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经阴道局部注射高渗葡萄糖液治疗异位妊娠

世界核心医学期刊文摘（妇产科学分册） 2006年第10期2卷 61-61页

作者： Goldberg J.m. bedaiwy m.a. 柳蕴 Department of Gynecology and Obstetrics Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland OH 44195 United States Dr.

BACKGROUND: We report the technique and long-term outcome after a conservative approach for the treatment of heterotopic pregnancy. CASE: Two women aged 31 and 30 years presented with heterotopic pregnancies after controlled ovarian hyperstimulation intrauterine insemination. Transvaginal ultrasound-guided needle aspiration of the ectopic gestational sac and instillation of hyperosmolar glucose were performed. The ectopic pregnancies resolved without further intervention in both cases. The intrauterine pregnancies resulted in live births by cesarean delivery. Bilateral tubal patency was subsequently confirmed in both patients. CONCLUSION: Local injection of 50%glucose after aspiration of the tubal gestational sac fluid under transvaginal ultrasonographic guidance proved effective in resolving the ectopic pregnancy without adversely affecting the concurrent intrauterine pregnancy. This is a simple and inexpensive treatment modality.

关键词：异位妊娠局部注射高渗葡萄糖宫内妊娠输卵管妊娠侧输卵管人工受精促排卵针吸局部注入

Structural, elastic and electronic properties for m_2 XC (m=Ti and Cr, X=Ga and Al) phases from.a. initio calculations

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Acta metallurgica Sinica(English Letters) 2011年第4期24卷 255-270页

作者： B. Ghebouli m.a. Ghebouli m. Fatmi N. Bouarissa m. Benkerri I.A. Ibrahim Laboratory of Study of Surfaces and Interfaces of Solids materials Department of Physics Faculty of Science University of Setif Department of Physics University Center Research Unit on Emerging materials Ferhat Abbas University of Setif Department of Physics Faculty of Sciences King Khalid University Central metallurgical Research and Development Institute P.O. Box: 87 Helwan 11424 Cairo Egypt

The first-principles study of the structural, elastic and electronic properties of the m2XC phases depending on the type of m transition metal （m.a.e Ti and Cr） and on X （X are Ga and A1） was reported. The calculations are performed using the pseudo-potential plane-wave approach in both the local density and generalized gradient approximations. The elastic constants are calculated using the static finite strain technique. Features such as structural and elastic parameters, Debye tem- perature, sound velocities and their pressure dependence have been investigated. In agreement with experimental and previous theoretical findings, it is found that the compressibility along a and c axis depends on the valence electron concentration （VEC）. Correlations revealing the governing role of the X and m elements on the machinability indices of the material have been examined. The electronic properties have been discussed in terms of chemical bonding showing that bonding is due to md-Cp and md-Xp hybridizations. m-C bonds are stiffer than m-X ones and A1-Ti （Cr-C） bonds are stiffer than those corresponding to Ti-C （A1-Cr）. It is shown that the stiffness of the m-X and m-C bonds increases with increasing the number of VEC.

关键词： m2XC phases ab initio Pressure effect Band structures

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： m.a.iah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly im.a.ts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them.a.tractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm.a.ainst JAK2 kinase and 200.9 nm.a.ainst PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment com.a.ed to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflam.a.ing-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, m.a.ing “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Com.a.ibility of Fibreglass Woven Roving and Commercially Available Phenolic Resins

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Journal of materials Science & Technology 1997年第5期13卷 379-382页

作者： Hayat, m.a. Suliman, S.m.a. Dept. of mechanical Engineering Bahrain University Box 32038 Isa Town Bahrain

Three commercially available phenolic resins are assessed for com.a.ibility with a fibreglass wovenroving reinforcement. Com.a.ibility assessment is based on laminate physical properties f flexuralstrength and modulus in three and four point bending, interlaminar shear strength, and tensilestrength and modulus. The physical properties are also used for assessment of hand laminatedglass/phenolic systems

关键词： Glass fibers

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

morphological, Optical and DC Conduction Properties of a-GaSe Semiconductor Nanoparticle Thin Films

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Journal of materials Science & Technology 2013年第12期29卷 1151-1155页

作者： Sushil Kumar m.a. majeed Khan materials Science Lab. Department of Physics Chaudhary Devi Lal University Sirsa 125 055 India King Abdullah Institute for Nanotechnology King Saud University Riyadh 11451 Saudi Arabia

Amorphous gallium selenide （a-GaSe） semiconductor nanoparticle thin films were deposited onto well cleaned glass substrates by inert gas condensation （IGC） technique under a vacuum of 400 x 10-6 Pa （3 x 10-6 Torr）. The films were characterized by different structural and optical techniques, including X-ray diffraction, field emission scanning electron microscopy （FESEm）, field emission transmission electron microscopy （FETEm）, UV-visible absorption spectroscopy and I-V m.a.urements. The particle size and size distribution were determined by TEm images which show the presence of spherical particles in the range of 5-50 nm in size. SEm images indicate that the a-GaSe film grown on glass substrate is almost smooth and dense. The optical properties of a-GaSe nanoparticle thin films were determined by optical absorption spectra. The optical bandgap of the film was estimated to be 2.19 eV and the transitions are allowed direct type. The electrical conductivity of the deposited films has been studied as a function of temperature. In the higher temperature range the dominance of thermally activated band conduction was observed; whereas in the low temperature ranqe the hoppinQ conduction in the band tails of localized states was found to be dominated.

关键词： Nanoparticles Thin film Optical bandgap Electrical conductivity

PREPARATION AND CHARACTERIZATION OF SCHIFF BASE POLYmERS DERIVED FROm 4,4'-mETHYLENEBIS(CINNAmALDEHYDE)

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Chinese Journal of Polymer Science 2007年第4期25卷 399-407页

作者： m.Y. Khuhawar A. Shah m.a. mughal Dr. m.a. Kazi Institute of Chemistry University of SindhJamshoroSindhPakistan

New Schiff base polymers poly[4,4＇-methylenebis（cinnamaldehyde）ethylenediimine] （PmBCen）, poly[4,4＇- methylenebis（cinnamaldehyde）1,2-propylenediimine] （PmBCPn）, poly[4,4＇-methylenebis（cinnamaldehyde）1,3-propylenediimine] （PmBCPR）, poly[4,4＇-methylenebis（cinnamaldehyde） 1,2-phenylenediimine] （PmBCPh）, poly[4,4＇-methylenebis（cinnamaldehyde）meso-stilbenediimine] （PmBCS）, poly[4,4＇-methylenebis（cinnamaldehyde）urea] （PmBCUR）, poly[4,4＇- methylenebis（cinnamaldehyde）semicarbazone] （PmBCSc）, poly[4,4＇-methylenebis（cinnamaldehyde）thiosemicarbazone] （PmBCTSc） and poly[4,4＇-methylenebis（cinnamaldehyde）hydrazone] （PmBCH） were formed by polycondensation of 4,4＇- methylenebis（cinnamaldehyde） with ethylenediamine, 1,2-propylenediamine, 1,3-propylenediamine, 1,2-phenylenediamine, meso-stilbenediamine, urea, semicarbazide, thiosemicarbazide and hydrazine, respectively. The dialdehyde and polymers have been characterized through elemental micro-analysis, IR, UV-Vis and ^1H-NmR spectroscopic techniques. Therm.a.alytical studies and viscous flow of dilute solutions of dialdehyde and its polymers have been examined and com.a.ed.

关键词： Schiff base polymers Synthesis Characterization Infrared spectroscopy Ultraviolet-visible spectroscopy Nuclear magnetic resonance Thermogravimetric analysis Differential thermal analysis.