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Should capecitabine replace 5-fluorouracil in the first-line treatment of metastatic colorectal cancer?

World Journal of Gastroenterology 2014年第20期20卷 6092-6101页

作者： Carlos Aguado beatriz garcía-paredes Miguel Jhonatan Sotelo Javier Sastre Eduardo Díaz-Rubio Department of Medical Oncology Hospital Clínico San Carlos 28040 Madrid Spain

Fluoropyrimidines play a central role in the first-line treatment of metastatic colorectal cancer. Our aim was to review whether capecitabine was a safer, non-inferior, economically superior and more convenient alternative to 5-fluorouracil. Capecitabine has previously been compared to 5-fluorouracil-either as a monotherapy or in combination with oxaliplatin, irinotecan, or biological drugs-and has been found to have comparable efficacy and safety profiles. Furthermore, pharmacoeconomic data and patients’ preferences for oral chemotherapy further favor capecitabine. Therefore, capecitabine appears to be an effective and safe alternative to fluorouracil in the first-line treatment of metastatic colorectal cancer.

关键词： Capecitabine 5-Fluorouracil Metastatic colorectal cancer

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Role of cetuximab in first-line treatment of metastatic colorectal cancer

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World Journal of Gastroenterology 2014年第15期20卷 4208-4219页

作者： Miguel Jhonatan Sotelo beatriz garcía-paredes Carlos Aguado Javier Sastre Eduardo Díaz-Rubio Center affiliate to the "Red Temática de Investigación Cooperativa (RD12/0036/006)" Instituto Carlos ⅢSpanish Ministry of Economy and Competitivity. Oncology DepartmentHospital Clínico San Carlos28040 MadridSpain Department of Medicine School of MedicineUniversidad Complutense de Madrid28040 MadridSpain

The treatment of metastatic colorectal cancer(mCRC)has evolved considerably in the last decade,currently allowing most mCRC patients to live more than two *** antibodies targeting the epidermal growth factor receptor(EGFR)and vascular endothelial growth factor play an important role in the current treatment of these ***,only antibodies directed against EGFR have a predictive marker of response,which is the mutation status of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS).Cetuximab has been shown to be effective in patients with KRAS wild-type *** CRYSTAL study showed that adding cetuximab to FOLFIRI(regimen of irinotecan,infusional fluorouracil and leucovorin)significantly improved results in the first-line treatment of KRAS wildtype ***,results that evaluate the efficacy of cetuximab in combination with oxaliplatin-based chemotherapy in this setting are *** the other hand,recent advances in the management of colorectal liver metastases have improved survival in these *** cetuximab to standard chemotherapy increases the response rate in patients with wild-type KRAS and can thus increase the resectability rate of liver metastases in this group of *** this paper we review the different studies assessing the efficacy of cetuximab in the first-line treatment of mCRC.

关键词： Cetuximab First-line Metastatic colorectal cancer Colorectal liver metastases Elderly patients

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