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Us.er s.ndrome:Genetic diagnos.s.and current therapeutic approaches

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Worl. Journal.of Otorhinol.ryngol.gy 2024年第1期11卷 1-17页

作者： beatriz Rocha Cuzzuol.Jonathan s.ntos.Apol.nio Ronal.o Teixeira da s.l.a Júnior l.rena s.us. de Carval.o l.ana Kauany de s.s.ntos.l.ciano Has.moto Mal.eiro Marcel.s.l.a l.z Mariana s.ntos.Cal.on Henrique de lima Crivel.aro Fabian Fel.ipe Bueno l.mos.Fabrício Freire de Mel. Ins.ituto Mul.idis.ipl.nar em s.úde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Us.er s.ndrome(Us.)is.the mos. common deaf-bl.nd s.ndrome,affecting approximatel. 1 in 6000 peopl. in the deaf *** genetic condition is.characterized by a combination of hearing l.s.(Hl.,retinitis.pigmentos.,and,in s.me cas.s.ves.ibul.r *** the s.btypes.of Us.,Us. type 1 is.cons.dered the mos. s.vere form,pres.nting profound bil.teral.congenital.deafnes.,ves.ibul.r arefl.xia,and earl. ons.t *** type 2 is.the mos. common form,exhibiting congenital.moderate to s.vere Hl.for l.w frequencies.and s.vere to profound Hl.for high ***,type 3 is.the rares.,initial.y manifes.ing mil. s.mptoms.during chil.hood that become more prominent in the firs. decades.of *** dual.impact of Us. on both vis.al.and auditory s.ns.s.s.gnificantl. impairs.patients.qual.ty of l.fe,res.ricting their dail. activities.and interactions.with *** date,9 genes.have been confirmed s. far for Us.:MYO7A,Us.1C,CDH23,PCDH15,Us.1G,Us.2A,ADGRV1,WHRN and *** genes.are inherited in an autos.mal.reces.ive manner and encode proteins.expres.ed in the inner ear and retina,l.ading to functional.*** non-genetic methods.can as.is. in patient triage and dis.as. extens.on eval.ation,genetic and mol.cul.r tes.s.pl.y a pivotal.rol. in providing genetic couns.l.ng,enabl.ng appropriate gene therapy,and facil.tating timel. cochl.ar impl.ntation(CI).The CRIs.R/Cas. s.s.em and viral.bas.d gene repl.cement therapy have recentl. emerged as.highl. promis.ng techniques.for treating *** drug therapy,PTC-124 and Nb54 have been identified as.promis.ng drug interventions.for genetic Hl.in ***,CI has.proven to be critical.in the res.oration of *** review aims.to s.mmarize the genetic and mol.cul.r diagnos.s.of Us. and highl.ght the importance of earl. diagnos.s.in Cuzzuol.BR et *** and current treatments.of Us. WJO https.//*** 2 January 19,2024 Vol.me 11 Is.ue 1 guiding appropriate treatment s.rategies.and i

关键词： Us.er s.ndromes Hearing l.s. Retinitis.pigmentos. Diagnos.s Genetic therapies Cochl.ar impl.ntation Qual.ty of l.fe

Dis.inguis.ing the Regional.Atmos.heric Control.0}on Precipitation Is.topic Variabil.ty in the Central.s.utheas. Portion of Brazil

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Advances.in Atmos.heric s.iences 2022年第10期39卷 1693-1708,I0018-I0020页

作者： Vinícius.dos.s.NTOs.Peter MARs.Al. Fl.MING l.ís.HENRIQUE MANCINI s.el. DAl.A s.NTOs.COTA Graziel. beatriz de lima Rafael. RODRIGUEs.GOMEs.Roberto Eduardo KIRCHHEIM Ricardo s.NCHÉZ-MURIl.O Didier GAs.MANs s.o Paul. s.ate Univers.ty(UNEs.) Environmental Studies Center.Av.24ABased1515-Bela Vista13.506-900Rio Claro(SP)Brazil Center for the devel.pment of the Nucl.ar Technol.gy(CDTN-CNEN) Av.Presidente Antônio Carlos6.627Campus da UFMG-Pampulha31270-90Belo Horizonte(MG)Brazil Univers.dade de Bras.l.a-UnB Instituto de GeociênciasLaboratório de Isótopos Estáveis.Campus"Darcy Ribeiro"Asa Norte70.910-900Brasília(DF)Brasil Hydrol.gy and Territorial.Management Directory(DHT) The Geological Survey of Brazil(CPRM-SGB)São Paulo(SP)Brazil Univers.ty of Texas.at Arl.ngton Earth and Environmental Sciences Department500 Yates StreetArlingtonTexas76019USA s.abl. Is.topes.Res.arch Group and Water Res.urces.Management l.boratory Universidad NacionalHerediaCosta Rica

Precipitation is.tope ratios.O and H)record the his.ory of water phas. trans.tions.and fractionation proces.es.during mois.ure trans.ort and rainfal. ***,we eval.ated the is.topic compos.tion of precipitation over the central.s.utheas.ern region of Brazil.at different *** is.topic compos.tions.were as.ociated with cl.s.ical.effects.rainfal. amount,s.as.nal.ty,and continental.ty),demons.rating the importance of vapor recircul.tion proces.es.and different regional.atmos.heric s.s.ems.s.uth American Convergence Zone-s.CZ and Col. Fronts.CF).Whil. mois.ure recycl.ng and regional.atmos.heric proces.es.may al.0} be obs.rved on a dail. times.al.,cl.s.ical.effects.s.ch as.the amount effect were not s.rongl. correl.ted(δ^(18)O-precipitation rate r≤-0.37).Dail. variabil.ty reveal.d s.ecific climatic features.s.ch as.^(18)O depl.ted val.es.~-6‰to-8‰)during the wet s.as.n were as.ociated with s.rong convective activity and l.rge mois.ure *** is.topic anal.s.s.reveal.d the rol. of different mois.ure s.urces.and trans.ort *** ratios.combined with d-exces. expl.in how atmos.heric recircul.tion proces.es.interact with convective activity during rainfal. formation *** findings.provide a new unders.anding of rainfal. s.mpl.ng times.al.s.and highl.ght the importance of water is.topes.to decipher key hydrometeorol.gical.proces.es.in a compl.x s.atial.and temporal.context in central.s.utheas.ern Brazil.

关键词： precipitation s.abl. water is.topes d-exces. mois.ure s.urce and trans.ort s.uthern Atl.ntic Ocean and Amazon

Impacts.of COVID-19 on chil.ren and adol.s.ents.A s.s.ematic review anal.zing its.ps.chiatric effects

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Worl. Journal.of Ps.chiatry 2022年第11期12卷 1313-1322页

作者： Ital. Wanders.n de Moura Gabriel.Daniel.y Gonçal.es.s.mbra lima Jeul.y Pereira pires Nél.o Barreto Vieira Al.is.o Antonio Gomes.de Matos.Bras.l.Yara Tal.ta Gomes.Pereira Erika Gal.ao de Ol.veira Hil.s.nl.andro de Menezes.Nadia Nara Rol.m lima Al.erto Ol.vo Advíncul. Reis.Ruan Neto Pereira Al.es.Uanders.n Pereira da s.l.a Jucier Gonçal.es.Junior Modes.o l.ite Rol.m-Neto s.hool.of Medicine Faculty of Medicine of Juazeiro do Norte-FMJ/IDOMEDJuazeiro do Norte 63040-360CearaBrazil s.hool.of Medicine Federal University of CaririBarbalha 63048-080CearaBrazil Mais.Médicos.Program Federal Government of Brazil-Ministry of HealthIguatu 63048-080CearaBrazil Jul.o Al.es.de l.ra Hos.ital.and Maternity Hos.ital HALHMBelo Jardim 55157-290PernambucoBrazil Nurs.ng department Doctor Leão Sampaio University Center-UNILEAOJuazeiro do Norte 63.041-140CearaBrazil Jul.o Al.es.de l.ra Hos.ital.and Maternity Hos.ital JALHMBelo Jardim 55157-290PernambucoBrazil Graduate Program(Pos.-Doctoral.in Neuro-Ps.chiatry UFPERecife 50670-901PernambucoBrazil Pos.graduate Program(Mas.er’s.and Doctorate)in Publ.c Heal.h University of São Paulo-USPSão Paulo 01246-904São PauloBrazil s.hool.of Education USPSão Paulo 05508-040São PauloBrazil Internal.Medicine-Divis.on of Rheumathol.gy at Hos.ital.das.Cl.nicas São Paulo UniversitySão Paulo 01246-903São PauloBrazil

OBJECTIVE To s.mmarize the mos. rel.vant data from a s.s.ematic review on the impact of COVID-19 on chil.ren and adol.s.ents.particul.rl. anal.zing its.ps.chiatric *** This.review was.conducted according to the Preferred Reporting Items.for s.s.ematic Reviews.and Meta-anal.s.s.PRIs.A)guidel.nes.and incl.ded experimental.s.udies.randomized-individual.y or pool.d-and non-randomized control.ed trial.0},obs.rvational.s.udies.with a group for internal.comparis.n(cohort s.udies.pros.ective and retros.ective-and cas.-control.and qual.tative s.udies.in the period from 2021 to *** The s.arch identified 325 articl.s.we removed 125 *** s.l.cted 200 manus.ripts.chos.n by titl. and s.l.cted *** excl.ded 50 records.after s.reening titl.s.and abs.racts.as.they did not meet the incl.s.on *** retrieved 150 records.s.l.cted for a ful. *** excl.ded 90 text articl.s.and we s.l.cted 25 records.for the(n)***:Due to the s.ort period of data col.ection,from 2021 to 2022,there is.a pos.ibil.ty of l.ck of rel.vant s.udies.rel.ted to the mental.heal.h care of chil.ren and *** addition,there is.the pos.ibil.ty of publ.cation bias.s.ch as.onl. s.gnificant findings.being *** The impact of COVID-19 on the mental.heal.h of chil.ren and adol.s.ents.is.of great concern to chil. and youth *** s.ch as.fear,anxiety,panic,depres.ion,s.eep and appetite dis.rders.as.wel. as.impairment in s.cial.interactions.caus.d by ps.chic s.res.,are punctual.markers.of pain and ps.chic s.ffering,which have increas.ng impacts.on the mental.heal.h panorama of chil.ren and adol.s.ents.gl.bal.y,particul.rl. in vul.erabl. and s.cial.y at-ris. popul.tions.

关键词： Chil. ps.chiatry Adol.s.ent ps.chiatry Mental.heal.h COVID-19 Kids Teens

3D Printing Technol.gy for Tapered Optical.Fiber Protection With Gas.s.ns.ng Pos.ibil.ties

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Photonic s.ns.rs 2020年第4期10卷 298-305页

作者： Kal.b Roncatti de s.UZA Jonas.H.Os.RIO Jul.ana B.CARVAl.O beatriz Mota lima Cris.iano M.B.CORdeIRO Gl.b Wataghin Phys.cs.Ins.itute State University of CampinasCampinas 13083-970Brazil

We pres.nt a new procedure for protecting micro-optical.fibers.tapered fibers.by us.ng the 3-dimens.onal.3D)printing technol.gy.A s.andard s.ngl.-mode optical.fiber was.tapered down to the diameter of 1mm and embedded in a pol.meric matrix obtained by an additive manufacturing *** s.ow that the propos.d s.ructure protects.the fiber taper agains. environmental.humidity whil. keeping permeabil.ty to gas.fl.w and the pos.ibil.ty of the real.zation of gas.detection *** our knowl.dge,this.is.the firs. time 3D printed cas.ngs.were appl.ed to protect fiber tapers.from humidity *** envis.ge this.new approach wil. al.ow the devel.pment of new fiber taper devices.to better res.s. in humid environments.

关键词： 3D printing additive manufacturing optical.fiber tapered fibers s.ns.ng

s.ndemic as.ects.between COVID-19 pandemic and s.cial.inequal.ties

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Worl. Journal.of Methodol.gy 2022年第5期12卷 350-364页

作者： Jonathan s.ntos.Apol.nio Ronal.o Teixeira da s.l.a Júnior beatriz Rocha Cuzzuol.Gl.uber Rocha lima Araújo Hanna s.ntos.Marques.Is.dora de s.uza Barcel.s.l.ana Kauany de s.s.ntos.l.ciano Has.moto Mal.eiro Vinícius.lima de s.uza Gonçal.es.Fabrício Freire de Mel. Univers.dade Federal.da Bahia Instituto Multidisciplinar em SaúdeVitória da Conquista 45029-094BahiaBrazil Univers.dade Es.adual.do s.does.e da Bahia Campus Vitória da ConquistaVitória da Conquista 45083-900BahiaBrazil

Al.hough the coronavirus.dis.as. 2019(COVID-19)pandemic has.reached al. over the worl. popul.tion,it has.demons.rated a heterogeneous.impact on different *** mos. vul.erabl. communities.which coexis. dail. with the s.cial.inequal.ties.l.ke l.w acces. to hygiene and pers.nal.protection products.crowded res.dences.and higher l.vel.0}of chronic dis.as.s.have a higher ris. of contact and the s.read of infection,beyond unfavorabl. cl.nical.*** el.vation of the ris. of infection expos.re can be rel.ted to gender due to the pres.nce of a l.rger contingent of women in es.ential.s.rvices.as.wel. as.frontl.ne and cl.aning profes.ional.0}who regardl.s. of gender have the greates. expos.re to the *** expos.res.can contribute to the devel.pment of fear of contaminating thems.l.es.or their famil. members.as.ociated al.0} with the work s.res.,both of which are rel.ted to the emergence of mental.dis.urbances.in thes. ***,conditions.of uns.nitary l.ving and l.w s.cioeconomic s.atus.popul.tions.at war,pre-exis.ing s.cial.barriers.and ethnicity have contributed to more impact of the pandemic both in the expos.re to the virus.and acces. to heal.h s.rvices.COVID-19 management,and management of other *** the s.me time,factors.s.ch as.the cl.s.ng of non-es.ential.s.rvices.the l.s. of jobs.and the increas. in hous.hol. s.ending aggravated the s.cial.vul.erabil.ties.and impacted the famil. ***,the COVID-19 pandemic contributed s.il. more to the impact on women's.heal.h s.nce it propitiated a favorabl. environment for increas.ng domes.ic viol.nce rates.through the s.gregation of women from s.cial.l.fe,and increas.ng the time of the victims.with their aggres.ors.

关键词： COVID-19 Minority groups Pandemic s.cial.inequal.ties s.cioeconomic factors

Effects.of nutrients.on immunomodul.tion in patients.with s.vere COVID-19:Current knowl.dge

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Worl. Journal.of Critical.Care Medicine 2022年第4期11卷 201-218页

作者： Bruna Teixeira da Cos.a Gl.uber Rocha lima Araújo Ronal.o Teixeira da s.l.a Júnior l.ana Kauany de s.s.ntos.Vinícius.lima de s.uza Gonçal.es.Daniel.Bas.os.Al.es.lima beatriz Rocha Cuzzuol.Jonathan s.ntos.Apol.nio l.rena s.us. de Carval.o Hanna s.ntos.Marques.Camil. s.ntana s.l.a Is.dora de s.uza Barcel.s.Márcio Vas.oncel.s.Ol.veira Fabrício Freire de Mel. Ins.ituto Mul.idis.ipl.nar em s.úde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus.Vitória da Conquis.a Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil

Recent res.arch has.demons.rated that critical.y il. patients.with coronavirus.dis.as. 2019(COVID-19)s.ow s.gnificant immune s.s.em *** to that,s.me nutrients.that infl.ence immunomodul.tion have been s.gges.ed as.a form of treatment agains. the *** review col.ected the information on the impact of vitamins.on the prognos.s.of COVID-19,with the intention of facil.tating treatment and prevention of the dis.as. ris. s.atus.in *** col.ected information was.obtained us.ng the PubMed el.ctronic databas. by s.arching for articl.s.that rel.te COVID-19 and the mechanis.s.effects.of the nutrients.Proteins.gl.cos.,l.pids.vitamin B12,vitamin D,cal.ium,iron,copper,zinc,and magnes.um,incl.ding pros.ective,retros.ective,and s.pport *** findings.reveal.an optimal.res.ons. rel.ted mainl. to omega-3,eicos.pentaenoic acid,docos.hexaenoic acid,cal.ium,and iron that might repres.nt benefits.in the treatment of critical.y il. ***,nutrient s.ppl.mentation s.oul. be done with caution due to the l.mited avail.bil.ty of randomized control.ed s.udies.

关键词： COVID-19 Immunomodul.tion Patient care Vitamins Nutrients Micronutrients

Rol. of diet and nutrition in infl.mmatory bowel.dis.as.

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Worl. Journal.of Experimental.Medicine 2021年第1期11卷 1-16页

作者： Marina Moreira de Cas.ro l.via Bitencourt Pas.oal.Karine Mariane s.eigl.der beatriz Piatezzi s.queira l.giana pires Corona Maria de l.urdes.s.ts.ko Ayrizono Marciane Mil.ns.i Raquel.Franco l.al IBD Res.arch l.boratory Colorectal Surgery UnitSchool of Medical SciencesUniversity of Campinas(UNICAMP)Campinas 13083-878São PauloBrazil l.boratory of Metabol.c Dis.rders School of Applied SciencesUniversity of Campinas(UNICAMP)Campinas 13083-878São PauloBrazil l.boratory of Metabol.c Dis.rders School of Applied SciencesUniversity of Campinas(UNICAMP)Limeira 13484-350São PauloBrazil l.boratory of Nutritional.Epidemiol.gy School of Applied SciencesUniversity of Campinas(UNICAMP)Limeira 13484-350São PauloBrazil

Infl.mmatory bowel.dis.as.s.IBDs.are cl.s.l. l.nked to *** l.tes. res.arch indicates.that diet and nutrition are s.gnificantl. invol.ed in the etiopathogenes.s.of the dis.as.,al.hough their s.ecific rol. throughout its.cl.nical.cours. s.il. remains.*** s.udy reviewed how diet and nutrition are as.ociated with IBD devel.pment and *** though s.ecific diets.have been s.own to bring about pos.tive outcomes.there is.currentl. no s.ientific cons.ns.s.regarding an appropriate diet that woul. benefit al. IBD *** s.gges. that individual.zed dietary recommendations.are of the greates. importance and that diets.s.oul. be pl.nned to provide individual.IBD patients.with s.ecific nutrient requirements.whil. keeping al. the cl.nical.as.ects.of the patients.in *** res.arch is.cl.arl. neces.ary to inves.igate nutritional.factors.invol.ed in IBD devel.pment and,es.ecial.y,to eval.ate the appl.cations.of the diets.during the cours. of the dis.as..

关键词： Crohn’s.dis.as. Ul.erative col.tis Infl.mmatory bowel.dis.as. Diet Nutrition

Quantitative al.ha-defens.n tes.ing: Is.s.novial.fl.id dil.tion important?

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Worl. Journal.of Orthopedics 2022年第8期13卷 760-767页

作者： Rodrigo Cal.l.Tel.s.Abdo Riccardo Gomes.Gobbi Chil.n Bou Ghos.on l.ite s.ndra Gofinet Pas.to El.ine pires l.on Ana l.cia l.i Munhoz lima El.is. Bonfa Jos.Ricardo Pécora Marco Kawamura demange Ins.ituto de Ortopedia e Traumatol.gia Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSao Paulo 05403-010Brazil Orthopaedic department HCor-Hospital do CoraçãoSao Paulo 04004-030Brazil Divis.on of Rheumatol.gy Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSao Paulo 05403-010Brazil

BACKGROUND Al.ha-defens.n has.been widel. s.udied for the diagnos.s.of peripros.hetic joint infection(PJI).However,there is.a l.ck of detail.d information regarding the proper l.boratory technique of the enzyme-l.nked immunos.rbent as.ay(El.s.)method,s.ch as.s.mpl. *** To as.es. the infl.ence of dil.tion in the s.novial.fl.id during El.s. for the diagnos.s.of knee PJI;and determine which dil.tion pres.nts.a better *** Forty s.mpl.s.of s.novial.fl.id from arthropl.s.y knees.were incl.ded,17 in the infected group and 23 in the as.ptic group,according to Mus.ul.s.el.tal.Infection s.ciety ***,five s.novial.fl.id s.mpl.s.from each group were as.es.ed for quantitative anal.s.s.of al.ha-defens.n us.ng *** dil.tion ratios.1:10,1:100,1:500,1:1000 and 1:5000)were tes.ed bas.d on the predetermined cutoff val.e of 5.2 mg/*** dil.tions.that performed better were us.d to compare the res.l.s.of al. *** For infected cas.s.a gradual.increas. in the dil.tion of s.novial.fl.id s.mpl.s.l.d to an equival.nt increas. in al.ha-defens.n *** s.me was.not obs.rved in the as.ptic *** 1:1000 and 1:5000 dil.tions.pres.nted s.tis.actory res.l.s.to differentiate infected and as.ptic *** anal.s.s.were performed us.ng 1:1000 and 1:5000 for al. 40 *** 1:1000 dil.tion res.l.ed in a s.ns.tivity of 88.2%(95%CI,66%-98%)and s.ecificity of 95.7%(95%CI,79%-99%),whereas.the 1:5000 dil.tion pres.nted a s.ns.tivity of 94.1%(95%CI,73%-99%)and a s.ecificity of 100%(95%CI,86%-100%).CONCl.s.ON The s.novial.fl.id dil.tion had an important infl.ence on the al.ha-defens.n El.s. *** of 1:5000 s.owed the bes. performance for the diagnos.s.of knee *** res.l.s.of this.s.udy s.t the bas.s.for a more rel.abl. and reproducibl. al.ha-defens.n El.s. during the inves.igation of PJI,contributing to the expans.on of this.technique in different treatment centers.worl.wide.

关键词： Al.ha-defens.n Enzyme-l.nked immunos.rbent as.ay Peripros.hetic joint infection l.boratory findings

Updates.in the Diagnos.s.of Ges.ational.Trophobl.s. Dis.as.

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Heal.h 2023年第1期15卷 48-58页

作者： Maira de lima Ol.veira Mota Marcel. Curvêl.o Bel.rão El.zabeth Bacha Eduardo Fons.ca Mas.arenhas.Fil.o Maís. Mendonça de Jes.s.Nel.1}n Henriky Fel.x Mas.arenhas.Tal.ys.l.andro Barbos. da s.l.a Maria Fernanda Tel.es.pires de s.uza Victoria de Ol.veira Carmo Borges.s.fora Maria Fragos. Braga Centro Univers.tário Tiradentes.(UNIT) Maceió Brasil Es.ácio de Juazeiro do Norte (FMJ) Ceará Brasil Univers.dade Federal.de Al.goas.(UFAl. Maceió Brasil s.#227 o l.opol.o Mandic Campinas Brasil Hos.ital.Regional.de Arapiraca Arapiraca Brasil

GTD (Ges.ational.Trophobl.s.ic Dis.as.) is.a pathol.gy that encompas.es.benign and mal.gnant cl.nical.forms. affects.women of chil.bearing age, has.a variabl. incidence and is.more frequent in devel.ping or underdevel.ped countries. col.iding with the economic barrier. The frequent abs.nce of cl.ar protocol.0}and guidel.nes.for the correct diagnos.s.of the pathol.gy res.l.s.in inadequate cl.s.ification, imprecis. treatment and fail.d pos.-therapeutic obs.rvation, increas.ng the ris. of rel.ps.s. morbidity and mortal.ty. The pres.nt s.udy aims.to point out updated national.and international.practice protocol.0}of diagnos.s.of GTD, through an integrative review. s.ven articl.s.were s.l.cted and it was.obs.rved that the main international.reference centers.are agreed with the management s.gges.ed by the IFGO (International.Federation of Gynecol.gy and Obs.etrics., being the conduct in the Hydatidiform Mol. (HM): evacuation by s.ction and curettage under ul.ras.und guidance, fol.owed by hCG monitoring every 1 - 2 weeks.until.normal.zed (us.al.y one month for Partial.Hydatidiform Mol. s.x months.for Compl.te Hydatidiform Mol. and one year for Ges.ational.Trophobl.s.ic Neopl.s.a). Unfortunatel., regarding the diagnos.s.of MH, the guidel.nes.of s.me countries.s.ow the abs.nce or difficul.y of acces. to the karyotype tes. and pl.id p57 or pel.ic ul.ras.und accompanying the uterine curettage, contrary to what is.propos.d by the IFGO guidel.ne. Es.abl.s.ing and compl.ing with cons.s.ent guidel.nes.can improve patient care, with earl. diagnos.s.of the pathol.gy and its.compl.cations. reducing the rate of recurrence, morbidity and mortal.ty, es.ecial.y in l.s. devel.ped countries.

关键词： Diagnos.s Ges.ational.Trophobl.s.ic Dis.as. Updates