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An Overview of the Synthesis and Gene Transfer Properties of Triblock Copolymers Poly(2-Methyl-2-Oxazoline-b-Tetrahydrofurane-b-2-Methyl-2-Oxazoline)

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Journal of Biomaterials and Nanobiotechnology 2014年第2期5卷 53-65页

作者： bazoly rasolonjatovo Bruno Pitard Philippe Guégan Hervé Cheradame Institut du Thorax INSERM UMR 915 8 Quai Moncousu Nantes France Laboratory LAMBE University of Evry UMR 8587 Bld Mitterrand 91025 Evry cedex France Polytheragene 4 rue Pierre Fontaine Evry France Université Pierre et Marie Curie Laboratoire de Chimie des Polymères 94200 Ivry sur Seine Paris France

The synthesis of poly(2-methyl-2-oxazoline-b-tetrahydrofurane-b-2-methyl-2-oxazoline) triblock copolymer of low molar mass has been carried out. Characterization of the purified polymer by 1H and 13C NMR spectroscopies is described. These block copolymers did not give DNA containing polyplexes. The in vivo transfection properties were investigated by injection of tibialis muscles and intratracheal administration of female Swiss mice. These triblock copolymers with a molar ratio [2-methyl-2-oxazoline units]/[tetrahydrofurane units] in the 3 - 5 range gave a higher transfection efficiency than that of Lutrol or of PE6400 which are the gold standards of this transfection technique. Hydrolysis increased the performances of muscle transfection, showing the beneficial effect of the presence of positive charges, but was clearly detrimental to the transfection efficiency of pulmonary epithelium.

关键词： Triblock Copolymer Cell Transfection Vector Gene Therapy Neutral Amphiphilic Block Copolymers

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Confrontation between Myelogram and Cytogenetics in 35 CML Malagasy Patients

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Journal of Cancer Therapy 2016年第12期7卷 919-923页

作者： Harioly Nirina Marie Osé Michael Hoahy Rasoanandrasana Raheritiana Todisoa Mahenina rasolonjatovo Anjaramalala Sitraka Rakoto Alson Aimée Olivat Rasamindrakotroka Andry Haematology Laboratory of University Hospital Joseph Ravoahangy Andrianavalona Antananarivo Madagascar Medecine Service of University Hospital Joseph Raseta Befelatanana Antananarivo Madagascar Medical Biology Laboratory Faravohitra Antananarivo Madagascar

Introduction: Chronic Myeloid Leukemia is a myeloproliferative disorder affecting hematopoietic stem cells. The specific cytogenetic abnormality is translocation (9;22) which leads to the BCR-ABL fusion gene. Methods: We did a bone marrow aspiration in our laboratory of haematology of university hospital Joseph Ravoahangy Andrianavalona Antananarivo. We studied myelogram and compared its result to the cytogenetic result. Results: Men were the most affected by this pathology and diagnostic average age was 51.2 years. Splenomegaly leukocytosis and myelemia were often present. Myelogram showed granulocytic hyperplasia and the t (9;22) were present in all the patients. Conclusion: Diagnosis is based on data from the NFS, the myelogram, the search for the Philadelphia chromosome and BCR-ABL fusion gene. These specialized techniques are still inaccessible for Malagasy patients.

关键词： Chronic Myeloid Leukemia Madagascar t (9 22) BCR-ABL

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儿童嵌顿性腹股沟疝

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世界核心医学期刊文摘（儿科学分册） 2005年第7期1卷 16-17页

作者： Rantomalala H.Y.H. Andriamanarivo M.L. rasolonjatovo T.Y. 郭战宏 Service d'Urologie CHUHJRA BP 4150 101 AntananarivoMadagascar

The inguinal hernia, malformations caused by persistence of peritonea-vaginal duct, is frequent in *** is a benign affection as long as it is not *** our five-year-retrospective study, we have found 32 cases (30 boys and 2 girls) of strangled inguinal *** are 78,12%of cases under five years *** 54%, the hernia was on the right *** and inguinoscrotal hernia are very exposed to *** observed obstruction syndrome in 81,25%of *** have to deplore one case of scrotal fistulae by intestinal necrosis and two cases of testicle *** all of our patients, the peritonea-vaginal duct was closed with ligature, associated with pre-funicular parietal *** case of recurrence is found in postoperative time.

关键词：嵌顿性腹膜鞘突肠坏死腹股沟阴囊疝睾丸坏死鞘管

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