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Insect-plant-pathogen interactions as shaped by future climate effects on biology, distribution, and implications for agriculture

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Insect Science 2017年第6期24卷 975-989页

作者： Piotr Trebicki beatriz Dader Simone Vassiliadis Alberto Fereres Biosciences Research Department of Economic Development Jobs Transport and Resources (DEDJTR) Horsham VIC Australia InRA UMR 385 BGPI (CIRAD-INRA-SupAgroM) Campus International de Baillarguet Montpellier France Biosciences Research DEDJTR La Trobe University AgriBio Centre 5 Ring Road Bundoora VIC Australia Institute of Agricultural Sciences-CSIC Madrid Spain

Carbon dioxide （CO2） is the main anthropogenic gas which has drastically increased since the industrial revolution, and current concentrations are projected to double by the end of this century. As a consequence, elevated CO2 is expected to alter the earths＇ climate, increase global temperatures and change weather patterns. This is likely to have both direct and indirect impacts on plants, insect pests, plant pathogens and their distribution, and is therefore problematic for the security of future food production. This review summarizes the latest findings and highlights current knowledge gaps regarding the influence of climate change on insect, plant and pathogen interactions with an emphasis on agriculture and food production. Direct effects of climate change, including increased CO2 concentration, temperature, patterns of rainfall and severe weather events that impact insects （namely vectors of plant pathogens） are discussed. Elevated CO2 and temperature, together with plant pathogen infection, can considerably change plant biochemistry and therefore plant defense responses. This can have substantial consequences on insect fecun- dity, feeding rates, survival, population size, and dispersal. Generally, changes in host plant quality due to elevated CO2 （e.g., carbon to nitrogen ratios in C3 plants） negatively affect insect pests. However, compensatory feeding, increased population size and distribution have also been reported for some agricultural insect pests. This underlines the importance of additional research on more targeted, individual insect-plant scenarios at specific locations to fully understand the impact of a changing climate on insect-plant-pathogen interactions.

关键词： carbon dioxide climate change food security pests trophic interactions

Particulate matter characterization in a steelworks using conventional sampling and innovative lidar observations

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Particuology 2016年第5期14卷 43-51页

作者： Benjamin Guinot beatriz Gonzalez Julia Perim De Faria Sumita Keclia Laboratoire d'Aerologie Universite de Toulouse CNRS Universite Paul-Sabatier 14 Avenue Edouard-Belin 31400 Toulouse France

Particulate matter （PM） emissions from steelworks cause public concern. Although end-of-pipe and pro- cess integrated measures have led to a significant drop in emissions of large particles from stacks, fine aerosols were not specifically considered, nor were emissions from fugitive and open sources. In this study, we deployed aerosol samplers together with a scanning ultra-violet （UV） lidar to characterize total suspended particles （TSP）, PM10, and PM2.5, in emissions from a large integrated steelworks in Spain over a 16-day period. We determined the content of carbonaceous, soluble inorganic, mineral dust, and metal species. A positive matrix factorization was carried out on our dataset. Despite mineral dust being predominant in all size fractions, the steelworks was clearly a source of carbonaceous species, resulting in production of secondary inorganic aerosols. In particular, stack emissions were a major contributor of fine particles, while open sources dominated the emissions of TSP, yielding up to 80% of particles larger than PM10. UV lidar provided 2D maps of aerosols in real time, with an ability to detect PM emissions and to visualize complex plumes. We suggest that air quality management of steelworks needs to focus on controlling large and coarse oarticle emissions, esoeciallv those from onen sources.

关键词： Fine aerosols Fugitive emissions Open sources Chemical composition Trace metals UV lidar

Efficacy of bevacizumab-containing chemotherapy in metastatic colorectal cancer and CXCL5 expression: Six case reports

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World Journal of Gastroenterology 2020年第16期26卷 1979-1986页

作者： Apolonia novillo María Gaibar Alicia Romero-Lorca María Fuencisla Gilsanz Laura Beltrán Miguel Galán beatriz Antón Diego Malón Amalia Moreno Ana Fernández-Santander Department of Pre-clinical Dentistry Health Sciences FacultyUniversidad Europea de MadridVillaviciosa de OdónMadrid 28670Spain Department of Health Sciences Health Sciences FacultyUniversidad Europea de MadridVillaviciosa de OdónMadrid 28670Spain Department of Medicine Health Sciences FacultyUniversidad Europea de MadridVillaviciosa de OdónMadrid 28670Spain Department of Oncology University Hospital of FuenlabradaFuenlabradaMadrid 28942Spain Department of Pathological Anatomy University Hospital of FuenlabradaFuenlabradaMadrid 28942Spain

BACKGROUnD In metastatic colorectal cancer(mCRC),the anti-vascular endothelial growth factor drug bevacizumab(BVZ)plus chemotherapy significantly improves progression-free survival compared to chemotherapy(CT)*** benefit is not,however,observed in all *** increased chemokine CXCL5 gene expression promoting angiogenesis has been proposed as a prognostic mCRC biomarker,few studies have examined its relationship with drug *** study sought to analyze tumor CXCL5 gene expression in six patients with different efficacy of BVZ-containing CT in terms of the tumor response to *** SUMMARY We report six cases of stage IV KRAS-mutated *** were given first line treatment with BVZ-containing chemotherapy in University Hospital of *** six patients differed in terms of primary tumor location(right/left side),tumor burden(mostly hepatic and peritoneal disease)and clinical disease *** treatment onset,total RnA was isolated from paraffinated tumor biopsy specimens and CXCL5 gene expression quantified through conventional RT-qPCR *** main finding was that CXCL5 expression levels were several times higher in three patients with lower progression free survival(under 6 mo)from the start of *** A higher expression of CXCL5 was observed in the three patients showing worse tumor response to treatment.

关键词： Colorectal cancer Bevacizumab Chemokine CXCL5 Gene expression Progression-free survival Case report

non-Protein-Coding RnAs and their Interacting RnA-Binding Proteins in the Plant Cell nucleus

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Molecular Plant 2010年第4期3卷 729-739页

作者： Celine Charon Ana beatriz Moreno Florian Bardou Martin Crespi University Paris-Sud Institut de Biologie des Plantes UMR8618 Orsay Cedex F-91405 France CnRS Orsay Cedex F-91405 France Institut des Sciences du Vegetal CNRS F-91198 Gif-sur-Yvette Cedex France

The complex responses of eukaryotic cells to external factors are governed by several transcriptional and post-transcriptional processes. Several of them occur in the nucleus and have been linked to the action of non-proteincoding RnAs （or npcRnAs）, both long and small npcRnAs, that recently emerged as major regulators of gene expression. Regulatory npcRnAs acting in the nucleus include silencing-related RnAs, intergenic npcRnAs, natural antisense RnAs, and other aberrant RnAs resulting from the interplay between global transcription and RnA processing activities （such as Dicers and RnA-dependent polymerases）. Generally, the resulting npcRnAs exert their regulatory effects through interactions with RnA-binding proteins （or RBPs） within ribonucleoprotein particles （or RnPs）. A large group of RBPs are implicated in the silencing machinery through small interfering RnAs （siRnAs） and their localization suggests that several act in the nucleus to trigger epigenetic and chromatin changes at a whole-genome scale. Other nuclear RBPs interact with npcRnAs and change their localization. In the fission yeast, the RnA-binding Mei2p protein, playing pivotal roles in meiosis, interact with a meiotic npcRnA involved in its nuclear re-localization. Related processes have been identified in plants and the EnOD40 npcRnA was shown to re-localize a nuclear-speckle RBP from the nucleus to the cytoplasm in Medicago truncatula. Plant RBPs have been also implicated in RnA-mediated chromatin silencing in the FLC locus through interaction with specific antisense transcripts. In this review, we discuss the interactions between RBPs and npcRnAs in the context of nuclear-related processes and their implication in plant development and stress responses. We propose that these interactions may add a regulatory layer that modulates the interactions between the nuclear genome and the environment and, consequently, control plant developmental plasticity.

关键词： Abiotic/environmental stress gene silencing Arabidopsis RnA-binding proteins non-protein-coding RnAs nucleus.

ECIEn-2020 study:the effect of COVID-19 on admissions for non-COVID-19 diseases

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World Journal of Pediatrics 2021年第1期17卷 85-91页

作者： beatriz Ramos-Lacuey Mercedes Herranz Aguirre Clara Calderón Gallego Andrea Ilundain López de Munain Eva Gembero Esarte Laura Moreno-Galarraga Department of Pediatrics CHNComplejo Hospitalario de NavarraServicio Navarro de SaludC/Irunlarrea 331080 PamplonaSpain Pediatric Infectious Diseases Department CHNComplejo Hospitalario de NavarraServicio Navarro de SaludPamplonaSpain Pediatric Hospitalization Department of PediatricsCHNComplejo Hospitalario de NavarraServicio Navarro de SaludPamplonaSpain IdiSnA Navarra Institute for Health ResearchPamplonaSpain Department of Preventive Medicine and Public Health School of MedicineUniversity of NavarraPamplonaSpain Pediatric Pulmonology Department of PediatricsCHNComplejo Hospitalario de NavarraServicio Navarro de SaludPamplonaSpain

Background The pandemic caused by severe acute respiratory coronavirus 2(SARS-CoV-2)has had great effects on health systems worldwide,not only in relation to coronavirus disease 2019(COVID-19)cases but also affecting patients with other *** ECIEn-2020 is an observational study conducted in a tertiary referral hospital in navarra,*** describes the effects of COVID-19 pandemic and the preventive measures adopted,in pediatric admissions for non-COVID-19 *** during March-June 2020(first wave of the COVID-19 pandemic in Spain)are described and compared with the same quarter in 2019.A sub-analysis was performed delving into *** characteristics(age,sex,past medical history),disease characteristics(symptoms,duration of symptoms,previous consultation in Primary Care Health Center),and admission characteristics(place and average stay)were *** A 33% reduction in the number of pediatric hospital admissions was observed,decreasing from 529 hospitaliza-tions in 2019 to 353 in 2020(Pn in patients admitted for pulmonary *** were no significant changes in average hospital-stay,percentage of intensive care unit admissions,or in admissions for other *** of patients admitted among those seen in the emergency department rose from 5.1%in 2019 to 10.9% in 2020,whereas the total number of consultations in the emergency department decreased by 68%.Conclusion The pandemic and the measures adopted due to SARS-CoV-2 have significantly decreased pediatric admissions for non-COVID-19 diseases,especially due to a reduction in the hospitalization for respiratory diseases.

关键词： Admission COVID-19 Hospitalization SARS-CoV-2

Recent Advances in One‑Dimensional Micro/nanomotors:Fabrication,Propulsion and Application

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nano-Micro letters 2023年第2期15卷 114-142页

作者： Yuhong Zheng He Zhao Yuepeng Cai beatriz Jurado‑Sanchez Renfeng Dong School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Department of Analytical Chemistry Physical Chemistryand Chemical EngineeringUniversidad de Alcala28871 Alcala de HenaresMadridSpain Chemical Research Institute“Andres M.del Rio” University of Alcala28871 Alcala de HenaresMadridSpain

Due to their tiny size,autonomous motion and functionalize modifications,micro/nanomotors have shown great potential for environmental remediation,biomedicine and micro/***-dimensional(1D)micro/nanomotors combine the characteristics of anisotropy and large aspect ratio of 1D materials with the advantages of functionalization and autonomous motion of micro/nanomotors for revolutionary *** this review,we discuss current research progress on 1D micro/nanomotors,including the fabrication methods,driving mechanisms,and recent advances in environmental remediation and biomedical applications,as well as discuss current challenges and possible *** continuous attention and innovation,the advancement of 1D micro/nanomotors will pave the way for the continued development of the micro/nanomotor field.

关键词： 1D micro/nanomotors Fabrication methods Driving mechanisms Applications

Geriatric assessment for oncologists

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Cancer Biology & Medicine 2015年第4期12卷 261-274页

作者： beatriz Korc-Grodzicki Holly M.Holmes Armin Shahrokni Memorial Sloan Kettering Cancer Center Weill Cornell Medical CollegeNew York Division of Geriatric and Palliative Medicine The University of Texas Health Science Center at Houston

The world is experiencing aging of its population. Age-specific incidence rates of cancer are higher and cancer is now recognized as a part of aging. Treating older patients can be challenging. The clinical behavior of some tumors changes with age and the aging process itself brings physiological changes leading to decline in the function of organs. It is essential to identify those patients with longer life expectancy, potentially more likely to benefit from aggressive treatment vs. those that are more vulnerable to adverse outcomes. A primary determination when considering therapy for an older cancer patient is a patient's physiologic, rather than chronologic age. In order to differentiate amongst patients of the same age, it is useful to determine if a patient is fit or frail. Frail older adults have multiple chronic conditions and difficulties maintaining independence. They may be more vulnerable to therapy toxicities, and may not have substantial lasting benefits from therapy. Geriatric assessment(GA) may be used as a tool to determine reversible deficits and devise treatment strategies to mitigate such deficits. GA is also used in treatment decision making by clinicians, helping to risk stratify patients prior to potentially high-risk therapy. An important practical aspect of GA is the feasibility of incorporating it into a busy oncology practice. Key considerations in performing the GA include: available resources, patient population, GA tools to use, and who will be responsible for using the GA results and develop care plans. Challenges in implementing GA in clinical practice will be discussed.

关键词： Geriatric oncology geriatric assessment(GA) frailty

Potential role of lava lizards as pollinators across the Galápagos Islands

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Integrative Zoology 2020年第2期15卷 144-148页

作者： Sandra HERVÍAS-PAREJO Manuel nOGAleS beatriz GUZMÁn María del Mar TRIGO Jens MOleSEn Pablo VARGAS Ruben HElenO Anna TRAVESET Global Change Research Group Mediterranean Institute for Advanced StudiesMallorcaBalearic IslandsSpain Island Ecology and Evolution Research Group Institute of Natural Products and AgrobiologyCanary IslandsSpain Royal Botanical Garden of Madrid MadridSpain Department of Plant Biology Málaga UniversityMálagaSpain Department of Bioscience Aarhus UniversityAarhusDenmark Centre for Functional Ecology Department of Life SciencesUniversity of CoimbraCoimbraPortugal

Lizards have been reported as important pollinators on several oceanic *** we evaluate the potential role of Galápagos lava lizards(Microlophus spp.)as pollinators across their *** 3 years,we sampled pollen transport by 9 lava lizard species on the 10 islands where they are present,including 7 single-island ***,only 25 of 296 individuals sampled(8.4%)transported pollen of 10 plant species,the most common being Prosopis juliflora,Exodeconus miersii,Sesuvium *** Cordia *** least 8 of these plant species were native,and none were confirmed as introduced to the *** the low overall proportion of individuals carrying pollen,this was observed in 7 of the nine lizard species,and on 8 of the ten main islands(Española,Fernandina,Floreana,Isabela,Marchena,Pinta,Santa Cruz and Santiago),suggesting that this is a widespread *** results reported here support the potential role of lava lizards as pollinators across their radiation,although they may represent a relatively modest contribution when compared with birds and ***,we cannot discard that lizards may be ecologically significant for particular plant species and ecosystems given the specific climatic condition and functional diversity of each island.

关键词： flower visitation Microlophus spp. mutualistic interactions pollination vertebrate radiation

Activation of 2D MoS_(2) electrodes induced by high-rate lithiation processes

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Journal of Energy Chemistry 2023年第3期78卷 56-70,I0003页

作者： Tianzhu Liu Georgian Melinte Oleksandr Dolotko Michael Knapp beatriz Mendoza-Sánchez Institute for Applied Materials-Energy Storage Systems(IAM-ESS) Karlsruhe Institute of Technology(KIT)Eggenstein-Leopoldshafen D-76344Germany Karlsruhe nano Micro Facility(KnMF) Karlsruhe Institute of Technology(KIT)Eggenstein-Leopoldshafen D-76344Germany Helmholtz-Institute Ulm for Electrochemical Energy Storage(HIU) Ulm 89081Germany

MoS_(2) is a highly promising material for application in lithium-ion battery anodes due to its high theoretical capacity and low ***,problems with a fast capacity decay over cycling,especially at the first cycles,and poor rate performance have deterred its practical ***,electrodes comprised solely of few-layers 2D MoS_(2) nanosheets have been manufactured by scalable liquid-phase exfoliation and spray deposition *** long-standing controversy questioning the reversibility of conversion processes of MoS_(2)-based electrodes was *** studies revealed that,in 2D MoS_(2) electrodes,conversion processes are indeed reversible,where nanostructure played a key *** of the electrodes at high current rates revealed an intriguing phenomenon consisting of a continuously increasing capacity after ca.100-200 *** phenomenon was comprehensively addressed by a variety of electrochemical and microscopy methods that revealed underlying physical activation mechanisms that involved a range of profound electrode structural *** mechanisms delivered a capacitive electrode of a superior rate performance and cycling stability,as compared to the corresponding pristine electrodes,and to MoS_(2) electrodes previously ***,we have devised a methodology to overcome the problem of cycling stability of 2D MoS_(2) ***,activation of electrodes constitutes a methodology that could be applied to enhance the energy storage performance of electrodes based on other 2D nanomaterials,or combinations thereof,strategically combining chemistries to engineer electrodes of superior energy storage properties.

关键词： 2D MoS_(2) Liquid-phase exfoliation Spray-deposition Conversion processes Activation mechanisms Energy storage mechanisms