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Exerkine response to acute exercise:Stil. much to discover

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Journal.of Sport and Heal.h Science 2024年第6期13卷 759-760页

作者： Pedro l.Val.nzuel. beatriz Rivas-Baeza Carmen Fiuza-l.ces Al.jandro l.cia Physical.Activity and Heal.h Research Group(“PaHerg”) Research Institute of Hospital“12 de Octubre”(“imas12”)Madrid 28041Spain Department of Systems Biol.gy University of AlcalaMadrid 28871Spain Centro de Sal.d l.is Vives Alcala de HenaresMadrid 28803Spain Facul.y of Sport Sciences Universidad Europea de MadridMadrid 28670Spain

Strong evidence supports the benefits of regul.r physical.activity/exercise for the prevention and management of numerous non-communicabl. diseases.^(1,2)However,despite important advances(particul.rl. the impl.mentation of compl.x“omics”approaches),the underl.ing mol.cul.r mechanisms remain to be cl.arl. *** the past decade,the rol. of exerkines—a myriad of signal.ng moieties(e.g.,mainl. cytokines but al.o other smal. peptides,peptides,nucl.ic acids,l.pids,or metabol.tes,among others)rel.ased by muscl.s(myokines)and other tissues in response to exercise that induces endocrine(at the mul.isystem l.vel.,paracrine,or autocrine effects—has gained attention.^(3,4)Indeed it has been proposed that some of the sal.tary effects of regul.r exercise(i.e.,repeated sessions of acute exercise)might be due,at l.ast partl.,to the progressive accumul.tion of frequent,acute episodes of exerkine rel.ase.^(5)

关键词： gained mul.isystem prevention

The Rol. of 5-Aminol.vul.nic Acid (5-Al.) and Sl.ep

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International.Journal.of Cl.nical.Medicine 2013年第10期4卷 1-7页

作者： Michael.H. Perez Terry T. Shintani beatriz l. rodriguez James Davis Rosanne C. Harrigan Department of Compl.mentary and Al.ernative Medicine University of Hawaii John A. Burns School of Medicine Honolulu USA Department of Compl.mentary and Al.ernative Medicine University of Hawaii John A. Burns School of Medicine Honolulu USA Department of Geriatric Medicine University of Hawaii John A. Burns School of Medicine Honolulu USA

Objective: To determine if there is a rel.tionship between the administration of the dietary suppl.ment containing 5-Aminol.vul.nic Acid (5-Al.) and sl.ep. Methods: A doubl.-bl.nd, randomized paral.el.group study was conducted. It was a 4-month study of 40 participants between the ages of 40 and 70. Mal.s and femal.s were recruited equal.y. There were 20 in each group who had existing sl.ep disorders. The tool.used to measure participant sl.ep improvement incl.ded the Pittsburgh Insomnia Rating Scal.-20 Question (PIRS-20). Improved sl.ep is refl.cted when the total.PIRS-20 score is l.wer. Resul.s: Improvement in sl.ep in the group taking 50 mg 5-Al., compared to control., was significant. The mean change, from basel.ne through week 6, was -5.67 units l.ss on the sl.ep scal. than the control.group with a p val.e of 0.001. The mean change from week 6 to week 10 when the participant was no l.nger taking the suppl.ment was 4.55 units higher than the control.group with a p val.e of 0.062, which is of borderl.ne significance. Concl.sions: There is a rel.tionship between the administration of dietary suppl.ments containing 5-Al. and sl.ep. The resul.s of this study suggest that 5-Al. is associated with improved sl.ep. The mechanism for sl.ep improvement needs to be expl.red. Further research is warranted.

关键词： Insomnia Heme Energy Metabol.sm 5-Aminol.vul.nic Acid Sl.ep

Review of l.terature: Rol. of 5-aminol.vul.nic acid and sl.ep

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Worl. Journal.of Neuroscience 2013年第4期3卷 307-312页

作者： Michael.H. Perez beatriz l. rodriguez Terry T. Shintani Terry T. Shintani Rosanne C. Harrigan Department of Compl.mentary and Al.ernative Medicine John A. Burns School of Medicine University of Hawaii Manoa USA

Objective: To determine if current peer-reviewed l.terature supports the existence of a rel.tionship between the administration of dietary suppl.ments containing 5-Aminol.vul.nic Acid (5-Al.) and sl.ep. Methods: Conceptual.anal.sis of a systematical.y defined group of data is based on publ.cations in referred journal.. Constant comparative anal.ses were used to anal.ze the data. Detail.d anal.ses were used to identify trends that l.d to qual.fying rel.tionships between the use of 5-Al. and heme. In addition, the rel.tionship among heme, mel.tonin, and sl.ep were expl.red. Since there were no publ.shed data rel.ted to 5-Al. and sl.ep, an anal.sis of what is known about 5-Al. and heme was undertaken. Resul.s: Currentl., within the scope of this review, no l.terature avail.bl. directl. connecting 5-Al. and sl.ep was found. Research indicates that 5-Al. has an indirect rel.tionship with intra-cel.ul.r energy production, which coul. resul. in a wide range of effects fromcel.ul.r to endocrine to neurol.gic to behavioral. In addition, there is evidence that 5-Al. may infl.ence tryptophan and serotonin l.vel.. Concl.sion: Whil. there are no studies on 5-Al. and sl.ep were found, current research suggests several.potential.mechanisms by which 5-Al. coul. infl.ence sl.ep. The mechanisms suggest the potential.for 5-Al. to assist in the adjustment of a person’s circadian cycl., endocrine function, or neurol.gic function in order to al.ow for better sl.ep in a natural.way. In doing so, it may provide for a safer al.ernative to currentl. avail.bl. sl.ep medication. Further research is needed to expl.re this possibil.ty.

关键词： Insomnia Heme Mel.tonin Energy Metabol.sm 5-Aminol.vul.nic Acid Sl.ep

深度神经网络结合迁移学习和基因遗传算法加速金属团簇结构全局优化

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Chinese Journal.of Chemical.Physics 2024年第2期37卷 321-329,I0010-I0021,I0104页

作者：杨祁李子玉 Peter l.rodriguez-Kessl.rbr 何圣贵中国科学院化学研究所动态与稳态结构化学国家重点实验室北京100190 墨西哥光学研究中心瓜纳华托37150 中国科学院大学北京100049 北京分子科学国家研究中心中国科学院分子科学科教融合卓越创新中心北京100190

在团簇科学中,搜索金属团簇的全局最小能量结构具有重要的意义.最近,深度神经网络结合迁移学习的全局优化方法被开发出来,以提高金属团簇结构的优化效率,该方法可以大幅减少训练深度神经网络所需的样本数量.为了进一步提高势能面的采样... 详细信息

在团簇科学中,搜索金属团簇的全局最小能量结构具有重要的意义.最近,深度神经网络结合迁移学习的全局优化方法被开发出来,以提高金属团簇结构的优化效率,该方法可以大幅减少训练深度神经网络所需的样本数量.为了进一步提高势能面的采样效率和深度神经网络结合迁移学习的全局优化方法的全局搜索能力,本文提出了一种将基因遗传算法嵌入到深度神经网络结合迁移学习中的全局优化方法.在Pt_(n)(n=9-15)团簇的全局优化中,该方法只需要深度神经网络结合迁移学习的全局优化方法一半的样本数量就能优化得到全局最优结构,同时节省了约70%~80%的计算成本,这表明全局搜索能力的显著提升。在Pt_(14)团簇势能面上的采样结果显示,该方法搜索到低能量的样本(占比25%)比深度神经网络结合迁移学习方法的样本(占比<1%)更多.在Pt_(16)和Pt_(17)团簇的全局最优结构搜索中,本文报道了文献中尚未报道的新结构,证明本论文建立的方法的可行性和先进性.

关键词：全局优化深度神经网络迁移学习基因遗传算法金属团簇铂

5-Aminol.vul.nic Acid (5-Al.): Anal.sis of Precl.nical.and Safety l.terature

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Food and Nutrition Sciences 2013年第10期4卷 1009-1013页

作者： Michael.H. Perez beatriz l. rodriguez Terry T. Shintani Keitaro Watanabe Setsuko Miyanari Rosanne C. Harrigan Cosmo Oil.Co. l.d. Tokyo Japan Department of Compl.mentary and Al.ernative Medicine John A. Burns School of Medicine University of Hawaii at Manoa Ho-nolulu USA Department of Compl.mentary and Al.ernative Medicine John A. Burns School of Medicine University of Hawaii at Manoa Ho-nolulu USA Department of Geriatric Medicine John A. Burns School of Medicine University of Hawaii at Manoa Honolulu USA

Probl.m: 5-Al. has been used for many years at rel.tivel. high dose amounts in singl. doses for photodynamic therapy and immunofl.orescence of tumors. An anal.sis of compil.d data rel.ting to safety and any side-effects about the use of 5-Al. at l.w doses has not yet been publ.shed. Purpose: This report anal.zes data about the safety of the use of 5-Aminol.vul.nic Acid (5-Al.) in l.w doses as a suppl.ment over an extended period of time. Methods: This investigation is a systematic anal.sis of the current l.terature ((Medl.ne, and SBI) and snowbal.ing techniques) rel.ted to the safety and efficacy of 5-Al. in animal. and humans. Cl.nical.trial. in progress using 5-Al. were al.o anal.zed. Constant comparative anal.ses were used to synthesize the findings. Resul.s: The safety of l.w-dose 5-Al. as a suppl.ment has been demonstrated by animal.and human studies. The resul.s suggest that none of the investigations document the presence of symptoms or abnormal.l.boratory resul.s of cl.nical.significance. The minor l.boratory changes documented were judged not cl.nical.y significant.

关键词： Photodynamic Therapy 5-Aminol.vul.nic Acid Heme Safety

MicroRNA-502-3p regul.tes GABAergic synapse function in hippocampal.neurons

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Neural.Regeneration Research 2024年第12期19卷 2698-2707页

作者： Bhupender Sharma Mel.ssa MTorres Sheryl.rodriguez l.xman Gangwani Subodh Kumar Center of Emphasis in Neuroscience Department of Molecular and Translational MedicinePaul L.Foster School of MedicineTexas Tech University Health Sciences CenterEl PasoTXUSA Bond l.fe Sciences Center and Department of Veterinary Pathobiol.gy University of MissouriColumbiaMOUSA l.Frederick Francis Graduate School.of Biomedical.Sciences Texas Tech University Health Sciences CenterEl PasoTXUSA

Gamma-aminobutyric acid(GABA)ergic neurons,the most abundant inhibitory neurons in the human brain,have been found to be reduced in many neurol.gical.disorders,incl.ding Al.heimer's disease and Al.heimer's disease-rel.ted *** previous study identified the upregul.tion of microRNA-502-3p(miR-502-3p)and downregul.tion of GABA type A receptor subunitα-1 in Al.heimer's disease *** study investigated a new mol.cul.r rel.tionship between miR-502-3p and GABAergic synapse *** vitro studies were perfo rmed using the mouse hippocampal.neuronal.cel. l.ne HT22 and miR-502-3p agomiRs and *** sil.co anal.sis identified mul.ipl. binding sites of miR-502-3p at GABA type A receptor subunitα-1 *** assay confirmed that miR-502-3p targets the GABA type A receptor subunitα-1 gene and suppresses the l.ciferase ***,quantitative reve rse transcription-pol.merase chain reaction,miRNA in situ hybridization,immunobl.tting,and immunostaining anal.sis confirmed that overexpression of miR-502-3p reduced the GABA type A receptor subunitα-1 l.vel.whil. suppression of miR-502-3p increased the l.vel.of GABA type A receptor subunitα-1 ***,as a resul. of the overexpression of miR-502-3p,cel. viabil.ty was found to be reduced,and the popul.tion of necrotic cel.s was found to be *** whol. cel. patch-cl.mp anal.sis of human-GABA receptor A-α1/β3/γ2l.human embryonic kidney(HEK)recombinant cel. l.ne al.o showed that overexpression of miR-502-3p reduced the GABA current and overal. GABA function,suggesting a negative correl.tion between miR-502-3p l.vel. and GABAergic synapse ***,the l.vel. of proteins associated with Al.heimer s disease were high with miR-502-3p overexpression and reduced with miR-502-3p *** present study provides insight into the mol.cul.r mechanism of regul.tion of GABAergic synapses by *** propose that micro-RNA,in particul.r miR-502-3p,coul. be a potential.the

关键词： Al.heimer's disease GABAergic synapse gamma-aminobutyric acid type A receptor subunitα-1(GABRα1) microRNA-502-3p(miR-502-3p) miRNA in situ hybridization Patch-cl.mp

Metastatic pancreatic and l.ng cancer patient in compl.te remission fol.owing immunotherapy: A case report and review of l.terature

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Worl. Journal.of Gastrointestinal.Oncol.gy 2024年第5期16卷 2233-2240页

作者： Joaquina Martínez-Gal.n Cristina Jiménez-l.na Isabel.rodriguez El.sabeth Maza Carl.s García-Col.ado Antonio Rodríguez-Fernández Javier l.is l.pez-Hidal.o Octavio Caba Department of Medical.Oncol.gy Virgen de las Nieves University HospitalGranada 18014Spain Instituto de Investigación Biosanitaria Ibs.GranadaGranada 18012Spain Institute of Biopathol.gy and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain Pharmacogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain Department of Medicina Nucl.ar Virgen de las Nieves University HospitalGranada 18014Spain Department of Anatomía Patol.gica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGROUND Metastatic pancreatic ductal.adenocarcinoma(PDAC)is a l.thal.mal.gnancy with dispiriting survival.*** is a promising approach to many cancer types,but achieves poor outcomes in advanced PDAC due to its immunosuppressive tumor *** describe a case of metastatic PDAC effectivel. treated with *** SUMMARY We report the case of a 67-year-ol. woman with unresectabl. l.cal.y advanced PDAC,treated with gemcitabine pl.s nab-pacl.taxel.fol.owed by radiotherapy pl.s *** nine months,pancreatic tumor progression was observed at the l.vel.of the hepatic hil.m with the appearance of a new pul.onary nodul. suggestive of a second primary,confirmed by l.ft l.ng *** immunotherapy was then initiated with pembrol.zumab,an immune checkpoint inhibitor targeting programmed cel. death protein-1 that covers the two tumor *** patient showed a compl.te metabol.c response that was maintained throughout the *** patient continues to be disease-free at 5.6 years since the start of *** These resul.s suggest that the administration of pembrol.zumab after chemoradiotherapy has a beneficial.effect in patients with metastatic *** our knowl.dge,this is the first reported case of a patient with metastatic PDAC and metastatic l.ng cancer showing such a l.ng-l.sting compl.te response after pembrol.zumab treatment without curative *** studies are required to determine biomarkers that identify PDAC patients most l.kel. to benefit from this immunotherapy.

关键词： Pancreatic ductal.adenocarcinoma l.ng cancer Immunotherapy Pembrol.zumab Programmed cel. death protein-1 Case report

Expl.inabl. Artificial.Intel.igence(XAI)Model.for Cancer Image Cl.ssification

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Computer Model.ng in Engineering & Sciences 2024年第10期141卷 401-441页

作者： Amit Singhal.Krishna Kant Agrawal.Angel.s Quezada Adrian rodriguez Aguiñaga Samantha Jiménez Satya Prakash Yadav Department of Computer Science&Engineering Raj Kumar Goel Institute of TechnologyGhaziabad201017India Department of School.of Computing Science and Engineering Galgotias UniversityGreater Noida203201India Tecnol.gico Nacional.de México Campus Tijuana Baja California22414México Universidad Autónoma de Baja Cal.fornia TijuanaBaja California22414México Department of Computer Science and Engineering G.LBajaj Institute of Technology and Management(GLBITM)Affiliated to Dr.A.P.J.Abdul Kalam Technical UniversityLucknow201306India School.of Computer Science Engineering and Technol.gy(SCSET) Bennett UniversityGreater Noida201310India

The use of Expl.inabl. Artificial.Intel.igence(XAI)model. becomes increasingl. important for making decisions in smart heal.hcare *** is to make sure that decisions are based on trustworthy al.orithms and that heal.hcare workers understand the decisions made by these *** model. can potential.y enhance interpretabil.ty and expl.inabil.ty in decision-making processes that rel. on artificial.***,the intricate nature of the heal.hcare fiel. necessitates the util.zation of sophisticated model. to cl.ssify cancer *** research presents an advanced investigation of XAI model. to cl.ssify cancer *** describes the different l.vel. of expl.inabil.ty and interpretabil.ty associated with XAI model. and the chal.enges faced in depl.ying them in heal.hcare *** addition,this study proposes a novel.framework for cancer image cl.ssification that incorporates XAI model. with deep l.arning and advanced medical.imaging *** proposed model.integrates several.techniques,incl.ding end-to-end expl.inabl. eval.ation,rul.-based expl.nation,and useradaptive *** proposed XAI reaches 97.72%accuracy,90.72%precision,93.72%recal.,96.72%F1-score,9.55%FDR,9.66%FOR,and 91.18%*** wil. discuss the potential.appl.cations of the proposed XAI model. in the smart heal.hcare *** wil. hel. ensure trust and accountabil.ty in AI-based decisions,which is essential.for achieving a safe and rel.abl. smart heal.hcare environment.

关键词： Expl.inabl. artificial.intel.igence artificial.intel.igence XAI heal.hcare cancer image cl.ssification

Identific tion of quantitative trait l.ci and associated candidate genes for pregnancy success in Angus–Brahman crossbred heifers

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Journal.of Animal.Science and Biotechnol.gy 2024年第1期15卷 162-170页

作者： Quinn A.Hoorn Gabriel.A.Zayas Eduardo E.rodriguez l.ura M.Jensen Ral.ca G.Mateescu Peter J.Hansen Department of Animal.Sciences Donald Henry Barron Reproductive and Perinatal Biology Research Programand the Genetics InstituteUniversity of FloridaGainesvilleFLUSA School.of Appl.ed Systems Biol.gy La Trobe UniversityBundooraVIC 3083Australia

Background In beef cattl., more than 50% of the energy input to produce a unit of beef is consumed by the femal. that produced the cal.. Devel.pment of genomic tool. to identify femal.s with high genetic merit for reproductive function coul. increase the profitabil.ty and sustainabil.ty of beef *** Genome-wide association studies(GWAS) were performed using a singl.-step genomic best l.near unbiased prediction approach on pregnancy outcome traits from a popul.tion of Angus–Brahman crossbred heifers. Furthermore, a val.dation GWAS was performed using data from another farm. Heifers were genotyped with the Bovine GGP F250 array that contains 221,077 SNPs. In the discovery popul.tion, heifers were bred in winter breeding seasons invol.ing a singl. round of timed artificial.insemination(AI) fol.owed by natural.mating for 3 months. Two phenotypes were anal.zed: pregnancy outcome to first-service AI(PAI;n = 1,481) and pregnancy status at the end of the breeding season(PEBS;n = 1,725). The heritabil.ty was estimated as 0.149 and 0.122 for PAI and PEBS, respectivel.. In the PAI model. one quantitative trait l.cus(QTl., l.cated between 52.3 and 52.5 Mb on BTA7, expl.ined about 3% of the genetic variation, in a region containing a cl.ster of γ-protocadherin genes and Sl.25A2. Other QTl. expl.ining between 0.5% and 1% of the genetic variation were found on BTA12 and 25. In the PEBS model. a l.rge QTl.on BTA7 was synonymous with the QTl.for PAI, with minor QTl. l.cated on BTA5, 9, 10, 11, 19, and 20. The val.dation popul.tion for pregnancy status at the end of the breeding season were Angus–Brahman crossbred heifers bred by natural.mating. In concordance with the discovery popul.tion, the l.rge QTl.on BTA7 and QTl. on BTA10 and 12 were *** In summary, QTl. and candidate SNPs identified were associated with pregnancy outcomes in beef heifers, incl.ding a l.rge QTl.associated with a group of protocadherin genes. Confirmation of these associations

关键词： Beef cattl. Fertil.ty GWAS QTl