of ex- periments alongside considering all interaction effects of controlling parameters carefully for green biodegradable polymeric systems, including polylactic acid （PLA）, polylactic acid-thermoplastic poly- urethane （PLA-TPU） and polylactic acid-thermoplastic starch （PLA-TPS）. The experiments were carried out using injection molding simulation software Autodesk Moldflov~~ in order to minimize warpage and volumetric shrinkage for each of the mentioned systems. The analysis was conducted by changing five significant processing parameters, including coolant temperature, packing time, packing pressure, mold temperature and melt temperature. Taguchi＇s [.27 （35） orthogonal array was selected as an efficient method for design of simulations in order to consider the interaction effects of the parameters and reduce spu- rious simulations. Meanwhile, artificial neural network （ANN） was also used for pattern recognition and optimization through modifying the processing conditions. The Taguchi coupled analysis of variance （ANOVA） and ANN analysis resulted in definition of optimum levels for each factor by two completely different methods. According to the results, melting temperature, coolant temperature and packing time had significant influence on the shrinkage and warpage. The ANN optimal level selection for minimiza- tion of shrinkage and/or warpage is in good agreement with ANOVA optimal level selection results. This investigation indicates that PLA-TPU compound exhibits the highest resistance to warpage and shrink- age defects compared to the other studied compounds.

关键词： Injection molding simulation Yaguchi Artificial neural networks Biodegradable plastic Disposable spoons

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