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BMPRⅡ^(+)neural precursor cells isolated.a.d characterized from organotypic neurospheres:an in vitro model of human fetal spinal cord development

2002年IEEE十区计算机、通信、控制和电机工程会议

作者： baxter d.a. Byrne,J.H. University of Texas Medical School at Houston Texas U.S.A. University of Texas Medical School at Houston Texas U.S.A.

A neural network consists of many neuronsconnected by synapses. It is able to process information andgenerate a specific pattern of electrical activity. To analyzeits interior stucture and exterior properties, one computersimulator was implemented. As the neural network iscomplicated.a.d the simulation is time consuming, so datastructure and computation scheme are critical to simulationprocess. In this paper, data structure is designed sharableand reusable, and parallel computation is applied to matchthe data structure. With the data structure and parallelcomputation, the simulation is made much more efficientand high performance was achieved.

关键词： Neural network Computer simulation data structure parallel computation

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Neural Regeneration Research 2024年第2期19卷 447-457页

作者： Michael W.Weible II Michael d.Lovelace Hamish d.Mundell Tsz Wai Rosita Pang Tailoi Chan-Ling Bosch Institute Discipline of Anatomy and Histology(F13)University of SydneySydneyNSWAustralia School of Environment and Science Griffith UniversityNathanQLDAustralia discipline of Medicine Nepean Clinical SchoolFaculty of Medicine and HealthUniversity of SydneyKingswoodNSWAustralia New South Wales Brain Tissue Resource Centre School of Medical SciencesFaculty of Medicine and HealthUniversity of SydneyCharles Perkins Centre(D17)SydneyNSWAustralia

Roof plate secretion of bone morphogenetic proteins(BMPs)directs the cellular fate of sensory neurons during spinal cord development,including the formation of the ascending sensory columns,though their biology is not well ***-ⅡBMP receptor(BMPRⅡ),the cognate receptor,is expressed by neural precursor cells during embryogenesis;however,an in vitro method of enriching BMPRⅡ^(+)human neural precursor cells(hNPCs)from the fetal spinal cord is *** was undertaken on intact second-trimester human fetal spinal cord using antibodies to BMPRⅡand leukemia inhibitory factor(LIF).Regions of highest BMPRⅡ^(+)immunofluorescence localized to sensory *** and meningeal-associated BMPRⅡ^(+)vascular cells were identified in both intact fetal spinal cord.a.d cortex by co-positivity with vascular lineage markers,Cd34/*** immunostaining identified.a.population of somas concentrated in dorsal and ventral horn interneurons,mirroring the expression of LIF receptor/Cd118.A combination of LIF supplementation and high-density culture maintained culture growth beyond 10 passages,while synergistically increasing the proportion of neurospheres with a stratified,*** neurospheres were characterized by BMPRⅡ^(+)/MAP2ab^(+/–)/βⅢ-tubulin^(+)/nestin^(–)/vimentin^(–)/GFAP^(–)/NeuN^(–)surface hNPCs surrounding a heterogeneous core ofβⅢ-tubulin^(+)/nestin^(+)/vimentin^(+)/GFAP^(+)/MAP2ab^(–)/NeuN^(–)multipotent *** cultures from tripotential neurospheres contained neuronal(βⅢ-tubulin^(+)),astrocytic(GFAP+),and oligodendrocytic(O4+)lineage ***-activated cell sorting-sorted BMPRⅡ^(+)hNPCs were MAP2ab^(+/–)/βⅢ-tubulin^(+)/GFAP^(–)/O4^(–)in *** is the first isolation of BMPRⅡ^(+)hNPCs identified.a.d characterized in human fetal spinal *** data show that LIF combines synergistically with high-density reaggregate cultures to support the organotypic reorganization of neurospheres,characterize

关键词： BMPRⅡ bone morphogenetic protein histotypic human spinal cord development leukemia inhibitory factor neurosphere organotypic reaggregate sensory columns

Effects of vitamin supplementation on inflammatory markers and psychological wellbeing among distressed women:a randomized controlled trial

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Journal of Integrative Medicine 2018年第5期16卷 322-328页

作者： J.M.Oliver-baxter H.S.Whitford d.a.Turnbull M.J.Bond School of Psychology The University of Adelaide Sansom Institute for Health Research University of South Australia School of Medicine Flinders University

Background： Multivitamins are a popular supplement taken to promote physical and mental health. during periods of stress, they may have a protective role for health and wellbeing, although the current evidence of their efficacy is mixed. Objective： To determine whether multivitamin supplementation impacts psychological and inflammatory markers of women who are experiencing psychological distress. design, setting, participants and interventions： An 8-week randomized controlled trial was conducted to assess changes in both psychological state and pro-inflammatory markers of patients receiving multivi- tamins or placebo. The sample comprised women who reported elevated psychological distress in the previous 4 weeks. Main outcome measures： Psychological state was assessed using Spielberger＇s State-Trait Personality Inventory to assess anxiety, curiosity, depression and.a.ger. Pro-inflammatory markers comprised interleukin （IL）-113, IL-5, IL-6, turnout necrosis factor （TNF）-α and TNF-6. Results： Improvements across time were observed for all psychological measures and cytokines, except IL-5, but were independent of the active intervention. Only TNF-β demonstrated.a.significant differential change between groups over the course of the intervention, in favour of multivitamin supplementation （active group mean rank decreased from 11.1 to 7.1 ; placebo group mean rank decreased from 8.9 to 7.8）. Conclusion： The results suggest that administration of multivitamins was not effective in improving psychological stare. However, some evidence supported the positive impact of multivitamin supplementation on pro-inflammatory cytokine profiles of women currently experiencing stress.

关键词： Psychological stress Cytokines Vitamins Randomized controlled trial

Metabolite profile comparisons between ascending and descending colon tissue in healthy adults

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World Journal of Gastroenterology 2020年第3期26卷 335-352页

作者： Bridget A baxter Kristopher d Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsFort CollinsCO 80523United States University of Colorado Health Gastroenterology Clinic Fort CollinsCO 80524United States department of Clinical Sciences Colorado State UniversityFort CollinsCO 80523United States Harmony Surgery Center Fort CollinsCO 80528United States director of Clinical Operations Harmony Surgery CenterFort CollinsCO 80523United States

BACKGROUNd Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is d.a.nosed,remains largely *** study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese *** To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer *** Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite *** colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal *** Ascending and descending colon contained 504 host,food.a.d microbiotaderived metabolites from normal weight,overweight and obese adults grouped.a.cording to body mass *** acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite *** weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(Pdults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending *** and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese *** There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy *** lipids and other metabolites in

关键词： Colon Ascending descending Metabolomics Obesity Stool

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调谐泵浦的微型YAG激光及其温度调谐

应用激光 1993年第5期13卷 211-212页

作者：邱明新 d.J.Booth G.baxter G.Bowkett 上海市激光技术研究所 200233 澳州维多利亚大学

用730至830nm调谐的钛兰宝石激光纵向泵浦微型YAG激光,最大连续输出为216mW,斜率效率为30％。改变YAG的工作温度从5℃到100℃,其输出波长从1.06398μm调谐至1.064541μm。随着温度的上升,输出功率下降。

关键词：调谐泵浦 YAG激光温度调谐

Choosing a Method to Reduce Selection Bias: A Tool for Researchers

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Open Journal of Epidemiology 2015年第3期5卷 155-162页

作者： Claire Keeble Graham Richard Law Stuart Barber Paul d. baxter division of Epidemiology and Biostatistics University of Leeds Leeds UK department of Statistics University of Leeds Leeds UK

Selection bias is well known to affect surveys and epidemiological studies. There have been numerous methods proposed to reduce its effects, so many that researchers may be unclear which method is most suitable for their study;the wide choice may even deter some researchers, for fear of choosing a sub-optimal approach. We propose a straightforward tool to inform researchers of the most promising methods available to reduce selection bias and to assist the search for an appropriate method given their study design and details. We demonstrate the tool using three examples where selection bias may occur;the tool quickly eliminates inappropriate methods and guides the researcher towards those to consider implementing. If more studies consider selection bias and.a.opt methods to reduce it, valuable time and resources will be saved, and should lead to more focused research towards disease prevention or cure.

关键词： Selection Bias Participation Bias Non-Response Methodology

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RO浓水-废水联合培养小球藻的实验研究

环境工程学报 2015年第2期9卷 971-976页

作者：赵璐 baxter Terry 党小虎宋世杰李楠西安科技大学地质与环境学院西安710054 美国北亚利桑那大学工程森林与自然科学学院弗拉格斯塔夫市86011

为了实现微藻培养基的低成本化和废水资源化利用多重目的的耦合,对反渗透浓缩液(RO浓水)作为培养基培养小球藻(Chlorella sp.)的可行性及其影响因素进行了探讨。实验取一级、二级处理出水和消化反应上清液及3种废水与RO浓水混合液制成6... 详细信息

为了实现微藻培养基的低成本化和废水资源化利用多重目的的耦合,对反渗透浓缩液(RO浓水)作为培养基培养小球藻(Chlorella sp.)的可行性及其影响因素进行了探讨。实验取一级、二级处理出水和消化反应上清液及3种废水与RO浓水混合液制成6种培养基培养小球藻,探究最佳培养基;在此基础上探究浓度与温度对小球藻生长的影响。结果表明,培养15 d后,3种添加了RO浓水的培养基比3种纯废水培养基更有利于小球藻的生长,其中消化反应上清液-RO浓水混合液是最佳培养基;浓水浓度0%~90%的该混合液中小球藻生物量增加315%~780%,且小球藻的生物量表现为随RO浓水浓度的增大先增加后减小的变化趋势,30%是小球藻最佳培养浓度;在10、20和30℃下,浓度0%~90%的培养基中小球藻生物量增加了140%~570%,各浓度中的小球藻均在20℃下生长最好。

关键词： RO浓水小球藻生物量可溶性矿物质

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肾上腺类固醇的作用

江西医药 1987年第4期23卷 397-399页

作者： John d.baxter

糖类皮质激素糖类皮质激素有着不同的作用,并以某种方式,作用于哺乳动物的大多数组织。它们也是生存所必需的,至少在应激期间是这样。【中间代谢】就其对糖类调节作用而言,糖类皮质激素对葡萄糖代谢有着多方面影响,引起不同的效果(图(?)... 详细信息

糖类皮质激素糖类皮质激素有着不同的作用,并以某种方式,作用于哺乳动物的大多数组织。它们也是生存所必需的,至少在应激期间是这样。【中间代谢】就其对糖类调节作用而言,糖类皮质激素对葡萄糖代谢有着多方面影响,引起不同的效果(图(?)29-4)。在多数组织中都是抑制对葡萄糖的摄取(但肝、心、脑和红细胞例外),其中还有很多组织,糖类皮质激素对其蛋白和核酸合成也有阻滞作用,并提高对这些巨分子物的更新.

关键词：类皮质激素中间代谢类固醇激素甾体激素葡糖异生肾上腺内分泌腺

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盐类皮质激素过多状态

江西医药 1987年第4期23卷 404-406页

作者： John d.baxter

原发性醛固酮增多症肾上腺对醛固酮分泌失调,产量过多,即形成原发性醛固酮增多症,可致钠潴留和高血压,血浆肾素减低,血钾减低及其伴随症象。主要病因皆为肾上腺皮质腺瘤、双侧性肾上腺皮质增生,少数为肾上腺癌。各年龄组皆可发病,而以30... 详细信息

原发性醛固酮增多症肾上腺对醛固酮分泌失调,产量过多,即形成原发性醛固酮增多症,可致钠潴留和高血压,血浆肾素减低,血钾减低及其伴随症象。主要病因皆为肾上腺皮质腺瘤、双侧性肾上腺皮质增生,少数为肾上腺癌。各年龄组皆可发病,而以30～40岁时居多。约70%腺瘤患者都是妇女。虽然原发性醛固酮增多症病例几乎都是高血压(血压正常者极为罕见),但在高血压病人中,由本综合征所致者只占很小一部分(不到2%)。虽然如此,在所有高血压病人中,他们都应认为是基本可逆的。

关键词：醛固酮增多症血钾腺体增生腺瘤综合征综合病症血浆醛固酮血浆肾素血管紧张素系统高血压病人特发性高血压类皮质激素原发性