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Effects of melatonin on the oxidative damage and pancreatic antioxidant defenses in ceruleininduced acute pancreatitis in rats

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Hepatobiliary & Pancreatic Diseases International 2014年第4期13卷 442-446页

作者： Cristina Carrasco Ana beatriz Rodríguez José A Pariente Department of Physiology Neuroimmunophysiology and Chrononutrition Research Group University of Extremadura

BACKGROUND： Oxidative stress is recognized as a pivotal effector of several pathogenic processes, including acute pancreatitis. Reactive oxygen species not just cause damage on the main cellular components, but also influence the expression of antioxidant system genes. Antioxidant molecules, such as melatonin, could be good candidates for the treatment of this multidimensional disease. The present study was to evaluate the chemopreventive effect of melatonin in a rat model of ceruleininduced acute ***： Four subcutaneous injections of cerulein（20 μg/kg body weight） were given to Wistar rats at two hours intervals;melatonin was injected intraperitoneally（25 mg/kg body weight）30 minutes before each injection of cerulein. Lipid peroxidation,protein oxidation（carbonyl groups）, total antioxidant status,and glutathione peroxidase activity were determined in pancreatic tissue using commercial ***： The chemopreventive administration of melatonin caused a reduction in lipid peroxidation and protein oxidation due to injections of cerulein. Additionally, melatonin treatment was also able to revert glutathione peroxidase activity and total antioxidant status near to control levels, suggesting that melatonin could prevent from oxidative phenomena in the pancreas, such as lipid peroxidation and protein oxidation,and could stimulate, directly or indirectly, the expression of antioxidant ***： Melatonin, a polyvalent antioxidant, protected the pancreatic damage via the decrease of oxidative stress andincrease of the activities of antioxidant enzymes in ceruleininduced acute pancreatitis.

关键词： acute pancreatitis antioxidants cerulein melatonin oxidative stress

郑小琼诗集《在机器的轰鸣声中》(顾爱玲/译)评论三题

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作家 2024年第7期 3-9页

作者： [美]安敏轩彼得·戈登 [澳]比阿特利斯·科佩罗汪辉燕(译) 美国康奈尔大学亚洲研究中心《亚洲书评》不详

诗歌能传播多远?在物理距离和社会距离上它能传播多远?有些人喜欢把诗歌说成是一种共情的实践,一种跨越人与人之间鸿沟的方式,但如果这种鸿沟不仅仅是存在的,如果我们想用诗歌与那些在身体、文化和经济上与我们差异极大的人们建立联系,... 详细信息

诗歌能传播多远?在物理距离和社会距离上它能传播多远?有些人喜欢把诗歌说成是一种共情的实践,一种跨越人与人之间鸿沟的方式,但如果这种鸿沟不仅仅是存在的,如果我们想用诗歌与那些在身体、文化和经济上与我们差异极大的人们建立联系,应该怎么办?所有的诗歌都能传播一通常来说,翻译能比其他类型的诗歌传播得更远一但有些诗集能够传播得相当远。

关键词：诗歌传播物理距离轰鸣声郑小琼诗集鸿沟

Use of agents stimulating erythropoiesis in digestive diseases

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World Journal of Gastroenterology 2009年第37期15卷 4675-4685页

作者： Rosario Moreno López beatriz Sicilia Aladrén Fernando Gomollón García Department of Nephrology San Juan de Dios Hospital Paseo Colón 14 50006 Zaragoza Spain Department of Medicine Universidad de Zaragoza 50009 Zaragoza Spain Department of Medicine (Gastroenterology) Alcaiz Hospital 44600 Alcaiz (Teruel) Spain Department of Gastroenterology Clinical University Hospital "Lozano Blesa" Department of Medicine University of Zaragoza IACS CIBEREHD 50009 Zaragoza Spain

Anemia is the most common complication of inflammatory bowel disease (IBD). Control and inadequate treatment leads to a worse quality of life and increased morbidity and hospitalization. Blood loss, and to a lesser extent, malabsorption of iron are the main causes of iron def iciency in IBD. There is also a variable component of anemia related to chronic inflammation. The anemia of chronic renal failure has been treated for many years with recombinant human erythropoietin (rHuEPO), which significantly improves quality of life and survival. Subsequently, rHuEPO has been used progressively in other conditions that occur with anemia of chronic processes such as cancer, rheumatoid arthritis or IBD, and anemia associated with the treatment of hepatitis C virus. Erythropoietic agents complete the range of available therapeutic options for treatment of anemia associated with IBD, which begins by treating the basis of the inflammatory disease, along with intravenous iron therapy as f irst choice. In cases of resistance to treatment with iron, combined therapy with erythropoietic agents aims to achieve near-normal levels of hemoglobin/hematocrit (11-12 g/dL). New formulations of intravenous iron (iron carboxymaltose) and the new generation of erythropoietic agents (darbepoetin and continuous erythropoietin receptor activator) will allow better dosing with the same eff icacy and safety.

关键词： Erythropoiesis-stimulating agents Recom-binant human erythropoietin Darbepoetin Continuous erythropoietin receptor activator Inflammatory bowel disease Anemia

Galápagos land iguana(Conolophus subcristatus)as a seed disperser

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Integrative Zoology 2016年第3期11卷 207-213页

作者： Anna TRAVESET Manuel NOGALES Pablo VARGAS beatriz RUMEU Jens M.OLESEN Esporles Mallorca 07190Balearic IslandsSpain Island Ecology and Evolution Research Group(CSIC-IPNA) Instituto de Productos Naturales y Agrobiología38206 TenerifeCanary IslandsSpain Real Jardín Botánico(CSIC-RJB) Department of Biodiversity and ConservationPlaza de Murillo 228014 MadridSpain Centre for Functional Ecology Department of Life SciencesUniversity of CoimbraCalçada Martim de FreitasCoimbra 3000-456Portugal Institute of Bioscience Aarhus UniversityAarhusDenmark and 6Charles Darwin FoundationPuerto AyoraSanta CruzGalápagosQuitoEcuador

The role of the most common land iguana(Conolophus subcristatus)in the Galápagos Islands as an effective seed disperser is explored in this study.A total of 5705 seeds of 32 plant species were identified from 160 scats,4545 of which(80%)appeared visually *** trials of 849 seeds from 29 species revealed that at least 10 species remained viable after passing through the iguana’s gut,although only a small proportion of those seeds(4%)*** any case,we argue that *** exerts an important role on the 7 Galapagos islands where it occurs because of its abundance and capacity to ingest and disperse seeds at long *** results strongly suggest that the Galápagos *** plays an important role as a seed disperser of not only of native species but also some introduced plants in the Galápagos Islands.

关键词： Conolophus subcristatus Fernandina Island Galápagos Islands Saurochory seed dispersal

Intraexaminer repeatability and agreement in stereoacuity measurements made in young adults

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 374-381页

作者： beatriz Antona Ana Barrio Isabel Sanchez Enrique Gonzalez Guadalupe Gonzalez Department of Optics II (Optometry and Vision) Faculty of Optics and Optometry Complutense University of Madrid

AIM: To determine the repeatability and agreement of stereoacuity measurements made using some of the most widely used clinical tests: Frisby, TNO, Randot and ***: Stereoacuity was measured in two different sessions separated by a time interval of at least 24 h but no longer than 1wk in 74 subjects of mean age 20.6y using the four methods. The study participants were divided into two groups: subjects with normal binocular vision and subjects with abnormal binocular ***: Best repeatability was shown by the Frisby and Titmus [coefficient of repeatability(COR): ±13 and±12s arc respectively] in the subjects with normal binocular vision though a clear ceiling effect was *** the subjects with abnormal binocular vision, best repeatability was shown by the Frisby(COR: ±69s arc)and Randot(COR: ±72s arc). In both groups, the TNO test showed poorest agreement with the other ***:Therepeatabilityofstereoacuitymeasures was low in subjects with poor binocular vision yet fairly good in subjects with normal binocular vision with the exception of the TNO test. The reduced agreement detected between the tests indicates they cannot be used interchangeably.

关键词： stereoacuity repeatability agreement tereopsis

Degradation of indomethacin in river water under stress and non-stress laboratory conditions:degradation products,long-term evolution and adsorption to sediment

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Journal of Environmental Sciences 2017年第1期29卷 13-20页

作者： Juan J.Jimenez Maria I.Sanchez Rafael Pardo beatriz E.Munoz Department of Analytical Chemistry Faculty of SciencesCampus Miguel DelibesUniversity of ValladolidPaseo de Belen 747012 ValladolidSpain I.U.CINQUIMA Campus Miguel DelibesUniversity of ValladolidPaseo de Belen 547011 ValladolidSpain Department of Analytical Chemistry School of Industrial EngineersUniversity of ValladoliclFrancisco Mendizdbal 147014 ValladolidSpain

The pharmaceutical compound indomethacin is not totally removed in wastewater treatment plants,whose effluents flow into aquatic environments;concentrations in the 0.1-100 ng/L range are commonly found in surface waters,and its fate is ***,biological,photochemical and thermal degradation assays were conducted under stress and non-stress conditions to estimate its degradation rate in river water and establish its degradation products over *** results revealed that direct sunlight irradiation promoted the complete degradation of indomethacin（2 μg/L） in less than 6 hr,but indomethacin was detected over a period of 4 months when water was kept under the natural day-night cycle and the exposure to sunlight was partially limited,as occurs inside a body of *** biological degradation in water was negligible,while the hydrolysis at pH 7.8 was *** were monitored by ultra-pressure liquid chromatography/quadrupole time-of-flight/mass spectrometry after solid-phase extraction,and six degradation products were found;their structures were proposed based on the molecular formulae and fragmentation observed in high-resolution tandem mass spectra.4-Chlorobenzoic and 2-acetamido-5-methoxybenzoic acids were the long-term transformation products,persisting for at least 30 weeks in water kept under non-stress ***,the degradation in the presence of sediment was also monitored over time,with some differences being *** adsorption coefficients of indomethacin and degradation products on river sediment were calculated;long-term degradation products did not have significant adsorption to sediment.

关键词： Indomethacin Degradation products River water Adsorption coefficients High-resolution mass spectrometry

Warm Forged Medium Carbon V Steel

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Journal of Iron and Steel Research International 2011年第S1期18卷 822-826页

作者： Carlos Garcia-Mateo beatriz Lopez Jose Maria Rodriguez-Ibabe MATERALIA Research Group.Department of Physical Metallurgy Centro Nacional de Investigaciones Metalúrgicas (CENIM-CSIC)Avda.Gregorio del Amo 8.E-28040MadridSpain CEIT and TECNUM (University of Navarra) Po Manuel de Lardizabal 15San SebastianE-20018Basque ContrySpain

Nowadays there is a continuous demand,particularly from the automotive industry,for cheaper,lighter and more reliable *** is not surprising then that steel research has been focused during the last decades in new qualities and *** paper is dealing with the use of vanadium microalloyed steels on one of those new processes,warm *** its low precipitation temperature and its recognised ability to strengthen steel microstructures via austenite grain growth control,precipitation hardening and interference of the static recrystallization process,vanadium in microalloyed steels seem to be an appropriate candidate for warm forging.

关键词： warm forging vanadium microalloyed steels

Lupeol:An antioxidant triterpene in Ficus pseudopalma Blanco(Moraceae)

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Asian Pacific Journal of Tropical Biomedicine 2014年第2期4卷 109-118页

作者： Librado A Santiago Anna beatriz R.Mayor Research Center for the Natural and Applied Sciences.University of Santo Tomas Manila.Philippines Department of Biochemistry Faculty of Pharmacy.University of Santo TomasManila.Philippines The Graduate School.University of Santo Tomas Manila.Philippines

Objective:To assess the antioxidant activity of Ficus pseudopalma Blanco(Moraceae)(***) and characterize the active components present in ***:Column chromatography of crude ethanol leaf extract of *** was performed and seven fractions were obtained,labeled as Ft.F2,F3,F4.F5,F6,***,Criess,Kenton and superoxide radical scavenging assays were performed to assess the antioxidant ability of the *** layer chromatography(TLC),high performance liquid chromatography and Fourier transfer infrared spectroscopy(FTIR) were performed to identify and characterize the bioactive component present in each fractions of ***:DPPH and FRAP assay showed that F5.F6 and F7 exhibited the good proton accepting ability and reducing power as compared to the other *** fractions exhibited a good nitric oxide radical scavenging activity wherein F1,F2 and F3 showed the highest ***,all of the fractions exhibited a stimulatory activity on hydroxyl and superoxide *** matched one of the spots on the thin layer chromatography chromatogram of the *** gradient high performance liquid chromatography and spiking of lupeol with the fraction revealed the presence of 5.84 mg/L lupeol in *** spectra of the fractions revealed the presence of C-C,OH,aromatic C=C and C=O ***:The identified lupeol in *** may be responsible for the exhibited antioxidant property of the ***,knowing the antioxidant capability of the plant,*** can be developed into products which can help prevent the occurrence of oxidative stress related diseases.

关键词： Antioxidant Oxidative stress Free radical scavenging Reducing power Phenolic acids Ficus pseudopalma Blanco

Social Vulnerability to Natural Hazards in Brazil

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International Journal of Disaster Risk Science 2016年第2期7卷 111-122页

作者： beatriz Maria de Loyola Hummell Susan L.Cutter Christopher T.Emrich American Red Cross Southwest Washington ChapterHumanitarian Services Hazards & Vulnerability Research Institute Department of Geography University of South Carolina

Although social vulnerability has recently gained attention in academic studies, Brazil lacks frameworks and indicators to assess it for the entire *** vulnerability highlights differences in the human capacity to prepare for, respond to, and recover from disasters. It varies over space and time, and among and between social groups, largely due to differences in socioeconomic and demographic characteristics. This article provides a social vulnerability index(SoVI~) replication study for Brazil and shows how SoVI~concepts and indicators were adapted to the country. SoVI~Brazil follows the place-based framework adopted in the Social Vulnerability Index initially developed for the United States. Using a principal component analysis(PCA), 45city-level indicators were reduced to 10 factors that explain about 67 % of the variance in the data. Clearly identified spatial patterns showed a concentration of the most socially vulnerable cities in the North and Northeast regions of Brazil, as well as the social vulnerability of metropolitan areas and state capitals in the South and Southeast *** least vulnerable cities are mainly concentrated in the inland regions of the Southeast. Although different factors contribute to the social vulnerability in each city, the overall results confirm the social and economic disparities among Brazilian’s regions and reflect a differential vulnerability to natural hazards at local to regional scales.

关键词： Brazil Natural hazards Social vulnerability Social vulnerability index(SoVI)