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Retinal circulation and its role in macular disorders in patients without systemic disease

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 585-589页

作者： Priyangshu Chandra Aditya Sudhalkar Souvik Mandal jay Chhablani Smt.Kanuri Santhamma Retina Vitreous Centre L.V.Prasad Eye Institute Kallam Anji Reddy Campus L.V.Prasad Marg Banjara Hills Hyderabad Andhra Pradesh500034 India

AIM: To determine whether retinal circulatory changes play a role in the pathogenesis of macular disorders in patients who are otherwise healthy. METHODS: Patients with macular disorders that required angiographic imaging were included in this prospective case series. After a complete ocular exam,fluorescein angiography was performed using a standardized technique on the HRA-II(Heidelberg Engineering, Heidelberg, Germany) with special focus on the posterior pole. Only patients with good quality images were included in the analysis. Circulatory parameters recorded included the arm-choroid time,choroid-retinal artery, and finally the retinal artery-vein time. Zonal asymmetry(between the upper and lower zones divided by a line passing through the centre of the fovea) in transit times, if any was also noted. Appropriate statistical analysis was done. Circulation times were compared with age matched historical controls. Changes in retinal dye transit times relative to historical age matched controls, if any, were noted and compared between various ***: A total of 156 eyes of 156 patients(120 males)were included in the study. Mean age: 49.14 ±14.93 *** disorders studied were age related degeneration,polypoidal vasculopathy, central serous chorioretinopathy(CSCR) and parafoveal telangiectasia. Delayed circulation time was noted in CSCR patients ***: CSCR patients appear to have delayed arterial filling, retinal circulatory disturbances do not seem to contribute to the pathogenesis of other macular disorders.

关键词： fluorescein angiography circulation parafoveal telangiectasia idiopathic polypoidal choroidal vasculopathy age-related macular degeneration central serous chorioretinopathy

Inverted internal limiting membrane flap technique for very large macular hole

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1230-1232页

作者： Mitali Khodani Pooja Bansal Raja Narayanan jay Chhablani Kanuri Santhamma Retina Vitreous Centre LV Prasad Eye Institute Kallam Anji Reddy Campus Dr. Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences

AIMTo assess the anatomical and visual outcome of idiopathic macular holes greater than 1000 µm using the inverted internal limiting membrane flap *** retrospective case series included 5 eyes of 5 patients with idiopathic macular hole with base diameter greater than 1000 µm who underwent inverted internal limiting membrane flap technique along with standard 23G pars plans vitrectomy with posterior hyaloid detachment and fluid gas exchange with 12%-14% perfluoropropane (C3F8). Preoperative and postoperative visual acuity and spectral domain optical coherence tomography images were evaluated. The main outcome measures were visual outcome and macular hole *** age was 63.2±8.4y with all 5 subjects being females. Mean duration of symptoms was 11±14mo with a mean postoperative follow up of 13.2±13mo. The mean base diameter of the macular holes was 1420±84.8 µm (1280-1480 µm). Type 1 closure was achieved in four out of five patients, while one patient had type 2 closure using the inverted internal limiting membrane (ILM) flap technique. Median baseline BCVA was 0.79 logMAR (Snellen’s equivalent 20/120) and median final BCVA 0.6 logMAR (Snellen’s equivalent 20/80) with mean visual improvement of approximately three lines improvement. No complications related to surgical procedure were *** inverted internal limiting membrane flap technique may be promising for very large macular holes with high rate of macular closure and good visual outcome.

关键词： inverted internal limiting membrane flap technique vitrectomy macular hole

APEX2- tagging of Sigma 1-receptor indicates subcellular protein topology with cytosolic N-terminus and ER luminal C-terminus

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Protein & Cell 2018年第8期9卷 733-737页

作者： Timur Mavylutov Xi Chen Lianwang Guo jay Yang Department of Anesthesiology University of Wisconsin SMPH Madison Wl 53705 USA Department of Surgery and Physiology & Cell Biology Ohio State University Columbus OH 43210 USA

Dear Editor, Deciphering the role of any protein in a cell requires knowl- edge of the structure, subcellular localization, and the topological orientation of the protein within the relevant cells. The Sigma-1 receptor （S1R） largely localized to the endo- plasmic reticulum （ER） serves as a pluripotent intracellular signaling molecule with diverse roles in the cell including ion channel modulation, stress signaling, and transcriptional regulation （reviewed in Suet al., 2016）, however, the basic topology of this protein within a cell remains controversial.

关键词： ENDOPLASMIC-RETICULUM RECEPTOR SITES

Minutes of Macro-Finance Salon(No. 12): Systemic Risk and Macro-prudential Regulation

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Minutes of Macro-Finance Salon(No. 12): Systemic Risk and Ma...

Vitreo-retinal interface changes on optical coherence tomography in the fellow eyes of patients with macular hole

作者： Nicholas beale Sciteb the Isaac Newton Institute

19 October 2014,Beijing Factors identified to explain the financial crack down in 2008 It is noticeable that financial regulation was unable to keep pace with financial *** system itself was fragmented and did not add... 详细信息

关键词： Systemic Risk and Macro-prudential Regulation

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International Journal of Ophthalmology(English edition) 2013年第4期6卷 526-530页

作者： Ajit Babu Majji jay Kumar Chhablani Bupesh Bagga Smt.Kanuri Santhamma Retina Vitreous Centre L.V.Prasad Eye InstituteKallam Anji Reddy CampusL.V.Prasad MargBanjara HillsHyderabad 500034India

AIM:To study the vitreo-retinal interface and macular changes on optical coherence tomography(OCT) in the fellow eyes of patients with macular hole.·METHODS:Patients with idiopathic macular hole in one or both eyes presented to our institute between January 2003 and December 2009 were evaluated *** details,best-corrected visual acuity and vitreo-retinal interface,and macular changes of the fellow eye on OCT were studied.·RESULTS:Seventy patients underwent OCT of both eyes during the study *** average age group was 61.96 years and 35(50%) were *** the fellow eyes,normal foveal contour was noted in 36(51.4%) eyes and 34(48.6%) eyes were observed to have vitreo-retinal interface *** them,13(18.6%) eyes had some stage of full thickness macular hole and 21(30.0%) eyes had interface *** was no statistical correlation between involved eye lesions(P =0.64) or visual acuity(P =0.55) as predictors of development of either fellow eye lesions or poor visual acuity.·CONCLUSION:There is a significant chance of having vitreo-retinal interface findings in the fellow eyes of patients presenting with macular *** should be considered in both eyes of patients with macular hole to detect early changes in the fellow eyes,which may require an early intervention.

关键词： macular hole fellow eye optical coherence tomography vitreo-retinal interface

Soil-Plant-Microbe Interactions in Stressed Agriculture Management:A Review

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Pedosphere 2017年第2期27卷 177-192页

作者： Shobhit Raj VIMAL jay Shankar SINGH Naveen Kumar ARORA Surendra SINGH Department of Environmental Microbiology Babashaeb Bhimrao Ambedkar (Central) University Lucknow 226025 (India) Department of Botany Banaras Hindu University Varanasi 221005 (India)

The expected rise in temperature and decreased precipitation owing to climate change and unabated anthropogenic activities add complexity and uncertainty to agro-industry. The impact of soil nutrient imbalance, mismanaged use of chemicals, high temperature, flood or drought, soil salinity, and heavy metal pollutions, with regard to food security, is increasingly being explored worldwide. This review describes the role of soil-plant-microbe interactions along with organic manure in solving stressed agriculture problems. Beneficial microbes associated with plants are known to stimulate plant growth and enhance plant resistance to biotic （diseases） and abiotic （salinity, drought, pollutions, etc.） stresses. The plant growth-promoting rhizobemteria （PGPR） and mycorrhizae, a key component of soil microbiota, could play vital roles in the maintenance of plant fitness and soil health under stressed environments. The application of organic manure as a soil conditioner to stressed soils along with suitable microbial strains could further enhance the plant-microbe associations and increase the crop yield. A combination of plant, stress-tolerant microbe, and organic amendment represents the tripartite association to offer a favourable environment to the proliferation of beneficial rhizosphere microbes that in turn enhance the plant growth performance in disturbed agro-ecosystem. Agriculture land use patterns with the proper exploitation of plant-microbe associations, with compatible beneficial microbial agents, could be one of the most effective strategies in the management of the concerned agriculture lands owing to climate change resilience. However, the association of such microbes with plants for stressed agriculture management still needs to be explored in greater depth.

关键词： beneficial microbes fungi microbial agents rnycorrhiza organic manure pathogen plant health plant growth-promoting rhizobacteria

Discharging of PCM in Various Shapes of Thermal Energy Storage Systems:A Review

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Journal of Thermal Science 2023年第3期32卷 1124-1154页

作者： DHAIDAN Nabeel HASHIM Hasan ABBAS Abdalrazzaq KHODADADI jay ALMOSAWY Wala AL-MOUSAWI Fadhel Engineering Faculty Kerbala UniversityKerbalaIraq Department of Mechanical Engineering Auburn University1418 Wiggins HallAuburnAL 36849-5341USA Al-Zahraa University for Women KerbalaIraq

Utilizing the phase change materials in different thermal storage applications attains valuable attention due to the fascinating thermal properties of these *** comprehension of the thermal behaviour of phase change materials during the melting and solidification is considered a significant priority in designing the shape of the different *** this review,analytical,computational and experimental investigations that address solidification/freezing of phase change materials within thermal energy storage systems are *** is placed on the role of the shape of adopted containers encompassing planar,spherical,cylindrical and annular *** storage for solar thermal applications,waste heat recovery,and thermal management of buildings/computing platforms/photovoltaics has been the topics that benefit from these *** all container shapes,the freezing process is controlled initially by natural convection,and a high solidification rate is ***,the conduction dominates the process,and the freezing rate *** temperature and flow of cooling heat transfer fluid affect the solidification process,but the impact of heat transfer fluid temperature is more significant than its flow ***,the freezing time increases with the container’s size and amount of contained *** aspect ratio of the planar and vertical cylindrical cavities substantially influences the discharging time and *** contrast,the orientation of the annular cavity has a lower impact on the discharging process.

关键词： containers freezing phase change materials phase transformation solidification

Forecasting cyberattacks with incomplete,imbalanced,and insignificant data

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Cybersecurity 2018年第1期1卷 263-278页

作者： Ahmet Okutan Gordon Werner Shanchieh jay Yang Katie McConky Computer Engineering Rochester Institute of TechnologyRochesterNYUSA Industrial&Systems Engineering Rochester Institute of TechnologyRochesterNYUSA

Having the ability to forecast cyberattacks before they happen will unquestionably change the landscape of cyber warfare and cyber *** work predicts specific types of attacks on a potential victim network before the actual malicious actions take *** challenge to forecasting cyberattacks is to extract relevant and reliable signals to treat sporadic and seemingly random acts of *** paper builds on multi-faceted machine learning solutions and develops an integrated system to transform large volumes of public data to aggregate signals with imputation that are relevant and predictive of cyber incidents.A comprehensive analysis of the individual parts and the integrated whole demonstrates the effectiveness and trade-offs of the proposed *** 16-months of reported cyber incidents by an anonymized victim organization,the integrated approach achieves up to 87%,90%,and 96% AUC for forecasting endpoint-malware,malicious-destination,and malicious-email attacks,*** assessed month-by-month,the proposed approach shows robustness to perform consistently well,achieving F-Measure between 0.6 and *** framework also enables an examination of which unconventional signals are meaningful for cyberattack forecasting.

关键词： Cyber security Forecasting Unconventional signals

Turbulent flame image classification using Convolutional Neural Networks

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能源与人工智能(英文) 2022年第4期10卷 87-94页

作者： Rathziel Roncancio Aly El Gamal jay P.Gore School of Mechanical Engineering Purdue UniversityWest LafayetteIN47907USA School of Electrical and Computer Engineering Purdue UniversityWest LafayetteIN 47907USA

Pockets of unburned material in turbulent premixed flames burning CHs,air,and CO_(2) were studied using OH Planar Laser-Induced Fuorescence(PLIF)images to improve current *** flames are ubiquitous in most natural gas air combustors running gas turbines with dry exhaust gas recirculation(EGR)for land-based power *** improvements continue in the charactenization and understanding of turbulent flames with EGR particularly for transient events like ignition and *** and/or islands of unburned material within bumed and unburned turbulent media are some of the features of these *** features reduce the heat release rates and increase the carbon monoxide and hydrocarbons *** present work involves Convolutional Neural Networks(CNN)based dassification of PIF images containing unburned pockets in three turbulent flames with 0%,5%,and 10%CO_(2).The CNN model was constructed using three convolutional layers and two fully connected layers using dropout and weight *** of 94.2%,92.3%and 89.2%were registered for the three flames,*** present approach represents significant computational time savings with respect to conventional image processing methods.

关键词： CNN Flame Neural network Turbulent