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Capillary electrophoresis to determine entrapment efficiency of a nanostructured lipid carrier loaded with piroxicam

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Journal of Pharmaceutical Analysis 2015年第1期5卷 70-73页

作者： Jessica Otarola Adriana guillermina Lista beatriz Fernandez Band Mariano garrido Analytical Chemistry Section INQUISUR(UNS-CONICET)Av.Alem 1253Bahia BlancaArgentina

A simple and fast capillary electrophoresis method has been developed to determine the amount of piroxicam loaded in a drug delivery system based on nanostructured lipid carriers（NLCs）.The entrapment efficiency of the nanostructured lipid carrier was estimated by measuring the concentration of drug not entrapped in a suspension of *** influence of different parameters on migration times,peak symmetry,efficiency and resolution was studied;these parameters included the pH of the electrophoretic buffer solution and the applied *** piroxicam peak was obtained with a satisfactory *** separation was carried out using a running buffer composed of 50 mM ammonium acetate and 13.75 mM ammonia at pH *** optimal voltage was 20 kV and the cartridge temperature was 20 ℃.The corresponding calibration curve was linear over the range of 2.7-5.4 μg/mL of NLC *** reproducibility of migration time and peak area were investigated,and the obtained RSD%values（n = 5） were 0.99 and ***.

关键词： Capillary electrophoresis Drug delivery system Nanostructured lipid carrier Piroxicam

Knowledge, Emotion, and Action Connected to Ethics Learning

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Journal of Philosophy Study 2013年第11期3卷 1025-1031页

作者： Elizabeth beatriz Ormart National University of La Matanza--University of Buenos Aires

In the following paper we try to analyze the main characteristics of teaching ethics at university. In this particular case the student is an adult; we found several special features, for instance that the student has certain ideas and appreciations, certain moral intuitions which may interfere with the learning process. The idea is not just add more information and knowledge to the existing one, but to solve inconsistencies by restructuring prior knowledge. This is a transformation process that relies not only on cognitive aspects but also on sensitivity and action. Knowledge, sensitivity and action are different gateways to the complexity of ethical object at university classrooms. To perform this kind of experience you will need methodological strategies which involve integral education.

关键词： ethics teaching university

Texture Filters and Fractal Dimension on Image Segmentation

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Journal of Signal and Information Processing 2018年第3期9卷 229-238页

作者： beatriz Marrón Universidad Nacional del Sur Bahía Blanca Argentina

Texture analysis is important in several image segmentation and classification problems. Different image textures manifest themselves by dissimilarity in both the property values and the spatial interrelationships of their component texture primitives. We use this fact in a texture discrimination system. This paper focuses on how to apply texture operators based on co-occurrence matrix, texture filters and fractal dimension to the problem of object recognition and image segmentation.

关键词： Textural Features Co-Occurrence Matrix Texture Spectrum Texture Classification Fractal Dimension

Appadtion of the NAC Transcription Factors Predates the Emergence of Land Plants

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Molecular Plant 2016年第9期9卷 1345-1348页

作者： Aude Maugarny-Cales beatriz gonqalves Stefan Jouannic Michael Melkonian gane Ka-Shu Wonge Patrick Laufs Institut Jean-Pierre Bourgin INRA AgroParisTech CNRS Universite ParisSaclay RD10 78026 Versailles Cedex France Univ. Pads-Sud Universite Paris-Saclay 91405 Orsay France IRD UMR DIADE 911 Avenue Agropolis BP6450134394 Mbntpellier Cedex 5 France LMI RICE IRD USTH National Key Laboratory for Plant Cell Biotechnology Agronomical Genetics Institute Pham Van Dong Road Hanoi Vietnam Botany Department Cologne Biocenter University of Cologne 50674 Cologne Germany Beijing genomics Institute-Shenzhen Shenzhen 518083 China Department of Biological Sciences University of Alberta Edmonton AB T6G 2E9 Canada Department of Medicine University of Alberta Edmonton AB T6G 2E Canada These authors contributed equally to this article.

Dear Editor The NAC （for NO APICAL MERISTEM [NAM], Arabidopsis TRANSCRII^TION ACTIVATOR FACTOR [ATAF] and CUP- SHAPED COTYLEDON [CUC]） proteins are one of the largest families of plant-specific transcription factors （Nagata et aL, 2015）. They are involved in many different biological processes including development and the response to biotic and abiotic stresses. To date, NAC transcription factors have only been identified in land plants （Zhu et al., 2012; Nagata et al., 2015）; and some of them control land-plant-specific processes, such as the formation of specialized water-conducting systems （Xu et al., 2014）. Therefore, it has been suggested that their appearance accompanied the emergence of land plants. Here, we exploited the transcriptomic data generated within the 1000 plants project （***, Wickett et al., 2014） to revisit the origin of NAC proteins. Our careful analysis shows that NAC transcription factors appeared before the ernergence of land plants as we detected their homologs in several groups of streptophyte green algae. The possible significance of this finding is discussed.

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3-D Characterization of CdSe Nanoparticles Attached to Carbon Nanotubes

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Nano Research 2008年第1期1卷 89-97页

作者： Ana B.Hungría beatriz H.Juárez Christian Klinke Horst Weller Paul A.Midgley Department of Materials Science and Metallurgy University of CambridgePembroke StreetCambridgeCB23QZUK 2 Institute of Physical ChemistryUniversity of Hamburg20146 HamburgGermany

The crystallographic structure of CdSe nanoparticles attached to carbon nanotubes has been elucidated by means of high resolution transmission electron microscopy and high angle annular dark field scanning transmission electron microscopy *** rod-like nanoparticles,grown in solution together with carbon nanotubes,undergo a morphological transformation and become attached to the carbon *** tomography reveals that the nanoparticles are hexagonal-based with the(001)planes epitaxially matched to the outer graphene layer.

关键词： Electron tomography CdSe nanoparticles STEM HRTEM carbon nanotubes

Health Care System in Portugal for People with Motor Problems

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Open Journal of Pathology 2023年第4期13卷 195-209页

作者： beatriz Ferreira Maria Carolina IADE-Faculty of Design Technology and Communication of the European University University of Lisbon Lisbon Portugal

Purpose: From a social and labor inclusion perspective, the article presents a digital prototype conceptualized to provide a “Diagnostic Page”, which delivers various prescribers and suppliers of support products that mitigate the problems of the respective patients. It also provides a “Patient Card Page”, where all the information about financing the respective products is placed, as well as all the documents likely to be needed for the commercial transactions to be carried out by all the parties involved. It also aims to provide a digital medium to grow a community in this niche market. In the action research methodology approach, the prototype was taken to funding competitions and conferences, where interviews and surveys were carried out, and a number of suggestions were collected on the type of platform to consider in order to respond to the concerns and needs of end users, such as patients, prescribers, suppliers and associations. Methods: The digital platform where the system is hosted uses algorithms that, on the diagnostic page, consider keywords used by patients and return a series of prescribers and suppliers of support products, in which the corresponding percentage of attenuation is taken into account and the best solution found to overcome the level of difficulty presented by the respective patients is delivered. Results and Conclusions: It is hoped that, with this platform, people with motor problems will be able to obtain their diagnosis instantly, through the algorithm implemented, and that they will immediately be provided with a series of prescribers, suppliers and support products best suited to their needs, as well as all the information or conditions necessary to purchase or finance them. On the other hand, prescribers, suppliers and associations have an online platform where they can offer their consultations, products and other support as freelancers who are part of a community.

关键词： Health Care System Marketplace Support Products Digital Community Patient Card

gSTM3, but not IZUMO1, is a cryotolerance marker of boar sperm

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Journal of Animal Science and Biotechnology 2019年第4期10卷 931-941页

作者： Marc Llavanera Ariadna Delgado-Bermúdez beatriz Fernandez-Fuertes Sandra Recuero Yentel Mateo Sergi Bonet Isabel Barranco Marc Yeste Biotechnology of Animal and Human Reproduction (Techno Sperm) Unit of Cell Biology Department of Biology Institute of Food and Agricultural Technology University of Girona

Background: Cryopreservation is currently the most efficient method for long-term preservation of mammalian gametes and is extensively used in swine artificial insemination(AI) centres. However, it is well-known that cryopreservation procedures induce changes in the water phase in both intra and extracellular compartments,which alter the content and localisation of several proteins and ends up curtailing the structural integrity of functional sperm(i.e., cryoinjuries). Alterations and deficiencies of sperm-oocyte binding proteins during gamete recognition are one of the causes of reproductive failure both in vitro and in vivo. In this sense, characterisation of cryopreservation effects upon oocyte-binding proteins of sperm, such as IZUMO1 and gSTM3, is essential when assessing the impact of this technique in swine ***: Cryopreservation was found to induce changes in the localisation of IZUMO1 and gSTM3 in boar ***, the relative content of both proteins was not altered after thawing. Furthermore, whereas IZUMO1 content was found not to be related to the cryotolerance of boar sperm, gSTM3 content was observed to be higher in poor(PFE) than in good(gFE) freezability ejaculates in both pre-frozen(1.00 INT·mm^2± 0.14 INT·mm^2 vs.0.72 INT·mm^2± 0.15 INT·mm^2;P gSTM3 levels were found to be higher in those spermatozoa that exhibited low mitochondrial activity, high reactive oxygen species(ROS) production, and high membrane lipid disorder postthaw(P gSTM3 content between gFE and PFE, together with this protein having been found to be related to poor sperm quality post-thaw, suggests that it could be used as a cryotolerance marker of boar spermatozoa. Furthermore, both IZUMO1 and gSTM3 relocate during cryopreservation, which could contribute to the reduced fertilising capacity of frozen-thawed boar

关键词： Boar Cryopreservation gSTM3 IZUMO1 ROS Sperm

Inflammatory bowel diseases: A disease (s) of modern times? Is incidence still increasing?

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World Journal of gastroenterology 2008年第36期14卷 5491-5498页

作者： Cristina Saro gismera beatriz Sicilia Aladrén Service of Digestive Diseases Hospital de Cabuees Gijón Spain Service of Digestive Diseases Alcaiz Hospital Spain

Inflammatory bowel diseases (IBD) are a heterogeneous group of diseases, not always easy to diagnose, even more difficult to classify, and diagnostic criteria are not always uniform. Well done population-based studies are not abundant, and so comparisons among different geographical areas or populations are not always very reliable. In this article, we have reviewed epidemiological studies available on the world’s population while making a critical review of published data.

关键词： Inflammatory bowel diseases Epidemiological Incidence Diagnostic criteria

Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer

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genes & Diseases 2024年第3期11卷 311-323页

作者： David Sanchez-Marin Macrina beatriz Silva-Cazares Fany Iris Porras-Reyes Rebeca g.rcia-Roman Alma D.Campos-Parra Posgrado en Ciencias Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unidad Academica Multidisciplinaria Region Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Servicio de Anatomia Patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto de Salud Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-coding RNAs(lncRNAs)are non-coding RNAs longer than 200 nucleotides with dynamic regulatory *** interact with a wide range of molecules such as DNA,RNA,and proteins to modulate diverse cellular functions through several mechanisms and,if deregulated,they can lead to cancer development and ***,it has been described that IncRNAs are susceptible to form gene fusions with mRNAs or other IncRNAs,breaking the paradigm of gene fusions consisting mainly of protein-coding ***,their biological significance in the tumor phenotype is still ***,their recent identification opens a new line of research to study their biological role in tumor-igenesis,and their potential as biomarkers with clinical relevance or as therapeutic *** present study aimed to review the IncRNA fusions identified so far and to know which of them have been associated with a potential *** address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window incancer.

关键词： Cancer genefusions IncRNAs ncRNAs Therapy