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Not yet IDEAL?-evidence and learning curves of minimally invasive pancreaticoduodenectomy

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Hepatobiliary Surgery and Nutrition 2020年第6期9卷 812-814页

作者： Felix Nickel Caelán Max Haney beat-Peter Müller-Stich Thilo Hackert Department of General Visceraland Transplantation SurgeryHeidelberg UniversityHospital HeidelbergHeidelbergGermany

In response to“What’s the next step in evaluating laparoscopic pancreaticoduodenectomy?”(http://***/article/view/29682/25710)by Fernando Burdío,Luís Grand and Ignasi *** and foremost,we would like to express our sincere condolences on the passing of Professor Ignasi *** were deeply saddened to hear of this and wish his family,friends and colleagues strength in these difficult times of grieving.

关键词： IDEAL learning Grand

E-selectin ligand complexes adopt an extended high-affinity conformation

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分子细胞生物学报:英文版 2016年第1期8卷 62-72页

作者： Roland C.Preston Roman P.Jakob Florian P.C.Binder Christoph P.Sager beat Ernst Timm Maier Institute of Molecular Pharmacy Universitat Basel4056 BaselSwitzerland Biozentrum Universitat Basel4056 BaselSwitzerland

E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early inflammatory response by binding to glycoproteins containing the tetrasaccharide sialyl Lewisx(sLex).Efficient leukocyte recruitment under vascular flow conditions depends on an increased lifetime of E-selectin/ligand complexes under tensile force in a so-called catch-bond binding ***-crystal structures of a representative fragment of the extracellular E-selectin region with sLex and a glycomimetic antagonist thereof reveal an extended E-selectin conformation,which is identified as a high-affinity binding state of E-selectin by molecular dynamics ***-angle X-ray scattering experiments demonstrate a direct link between ligand binding and E-selectin conformational transition under static conditions in *** permits tracing a series of concerted structural changes connecting ligand binding to conformational stretching as the structural basis of E-selectin catch-bond-mediated leukocyte *** detailed molecular view of the binding site paves the way for the design of a new generation of selectin *** is of special interest,since their therapeutic potentialwas recently demonstrated with the pan-selectin antagonists GMI-1070(Rivipansel).

关键词： inﬂammation leukocyte adhesion E-selectin glycomimetic antagonist sialyl Lewisx conformational change

The constant electric field effect on the radio absorption of crystals BaTiO_(3) and piezoceramics PCR-1

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Journal of Advanced Dielectrics 2020年第1期10卷 144-151页

作者： Eugeny Sidorenko Chan Thi beat Ngoc Gennady Prikhodko Ivan Natkhin Alexander Shloma Diana Kharchenko Southern Federal University Stachki Avenue 194 Rostov-on-Don 344090Russia University of Transport and Communications Hanoi Vietnam

The effect of a constant electric field(E)on the absorption of microwave electromagnetic energy(L)by BaTiO_(3) crystals and the highly sensitive PCR-1 piezoceramic was *** field dependence of the absorption value LeET at the maximum of the spectrum Lef T has the form of a“butterfly”,and the dependence of the frequency shift of the maximum on the field strength f eET has a hysteretic *** PCR-1 Lef T absorption spectrum at high E is modulated by pulses in a wide frequency *** is assumed that the cause of the amplitude-frequency modulation of the spectrum may be the electromagnetic radiation of incomplete local discharges at the surface of *** change in the magnitude and position of the resonance maximum in the absorption spectra and the appearance of amplitude-frequency modulation Lef T when exposed to a constant field is interpreted from the point of view of changes in the parameters and concentration of the domains walls,as well as the a-and c-domain wedges of mechanical twins resonating in the electromagnetic field.

关键词： Microwave absorption spectrum piezoceramics dispersion domain walls micro breakdowns

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工具磨削发展趋势

制造技术与机床 2005年第4期 138-139页

作者： beat Oderbolz 瑞士EWAG公司

位于瑞士Etziken的Ewag公司是国际知名和领先的精密工具磨床开发与生产企业。在这一领域，Ewag以其有竞争力的研发工作创建了创新的磨削理念，对工具磨削技术的重大影响而著称。公司一直与汽车、航天、医疗、电子和手表制造业的用户紧... 详细信息

位于瑞士Etziken的Ewag公司是国际知名和领先的精密工具磨床开发与生产企业。在这一领域，Ewag以其有竞争力的研发工作创建了创新的磨削理念，对工具磨削技术的重大影响而著称。公司一直与汽车、航天、医疗、电子和手表制造业的用户紧密合作，不断积累在用户所用刀具开发方面的经验。当今的发展趋势集中在三个方面：

关键词： Ewag公司工具磨削发展趋势标准砂轮修整系统

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对职业教育装备发展的一点见解

对职业教育装备发展的一点见解

花生四烯酸氧化产物对肾毒性肾炎肾脏血液动力学的影响

中国职业技术教育学会2006年学术年会

作者： beat Jost 世界教具联合会

在传统教育中,从没有把设备和计算机联合在一起,而现在的趋势是比如说像西门子他们的磨床、铣床都是需要计算机来控制,是需要数字进行控制,所以普通的工人必须学习数字化的控制技术才能掌握这些新的设备。众所周知,书籍会存在几十年,而...

在传统教育中,从没有把设备和计算机联合在一起,而现在的趋势是比如说像西门子他们的磨床、铣床都是需要计算机来控制,是需要数字进行控制,所以普通的工人必须学习数字化的控制技术才能掌握这些新的设备。众所周知,书籍会存在几十年,而不会被 CD 和其他形式所替代

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中国病理生理杂志 1995年第1期11卷 66-69页

作者：吴升华 beat.,H 南京医学院第一附属医院

应用血栓素合成抑制剂、５－脂氧化酶抑制剂及１２－脂氧化酶抑制剂对肾毒性肾炎大鼠进行预处理，测定其肾小球滤过率、肾血流量及肾小球合成的前列腺素Ｅ２、血栓素Ｂ－２、白三烯Ｂ－４及１２－羟二十碳四烯酸。发现这三种抑制剂分别... 详细信息

应用血栓素合成抑制剂、５－脂氧化酶抑制剂及１２－脂氧化酶抑制剂对肾毒性肾炎大鼠进行预处理，测定其肾小球滤过率、肾血流量及肾小球合成的前列腺素Ｅ２、血栓素Ｂ－２、白三烯Ｂ－４及１２－羟二十碳四烯酸。发现这三种抑制剂分别抑制肾小球合成血栓索Ｂ－２、白三烯Ｂ－４及１２－羟二十碳四烯酸，并缓解了肾小球滤过率及肾血流量的下降程度。由此证实以上三种物质参与肾毒性肾炎中的肾脏血液动力学紊乱。

关键词：肾炎血液动力学花生四烯酸类

Nephila edulis蜘蛛牵引丝形态的13C NMR研究

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Nephila edulis蜘蛛牵引丝形态的13C NMR研究

第十三届全国波谱学学术会议

作者：周平 beat H.Meier 复旦大学聚合物分子工程教育部重点实验室复旦大学高分子科学系 ETH Zurich Physical ChemistryETH-HonggerbergCH-8093 ZurichSwitzerland

蜘蛛牵引丝因其出色的材料力学性能近年来引起人们广泛的重视。然而,人们却对丝的加工及形成过程的机理知之甚少。这里,我们报道了用C 核磁共振研究 Nephila edulis 蜘蛛牵引丝在各种形态下的结构,如液态腺体、脱水薄膜、伴随旋转干燥...

蜘蛛牵引丝因其出色的材料力学性能近年来引起人们广泛的重视。然而,人们却对丝的加工及形成过程的机理知之甚少。这里,我们报道了用C 核磁共振研究 Nephila edulis 蜘蛛牵引丝在各种形态下的结构,如液态腺体、脱水薄膜、伴随旋转干燥的腺体以及受迫抽丝后的丝线。用产生牵引丝的主腺体中所含的氨基酸(主要为甘氨酸 Ala 和丙氨酸 Gly)经C 标记后喂养蜘蛛约3周,由此获得所需的丝线和腺体样品。

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PCD和PCBN刀片的经济磨削

制造技术与机床 2003年第4期 108-109页

作者： beat Oderbolz from Ewag AG 沈捷瑞士

现在，当重磨小型PCD和PCBN可转位刀片时，应用CNC技术具有很多优点。例如，一台革新的工具磨床能利用现有工艺并兼顾针对将来的工艺，这就是证明。这种机床的基本特点是自动修磨砂轮、有一个集成的三维(3D)测量系统和编程简单。

关键词：磨削可转位刀片经济性 PCD PCBN

Can High Dose Metamizol Medication Contribute to Postsurgical Hemorrhage:A Case Report

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Open Journal of Modern Neurosurgery 2015年第2期5卷 53-58页

作者： Dagmar Wildpaner beat Flueckiger Urs Dieter Schmid Dominik Weishaupt Robert Theiler Department of Rheumatology Stadtspital Triemli Zurich Switzerland Division of Neurosurgery Stadspital Triemli Zurich Switzerland Department of Radiology Stadtspital Triemli Zurich Switzerland

The use of metamizol significantly increased in the last decade, especially in non US countries [1]. Although metamizol is known to be a non selective COX inhibitor and therefore has platelet inhibiting potential, it is widely used in pain management in postsurgical setting. Methods: We present a case of bleeding after microsurgical decompression of a narrow lumbar spinal canal. Our patient developed a bleeding complication 3 days after the surgery. The bleeding spontaneously resolved after stopping the application of metamizol. Metamizol is a non selective COX inhibitor and is used as standard analgetic drug after surgery in our department, whereas other COX inhibitors are not. We made an intensive literature research to evaluate the prohaemorrhagic potential of metamizol. Metamizol has proven dose dependent platelet inhibiting effect. Conclusions: This is a quite ordinary case and there is no proof of metamizol being responsible for the bleeding in this case, it still poses questions at our daily routine and the question about a dose dependent clinically relevant prohaemorrhagic effect of metamizol remains unanswered. A proper study is needed.

关键词： Metamizol Narrow Lumbar Spinal Canal Postsurgical Analgesia Bleeding Complication