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Hepatoprotective and cytoprotective properties of Hyptis suaveolens against oxidative stress-induced damage by CCl_4 and H_2O_2

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Asian Pacific Journal of Tropical Medicine 2012年第11期5卷 868-874页

作者： Hadi Ghaffari behrouz jalali ghassam HS Prakash Department of Studies in Biotechnology University of MysoreManasagangotriMysore570006KarnatakaIndia

Objective:To investigate capacity of Hyptis suaveolens(***) methanol extract as an antioxidant to protect against carbon tetrachloride(CCl_4)-indueed oxidative stress,hepatotoxicitv in Albino Wistar rats and cytoprotective effect of hydrogen peroxide(H_2O_2) induced cell death in HepG_2 cell ***:Two different doses of methanol extract of *** were evaluated for the hepatoprotective activity against carbon tetrachloride(CCl_4) induced hepatotoxicitv in *** in GroupⅠ:served as control,groupⅡ:***(100 mL/ kg b.w),groupⅢ:***(50 mL/kg b.w) + CCl_4(1 mg/kg),groupⅣ:***(100 mL/kg b.w) + CCl_4(1 ml/kg)and groupⅤ:CCl_4(1 mL/kg).Histopathologic changes of liver were also *** was also determined by 3,(4,5-dimethylthiazol-2-yl)2,5-diphenyl-tetrazolium bromide(MTT) ***:Oral sigle dose treatment of CCl_4 produced a marked elevation in the serum levels of aspartate transaminase(AST),alanine transaminase(ALT), alkaline phosphatase(ALP) and Lactate dehydrogenase(LDH).Histopathological analysis of the liver of CCl_4-induced rats revealed marked liver cell necrosis with inflammatory collections that were conformed to increase in the levels of SOD,GSH,GST,GR and *** with H_2O_2 significantly induced death of HepG_2 *** with *** methanol extract inhibited or attenuated H_2O_2 induced ***:This study shows that *** methanol extract can be proposed to protect the liver against CCl_4-induced oxidative damage in rats and protect the cells against H_2O_2-induced oxidative damage in HepG_2 *** hepatoprotective and cytoprotective effects might be correlated with its antioxidant and free radical scavenger effects.

关键词： Hyptis suaveolens Antioxidant enzymes Lipid peroxidation HepG_2 cell line Hydrogen peroxide MTT assay

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