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Hepatitis B virus pre-S2 start codon mutations in Indonesian liver disease patients

World Journal of Gastroenterology 2012年第38期18卷 5418-5426页

作者： Andi Utama Marlinang Diarta Siburian Ismail Fanany Mariana Destila bayu intan Rama Dhenni Tri Shinta Kurniasih Syafruddin AR Lelosutan Wenny Astuti Achwan Nasrul Zubir Arnelis Benyamin Lukito Irawan Yusuf Laurentius Adrianus Lesmana Ali Sulaiman Molecular Epidemiology Division Mochtar Riady Institute for Nanotechnology Universitas Pelita Harapan Lippo Karawaci Tangerang 15810 Banten Indonesia Gastroentero-Hepatology Division Department of Internal Medicine Gatot Soebroto Hospital Jakarta 10410 Indonesia Department of Internal Medicine Mataram General Hospital Mataram 83127 Indonesia Gastroentero-Hepatology Division Department of Internal Medicine M. Djamil Hospital Padang 25127 Indonesia Department of Internal Medicine Siloam Hospital Lippo Karawaci Tangerang 15810 Banten Indonesia Faculty of Medicine Hasanuddin University Makassar 90245 Indonesia Hepatology Division Department of Internal Medicine Faculty of Medicine University of Indonesia Jakarta 10430 Indonesia

AIM: To identify the prevalence of pre-S2 start codon mutations and to assess their association with liver disease progression. METHODS: The mutations were identified by direct sequencing from 73 asymptomatic carriers, 66 chronic hepatitis (CH), 66 liver cirrhosis (LC) and 63 hepatocellular carcinoma (HCC) patients. Statistical significances were determined using Fisher's exact test, χ 2 test, and t -test analyses whenever appropriate. Pre-S mutation as a risk factor for advanced liver disease was estimated by unconditional logistic regression model adjusted with age, sex, and hepatitis B e antigen (HBeAg). P < 0.05 was considered significant. RESULTS: Mutation of the hepatitis B virus (HBV) pre-S2 start codon was found in 59 samples from 268 subjects (22.0%), with higher prevalence in patients with cirrhosis 27/66 (40.9%) followed by HCC 18/63 (28.6%), chronic hepatitis 12/66 (18.2%) and asymptomatic carriers 2/73 (2.7%) (P < 0.001). Logistic regression analysis showed that pre-S2 start codon mutation was an independent factor for progressive liver disease. Other mutations, at T130, Q132, and A138, were also associated with LC and HCC, although this was not statistically significant when adjusted for age, sex, and HBeAg. The prevalence of pre-S2 start codon mutation was higher in HBV/B than in HBV/C (23.0% vs 19.1%), whilst the prevalence of T130, Q132, and A138 mutation was higher in HBV/C than in HBV/B. The prevalence of pre-S2 start codon mutation was higher in LC (38.9%) and HCC (40.0%) than CH (5.6%) in HBeAg(+) group, but it was similar between CH, LC and HCC in HBeAg(-) group. CONCLUSION: Pre-S2 start codon mutation was higher in Indonesian patients compared to other Asian countries, and its prevalence was associated with advanced liver disease, particularly in HBeAg(+) patients.

关键词：乙型肝炎病毒起始密码子突变患者 Fisher精确检验 Logistic回归模型 Logistic回归分析印尼

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Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients

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World Journal of Gastroenterology 2011年第6期17卷 708-716页

作者： Andi Utama Marlinang Diarta Siburian Sigit Purwantomo Mariana Destila bayu intan Tri Shinta Kurniasih Susan Tai Rino Alvani Gani Laurentius Adrianus Lesmana All Sulaiman Wenny Astuti Achwan Soewignjo Soemohardjo Arnelis Nasrul Zubir Julius Syafruddin AR Lelosutan Benyamin Lukito Tantoro Harmono Molecular Epidemiology Division Mochtar Riady Institute for Nanotechnology Universitas Pelita Harapan Lippo Karawaci Tangerang 15810 Indonesia Hepatology Division Department of Intemal Medicine Faculty of Medicine University of Indonesia Jakarta 10430 Indonesia Department of Internal Medicine Mataram General Hospital Mataram 83127 Indonesia Gastroentero-Hepatology Division Department of Internal Medicine Dr. M. Jamil Hospital Padang 25127 Indonesia Gastroentero-Hepatology Division Department of Intemal Medicine Dr. Gatot Soebroto Hospital Jakarta 10410 Indonesia Department of Internal Medicine Siloam Hospital Lippo Village Tangerang 15810 Indonesia Department of Internal Medicine Dr. Moewardi Hospital Surakarta 57126 Indonesia

AIM:To identify the prevalence of hepatitis B e antigen (HBeAg) and to assess the association of hepatitis B virus (HBV) core promoter mutations and viral load in Indonesian ***:Sixty-four patients with chronic hepatitis,65 with liver cirrhosis and 50 with hepatocellular carcinoma were included in this *** and hepatitis B e antibody (HBeAb) tests were performed using enzyme-linked immunosorbent assay and the mutations were analyzed by *** load was measured by real-time polymerase chain ***:Of 179 patients,108 (60.3%) were HBeAg(-) and 86 (79.6%) of these HBeAg(-) patients had been *** A1896 mutation was not found in HBeAg(+) patients,however,this mutation was detected in 70.7% of HBeAg(-) *** mutation was frequently found when HBeAg was not expressed (87.7%),compared to that found in HBeAg seroconverted patients (65.1%).The A1899 mutation was also more prevalent in HBeAg(-) than in HBeAg(+) patients (P=0.004).The T1762/A1764 mutation was frequently found in both HBeAg(+) and HBeAg(-) patients,however,the prevalence of this mutation did not significantly differ among the two groups (P=0.054).In HBeAg(+) patients,the T1762/A1764 mutation was correlated with lower HBV DNA (P < 0.001).The A1899 mutation did not correlate with HBV DNA (P=0.609).In HBeAg(-) patients,the T1762/A1764 mutation alone was not correlated with HBV DNA (P=0.095),however,the presence of either the T1762/A1764 or A1896 mutations was associated with increased HBV DNA (P < 0.001).CONCLUSION:The percentage of HBeAg(-) patients is high in Indonesia,and most of the HBeAg(-) patients had been *** A1896 mutation was most likely the major cause of HBeAg *** T1762/A1764 mutation alone was associated with lower viral loads in HBeAg(+) patients,but not in HBeAg(-) patients.

关键词：乙型肝炎病毒 HBeAg 突变检测核心启动子患者载量酶联免疫吸附试验协会

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Numerical Simulations of One-Directional Fractional Pharmacokinetics Model

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Computers, Materials & Continua 2022年第12期73卷 4923-4934页

作者： Nursyazwani Mohamad Noor Siti Ainor Mohd Yatim Nur intan Raihana Ruhaiyem School of Distance Education Universiti Sains MalaysiaUSM PenangPenang11800Malaysia School of Computer Science Universiti Sains MalaysiaUSM PenangPenang11800Malaysia

In this paper,we present a three-compartment of pharmacokinetics model with irreversible rate *** compartment consists of arterial blood,tissues and venous ***’s principle and the law of mass action were used to develop the model based on the diffusion *** model is modified into a fractional pharmacokinetics model with the sense of Caputo *** existence and uniqueness of the model are investigated and the positivity of the model is *** behaviour of the model is investigated by implementing numerical algorithms for the numerical solution of the system of fractional differential *** software is used to plot the graphs for illustrating the variation of drug concentration concerning ***,the numerical simulations of the model are presented for different values ofαwhich verified the theoretical ***,we also observed the pattern of the simulations at the three-compartment of the model by using different values of initial conditions.

关键词： Pharmacokinetics model Irreversible rate Fractional order Numerical simulations

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Framework for a Computer-Aided Treatment Prediction (CATP) System for Breast Cancer

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Intelligent Automation & Soft Computing 2023年第6期36卷 3007-3028页

作者： Emad Abd Al Rahman Nur intan Raihana Ruhaiyem Majed Bouchahma Kamarul Imran Musa School of Computer Sciences Universiti Sains MalaysiaPenang11800Malaysia School of Computer Science Higher Colleges of TechnologyRAKUAE Department of Community Medicine School of Medical SciencesUniversiti Sains MalaysiaKubang KerianKelantan16150Malaysia

This study offers a framework for a breast cancer computer-aided treat-ment prediction(CATP)*** rising death rate among women due to breast cancer is a worldwide health concern that can only be addressed by early diagno-sis and frequent *** has been the most utilized breast ima-ging technique to *** have begun to use computer-aided detection and diagnosis(CAD)systems to improve the accuracy of breast cancer diagnosis by minimizing human *** the progress of artificial intelligence(AI)in the medical field,this study indicates that systems that can anticipate a treatment plan once a patient has been diagnosed with cancer are few and not widely *** such a system will assist clinicians in determining the optimal treatment plan and avoid exposing a patient to unnecessary hazardous treatment that wastes a significant amount of *** develop the prediction model,data from 336,525 patients from the SEER dataset were split into training(80%),and testing(20%)*** Trees,Random Forest,XGBoost,and CatBoost are utilized with feature importance to build the treatment prediction *** best overall Area Under the Curve(AUC)achieved was 0.91 using Random Forest on the SEER dataset.

关键词： Breastcancer machinelearning featureimportance featureselection treatment prediction SEER dataset computer-aided treatment prediction(CATP) clinical decision support system

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Effect of PEG Incorporation on Physicochemical and in vitro Degradation of PLLA/PDLLA Blends:Application in Biodegradable Implants

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Journal of Renewable Materials 2023年第7期11卷 3043-3056页

作者： Mochamad Chalid Gifrandy Gustiraharjo Azizah intan Pangesty Alyssa Adyandra Yudan Whulanza Sugeng Supriadi Department of Metallurgical and Material Engineering Faculty of EngineeringUniversity of IndonesiaDepok City16424Indonesia Department of Mechanical Engineering Faculty of EngineeringUniversity of IndonesiaDepok City16424Indonesia

Polyethylene glycol(PEG)was added at different concentrations to the blend of poly(L-lactic acid)(PLLA)and poly(D,L-lactic acid)(PDLLA)to tailor the *** differential scanning calorimetry(DSC)measurement showed that all blends were miscible due to shifting a single glass transition temperature into a lower temperature for increasing PEG *** DSC,FTIR,and XRD results implied the crystallinity enhancement for PEG content until 8 wt%,then decreased at 12 wt%*** XRD result indicated the homo crystalline phase formation in all blends and no stereocomplex *** in vitro degradation study indicated that PEG content is proportional to the degradation *** highest weight loss after 28 days was achieved at 12 wt%*** FTIR analysis showed a structural evolution overview during hydrolytic degradation,*** and decreasing crystallinity during 14 days for the blend without and with PEG,*** conclusion,the PEG addition increased crystallinity and degradation rate of the PLLA/PDLLA mixture,but PEG higher amounts led to a decrease in crystallinity,and the weight loss was *** can be useful for tuning PLA-based biomaterials with the desired physicochemical properties and appropriate degradation rates for applications in drug delivery/tissue engineering.

关键词： PLLA PDLLA PEG crystallinity degradation

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Physical activity and immunity in obese older adults:A systematic bibliographic analysis

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Sports Medicine and Health Science 2023年第3期5卷 181-189页

作者： Novita intan Arovah Dang Thi Anh Thu Juni Kurniawaty Hartiah Haroen Department of Sports Science Faculty of Sports ScienceUniversitas Negeri YogyakartaJalan Colombo No 1 KarangmalangYogyakarta55228Indonesia School of Science Faculty of Public HealthHue University of Medicine and Pharmacy06 Ngo QuyenVinh Ninh WardHue CityViet Nam Department of Anaesthesiology Faculty of MedicineUniversitas Gadjah MadaDepartemen Anestesiologi dan Terapi Intensif RSUP Dr.SardjitoJln.Kesehatan No.1SekipYogyakarta55231Indonesia Department of Nursing Faculty of NursingUniversitas PadjajaranHegarmanahKec.JatinangorKabupaten SumedangBandungJawa Barat45363Indonesia

Extensive research has been conducted on the roles of physical activity in immune ***,reviews on the effect of physical activity on immune function among obese older adults are *** study aimed to map the trend and development of the key terms and prominent sources to identify potential research opportunities through a systematic bibliographic analysis.A systematic search was conducted in the Scopus database on the following query:(sport^(*)OR“physical activity”OR exercise)AND(elderly OR“older adult^(*)”OR aging)AND(immun^(*))AND(obes^(*))AND NOT(animal),in March *** timing and citation were descriptively analyzed,followed by the bibliographic coupling and the term co-occurrence analyses for generating network and overlay visualization mapping using the VOSviewers *** search resulted in 426 articles dating back from 1991 to the present and were dominated by authors from Western *** thematic clusters of this research area were generated,covering(1)the impact of physical activity or inactivity on health,(2)physical activity assessments and the use of association and cross-sectional study as the primary type of research,and(3)the physical activity impacts at the population *** future research,more intervention studies are needed to understand how exercise affects immune response in older obese adults and to explore optimal duration,type,and intensity of the exercise,using a multi-omics *** in non-Western populations and systematic reviews are recommended to complement this bibliographic analysis.

关键词： Aging Exercise Sports Obesity Immune responses

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Human Stress Recognition from Facial Thermal-Based Signature:A Literature Survey

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Computer Modeling in Engineering & Sciences 2022年第2期130卷 633-652页

作者： Darshan Babu L.Arasu Ahmad Sufril Azlan Mohamed Nur intan Raihana Ruhaiyem Nagaletchimee Annamalai Syaheerah Lebai Lutfi Mustafa M.Al Qudah School of Computer Sciences Universiti Sains MalaysiaPenang11800Malaysia School of Distance Education Universiti Sains MalaysiaPenang11800Malaysia

Stress is a normal reaction of the human organism which triggered in situations that require a certain level of *** reaction has both positive and negative effects on everyone’s ***,stress management is of vital importance in maintaining the psychological balance of a ***-based imaging technique is becoming popular among researchers due to its non-contact conductive ***,thermal-based imaging has shown promising results in detecting stress in a non-contact and non-invasive *** to other non-contact stress detection methods such as pupil dilation,keystroke behavior,social media interaction and voice modulation,thermal-based imaging provides better features with clear boundaries and requires no heavy *** paper presented a brief review of previous work on thermal imaging related stress detection in *** paper also presented the stages of stress detection based on thermal face signatures such as dataset type,thermal image face detection,feature descriptors and classification performance comparisons are *** paper can help future researchers to understand stress detection based on thermal imaging by presenting the popular methods previous researchers use for stress detection based on thermal images.

关键词： Stress state stress recognition skin temperature thermal signature thermal imaging

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The Role of Clay Mineral Composition on Silicified Coal Genesa Based on X-Ray Diffraction (XRD)

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Journal of Geoscience and Environment Protection 2021年第7期9卷 192-208页

作者： Basuki Rahmad Gerhana Prasetya Sugeng Ediyanto Muchamad Ocky bayu Nugroho intan Permata Hatty Hariyadi Geological Engineering Department Faculty of Technology Mineral Universitas Pembangunan Nasional “Veteran” Yogyakarta Kota Yogyakarta Indonesia PT. Adaro Indonesia Jakarta Indonesia

The interesting concern in this study is that in the same outcrop it was found that the first coal seam (coal seam-D) contains silicified coal and the second coal seam (coal seam-E) does not contain silicified coal and how to find out the cause. In general, the characteristics of silicified coal seam-D are in the form of lenses; the distribution extends from a few meters to several tens of meters with a thickness of three to five centimeters and some are in nodules. Environmental conditions are the main factor in the formation of silicified coal where the acidity level of coal bearing sediment seam-D which is between 3.4 (roof sediment) to 4.2 (floor sediment) is higher than coal bearing sediment seam-E which has a pH of 5.4. This condition indicates that the coal bearing sediment seam-D environment is more acidic than coal seam-E. The results of XRD analysis show that the seam-D containing silicified coal has a composition of 47.47% kaolinite, 21.27% illite, 23.73% smectite and 17.54% mixed layer, while the seam-E which does not contain silicified coal has a composition of kaolinite 35.78%, illite 17.88%, smectite 21.59% and mixed layer 24.76%. Acidic environmental conditions (pH) and silica enrichment in clay minerals (kaolinite) in the roof sediments during sedimentation, accelerated the process of deposition of colloidal silica in the wood structure of coal seams into silicified coal.

关键词： Silicified Coal Roof Sediment pH Kaolinite Acid

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Movements and home range of a common species of tree-shrew,Tupaia glis,surrounding houses of otoacariasis cases in Kuantan,Pahang,Malaysia

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Asian Pacific Journal of Tropical Medicine 2010年第6期3卷 427-434页

作者： Mariana A Shukor MN Muhd Norhazizi H intan Nurlemsha B Ho TM Acarology Unit Infectious Diseases Research CentreInstitute for Medical Research50588 Kuala LumpurMalaysia School of Environmental and Natural Resources Sciences Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiSelangorMalaysia

Objective:To document movement patterns,home range,nesting behaviour and social organization of 5 individuals(3 males and 2 females) of a common species of tree-shrew,Tupaia glis(***) surrounding houses of otoacariasis ***:Each shrew was fitted with a transmitter chip radio-collar which operates between the frequencies of 154.13 MHz to 154.21 *** transmitter was then tracked with a Portable Telemetry Receiver(Sirtrack,New Zealand) fitted with a 3-element Yagi *** shrews were located using standard methods of ground-based *** location was taken from at least 2 directional fixes and a minimum of 3 compass *** were taken hourly for each collared individual from the time of emergence from nest(beginning of activity) till time of entry into the nest(end of activity) every day for 5 to 7 continuous *** series of radio telemetry observations were carried *** bearings,time and positions of an observer were recorded and later plotted on a graph paper in order to derive coordinates of the collared animal.[These coordinates then analyzed using Ecological Software Solutions(Biotas Version 1.03)].Results:Nests were found in a jack fruit tree,long bushes,and 2 *** telemetry detections demonstrated 2 individuals of different sex having nests(or a nest) in the same *** shrews emerged from and returned to their nests between 0601 to 0659 hours and 1901 to 1959 hours,respectively. Both the time of exit from and entry into nest were the same between sexes(P>0.05).Their average total active period was 4.90 to 7.00 hours with a total daily travel distant of 270 m to 382 m.A male and a female shrew can move as far as 3 285 m and 4 591 m,*** movements of *** were during *** regularly entered some houses in the area during day and night except for one individual which visited during daytime *** sizes of home range and core area for the shrews were 2.00-3.40 ha and 0.05-0.4

关键词： Movements Home range Tree-shrew Otoacariasis cases Malaysia

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Composition and source apportionment of dust fall around a natural lake

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Journal of Environmental Sciences 2015年第7期27卷 143-155页

作者： Mohd Talib Latif Sofia Aida Ngah Doreena Dominick intan Suraya Razak Xinxin Guo Thunwadee Srithawirat Idris Mushrifah School of Environmental and Natural Resource Sciences Faculty of Science and Technology Universiti Kebangsaan Malaysia Institute for Environment and Development (LESTARI) Universiti Kebangsaan Malaysia Centre for Atmospheric Chemistry University of Wollongong Department of Environmental Engineering Faculty of Engineering and Green Technology Universiti Tunku Abdul Rahman Department of Environmental Science Faculty of Science and Technology Pibulsongkram Rajabhat University Pusat Penyelidikan Tasik Chini (PPTC) Faculty of Science and Technology Universiti Kebangsaan Malaysia

The aim of this study was to determine the source apportionment of dust fall around Lake Chini, Malaysia. Samples were collected monthly between December 2012 and March2013 at seven sampling stations located around Lake Chini. The samples were filtered to separate the dissolved and undissolved solids. The ionic compositions（NO-3, SO2-4, Cl-and NH＋4） were determined using ion chromatography（IC） while major elements（K, Na, Ca and Mg） and trace metals（Zn, Fe, Al, Ni, Mn, Cr, Pb and Cd） were determined using inductively coupled plasma mass spectrometry（ICP-MS）. The results showed that the average concentration of total solids around Lake Chini was 93.49 ± 16.16 mg/（m2·day）. SO2-4, Na and Zn dominated the dissolved portion of the dust fall. The enrichment factors（EF） revealed that the source of the trace metals and major elements in the rain water was anthropogenic, except for Fe. Hierarchical agglomerative cluster analysis（HACA） classified the seven monitoring stations and 16 variables into five groups and three groups respectively. A coupled receptor model, principal component analysis multiple linear regression（PCA-MLR）, revealed that the sources of dust fall in Lake Chini were dominated by agricultural and biomass burning（42%）,followed by the earth＇s crust（28%）, sea spray（16%） and a mixture of soil dust and vehicle emissions（14%）.

关键词： Trace metal Major element Anion Source apportionment Lake Ghini Malaysia

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