检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

诉讼案件频发巴西航司有苦难言

商业周刊（中文版） 2024年第4期 15-15页

作者： Martha Viotti Beck beatriz Reis 杜然(译) 不详

●严厉的消费者法律催生了数以干计的诉讼,愤怒的乘客可能会获得高达3000美元的赔偿在大多数国家,航班延误和行李丢失是航空旅行的不幸现实。在巴西,它们却有可能带来一笔意外收人。贝尔纳迪一施纳普律师事务所(Bernardi & Schnapp)的... 详细信息

●严厉的消费者法律催生了数以干计的诉讼,愤怒的乘客可能会获得高达3000美元的赔偿在大多数国家,航班延误和行李丢失是航空旅行的不幸现实。在巴西,它们却有可能带来一笔意外收人。贝尔纳迪一施纳普律师事务所(Bernardi & Schnapp)的航空法专家、国际航空运输协会(IATA)在巴西的法律顾问里卡多·贝尔纳迪(Ricardo Bernardi)表示,在这里,不满意的乘客可以轻易将航空公司告上法庭,并有望赢得8000~1.5万雷亚尔(相当于1600~3000美元)的赔偿。

关键词：律师事务所航空法航空旅行贝尔纳法律顾问航班延误诉讼案件里卡多

Lipid droplets as metabolic determinants for stemness and chemoresistance in cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2021年第9期13卷 1307-1317页

作者： Alba Royo-Garcia Sarah Courtois beatriz Parejo-Alonso Pilar Espiau-Romera Patricia Sancho Hospital Universitario Miguel Servet IIS AragónZaragoza 50009Spain

Previously regarded as simple fat storage particles,new evidence suggests thatlipid droplets(LDs)are dynamic and functional organelles involved in keycellular processes such as membrane biosynthesis,lipid metabolism,cellsignalling and ***,an increased LD content is one of the mostapparent features resulting from lipid metabolism reprogramming necessary tosupport the basic functions of cancer *** have been associated to differentcellular processes involved in cancer progression and aggressiveness,such astumorigenicity,invasion and metastasis,as well as ***,all of these processes are controlled by a subpopulation of highly aggressivetumoral cells named cancer stem cells(CSCs),suggesting that LDs may befundamental elements for stemness in *** the key role of CSCs onchemoresistance and disease relapse,main factors of therapy failure,the design ofnovel therapeutic approaches targeting these cells may be the only chance forlong-term survival in cancer *** this sense,their biology and functionalproperties render LDs excellent candidates for target discovery and design ofcombined therapeutic *** this review,we summarise the currentknowledge identifying LDs and CSCs as main contributors to cancer aggressiveness,metastasis and chemoresistance.

关键词： Lipids Lipid droplets Lipid metabolism Stemness Cancer stem cells Chemoresistance

Exercise and antioxidant supplements in the elderly

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2013年第2期2卷 94-100页

作者： Mari Carmen Gomez-Cabrera beatriz Ferrando Thomas Brioche Fabian Sanchis-Gomar Jose Vina Department of Physiology Faculty of MedicineUniversity of ValenciaFundacionInvestigacion Hospital Clinico Universitario/INCLIVAValencia 46010Spain Laboratory "Movement Sport and Health Sciences" University of RennesRennes EA1274France

Both exercise and aging increase reactive oxygen species （ROS）, which can result in damage to cells. Aging is the result of damage caused by ROS to the mitochondrial genome in post mitotic cells and numerous studies have demonstrated an increase in ROS or their byproducts with exercise. ROS can cause oxidative stress as they overwhelm the antioxidant cellular defenses. Therefore interventions aimed at limiting or inhibiting ROS production, such as supplementation with antioxidant vitamins, should be able to reduce fatigue during muscle contraction and the rate of formation of aging changes with a consequent reduction of the aging rate and disease pathogenesis. However, it has been shown that ROS are essential signaling molecules which are required to promote the health benefits of exercise and longevity. In young individuals, ROS are required for normal force production in skeletal muscle, for the development of training-induced adaptations in endurance performance, as well as for the induction of the endogenous defense systems. Thus, taking antioxidants during training, in young athletes, seems to be detrimental. However, antioxidant supplementation may be expected to be beneficial and is receiving growing attention in the active old population. In this manuscript we review the literature associated with the main areas of interest in this topic.

关键词： Adaptations Aging Antioxidant enzymes NF-κB Oxidative stress PGC-1α Skeletal muscle

Visual function,performance,and processing of basketball players *** individuals

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2020年第6期9卷 587-594页

作者： Jesús Vera Raimundo Jiménez David Cárdenas beatriz Redondo José Antonio García Department of Optics Faculty of ScienceUniversity of GranadaGranada 18071Spain Department of Physical Education and Sport Faculty of Sport ScienceUniversity of GranadaGranada 18071Spain Sport and Health University Mixed Institute University of GranadaGranada 18071Spain

Background:Athletes tend to have better visuo-motor performance than do sedentary ***,several basic visual-function and perceptual parameters remain unexplored to *** this study,we investigated whether differences exist in visual function,performance,and processing between basketball players and individuals without a sport-involvement ***:A total of 33 healthy men with no visual impairment or pathology were divided into 2 groups,depending on the involvement in sport(semi-professional basketball players and sedentary individuals).We tested their baseline heart-rate variability in the resting position apart from subjective questionnaires to determine their physical fitness level,and we checked their visual function,performance,and processing through an extended battery of optometric ***:The 2 groups differed in resting heart-rate variability parameters(p<0.001),confirming their dissimilarities in regular time practising sports per *** basketball players showed a closer breakpoint and recovery nearpoint of convergence,a higher fusional-vergence rate,better discriminability halos,and better eye-hand coordination(all p values<0.05).Conclusion:These results show evidence that athletes,basketball players in this case,exhibit better performance in several visual abilities in comparison to a group of individuals without sporting backgrounds,suggesting an improvement due to the systematic involvement of those skills during basketball practice.

关键词： Exercise Fitness level Health Heart rate variability Visual skills Team sport

Role of cetuximab in first-line treatment of metastatic colorectal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第15期20卷 4208-4219页

作者： Miguel Jhonatan Sotelo beatriz García-Paredes Carlos Aguado Javier Sastre Eduardo Díaz-Rubio Center affiliate to the "Red Temática de Investigación Cooperativa (RD12/0036/006)" Instituto Carlos ⅢSpanish Ministry of Economy and Competitivity. Oncology DepartmentHospital Clínico San Carlos28040 MadridSpain Department of Medicine School of MedicineUniversidad Complutense de Madrid28040 MadridSpain

The treatment of metastatic colorectal cancer(mCRC)has evolved considerably in the last decade,currently allowing most mCRC patients to live more than two *** antibodies targeting the epidermal growth factor receptor(EGFR)and vascular endothelial growth factor play an important role in the current treatment of these ***,only antibodies directed against EGFR have a predictive marker of response,which is the mutation status of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS).Cetuximab has been shown to be effective in patients with KRAS wild-type *** CRYSTAL study showed that adding cetuximab to FOLFIRI(regimen of irinotecan,infusional fluorouracil and leucovorin)significantly improved results in the first-line treatment of KRAS wildtype ***,results that evaluate the efficacy of cetuximab in combination with oxaliplatin-based chemotherapy in this setting are *** the other hand,recent advances in the management of colorectal liver metastases have improved survival in these *** cetuximab to standard chemotherapy increases the response rate in patients with wild-type KRAS and can thus increase the resectability rate of liver metastases in this group of *** this paper we review the different studies assessing the efficacy of cetuximab in the first-line treatment of mCRC.

关键词： Cetuximab First-line Metastatic colorectal cancer Colorectal liver metastases Elderly patients

Effects of chlorpyrifos on enzymatic systems of Cydia pomonella （Lepidoptera： Tortricidae） adults

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2017年第3期24卷 455-466页

作者： Laura beatriz Parra Morales Raul Adolfo Alzogaray Liliana Cichon Silvina Garrido Jimena Soleno Cristina Monica Montagna Laboratorio de Investigaciones Bioquimicas Quimicas y de Medio Ambiente Facultad de Ingenieria Universidad Nacional del ComahueBuenos Aires 1400 (Q83001BX) Neuquen Facultad de Ciencias del Ambiente y la Salud Universidad Nacional del Comahue Buenos Aires 1400 Neuquen Centro de Investigaciones de Plagas e Insecticidas (CIPEIN-UNIDEFICONICET) Villa Martelli Buenos Aires Instituto de Investigacion e Ingenieria Ambiental (3iA-UNSAM) San Martin Provincia de Buenos Aires Instituto Nacional de Tecnologia Agropecuaria Estacion Experimental Alto Valle General Roca Argentina

The control program of codling moth （Cydia pomonella L.） in the Rio Negro and Neuqu6n Valley is intended to neonate larvae. However, adults may be subjected to sublethal pesticide concentrations generating stress which might enhance both mutation rates and activity of the detoxification system. This study assessed the exposure effects of chlorpyrifos on target enzyme and, both detoxifying and antioxidant systems of surviving adults from both a laboratory susceptible strain （LSS） and a field population （FP）. The results showed that the FP was as susceptible to chlorpyrifos as the LSS and, both exhibited a similar chlorpyrifos-inhibitory concentration 50 （IC50） of acetylcholinesterase （ACHE）. The FP displayed higher carboxylesterase （CarE） and 7-ethoxycoumarine O-deethylase （ECOD） activities than LSS. Both LSS and FP showed an increase on CarE activity after the exposure to low-chlorpyrifos concentrations, followed by enzyme inhibition at higher concentrations. There were no significant differences neither in the activities of glutathione S-transferases （GST）, catalase （CAT） and superoxide dismutase （SOD） nor in the reduced glutathione （GSH） content between LSS and FP. Moreover, these enzymes were unaffected by chlorpyrifos. In conclusion, control adults from the FP exhibited higher CarE and ECOD activities than control adults from the LSS. AChE and CarE activities were the most affected by chlorpyrifos. Control strategies used for C. pomonella, such as rotations of insecticides with different modes of action, will probably delay the evolution of insecticide resistance in FPs from the study area.

关键词： acetylcholinesterase antioxidant system chlorpyrifos codling moth detoxification enzymes

Should capecitabine replace 5-fluorouracil in the first-line treatment of metastatic colorectal cancer?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第20期20卷 6092-6101页

作者： Carlos Aguado beatriz García-Paredes Miguel Jhonatan Sotelo Javier Sastre Eduardo Díaz-Rubio Department of Medical Oncology Hospital Clínico San Carlos 28040 Madrid Spain

Fluoropyrimidines play a central role in the first-line treatment of metastatic colorectal cancer. Our aim was to review whether capecitabine was a safer, non-inferior, economically superior and more convenient alternative to 5-fluorouracil. Capecitabine has previously been compared to 5-fluorouracil-either as a monotherapy or in combination with oxaliplatin, irinotecan, or biological drugs-and has been found to have comparable efficacy and safety profiles. Furthermore, pharmacoeconomic data and patients’ preferences for oral chemotherapy further favor capecitabine. Therefore, capecitabine appears to be an effective and safe alternative to fluorouracil in the first-line treatment of metastatic colorectal cancer.

关键词： Capecitabine 5-Fluorouracil Metastatic colorectal cancer

Corrosion behaviour of as-cast ZK40 with CaO and Y additions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2018年第3期28卷 427-439页

作者： Ricardo Henrique BUZOLIN Marta MOHEDANO Chamini Lakshi MENDIS beatriz MINGO Domonkos TOLNAI Carsten BLAWERT Karl Ulrich KAINER Haroldo PINTO Norbert HORT Magnesium Innovation Centre Helmholtz-Zentrum Geesthacht Institute of Materials Science Joining and Forming Graz University of Technology Departamento de Ciencia de Materiales Facultad de Ciencias Químicas Universidad Complutense Brunel Centre for Advanced Solidification Technology Brunel University London Department of Materials Engineering University of Sao Paulo

The microstructures of as-cast ZK40,ZK40 with 2%(mass fraction)CaO and ZK40 with 1%(mass fraction)Y were investigated,and the intermetallic phase morphology and the distribution were *** having discrete intermetallic particles at the grain boundaries for the ZK40,the microstructure was modified to a semi-continuous network of intermetallic compounds along the grain boundaries for the ZK40 with CaO or Y *** CaO was not found in the ***,Ca was present in Ca2Mg6Zn3 intermetallic compounds which were formed during *** evolution and electrochemical impedance spectroscopy tests revealed that the addition of CaO slightly enhanced the corrosion resistance whereas Y had a negative effect on the corrosion resistance of *** tests showed that severe localised corrosion as well as corrosion along the intermetallic compounds played an important role in the corrosion process of ZK40-Y whereas the localised corrosion was not pronounced for ZK40 or ZK40?CaO ***-segregation in theα-Mg matrix was notably higher for the ZK40 alloy compared with the modified *** combination of this effect with a possible formation of a more stable corrosion layer for the ZK40-CaO was attributed as the main reason for an improved corrosion resistance for the ZK40-CaO alloy.

关键词： Mg alloy ZK40 Y addition CaO addition corrosion behaviour

Rice Husk Bio-Chars as Adsorbent for Methylene Blue and Ethinylestradiol from Water

在线全文

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2020年第3期8卷 275-287页

作者： Jonathan Lacuesta Iris beatriz Vega Erramuspe Liji Sobhana Dennis Kronlund Jouko Peltonen Soledad Gutiérrez Pedro Fardim Department of Chemical Engineering University of the RepublicJulio Herrera y Reissig 565Montevideo11300Uruguay Laboratory of Fibre and Cellulose Technology Åbo Akademi UniversityPorthansgatan 3Turku/ÅboFI-20500Finland Laboratory of Physical Chemistry and Center of Excellence for Functional Materials Åbo Akademi UniversityPorthansgatan 3Turku/ÅboFI-20500Finland Department of Chemical Engineering KU LeuvenCelestijnenlaan 200FLeuvenB-3001Belgium

Biobased adsorbents are eco-friendly materials used for water and wastewater treatment and air *** research work explores the potential use of rice husk chars as a low-cost adsorbent for pollutants from water,such as methylene blue and *** husk chars are prepared by combustion of rice husks(RH-Char)or pre-treated rice husks(PT-Char).A third char(M-Char)supplied by a local company which uses rice husks as combustion material is also *** chars are characterized by field emission scanning electron microscopy(FE-SEM)in conjunction with energy dispersive X-ray spectroscopy(EDX),X-ray powder diffraction(XRD),and zeta-potential *** three bio-chars are tested as adsorbent for the removal of two wastewater contaminants:methylene blue(MB)and ethinylestradiol(EE2).According to the results,RH-Char and PT-Char present zeta-potential values near−52 mV,whereas M-Char shows a zeta-potential value of−32 *** RH-Char and PTChar are rich in amorphous SiO_(2) and M-Char has crystalline SiO_(2)(cristobalite).The bio-chars remove MB and EE2 efficiently showing the following results for the adsorption capacity of MB(inμmol g^(−1)):769.2(RH-Char),41.2(PT-Char),and 31.7(M-Char).The adsorption capacity values for EE2(inμmol g^(−1))are:33.1(RH-Char),19.1(PT-Char),and 16.9(M-Char).The information gathered in the present work evidences the potential of rice husks bio-chars for bio-remediation and may in future contribute to the conversion of a side-stream from the rice industry into value-added materials.

关键词： Rice husk bio-char thermal treatment adsorption methylene blue ethinylestradiol