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miR-99a-5p modulates doxorubicin resistance via the COX-2/ABCG2 axis in triple-negative breast cancer: from the discovery to in vivo studies

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Cancer Communications 2022年第12期42卷 1412-1416页

作者： Iris Garrido-Cano Anna Adam-Artigues Ana Lameirinhas Juan F.Blandez Vicente Candela-Noguera Federico Rojo Sandra Zazo Juan Madoz-Gúrpide Ana Lluch begoña bermejo Felix Sancenón Juan Miguel Cejalvo Ramón Martínez-Mañez Pilar Eroles Biomedical Research Institute INCLIVA Valencia 46010Spain Bioengineering Biomaterials and Nanomedicine Networking Biomedical Research Centre(CIBER-BBN)Madrid 28029Spain Interuniversity Research Institute for Molecular Recognition and Technological Development(IDM) Polytechnic University of ValenciaUniversity of ValenciaValencia 46010Spain Joint Unit CIPF-UPV of Mechanisms of Diseases and Nanomedicine ValenciaPolytechnic University of ValenciaPrince Felipe Research CenterValencia 46012Spain Joint Research Unit in Nanomedicine and Sensors Polytechnic University of ValenciaMedical Research Institute Hospital La FeValencia 46026Spain Biomedical Research Networking Center in Oncology(CIBERONC) Madrid 28029Spain Department of Pathology Fundación Jiménez Díaz University Hospital Health Research InstituteMadrid 28040Spain Department of Clinical Oncology University Clinical Hospital of ValenciaValencia 46010Spain Department of Medicine University of ValenciaValencia 46010Spain Department of Physiology University of ValenciaValencia 46010Spain

Dear Editor,Breast cancer(BC)is the most commonly diagnosed cancer and the fifth cause of cancer-related death worldwide[1].Despite the advances in BC targeted therapies,cytotoxic chemotherapy is still widely used[2].However,around 20%-30%of BC patients develop metastasis after treatment as a consequence of drug resistance[3].In this context,microRNAs have emerged as potential therapeutic targets to overcome therapy resistance[4].Therefore,we aimed to elucidate the molecular mechanisms underlying resistance to doxorubicin,one of the most effective chemotherapeutic agents used in *** are detailed in Supplementary Materials.

关键词： doxorubicin ABCG2 chemotherapy

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A Comparison of Semi-Lagrangian and Lagrange-Galerkin hp-FEM Methods in Convection-Diffusion Problems

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Communications in Computational Physics 2011年第4期9卷 1020-1039页

作者： Pedro Galan del Sastre Rodolfo bermejo Departamento de Matematica Aplicada al Urbanismo a la Edificacion y al Medio AmbienteE.T.S.A.M.Universidad Politecnica de MadridAvda.Juan de Herrera 428040 MadridSpain Departamento de Matematica Aplicada E.T.S.I.I.Universidad Politecnica de MadridC/Jose Gutierrez Abascal 228006 MadridSpain

We perform a comparison in terms of accuracy and CPU time between second order BDF semi-Lagrangian and Lagrange-Galerkin schemes in combination with high order finite element *** numerical results show that for polynomials of degree 2 semi-Lagrangian schemes are faster than Lagrange-Galerkin schemes for the same number of degrees of freedom,however,for the same level of accuracy both methods are about the same in terms of CPU *** polynomials of degree larger than 2,Lagrange-Galerkin schemes behave better than semi-Lagrangian schemes in terms of both accuracy and CPU time;specially,for polynomials of degree 8 or ***,we have performed tests on the parallelization of these schemes and the speedup obtained is quasi-optimal even with more than 100 processors.

关键词： Navier-Stokes equations convection-diffusion equations semi-Lagrangian LagrangeGalerkin second order backward difference formula hp-finite element method

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Hybrid Security Assessment Methodology for Web Applications

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Computer Modeling in Engineering & Sciences 2021年第1期126卷 89-124页

作者： Roddy A.Correa Juan Ramon bermejo Higuera Javier bermejo Higuera Juan Antonio SiciliaMontalvo Manuel Sanchez Rubio A.Alberto Magrenan Universidad Tecnica Particular de Loja San Cayetano AltoLojaEcuador Escuela Superior de Ingenieria y Tecnologia Universidad Internacional de La RiojaLogrono26006Spain Universidad de la Rioja Logrono26006Spain

This study presents a methodology to evaluate and prevent security vulnerabilities issues for web *** analysis process is based on the use of techniques and tools that allow to perform security assessments of white box and black box,to carry out the security validation of a web application in an agile and precise *** objective of the methodology is to take advantage of the synergies of semi-automatic static and dynamic security analysis tools and manual *** one of the phases contemplated in the methodology is supported by security analysis tools of different degrees of coverage,so that the results generated in one phase are used as feed for the following phases in order to get an optimized global security analysis *** methodology can be used as part of other more general methodologies that do not cover how to use static and dynamic analysis tools in the implementation and testing phases of a Secure Software Development Life Cycle(SSDLC).A practical application of the methodology to analyze the security of a real web application demonstrates its effectiveness by obtaining a better optimized vulnerability detection result against the true and false positive *** analysis with manual checking is used to audit the results,24.6 per cent of security vulnerabilities reported by the static analysis has been checked and it allows to study which vulnerabilities can be directly exploited *** phase is very important because it permits that each reported vulnerability can be checked by a dynamic second tool to confirm whether a vulnerability is true or false positive and it allows to study which vulnerabilities can be directly exploited *** analysis finds six(6)additional critical *** control analysis finds other five(5)important vulnerabilities such as Insufficient Protected Passwords or Weak Password Policy and Excessive Authentication Attacks,two vulnerabilities that permit brute force at

关键词： Web applications security vulnerability weakness security analysis white box black box interactive application security testing static application security testing dynamic application security testing

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Benchmarking Approach to Compare Web Applications Static Analysis Tools Detecting OWASP Top Ten Security Vulnerabilities

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Computers, Materials & Continua 2020年第9期64卷 1555-1577页

作者： Juan R.bermejo Higuera Javier bermejo Higuera Juan A.Sicilia Montalvo Javier Cubo Villalba Juan JoséNombela Pérez Escuela Superior de Ingeniería y Tecnología Universidad Internacional de La RiojaLa Rioja26006Spain

To detect security vulnerabilities in a web application,the security analyst must choose the best performance Security Analysis Static Tool(SAST)in terms of discovering the greatest number of security vulnerabilities as *** compare static analysis tools for web applications,an adapted benchmark to the vulnerability categories included in the known standard Open Web Application Security Project(OWASP)Top Ten project is *** information of the security effectiveness of a commercial static analysis tool is not usually a publicly accessible research and the state of the art on static security tool analyzers shows that the different design and implementation of those tools has different effectiveness rates in terms of security *** the significant cost of commercial tools,this paper studies the performance of seven static tools using a new methodology proposal and a new benchmark designed for vulnerability categories included in the known standard OWASP Top Ten ***,the practitioners will have more precise information to select the best tool using a benchmark adapted to the last versions of OWASP Top Ten *** results of this work have been obtaining using widely acceptable metrics to classify them according to three different degree of web application criticality.

关键词： Web application benchmark security vulnerability Security Analysis Static Tools assessment methodology false positive false negative precision f-measure

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The variability of juvenile dispersal in an opportunistic raptor

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Current Zoology 2023年第3期69卷 244-254页

作者： Jorge Garcia-Macia Gabriel Lopez-Poveda Javier De La Puente Ana bermejo-bermejo Manuel Galan Ernesto Alvarez Sara Morollon Vicente Urios Vertebrates Zoology Research Group University of AlicanteApdo.99E-03080 AlicanteSpain SEO/BirdLife Bird Monitoring UnitC/Melquiades Biencinto34E-28053MadridSpain GREFA C/MontedelPilarS/NE-28220 MajadahondaMadridSpain

The juvenile dispersal of raptors is a crucial stage that stretches from parental independence to the establishment of the first breeding *** 2012 and 2020,44 juvenile red kites Milvus milvus from the Spanish breeding population were tagged using GPS telemetry to study their *** left the parental breeding area at the end of their first summer and performed wandering movements throughout the Iberian Peninsula,returning to the parental breeding area the following year,repeating the same pattern until they settled in their first breeding *** analyzed the mean distance from the nest,the maximum reached distances,and the traveled distances(daily and hourly)during the first 2 years of dispersal and compared *** the high individual variability,variables describing the dispersal movements of juveniles showed a decreasing trend during the second dispersal year:80% of individuals reached a shorter maximum distance in the second year,70% decreased their mean distance to the nest,65% decreased their hourly traveled distances,and 50% decreased their daily traveled *** the other hand,the red kites usually combined wandering movements with the establishment of temporary settlement areas(TSA).The average duration of settlement in the TSAs was 75±40 days(up to 182 days)and was located at 182±168 km from the *** those areas,juveniles used 781.0±1895.0 km^(2)(KDE 95%).Some of the TSAs were used by several individuals,which suggests that these areas might be good targets for conservation in future management plans.

关键词： GPS telemetry landfills movement ecology natal dispersal red kite spatial ecology

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Systematic Approach for Web Protection Runtime Tools’Effectiveness Analysis

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Computer Modeling in Engineering & Sciences 2022年第12期133卷 579-599页

作者： Tomás Sureda Riera Juan Ramón bermejo Higuera Javier bermejo Higuera Juan Antonio Sicilia Montalvo José Javier Martínez Herráiz Computer Science Department University of AlcaláMadrid28801Spain Escuela Superior de Ingeniería y Tecnología Universidad Internacional de La RiojaLogrono26006Spain

Web applications represent one of the principal vehicles by which attackers gain access to an organization’s network or ***,different approaches to protect web applications have been proposed to *** them,the two major approaches are Web Application Firewalls(WAF)and Runtime Application Self Protection(RASP).It is,thus,essential to understand the differences and relative effectiveness of both these approaches for effective decisionmaking regarding the security of web *** we present a comparative study between WAF and RASP simulated settings,with the aim to compare their effectiveness and efficiency against different categories of *** this,we used computation of different metrics and sorted their results using F-Score *** found that RASP tools scored better than WAF *** this study,we also developed a new experimental methodology for the objective evaluation ofweb protection tools since,to the best of our knowledge,nomethod specifically evaluates web protection tools.

关键词： Web Application Firewall(WAF) Runtime Application Self Protection(RASP) F-Score web attacks experimental methodology

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Combinatorial Method with Static Analysis for Source Code Security in Web Applications

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Computer Modeling in Engineering & Sciences 2021年第11期129卷 541-565页

作者： Juan Ramon bermejo Higuera Javier bermejo Higuera Juan Antonio Sicilia Montalvo Tomas Sureda Riera Christopher I.Argyros A.Alberto Magrenan Escuela Superior de Ingenierıa y Tecnologıa Universidad Internacional de La RiojaLogronoLa Rioja26006Spain Computer Science Department University of AlcalaMadrid28801Spain Department of Computing and Technology Cameron UniversityLawton73505OklahomaUSA Universidad de la Rioja LogronoLa Rioja26006Spain

Security weaknesses in web applications deployed in cloud architectures can seriously affect its data confidentiality and *** construction of the procedure utilized in the static analysis tools of source code security differs and therefore each tool finds a different number of each weakness type for which it is *** utilize the possible synergies different static analysis tools may process,this work uses a new method to combine several source codes aiming to investigate how to increase the performance of security weakness detection while reducing the number of false ***,five static analysis tools will be combined with the designed method to study their behavior using an updated benchmark for OWASP Top Ten Security Weaknesses(OWASP TTSW).The method selects specific metrics to rank the tools for different criticality levels of web applications considering different weights in the *** findings show that simply including more tools in a combination is not synonymous with better results;it depends on the specific tools included in the combination due to their different designs and techniques.

关键词： Weakness benchmark security testing analysis comparative methodology tools combination web application

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Non-alcoholic fatty liver disease in patients with intestinal, pulmonary or skin diseases: Inflammatory cross-talk that needs a multidisciplinary approach

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World Journal of Gastroenterology 2021年第41期27卷 7113-7124页

作者： Mercedes Perez-Carreras begoña Casis-Herce Raquel Rivera Inmaculada Fernandez Pilar Martinez-Montiel Victoria Villena Gastroenterology and Hepatology Unit 12 de Octubre Universitary HospitalMadrid 28041Spain Faculty of Medicine Complutense UniversityMadrid 28040Spain Dermatology Department 12 de Octubre Universitary HospitalMadrid 28041Spain Pneumology Service 12 de Octubre Universitary HospitalMadrid 28041Spain

Non-alcoholic fatty liver disease(NAFLD)is currently considered the most common cause of liver *** prevalence is increasing in parallel with the obesity and type 2 diabetes mellitus(DM2)epidemics in developed *** recent studies have suggested that NAFLD may be the hepatic manifestation of a systemic inflammatory metabolic disease that also affects other organs,such as intestine,lungs,skin and vascular *** appears that local and systemic proinflammatory/anti-inflammatory cytokine imbalance,together with insulin resistance and changes in the intestinal microbiota,are pathogenic mechanisms shared by NAFLD and other *** is more common in patients with extrahepatic diseases such as inflammatory bowel disease(IBD),obstructive syndrome apnea(OSA)and psoriasis than in the general ***,there is evidence that this association has a negative impact on the severity of liver *** risk characteristics for NAFLD have been identified in populations with IBD(***,obesity,DM2,previous bowel surgery,IBD evolution time,methotrexate treatment),OSA(***,DM2,OSA severity,increased transaminases)and psoriasis(***,metabolic factors,severe psoriasis,arthropathy,elevated transaminases,methotrexate treatment).These specific phenotypes might be used by gastroenterologists,pneumologists and dermatologists to create screening algorithms for *** algorithms should include non-invasive markers of fibrosis used in NAFLD to select subjects for referral to the ***,controlled studies in NAFLD patients with extrahepatic comorbidities are required to demonstrate a causal relationship and also that appropriate multidisciplinary management improves these patients’prognosis and survival.

关键词： Non-alcoholic fatty liver disease Liver fibrosis Psoriasis Obstructive sleep apnea Metabolic syndrome Inflammatory bowel disease

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MMALE—A Methodology for Malware Analysis in Linux Environments

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Computers, Materials & Continua 2021年第5期67卷 1447-1469页

作者： JoséJavier de Vicente Mohino Javier bermejo Higuera Juan Ramón bermejo Higuera Juan Antonio Sicilia Montalvo Manuel Sánchez Rubio JoséJavier Martínez Herraiz Escuela Superior de Ingeniería y Tecnología Universidad Internacional de La RiojaLogroño26006La RiojaSpain Departamento de Ciencias de la Computación de la Escuela Politécnica Superior Universidad de Alcaláde HenaresAlcaláde HenaresMadridSpain

In a computer environment,an operating system is prone to malware,and even the Linux operating system is not an *** recent years,malware has evolved,and attackers have become more qualified compared to a few years ***,Linux-based systems have become more attractive to cybercriminals because of the increasing use of the Linux operating system in web servers and Internet of Things(IoT)*** is the most employed OS,so most of the research efforts have been focused on its malware protection rather than on other operating *** a result,hundreds of research articles,documents,and methodologies dedicated to malware analysis have been ***,there has not been much literature concerning Linux security and protection from *** address all these new challenges,it is necessary to develop a methodology that can standardize the required steps to perform the malware analysis in depth.A systematic analysis process makes the difference between good and ordinary malware ***,a deep malware comprehension can yield a faster and much more efficient malware *** order to address all mentioned challenges,this article proposed a methodology for malware analysis in the Linux operating system,which is a traditionally overlooked field compared to the other operating *** proposed methodology is tested by a specific Linux malware,and the obtained test results have high effectiveness in malware detection.

关键词： Malware analysis methodology analysis Linux malware IoT malware

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Grasp Planning and Visual Servoing for an Outdoors Aerial Dual Manipulator

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Engineering 2020年第1期6卷 77-88页

作者： Pablo Ramon-Soria begoña CArrue Anibal Ollero Robotics Visionand Control GroupSchool of EngineeringUniversity of SevilleSeville 41092Spain

This paper describes a system for grasping known objects with unmanned aerial vehicles (UAVs) provided with dual manipulators using an RGB-D camera. Aerial manipulation remains a very challenging task. This paper covers three principal aspects for this task: object detection and pose estimation, grasp planning, and in-flight grasp execution. First, an artificial neural network (ANN) is used to obtain clues regarding the object’s position. Next, an alignment algorithm is used to obtain the object’s sixdimensional (6D) pose, which is filtered with an extended Kalman filter. A three-dimensional (3D) model of the object is then used to estimate an arranged list of good grasps for the aerial manipulator. The results from the detection algorithm—that is, the object’s pose—are used to update the trajectories of the arms toward the object. If the target poses are not reachable due to the UAV’s oscillations, the algorithm switches to the next feasible grasp. This paper introduces the overall methodology, and provides the experimental results of both simulation and real experiments for each module, in addition to a video showing the results.

关键词： Aerial manipulation Grasp planning Visual servoing

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