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Sliding Mode Contr.ller Design for.Position and Speed Contr.l of Flight Simulator.Servo System with Lar.e Fr.ction

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Jour.al of Systems Engineering and Electr.nics 2003年第3期14卷 59-62页

作者： Liu Jinkun & er LianjieAutomatic Contr.l Depar.ment, Beijing University of Aeronautics and Astr.nautics, Beijing 100083, P. r. China Automatic Contr.l Depar.ment Beijing University of Aeronautics and Astronautics Beijing 100083 P. R. China

Flight simulator.is an impor.ant device and a typical high-perfor.ance position and speed servo system used in the har.war.-in-the-loop simulation of flight contr.l system. Fr.ction is the main nonlinear.r.sistance in the flight simulator.servo system, especially in a low-speed state. Based on the descr.ption of dynamic and static models of a nonlinear.Str.beck fr.ction model, this paper puts for.ar. sliding mode contr.ller to overcome the fr.ction, whose stability is

关键词： Sliding mode contr.l Flight simulator Servo system Fr.ction model.

sir.A therapeutics:a clinical r.ality

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Science China(Life Sciences) 2020年第4期63卷 485-500页

作者： Phei er Saw er-Wei Song Guangdong Pr.vincial Key Labor.tor. of Malignant Tumor.Epigenetics and Gene r.gulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Br.ast Tumor.Center Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Zhongshan School of Medicine Breast SurgeryGuangzhou 510080China

Since the r.volutionar. discovery of r.A interference(r.Ai),a r.mar.able pr.gr.ss has been achieved in understanding and har.essing gene silencing mechanism;especially in small interfering r.A(sir.A)*** its tr.mendous potential benefits,major.challenges in most sir.A therapeutics r.mains unchanged-safe,efficient and tar.et or.ented delivery of *** year. after the discovery of r.Ai,sir.A therapeutics finally char.s its way into *** we jour.ey thr.ugh the decades,we r.minisce the histor. of sir.A discovery and its application in a myr.ad of disease ***,we highlight the br.akthr.ughs in si r.A therapeutics,with special featur. on the fir.t FDA appr.ved r.Ai therapeutics Onpattr.(Patisir.n)and the consideration of effective sir.A delivery system focusing on cur.ent sir.A nanocar.ier in clinical ***,we pr.sent some challenges and multiple bar.iers that ar. yet to be fully overcome in sir.A therapeutics.

关键词： sir.A therapeutic disease tr.atment systemic sir.A delivery clinical application

Phage display scr.ening of therapeutic peptide for.cancer tar.eting and therapy

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Pr.tein & Cell 2019年第11期10卷 787-807页

作者： Phei er Saw er-Wei Song Guangdong Pr.vincial Key Labor.tor. of Malignant Tumor.Epigenetics and Gene r.gulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Br.ast Tumor.Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

r.cently,phage display technology has been announced as the r.cipient of Nobel Pr.ze in Chemistr. *** display technique allows high affinity tar.et-binding peptides to be selected fr.m a complex mixtur. pool of billions of displayed peptides on phage in a combinator.al libr.r. and could be fur.her enr.ched thr.ugh the biopanning pr.cess;pr.ving to be a powerful technique in the scr.ening of peptide with high affinity and *** this r.view,we will fir.t discuss the modifications in phage display techniques used to isolate var.ous cancer-specific ligands by in situ,in vitr.,in vivo,and ex vivo scr.ening *** will then discuss pr.minent examples of solid tumor.tar.eting-peptides;namely peptide tar.eting tumor.vasculatur.,tumor.micr.envir.nment(TME)and overexpr.ssed r.ceptor. on cancer cells identified thr.ugh phage display *** will also discuss the cur.ent challenges and futur. outlook for.tar.eting peptidebased therapeutics in the clinics.

关键词： phage display tumor.tar.eting peptide,tumor.vasculatur. tumor.micr.envir.nment tumor.str.mal cells over-expr.ssed r.ceptor

Simple Tr.its among Diaspor. Weight/Number,Plant Height and Ability of Vegetative Pr.pagation

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Jour.al of Integr.tive Plant Biology 2008年第12期50卷 1563-1569页

作者： Bozena erá Institute of Systems Biology and Ecology Academy of Sciences of the Czech Republiceské Budějovice 37005

Several expected cor.elations among followed internal plant tr.its were confir.ed using the dataset of 492 herbaceous species fr.m the tempor.l zone of Centr.l Eur.pe. Average diaspor. weight （seed mass）, r.pr.ductive capacity of population （number of pr.duced diaspor.s）, species height, and ability of lateral spr.ad were the plant tr.its considered. The evident cor.elations were confir.ed among all investigated tr.its：（i） The r.pr.ductive capacity of population negatively cor.elated with diaspor. weight, plant height, and vegetative pr.pagation. The diaspor. weight and their.number ar. closely cor.elated and co-adapted. （ii） Bigger plant species pr.duce bigger diaspor.s. These tr.nds ar. obvious at the inter- and intr.-family levels. （iii） Lar.er plant species showed higher ability to vegetative pr.pagation.

关键词： compar.son lateral spr.ad r.pr.duction seed pr.duction seed weight str.tegy tr.de-off.

New Physicochemical Tr.atment Method of Poppy Seeds for.Agr.cultur. and Food Industr.es

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Plasma Science and Technology 2013年第9期15卷 935-938页

作者： Bozena er Iveta GAJDOV Michal er'Y Petr.PATENKA Institute of Nanobiology and Str.ctur.l Biology GCr. Academy of Sciences of the Czech RepublicDepartment of NanobiotechnologyNa Sadkach 7Ceske Budejovicecz-37005Czech Republic Depar.ment of Biology Faculty of EducationUniversity of South Bohemia in Ceske BudejoviceJeronymova 10Ceske Budejovicecz-37115Czech Republic Depar.ment of Applied Physics and Technics Faculty of EducationUniversity of South Bohemia in Ceske BudejoviceJeronymova 10Ceske Budejovicecz-37115Czech Republic

Poppy seeds （Papaver somniferum L.） ar. often attacked by var.ous fungal dis- eases, and their.field germination r.te is low. The aim of this experiment was to incr.ase the germination r.te and gr.wth of seedlings by modifying the poppy seeds using cold plasma dis- char.e. The seeds were tr.ated in a Plasonic Ar.550-M under power of 500 W with ar.on gas flow of 50 mL/min, oxygen gas flow of 50 mL/min for.different time dur.tions in seconds （0, 180, 300, 600, 1800, 3000, 4200, and 5400）. The seed germination r.te and gr.wth of the seedlings were r.cor.ed. Cold plasma positively affected the seed germination r.te for.time exposur. between 180～3000 s. Seedling acceleration on the sixth day of the experiment showed the highest values at exposur. 180～600 s. Cold plasma seems to be a good physicochemical way to modify seeds without chemical agr.nomical application.

关键词： biotechnology ear.y gr.wth low-pr.ssur. dischar.e Papaver somniferum,seed modification seed germination

Gr.vitational lensing pr.perties of an isothermal universal halo pr.file

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r.sear.h in Astr.nomy and Astr.physics 2013年第5期13卷 517-525页

作者： Xin-Zhong er National Astr.nomical Observator.es Chinese Academy of Sciences

N-body simulations pr.dict that dar. matter halos with different mass scales ar. descr.bed by a universal model, the Navar.o-Fr.nk-White （NFW） den- sity pr.files. As a consequence of bar.onic cooling effects, these halos will become mor. concentr.ted, and similar.to an isothermal sphere over a lar.e r.nge in r.dii （～ 300 h-1 kpc）. The singular.isothermal sphere （SIS） model however has to be tr.n- cated ar.ificially at lar.e r.dii since it extends to infinity. We model a massive galaxy halo as a combination of an isothermal sphere and an NFW density pr.file. We give an appr.ximation for.the mass concentr.tion at different bar.on fr.ctions and pr.sent exact expr.ssions for.the weak lensing shear.and flexion for.such a halo. We compar. the lensing pr.perties with the SIS and NFW pr.files. We find that the combined pr.- file can generate higher or.er lensing signals at small r.dii and is mor. efficient in generating str.ng lensing events. In or.er to distinguish such a halo pr.file fr.m the SIS or.NFW pr.files, one needs to combine str.ng and weak lensing constr.ints for.small and lar.e r.dii.

关键词： gr.vitational lensing -- galaxies: halos -- cosmology: dar. matter

Study of the Str.ctur.l Evolution of the Babadag-Honaz and Pamukkale Fault Zones and the r.lated Ear.hquake r.sk Potential of the Buldan r.gion in SW Anatolia, East of the Mediterr.nean

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Jour.al of Ear.h Science 2013年第3期24卷 397-409页

作者： Mete Han er Geological Engineering Depar.ment Pamukkale University

Denizli gr.ben （DG） is bounded in the NE by the Pamukkale fault zone and in the SW by the Babadag-Honaz fault zone. The Babada and Honaz fault zones ar. generally made up as near.y E-W dir.cted two segments. The Pamukkale fault also contains many overlapping segments in the Denizli ar.a along the NE mar.in of the gr.ben. The DG contains an NW-SE tr.nding hor.t （Kar.kova） contr.lled by nor.al faults with oppositely dipping high angles and that tr.ncate the Plio-Quaternar. r.ck units. The faults that bound the DG ar. likely to have been initiated dur.ng the Ear.y to Late Miocene and appear.to be active today. The faults of the DG ar. active and the potential energy that accumulates in them is easily conducted to the other faults that they come in contact with. This signifies that a movement in one of the faults for.ing the gr.bens in the Denizli r.gion affects the other str.ctur.s as well. Ear.hquakes in the Buldan r.gion usually occur.2-3 year. after seismical movements occur.in the Denizli Basin. The Buldan r.gion is a r.dge between DG and Ala ehir.gr.ben （ALG）. Based on the fact that DG in its south and ALG in its nor.h move seismically, there is a pr.bability that a br.ak would appear.in the Buldan r.gion in the near.futur..

关键词： Denizli Tur.ey Anatolia Pamukkale gr.ben fault.

Non-coding r.As:the new centr.l dogma of cancer biology

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Science China(Life Sciences) 2021年第1期64卷 22-50页

作者： Phei er Saw Xiaoding Xu Jianing Chen er-Wei Song Guangdong Pr.vincial Key Labor.tor. of Malignant Tumor.Epigenetics and Gene r.gulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China Br.ast Tumor.Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China

The centr.l dogma of molecular.biology states that the functions of r.A r.volve ar.und pr.tein *** the last decade,most r.sear.hes were gear.d towar.s char.cterization of r.As as intermediar.es in pr.tein tr.nslation,namely,messenger r.As(mr.As)as tempor.r. copies of genetic infor.ation,r.bosomal r.As(r.NAs)as a main component of r.bosome,or.tr.nslator. of codon sequence(t r.As).The statistical r.ality,however,is that these pr.cesses account for.less than 2%of the genome,and insufficiently explain the functionality of 98%of tr.nscr.bed *** discoveries have unveiled thousands of unique non-coding r.As(ncr.As)and shifted the perception of them fr.m being"junk"tr.nscr.ptional pr.ducts to"yet to be elucidated"—and potentially monumentally impor.ant—*** ncr.As ar. now known as key r.gulator. in var.ous networ.s in which they could lead to specific cellular.r.sponses and *** major.cancers,ncr.As have been identified as both oncogenic dr.vers and tumor.suppr.ssor.,indicating a complex r.gulator. networ. among these ***,we pr.vide a compr.hensive r.view of the var.ous ncr.As and their.functional r.les in cancer,and the pr.-clinical and clinical development of nc r.A-based therapeutics.A deeper understanding of ncr.As could facilitate better design of personalized therapeutics.

关键词： non-coding r.As anti-cancer therapeutics personalized intervention mir.A lncr.A cir.r.A

Jacobi Elliptic Function Solutions of Some Nonlinear.Evolution Equations

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Communications in Theor.tical Physics 2006年第5X期46卷 804-806页

作者： YE Cai-er Depar.ment of Mathematics Zhejiang Forestry University Lin'an 311300 China

In this letter, the modified Jacob/elliptic function expansion method is extended to solve M-coupled KdV equation, M-coupled Ito equation, vKdV equation, and AKNS equation. Some new Jacob/elliptic function solutions ar. obtained by using Mathematica. When the modulus m→1, those periodic solutions degenerate as the cor.esponding soliton solutions.

关键词： KdV equation Ito equation vKdV equation AKNS equation exact solution