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Effects of L-arginine supplementation on glycemic profile: Evidence from a systematic review and meta-analysis of clinical trials

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Journal of Integrative Medicine 2020年第4期18卷 284-291页

作者： Esmaeil Yousefi Rad behzad nazarian Somayeh Saboori Ebrahim Falahi Azita Hekmatdoost Nutritional Health Research Center Lorestan University of Medical SciencesKhorramabad ***Iran Student Research Committee Lorestan University of Medical SciencesKhorramabad ***Iran Department of Clinical Nutrition and Dietetics Faculty of Nutrition and Food TechnologyNational Nutrition and Food TechnologyResearch InstituteShahid Beheshti University of Medical SciencesTehran ***Iran Division of Gastroenterology Hepatology and NutritionBritish Columbia’s Children’s Hospital and Child and Family Research Institutethe University of British ColumbiaBritish Columbia ***Canada

Background:The effects of l-arginine supplementation on indices of glycemic control and the role of many factors influencing this intervention have been controversial in clinical ***:This meta-analysis was performed to assess the effects of l-arginine supplementation on indices of glycemic control,including fasting blood glucose(FBG),hemoglobin A1c(HbA1c),serum insulin and homeostatic model assessment of insulin resistance(HOMA-IR)levels in randomized controlled trials(RCTs).Search strategy:This study conducted a systematic review of RCTs published in PubMed,Scopus,Web of Science,Cochrane Library and Embase,up to 5 May,*** criteria:Studies were included in this meta-analysis if they were RCTs with parallel design and reported sufficient data on participants before and after intervention,and outcomes of glycemic profile parameters in both the arginine supplementation and control *** extraction and analysis:The screening of titles and abstracts was performed independently by two *** articles were considered if they met the study’s inclusion *** quality of included studies was assessed by using the Cochrane Collaboration modified *** 710 articles retrieved in the initial search,only 10 trials were suitable for pooling the effects of arginine supplementation on serum glucose,insulin,HOMA-IR and HbA1c levels,with effect sizes of nine,eight,five and five,***:Pooled random-effect analysis revealed that l-arginine supplementation could significantly decrease FBG level(weighted mean difference[WMD]:3.35 mg/dL;95%confidence interval[CI]=[−6.55,−0.16];P=0.04)and serum insulin level(WMD:−2.19μIU/mL;95%CI=[−3.70,−0.67];P=0.005).However,the effects of l-arginine supplementation on HOMA-IR and HbA1c were not *** of subgroup analysis showed that supplementation with l-arginine could significantly decrease serum insulin levels when the dosage of l-arginine is>6.5 g/d(WMD:−3.49μIU/mL;95%CI=

关键词： l-arginine Fasting blood glucose Insulin resistance Hemoglobin A1c Glycemic profile Meta-analysis

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