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Combinative approach of transzonular triamcinolonemoxifloxacin and perioperative drops to minimize postoperative complications of cataract surgery

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 845-851页

作者： behnam Rabiee Muhamad Festok Michael Gaspari Abid Haseeb Aaila Chaudhry Layla Kamoun Imtiaz Chaudhry Iftikhar Chaudhry Department of Ophthalmology Trinity Health Mid-AtlanticNazareth HospitalPhiladelphiaPA 19020USA IC Laser Eye Care BensalemPA 19020USA

AIM: To investigate the effectiveness of combinationtherapy with transzonular triamcinolone-moxifloxacin andconventional perioperative drops in reducing postoperativecomplications of cataract surgery. METHODS: Electronic medical records of cataractsurgery patients (single surgeon) were reviewed fromJanuary 2018 to September 2021. The rate of postoperativecomplications including prolonged and/or recurrentpostoperative inflammation, endophthalmitis, cystoid macularedema (CME), and intraocular pressure (IOP) was comparedbetween the patients receiving combinative therapy andpatients receiving drops only. RESULTS: Totally 596 patients and 1057 eyes(Combinative-Therapy group 493 and Drop-Only group 564)were included in this study. Using combination therapyreduced the relative risk of postoperative inflammationby 26.9% (16.6% Combinative-Therapy vs 22.7% Drop-Only, P=0.013). The incidence of endophthalmitis was 0in Combinative-Therapy group vs 0.5% in Drop-Only group(relative risk reduction 100%), although not statisticallysignificant (P=0.10). The incidence of severe IOP spikeswas not significantly different between Combinative-Therapy (2.4%) and Drop-Only (1.6%) groups (P=0.33).The relative risk of postoperative CME was 51.4% less inthree months follow up visit in Combinative-Therapy group,although not statistically significant (P=0.07). The visualoutcome 1-month postop. (best corrected visual acuity) wassignificantly better in Combinative-Therapy (logMAR 0.10)compared to Drop-Only (logMAR 0.14) groups (P=0.02) whilethe baseline visual acuity was not significantly different. CONCLUSION: The combinative approach oftranszonular triamcinolone-moxifloxacin plus perioperativeeyedrops is an effective method to minimize postoperativeinflammation, with better visual outcomes. It couldpotentially reduce the risk of postoperative endophthalmitisand CME (near-significant P-values;larger studies couldanalyze better considering low incidence).

关键词： cataract endophthalmitis cystoid macular edema postoperative complications transzonular injection

Effect of alumina and silica nanocomposite based on polyacrylamide on light and heavy oil recovery in presence of formation water using micromodel

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Petroleum 2024年第2期10卷 338-353页

作者： Ashkan Maleki behnam Sedaee Alireza Bahramian Sajjad Gharechelou Nahid Sarlak Arash Mehdizad Mohammad reza Rasaei Aliakbar Dehghan Science and Research Branch Islamic Azad University Institute of Petroleum Engineering School of Chemical Engineering University of Tehran School of Geology College of Science University of Tehran Department of Chemistry Lorestan University Iranian Offshore Oil Company

Increasing world request for energy has made oil extraction from reservoirs more desirable. Many novel EOR methods have been proposed and utilized for this purpose. Using nanocomposites in chemical flooding is one of these novel methods. In this study, we investigated the impact of six injection solutions on the recovery of light and heavy oil with the presence of two different brines as formation water using a homogenous glass micromodel. All of the injection solutions were based on a 40,000 ppm Na Cl synthetic seawater(SSW), one of which was additive free and the others were prepared by dispersing nanocomposite silica-based polyacrylamide(NCSP), nanocomposite alumina-based polyacrylamide(NCAP), the combination of both nanocomposites silica and alumina based on polyacrylamide(NCSAP),surfactant(CTAB) and polyacrylamide(PAM) with a concentration of 1000 ppm as additives. The Stability of nanocomposites was tested against the salinity of the brine and temperature using salinity and DSC tests which were successful. Alongside stability tests, IFT, contact angle and oil recovery measurements were made. Visual results revealed that in addition to the effect of silica and alumina nanocomposite in reducing interfacial tension and wettability alteration, control of mobility ratio caused a major improvement in sweeping efficiency and oil recovery. According to the sweeping behavior of injected fluids, it was found that the main effect of surfactant was wettability alteration, for polyacrylamide was mobility control and for nanocomposites was the reduction of interfacial tension between oil and injected fluid, which was completely analyzed and checked out. Also, NCSAP with 95.83% and 70.33% and CTAB with 84.35% and 91% have the highest light oil recoveries at 250,000 ppm and 180,000 ppm salinity, respectively which is related to the superposition effect of interactions between nanocomposites, solution and oil. Based on our results it can be concluded that the most effective me

关键词： Enhanced oil recovery Micromodel Polyacrylamide Nanocomposite Salinity Alumina and silica nanoparticles

Effects of L-carnitine on treatment outcomes of COVID-19 patients hospitalized in intensive care units:A double-blind randomized clinical trial

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Journal of Acute Disease 2024年第3期13卷 100-105页

作者： Hesameddin Modir behnam Mahmoudieh Seyed Yousef Shahtaheri Fariba Farokhi Department of Anesthesiology and Critical Care Arak University of Medical SciencesArakIran Clinical Research Development Valiasr HospitalArak University of Medical SciencesArakIran

Objective:To assess the effects of L-carnitine on the outcomes of patients with moderate to severe coronavirus disease 2019(COVID-19)in intensive care unit(ICU).Methods:This double-blind clinical trial was carried out in 2022-2023.64 Patients with COVID-19 were selected from Amiralmomenin and Khansari hospitals in Arak,*** were randomly assigned to the control and the L-carnitine treatment group via block *** blood gases,disease severity,and levels of D-dimer,lactate dehydrogenase,ferritin,and C-reactive protein were daily assessed during the seven days of the intervention,and the length of ICU stay,the need for endotracheal intubation,and mortality rate were ***:There were significant differences in length of ICU stay,the need for endotracheal intubation,and levels of D-dimer,lactate dehydrogenase,ferritin,APACHE栻score,and C-reactive protein between the two groups(P0.05).Conclusions:L-carnitine can improve outcomes of patients with ***,it can be used as an adjuvant therapy for these patients.

关键词： L-carnitine COVID-19 ICU Critically ill Mortality Clinical outcome

Modelling the development of biological structures displaying longitudinal geometries in vitro:culturing pluripotent stem cells on plasma-treated,growth factor-coupled polycaprolactone fibres

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Engineered Regeneration 2024年第1期5卷 124-138页

作者： Badwi B.Boumelhem Stuart T.Fraser Syamak Farajikhah Rachel A.Shparberg Michael B.Morris Marcela M.M.Bilek Anyu Zhang behnam Akhavan Simon Fleming Maryanne Large School of Physics Faculty of ScienceUniversity of SydneyAustralia Sydney Nano Institute University of SydneyAustralia School of Chemical and Biomolecular Engineering University of SydneyAustralia School of Medical Sciences Faculty of Medicine and HealthUniversity of SydneyAustralia School of Biomedical Engineering Faculty of EngineeringUniversity of SydneyAustralia School of Engineering University of NewcastleCallaghanNSW 2308Australia Hunter Medical Research Institute(HMRI) Precision Medicine ProgramNew Lambton Heights NSW 2305Australia

Many biological structures such as nerves,blood and lymphatic vessels,and muscle fibres exhibit longitudinal ge-ometries with distinct cell types extending along both the length and width of internal linear *** these three-dimensional structures in vitro is challenging:the best-defined stem-cell differentiation systems are mono-layer cultures or organoids using pluripotent stem *** stem cells can differentiate into functionally mature cells depending on the signals received,holding great promise for regenerative ***,the integration of in vitro differentiated cell types into diseased tissue remains a *** scaffolds can bridge this gap if the appropriate signalling systems are incorporated into the ***,we have taken a biomimicry approach to generate longitudinal structures in *** this approach,mouse embryonic stem cells are directed to differentiate to specific cell types on the surface of polycaprolactone(PCL)fibres treated by plasma-immersion ion implantation and to which with lineage-specifying molecules have been covalently *** demonstrate the simplicity and utility of our method for efficiently generating high yields of the following cell types from these pluripotent stem cells:neurons,vascular endothelial cells,osteoclasts,adipocytes,and cells of the erythroid,myeloid,and lymphoid *** arranged plasma-treated scaffolds with differentiated cell types could ultimately serve as a means for the repair or treatment of diseased or damaged tissue.

关键词： Pluripotent stem cells Lineage commitment Growth factors Biomaterial engineering Plasma-immersion ion implantation Covalent biomolecule attachment Polycaprolactone

Efficacy and safety of bamlanivimab in patients with COVID-19:A systematic review and meta-analysis

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World Journal of Virology 2024年第1期13卷 120-132页

作者： behnam Amani Lida Khodavirdilou Kourosh Rajabkhah Vida Kardan Moghaddam Arash Akbarzadeh Bahman Amani Department of Health Management and Economics School of Public HealthTehran University of Medical SciencesTehran ***Iran Department of Pharmaceutical Sciences Jerry H.Hodge School of PharmacyTexas Tech University Health Sciences CenterAmarilloTX 79106United States Deputy of Research and Technology Tehran University of Medical SciencesTehran ***Iran School of Medicine and Dentistry Griffith UniversityQueenslandBrisbane 4222Australia Department of Epidemiology and Biostatistics School of Public HealthTehran University of Medical SciencesTehran ***Iran

BACKGROUND Monoclonal antibodies(mAbs)have shown clinical benefits against coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Several studies have reported the use of bamlanivimab as a promising treatment option for *** To synthesize the latest evidence for the efficacy and safety of bamlanivimab alone in the treatment of adult patients with *** A literature search was conducted in PubMed,Cochrane Library,Web of Science,medRxiv,and Google Scholar using“SARS-CoV-2”,“COVID-19”,“LY-CoV555”,and“Bamlanivimab”keywords up to January 25,*** quality of included studies was assessed using the Cochrane bias *** Comprehensive Meta-Analysis software version 3.0 was used to analyze the *** A total of 30 studies involving 47368 patients were included.A significant difference was observed between the bamlanivimab and standard of care/placebo groups in terms of mortality rate[risk ratio(RR)=50,95%confidence interval(CI):0.36-0.70],hospitalization rate(RR=0.51;95%CI:0.39-0.68),and emergency department(ED)visits(RR=0.69;95%CI:0.47-0.99);while the two groups exhibited no significant difference in terms of intensive care unit(ICU)admission(P>0.05).Compared to other mAbs,bamlanivimab was associated with a higher rate of hospitalization(RR=1.44;95%CI:1.07-1.94).However,no significant difference was detected between the bamlanivimab and other mAbs groups in terms of mortality rate,ICU admission,and ED(P>0.05).The incidence of any adverse events was similar between the bamlanivimab and control groups(P>0.05).CONCLUSION Although the results suggest the efficacy and safety of bamlanivimab in COVID-19 patients,further research is required to confirm the efficacy of this drug for the current circulating SARS-CoV-2 variants.

关键词： SARS-CoV-2 COVID-19 Bamlanivimab Monoclonal antibody Meta-analysis

Post-discharge follow-up of patients with spine trauma in the National Spinal Cord Injury Registry of Iran during the COVID-19 pandemic:Challenges and lessons learned

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Chinese Journal of Traumatology 2024年第3期27卷 173-179页

作者： Zahra Azadmanjir Moein Khormali Mohsen Sadeghi-Naini Vali Baigi Habibollah Pirnejad Mohammad Dashtkoohi Zahra Ghodsi Seyed behnam Jazayeri Aidin Shakeri Mahdi Mohammadzadeh Laleh Bagheri Mohammad-Sajad Lotfi Salman Daliri Amir Azarhomayoun Homayoun Sadeghi-Bazargani Gerard O'reilly Vafa Rahimi-Movaghai Health Information Management Department School of Allied Medical SciencesTehran University of Medical SciencesTehranIran Sina Trauma and Surgery Research Center Tehran University of Medical SciencesTehranIran Department of Neurosurgery Lorestan University of Medical SciencesKhoram-AbadIran Department of Epidemiology and Biostatistics School of Public HealthTehran University of Medical SciencesTehranIran Patient Safety Research Center Clinical Rsearch Institute Urma Universty of Medical SciencesUrmaIran Erasmus School of Health Policy&Management(ESHPM) Erasmus University RotterdamRoterdamthe Netherlands Brain and Spinal Cord Injury Research Center Neuroscience InstituteTehran University of Medical SciencesTehranIran Students Scientifc Research Center(SSRC) Tehran University of Medical SciencesTehranIran Department of Neurosurgery Arak University of Medical SciencesArakIran Trauma Research Center Kashan University of Medical SciencesKashanIran Shahid Rahnemoun Hospital Shahid Sadoughi University of Medical SciencesYazdIran Trauma Nuring Rearch entre Faculty of Nursing and Midwifry Kahan Universty of Medical Sciences Kahan Iran Clinical Research Development Unit Imam Hossein HospitalShahroud University of Medical SciencesShahroudIran Research Center for Evidence Based Medicine Faculty of MedicineTabriz University of Medical SciencesTabrizIran Road Trafic Injury Research Center Tabriz University of Medical SciencesTabrizIran School of Public Health and Preventive Medicine Monash UniversityMelbourneAustralia National Trauma Research Institute The AlfredMelbourneAustralia Department of Neurosurgery Shariati HospitalTehran University of Medical SciencesTehranIran Universal Scientific Education and Research Network(USERN) TehranIran Institute of Biochemistry and Biophysics University of TehranTehranIran

Purpose:The purpose of the National Spinal Cord Injury Registry of Iran(NSCIR-IR)is to create an infrastructure to assess the quality of care for spine trauma and in this study,we aim to investigate whether the NSCIR-IR successfully provides necessary post-discharge follow-up data for these ***:An observational prospective study was conducted from April 11,2021 to April 22,2022 in 8 centers enrolled in NSCIR-IR,respectively Arak,Rasht,Urmia,Shahroud,Yazd,Kashan,Tabriz,and *** were classified into 3 groups based on their need for care resources,respectively:(1)non-spinal cord injury(SCI)patients without surgery(group 1),(2)non-SCI patients with surgery(group 2),and(3)SCI patients(group 3).The assessment tool was a self-designed questionnaire to evaluate the care quality in 3 phases:pre-hospital,in-hospital,and *** data from the first 2 phases were collected through the *** post-hospital data were collected by conducting follow-up *** follow-ups were conducted for groups 1 and 2(non-SCI patients),while group 3(SCI patients)had a face-to-face *** study took place during the COVID-19 *** on age and time interval from injury to follow-up were expressed as mean±standard deviation(SD)and response rate and follow-up loss as a ***:Altogether 1538 telephone follow-up records related to 1292 patients were registered in the *** the total calls,918(71.05%)were related to successful follow-ups,but 38 cases died and thus were excluded from data *** the end,post-hospital data from 880 patients alive were *** success rate of follow-ups by telephone for groups 1 and 2 was 73.38%and 67.05%respectively,compared to 66.67%by face-to-face visits for group 3,which was very hard during the COVID-19 *** data completion rate after discharge ranged from 48%-100%,22%-100%and 29%-100%for groups ***:To improve patient accessibility,NSCIR-IR should take me

关键词： Follow-up studies Spinal injuries Spinal cord injuries COVID-19 NSCIR-IR

Pure annihilation decay of strange beauty meson into two charm heavy mesons

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Chinese Physics C 2022年第2期46卷 62-69页

作者： behnam Mohammadi Department of Physics Urmia UniversityUrmiaIran

In this study,the heavy to heavy decay of D^(0)_(s)→D^(*+)D^(-)is evaluated through the factorization approach by using the final state interaction as an effective *** the factorization approach,this decay mode occurs only through the annihilation process,so a small amount is ***'s rules state that six meson pairs can be assumed for the intermediate states before the final meson pairs are *** taking into account the effects of twelve final state interaction diagrams in the calculations,a significant correction is *** effects correct the value of the branching ratio obtained by the pure factorization approach from(2.41±1.37)×10^(-5)to(8.27土2.23)×10^(-5).The value obtained for the branching ratio of the D^(0)_(s)→D^(*+)D^(-)decay is consistent with the experimental results.

关键词： standard model factorization approach final state interaction

Morphological peculiarities of the lithium electrode from the perspective of the Marcus-Hush-Chidsey model

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Journal of Energy Chemistry 2023年第5期80卷 452-457,I0011页

作者： behnam Ghalami Choobar Hamid Hamed Mohammadhosein Safari Institute for Materials Research(IMO-imomec) UHasseltMartelarenlaan 42B-3500 HasseltBelgium Energyville Thor Park 8320B-3600 GenkBelgium IMEC Division IMOMEC BE-3590Belgium

This study employs the kinetics framework of Marcus-Hush-Chidsey(MHC)to investigate the charge transfer at the interface of lithium electrode and electrolyte in lithium(ion)-*** chargetransfer rate constant is evaluated for different facets of lithium,namely(100),(110),(101),and(111)as a function of surface charge density with the aid of density functional theory(DFT)*** results highlight and quantify the sensitivity of the rate of lithium plating and stripping to the surface orientation,surface charge density,and charge-transfer *** intrinsic kinetics competition among the different surface orientations is identified together with an asymmetry between the lithium plating and stripping and showcased to influence the deposit morphology and surface protrusions and indentations.

关键词： Marcus-Hush-Chidsey kinetics Surface orientation Surface charge Lithium electrode

Mechanistic simulation of fracture effects on miscible CO_(2)injection

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Petroleum Research 2022年第4期7卷 437-447页

作者： Seyed Mohammad Hossein Hashemi behnam Sedaee Institute of Petroleum Engineering School of Chemical EngineeringCollege of EngineeringUniversity of TehranIran

Miscible injection of carbon dioxide(CO_(2))into oil reservoirs as an Enhanced Oil Recovery(EOR)method has proved to be highly *** to the volume of the world's recoverable oil resides inside the fractured reservoirs,investigation of the controlling parameters in the efficient injection of miscible CO_(2) is of paramount importance,mainly owing to the intricacies and complexities associated with this *** complexity in fractured reservoirs arises due to the presence of two distinct media for fluid transfer(i.e.,matrix and fracture network)and the corresponding differences in fluid ***,performance of miscible carbon dioxide injection in these reservoirs was investigated through mechanistic simulation model in the form of dual-porosity(DP),and dual porosity-dual permeability(DPP).Moreover,due to limited supply and high injection costs of this gas in its pure form,performance of the miscible CO_(2) injection combined with C_(1),N_(2),and H_(2)S was also surveyed and compared to pure gas injection case.A sensitivity analysis was also performed based on fracture porosity,fracture horizontal and vertical permeability,matrix horizontal permeability,block height shape factor,matrix capillary pressure,and impure injected components in DP and DPP models,showing that matrix horizontal permeability and capillary pressure have the greatest,and porosity has the lowest impact on miscibility performance and oil recovery in these *** the end,after investigating the effect of different injection cases on miscibility performance and oil recovery,it was concluded that the highest oil recovery in miscible gas injection obtained through optimization of a gas composition having the lowest minimum miscibility pressure(MMP)and the lowest density.

关键词： Naturally fractured reservoir Carbon dioxide Miscibility Impurity Simulation