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Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus

Animal Models and Experimental Medicine 2020年第4期3卷 304-315页

作者： Giorgio Silva-Santana Juliet Cunha bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi Health Sciences Center Institute of Microbiology Paulo de GóesFederal University of Rio de JaneiroRio de JaneiroRJBrazil Laboratory of Diphtheria and Corynebacteria of Clinical Relevance Faculty of Medical SciencesUniversity of the State of Rio de JaneiroRio de JaneiroRJBrazil The Collaborating Centre for Reference and Research on Diphtheria/National Health Foundation/Ministry of Health Rio de JaneiroRJBrazil Laboratory of Clinical Research and Molecular Diagnostic Prof.Marcílio Dias do Nascimento Department of Clinical Practice and PathologyFluminense Federal UniversityNiteróiRJBrazil Laboratory Bacterial Vaccines Department of ImmunologyNational Institute for Quality Control in HealthOswaldo Cruz FoundationRio de JaneiroRJBrazil Institute of Science and Technology in Biomodels Oswaldo Cruz FoundationRio de JaneiroRJBrazil Institute of Biology Federal Fluminense UniversityNiteróiRJBrazil Biomedical Center College of Medical SciencesUniversity of the State of Rio de JaneiroRio de JaneiroRJBrazil

Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental *** lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific *** study seeks to establish reference values for hematological and biochemical parameters of four lineages of ***:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 *** were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical ***:Results are shown as means and standard deviation,grouped by lineage and *** the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual ***:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model.

关键词： B6D2F1 BALB/c biochemical C57BL/6 hematological Swiss

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多巴酚丁胺应激超声心动描记术后的7年随访:性别对于预后的影响

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世界核心医学期刊文摘（心脏病学分册） 2005年第5期1卷 60-61页

作者： Biagini E. Elhendy A. bax J.J. 郝华

The aim of this study was to investigate the effects of gender on long-term prognosis of patients undergoing dobutamine stress echocardiography(DSE). Gender differences in the predictors of outcome among patients with known or suspected coronary artery disease undergoing DSE have not been adequately studied. We studied 2,276 men and 1,105 women with known or suspected coronary artery diseasewho underwent DSE. Followup events were cardiac death and nonfatal myocardial infarction(MI). Dobutamine stress echocardiography was normal in 687 men(30%)and 483 women(44%)(p 0.0001). Ischemia on DSE was present in 1,194 men(52%)and 416 women(38%)(p 0.001). During a mean follow-up of 7±3.4 years, there were 894(26%)deaths(442 attributed to cardiac causes)and 145(4%)nonfatal MIs. The annual cardiac event rate was 2.5%in men and 1.2%in women with normal DSE. Independent predictors of cardiac events in patients with normal DSE using a Cox proportional hazards regression analysis were male gender(hazard ratio [HR]: 1.7 [range 1.1 to 2.8]), age(HR: 1.02 [range 1.01 to 1.04]), history of heart failure(HR: 3.4 [range 1.5 to 7.9]), previous MI(HR: 1.7 [range 1.1 to 2.8]), and diabetes(HR: 2.4 [range 1.3 to 4.5]). Independent predictors of cardiac events in patients with an abnormal DSE were age(HR: 1.03 [range 1.02 to 1.04]), history of heart failure(HR: 1.7[range 1.3 to 2.1]), diabetes(HR: 1.4 [range 1.1 to 1.8]), heart rate at rest(HR: 2.8[range 1.4 to 5.8]), wall motion abnormalities at rest(HR: 1.06 [range 1.04 to 1.09]), and ischemia on DSE(HR: 1.04 [range 1.02 to 1.07]). Myocardial ischemia was an independent predictor of cardiac events in both men and women. Dobutamine stress echocardiography provides independent prognostic information in both men and women. In patients with normal DSE, gender is independently associated with cardiac events. The outcome of patients with abnormal DSE is not related to gender, after adjusting for stress echocardiographic abnormalities.

关键词：多巴酚丁胺超声心动描记术致命性心肌梗死心脏事件心脏性死亡超声心动图预后信息静息心率运动异常回归分析研究

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是否应该将感染的金属杆取出

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世界核心医学期刊文摘（儿科学分册） 2006年第2期2卷 34-35页

作者： Van Renterghem K.M. Von Bismarck S. bax N.M.A. 贺莉 Department of Pediatric Surgery Wilhelmina Children' s Hospital University Medical Center PO Box 85090 3508AB Utrecht Netherlands

Background: The Nuss procedure is a minimally invasive procedure for correction of pectus excavatum. It involves insertion of a substernal metal bar. A feared complication of any implanted device is infection, which often necessitates removal. The purpose of this report is to describe the authors’ experience with infectious complications after the Nuss procedure. Methods: From February 2000 to July 2002, 102 patients underwent the Nuss procedure in 2 pediatric surgical centers. In a retrospective way, the files of those patients in whom a postoperative infection developed were studied. Results: Seven patients suffered postoperative infectious complications. Only one bar needed to be removed. Conclusion: The authors’ experience indicates that there is no need for immediate removal of an infected Nuss bar. Most of these infections can be managed conservatively. However, early antibiotic treatment is warranted to ensure salvage of the bar.

关键词：手术后感染取出金属治疗经验早期使用植入物矫形术漏斗胸创伤性患儿

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在急性给予β阻断剂后的恢复阶段观察心室壁运动异常增强了多巴酚丁胺负荷超声心动图的灵敏性

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世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 32-33页

作者： Karagiannis S.E. bax J.J. Elhendy A. D. Poldermans 姜朝晖 Department of Cardiology Erasmus MC Rotterdam Netherlands Dr.

Dobutamine stress echocardiography(DSE) has a modest sensitivity for detecting single- vessel coronary artery disease(CAD). This study assessed the additional diagnostic value of new or worsening wall motion abnormalities during recovery after acute administration of β blockers. The study population consisted of 200 patients(mean 59± 11 years of age, 144 men), who underwent DSE. Images were acquired at rest, low dose, peak dose, and during recovery. Patients received intravenous metoprolol(1 to 5 mg/min). The dose was adjusted to achieve a recovery heart rate within a 10% range of heart rate at rest. Coronary angiography was performed within 2 months. Inducible new wall motion abnormalities were observed in 168 patients(84% ) at peak stress. An additional 14 patients(7% )developed new or worsening wall motion abnormalities during recovery. CAD was detected in 182 patients(86 had single- vessel CAD). Sensitivity, specificity, and accuracy of DSE were 88% , 65% , and 73% at peak stress and 97% , 65% , and 74% during recovery. Sensitivity was particularly higher during recovery than during peak stress in patients with single- vessel CAD(98% vs 81% , p 0.001). In conclusion, assessment of wall motion abnormalities during the recovery phase after acute β blockade improves sensitivity of DSE, particularly in patients with single- vessel CAD.

关键词：多巴酚丁胺负荷超声心动图室壁运动异常 β阻断剂灵敏性恢复阶段急性单支血管病变 AD患者冠状动脉疾病冠状动脉造影

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64层CT冠状动脉造影评价支架内再狭窄的效果

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世界核心医学期刊文摘(心脏病学分册) 2007年第9期 59-60页

作者： Cademartiri F. Schuijf J.D. Pugliese F. J.J. bax 赵君 Department of Radiology and Cardiology Leiden University Medical Center Leiden Netherlands

目的:旨在分析64层多层CT(MSCT)冠状动脉造影在对曾行冠状动脉支架置入患者的随访中的诊断准确性。背景:近来的研究表明,与前一代的MSCT相比,64层MSCT无创性冠状动脉造影的图像质量和诊断准

关键词：支架内再狭窄冠状动脉造影冠脉造影心血管造影 CT

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接受腹主动脉瘤或下肢旁路手术治疗的患者中血浆N末端B型利钠肽前体与术后心脏事件的关系

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世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 36-37页

作者： Feringa H.H.H. bax J.J. Elhendy A. D. Poldermans 黄浙勇 Department of Anesthesiology Erasmus Medical College University Medical Center Rotterdam Netherlands Dr.

Postoperative cardiac events are related to myocardial ischemia and reduced left ventricular function. The utility of N-terminal pro-B-type natriuretic peptide(NT-pro-BNP) for preoperative cardiac risk evaluation has not been evaluated. The objective of this study was to assess whether plasma NT-pro-BNP predicts postoperative cardiac events in patients who undergo major vascular surgery in addition to clinical and dobutamine stress echocardiographic data. One hundred seventy consecutive patients scheduled for major noncardiac vascular surgery were prospectively evaluated by dobutamine stress echocardiographic andNT-pro-BNP measurements. Multivariable logistic regression analysis was performed to evaluate the predictors of cardiac death and nonfatal myocardial infarction during a follow-up of 30-days. Receiver-operating characteristic analysis was performed to determine the optimal cut-off value of NT-pro-BNP to predict outcome. Patients’mean age was 59±13 years, and 71%were men. The median NT-pro-BNP level was 110 pg/ml(interquartile range 42 to 389). Cardiac events occurred in 2 of 144 patients(1.4%) with NT-pro-BNP 533 pg/ml(i.e., the optimal cut-off value to predict cardiac events) and in 11 of 26 patients(42%) with NT-pro-BNP ≥533 pg/ml(unadjusted odds ratio 52, 95%confidence interval 11 to 256, p 0.0001). After adjustment for cardiac risk factors and dobutamine stress echocardiographic results, NT-pro-BNP remained significantly associated with cardiac events(adjusted odds ratio 17, 95%confidence interval 3 to 106, p=0.002). In conclusion, in patients scheduled for major vascular surgery, elevated plasma NT-pro-BNP levels are independently associated with an increased risk for postoperative cardiac events. Further studies in a larger number of patients are required to confirm these findings.

关键词： B型利钠肽腹主动脉瘤心脏事件旁路手术负荷超声心动图多巴酚丁胺心脏性死亡非致死性左室功

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窦性节律与慢性房颤患者对心脏再同步化治疗反应的比较

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世界核心医学期刊文摘（心脏病学分册） 2005年第7期1卷 54-55页

作者： Molhoek S.G. bax J.J. Bleeker G.B. 刘文秀 Dr. Department of Cardiology Leiden University Medical Center Albinusdreef 2 2333 ZA Leiden Netherlands

Cardiac resynchronization therapy(CRT) is a new therapeutic option for patients who have drug-refractory end-stage heart failure. Much information has been obtained from patients who have sinus rhythm, but the use of CRT in patients who have chronic atrial fibrillation(AF) has not been studied extensively. Accordingly, we evaluated the clinical response and long-term survival rate of CRT in patients who had heart failure and chronic AF, and the results were compared with those in patients who had sinus rhythm and who underwent CRT. Sixty patients who had end-stage heart failure(30 had sinus rhythm and 30 had chronic AF), New York Heart Association classes III to IV, left ventricular ejection fraction 35%, QRS interval >120 ms, and a left bundle branch block received a biventricular pacemaker. New York Heart Association class, Minnesota Quality of Life score, and 6-minutew-alking distance were evaluated at baseline and after 6 months of CRT. Longterm follow-up was ≤2 years. New York Heart Association class, Minnesota Quality of Life score, and 6-minute walking distance improved significantly in the 2 groups after 6 months of CRT. The number of nonresponders was greater among patients who had ***, the long-term survival rate was comparable between patients who had sinus rhythm and those who had AF. Patients who had AF demonstrated comparable benefit from CRT as those who had sinus rhythm.

关键词：慢性房颤心脏再同步化窦性节律左束支传导阻滞心脏协会射血分数窦性心律心功能双心室长期生存率

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血管外科患者接受大剂量β受体阻断剂及严格心率控制治疗可减少心肌缺血及肌钙蛋白T释放

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世界核心医学期刊文摘（心脏病学分册） 2007年第1期3卷 25-26页

作者： Feringa H.H.H. bax J.J. Boersma E. D. Poldermans 罗亮 Erasmus Medical Center University of Rotterdam Dr. Molewaterplein 40 3015 GD Rotterdam NetherlandsDr.

背景:尽管围术期使用了β受体阻断剂,但不良心脏事件仍时常发生。本研究旨在探讨使用较大剂量的β受体阻断剂以及严格心率控制与减少围术期心肌缺血、肌钙蛋白T释放及改善长期预后之间是否存在相互联系。方法和结果:在此观察性队列研究...

背景:尽管围术期使用了β受体阻断剂,但不良心脏事件仍时常发生。本研究旨在探讨使用较大剂量的β受体阻断剂以及严格心率控制与减少围术期心肌缺血、肌钙蛋白T释放及改善长期预后之间是否存在相互联系。方法和结果:在此观察性队列研究中,272例血管外科患者接受心脏危险因素及β受体阻断剂使用情况的术前筛查。β受体阻断剂使用情况采用最大推荐治疗剂量的百分比来表示。

关键词： β受体阻断剂血管外科肌钙蛋白心率控制不良心脏事件队列研究观察性全因死亡导联心电图心

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左室不同步性可预示心脏再同步化治疗的效果和预后

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世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 49-50页

作者： bax J. J. Bleeker G. B. Marwick T. H. 尚福军

This study was designed to predict the response and prognosis after cardiac re synchronization therapy(CRT) in patients with end-stage heart failure(HF). Card iac resynchronization therapy improves HF symptoms, exercise capacity, and left ventricular(LV) function. Because not all patients respond, preimplantation iden tification of responders is needed. In the present study, response to CRT was pr edicted by the presence of LV dyssynchrony assessed by tissue Doppler imaging. M oreover, the prognostic value of LV dyssynchrony in patients undergoing CRT was assessed. Eighty-five patients with end-stage HF, QRS duration >120 ms, and le ft bundle-branch block were evaluated by tissue Doppler imaging before CRT. At baseline and six months follow-up, New York Heart Association functional class, quality of life and 6-min walking distance, LV volumes, and LV ejection fracti on were determined. Events (death, hospitalization for decompensated HF) were ob tained during one-year follow-up. Responders(74%) and nonresponders(26%) had comparable baseline characteristics, except for a larger dyssynchrony in respon ders (87±49 ms vs. 35±20 ms, p 0.01). Receiver-operator characteristic curve analysis demonstrated that an optimal cutoff value of 65 ms for LV dyssynchrony yielded a sensitivity and specificity of 80%to predict clinical improvement an d of 92%to predict LV reverse remodeling. Patients with dyssynchrony ≥65 ms ha d an excellent prognosis(6%event rate) after CRT as compared with a 50%event r ate in patients with dyssynchrony 65 ms(p 0.001). Patients with LV dyssynchron y 65 ms respond to CRT and have an excellent prognosis after CRT.

关键词：心脏再同步化组织多普勒显像再同步预测意义心功能级别射血分数左束支传导阻滞终点事件心脏协会步行距离

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远端有瘘管的食管闭锁修补术后常规术后扩张是否优于症状出现后扩张——欧洲两小儿外科中心的结果比较

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世界核心医学期刊文摘（儿科学分册） 2005年第4期1卷 51-52页

作者： Koivusalo A. Turunen P. Rintala R. J. N. M. A. bax 肖莉 Willhelmina Children's Hospital University Medical Center Utrecht The Utrecht Netherlands

背景/目的:确定对远端有瘘管的食道闭锁(EADF),在修补术后进行常规扩张是否比保守观察,仅当症状出现时才扩张的效果好。方法:回顾在欧洲两个小儿外科中心100例EADF患儿的手术纪录[A(n=63),B(n=37)]。在A中心,吻合口扩张术只对有症状的...

背景/目的:确定对远端有瘘管的食道闭锁(EADF),在修补术后进行常规扩张是否比保守观察,仅当症状出现时才扩张的效果好。方法:回顾在欧洲两个小儿外科中心100例EADF患儿的手术纪录[A(n=63),B(n=37)]。在A中心,吻合口扩张术只对有症状的病例实施,然而在B中心。

关键词：食管闭锁小儿外科扩张术常规扩张吻合口术后并发症 atresia dilatation 气管软化 anastomosis

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