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皱胃碳水化合物对生长肉牛皮下、网膜和肠系膜脂肪生成与分解比率的影响

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饲料博览（技术版） 2007年第11期 66-66页

作者： Baldwin r L McLeod K r McNamara J P Elsasser T H baumann r g

试验旨在检测对碳水化合物输送到消化道的形式和位置改变的应答,体外比较肠系膜(MESA)、网膜(OMA)和皮下(SQA)脂肪蓄积组织脂肪生成与分解比率。40头平均体重为(243±2)kg的杂交肉牛,代谢能水平按代谢体重分别为161 kcal·d^(-1)(LI组),... 详细信息

试验旨在检测对碳水化合物输送到消化道的形式和位置改变的应答,体外比较肠系膜(MESA)、网膜(OMA)和皮下(SQA)脂肪蓄积组织脂肪生成与分解比率。40头平均体重为(243±2)kg的杂交肉牛,代谢能水平按代谢体重分别为161 kcal·d^(-1)(LI组),214 kcal.d^(-1)(HI组):或者在LI组基础上从瘤胃(r)或皱胃(A)注入淀粉分解产物(SH)或从皱胃(A)注入葡萄糖(g),持续35d。从颈静脉采集血样;将牛屠宰,采集脂肪蓄积组织,用于体外分析脂肪生成与分解。与LI组相比,HI组血液胰高血糖素浓度升高(P=0.04);与r-SH相比,A-SH有增加胰岛素样生长因子-1(IgF-I)循环的趋势(P=0.08);与A-SH相比,A-g有提高T_3浓度的趋势(P=0.09)。脂肪分解,由非酯化脂肪酸(NEFA)释放评价,各处理间没有差异。与LI组相比,HI组肠系膜和皮下甘油释放增加或有增加的趋势(P≤0.08)。与A-SH组相比,A-g组网膜甘油释放增加(P=0.008),皮下甘油释放趋向增加(P=0.08)。随代谢能摄入量的增加和淀粉分解产物的注入,所有脂肪蓄积组织中,合成总中性脂肪(TNL)的醋酸盐增加或有增加的趋势(P≤0.09)。随淀粉分解产物的注入,所有脂肪蓄积组织中,合成脂肪酸(FA)的醋酸盐比率增大或有增大的趋势(P≤0.1);但随代谢能摄入量的增加,只有皮下脂肪蓄积组织中,合成脂肪酸的醋酸盐比率增大(P=0.02)。与r-SH组相比,A-SH组,在肠系膜脂肪蓄积组织中,合成脂肪酸和总中性脂肪的醋酸盐比率显著增加(P≤0.03);但是淀粉分解产物的注入位置对皮下和网膜脂肪蓄积组织中的比率没有影响。采食日粮和注入能量,肠系膜和皮下脂肪蓄积组织中,合成总中性脂肪的葡萄糖增加或有增加的趋势(P≤0.1);然而网膜组织中,只有注入淀粉分解产物,其才有增加的趋势(P=0.1)。相对而言,合成脂肪酸的葡萄糖,不受提供的能量影响;注入淀粉分解产物,对肠系膜组织中合成脂肪酸的葡萄糖有增加的趋势(P=0.07);与A-SH组相比,A-g组网膜组织中合成脂肪酸的葡萄糖趋向增加(P=0.08)。全身脂肪蓄积组织中,合成脂肪酸和总中性脂肪的醋酸盐混合比率关系为:皮下>网膜>肠系膜,而葡萄糖混合比率相当。试验结果证明,能量过瘤胃供给,尤其是碳水化合物,刺激来源于醋酸盐和葡萄糖的脂肪生成,与皮下脂肪蓄积组织相比,腹部组织更显著。

关键词：牛碳水化合物脂肪代谢

Optimizing the cancer research landscape for the benefit of patients and society: A strategic perspective of the german Cancer research Center (DKFZ) and its partnerships with university medical centers

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Cancer Biology & Medicine 2022年第11期19卷 1517-1522页

作者： Michael baumann german Cancer research Center(DKFZ) Heidelberg 69120Germany

This issue of Cancer Biology & Medicine, a premium Chinese international scientific journal in this field, focuses on cooperation between Chinese and german cancer research, particularly between the Tianjin Medical University Cancer Institute & Hospital and the german Cancer research Center(DKFZ) with its networking partners. This editorial provides a brief overview on DKFZ’s research strategy with a focus on how a national integrated cancer research and care ecosystem is evolving that benefits patients and society.

关键词： Cancer landscape centers

Validation of a Questionnaire to Diagnose the baumann Skin Type in All Ethnicities and in Various geographic Locations

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Journal of Cosmetics, Dermatological Sciences and Applications 2016年第1期6卷 34-40页

作者： Leslie baumann baumann Cosmetic and research Institute Miami USA Division of Cosmetic Dermatology University of Miami Miami USA

The baumann Skin Typing System diagnoses patients as having one of 16 skin types based on their answers to a validated questionnaire [i] known as the baumann Skin Type Indicator [ii]. The BSTI questionnaire has been tested over the last decade on over 200,000 people of various ages and ethnicities in different geographic locations around the world. In this study, data were collected from 52,862 patients to compare skin type prevalence between those who presented to doctor’s offices and those who took the quiz without supervision online. The most common skin types varied only slightly between patients that took the quiz online and those that completed the questionnaire in their doctor’s office. This indicates that the prevalence of skin types seen in the doctor’s office is similar to that in the general population and that supervision is not necessary to get an accurate result on the BSTI. [iii] In addition, comparison of data gathered in China, Korea, and the US did not show a significant difference in skin type prevalence between Asian and Caucasian skin types. [iv] This study demonstrates that the English version of the BSTI is valid for English speaking patients online, and in doctors’ offices in the US, China and Korea.

关键词： Skin Type regimen Cosmeceutical Skin Care Oily Dry Sensitive Pigmented Wrinkled Photoaged Melasma Pre-Operative Post-Operative Acne rosacea Contact Dermatitis Antioxidants retinoids baumann Skin Type BSTI Skin IQ Skin Type Solutions Systems-Based Approach Standardized Methodology Validated Validation Scientific Ethnicity Asian Hispanic Caucasian Questionnaire Diagnostic Diagnose Prescribe Educate Outcomes Compliance

Transition after pediatric liver transplantation-Perceptions of adults, adolescents and parents

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World Journal of gastroenterology 2017年第13期23卷 2365-2375页

作者： Norman Junge Katarina Migal Imeke goldschmidt Ulrich baumann Department of Pediatric gastroenterology and Hepatology Hannover Medical School

AIM To develop a locally adapted, patient-focused transitionprogram, we evaluated the perceptions of adult and adolescent patients and parents regarding transitionprograms and *** We evaluated these perceptions by analyzing the responses of pre-transfer adolescents(n = 57), their parents(n = 57) and post-transfer adults(n = 138) from a cohort of pediatric-liver-transplant-patients using a self-designed questionnaire. Furthermore, we compared a responder group with a non-responder group as well as the provided answers with baseline characteristics and clinical outcomes to exclude selection bias, characterize high-risk patients for nonadherence and test for gender differences. Included in our study were all pre-transfer liver transplant and combined liver-kidney transplant recipients aged 11-19 currently under our care and their parents, as well as all post-transfer liver transplant and combined liverkidney transplant recipients aged ≥ 17 years who had received a liver transplant and were treated at our center during *** Fifty-seven(24 female) pre-transfer patients who received a transplant in the previous 8-186 mo(mean 93.9 mo, median 92 mo, SD 53.8 mo) and 138(57 female) post-transfer patients who received a transplant in the preceding 2-29 years(mean 15.6 years, median 17, SD 6.90) met the inclusion criteria. A total of 67% of pre-transfer patients(71% of female; 64% of male; P = 0.78) and their parents replied. Additionally, 54% of post-transfer patients(26% of female; 48% of male; P = 0.01) replied. No differences in clinical outcomes were observed between the responder and non-responder groups, and responses did not differ significantly based on clinical complication rates, although they did differ based on gender and the location of medical follow-up after transfer. Adolescents were generally ambivalent toward transition programs. However, adults strongly supported transition programs. CONCLUSION Transition programs need to be develop

关键词： Pediatric liver transplant Transfer Transition Non-adherence gender differences

Form-induced stress in non-uniform steady and unsteady open channel flow over a static rough bed

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International Journal of Sediment research 2015年第04期30卷 297-305页

作者： Stephan M.Spiller Nils ruther Benjamin baumann Hydraulic Engineering Department of Hydraulic and Environmental EngineeringNorwegian University of Science and Technology

This paper presents a series of 18 steady and 45 unsteady flow experiments over an artificial,rough surface,obtained by a novel molding technique for gravel *** data are obtained by a Particle Image Velocimetry（PIV） *** vertical distributions of the form-induced stresses（u2） and-（uw） are compared for all ***,quadrant maps are drawn to analyze the near bed spatial velocity fluctuations u and w in a vertical plane parallel to the flow *** experiments were done under non-uniform *** is shown that（1） the qualitative shape of the vertical form-induced stress distributions2> and-（uw） is independent from the discharge,as stated in the literature,as well as from the unsteadiness of the flow.（2） The magnitude of the form-induced stress2> and-（uw） in the roughness layer increases with increasing discharge for non-uniform flow,while uniform flow experiments in the literature report the form-induced stresses to be independent from the discharge.A hypothesis is,therefore,proposed,that the independence of the form-induced stress magnitude from the discharge is only valid for uniform flow.（3） Quadrant maps,describing the distribution of the spatial fluctuations u and w in a twodimensional plane are independent from discharge and unsteadiness of the flow.

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LABEL-FrEE 3D OPTICAL MICrOANgIOgrAPHY IMAgINg OF FUNCTIONAL VASA NErVOrUM AND PErIPHErAL MICrOVASCULAr TrEE IN THE HIND LIMB OF DIABETIC MICE

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Journal of Innovative Optical Health Sciences 2010年第4期3卷 307-313页

作者： YALI JIA THOMAS K.baumann rUIKANg K.WANg Department of Biomedical Engineering Oregon Health&Science University 3303 SW Bond Avenue PortlandOregon 97239USA Departments of Neurological Surgery Physiology and Pharmacology Oregon Health&Science University 3181 SW Sam Jackson Park Road PortlandOregon 97239USA Department of Bioengineering University of Washington 372015th Ave NESeattleWashington 98195USA

Diabetic neuropathy(DN)is,at least in part,associated with the functional attenuation of vasa nervorum,the microvascular structure of peripheral *** imaging options for vasa nervorum still remain *** this work,optical microangiography(OMAg),a volumetric,label-free imaging technique,is utilized for characterizing,with high resolution,blood perfusion of peripheral nerve in diabetic *** demonstrate that OMAg is able to visualize the structure of microvasculature and to quantify the changes of dynamic blood flow and vessel diameters during administration of vessel stimulant in both diabetic and normal *** results indicate the potential of OMAg to assess the blood supply of nerve involved in the pathology and treatment of DN.

关键词： Vasa nervorum microcirculation peripheral nerve diabetes optical microangiography

Point-based tool representations for modeling complex tool shapes and runout for the simulation of process forces and chatter vibrations

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Advances in Manufacturing 2018年第3期6卷 301-307页

作者： P. Wiederkehr T. Siebrecht J. baumann D. Biermann Institute of Machining Technology TU Dortmund University Dortmund Germany Virtual Machining Department of Computer Science TU Dortmund University Dortmund Germany

geometric physically-based simulation systemscan be used for analyzing and optimizing complex millingprocesses, for example in the automotive or aerospaceindustry, where the surface quality and process efficiencyare limited due to chatter vibrations. Process simulationsusing tool models based on the constructive solid geometry（CSg） technique allow the analysis of process forces, tooldeflections, and surface location errors resulting from five-axis machining operations. However, modeling complextool shapes and effects like runout is difficult using CSgmodels due to the increasing complexity of the shapedescriptions. Therefore, a point-based method for modelingthe rotating tool considering its deflections is presented inthis paper. With this method, tools with complex shapesand runout can be simulated in an efficient and flexibleway. The new modeling approach is applied to exemplarymilling processes and the simulation results are validatedbased on machining experiments.

关键词： Modeling Tool geometry Milling

Liver disease epidemiology and burden in patients with alterations in plasma protein metabolism:german retrospective insurance claims analysis

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World Journal of Hepatology 2023年第10期15卷 1127-1139页

作者： Nils Picker May Hagiwara Severin baumann Ed g Marins Thomas Wilke Kaili ren Ulf Maywald ChitraKarki Pavel Strnad real-World Evidence Cytel Inc.Ingress-Health HWM GmbHWismar 23966Germany r&D Global Evidence and OutcomesTakeda Development Center AmericasInc.CambridgeMA 02139United States global Medical Affairs Takeda Development Center AmericasInc.CambridgeMA 02139United States IPAM Institute IPAM E.V.Wismar 23966Germany Statistics and Quantitative Sciences Data Science InstituteTakeda Development Center AmericasInc.CambridgeMA 02139United States Drug Department AOK PLUSDresden 01058Germany Medical Clinic III GastroenterologyMetabolic Diseases and Intensive CareUniversity Hospital RWTH AachenAachen 52074Germany

BACKgrOUND Alpha-1 antitrypsin deficiency is a rare genetic disease and a leading cause of inherited alterations in plasma protein metabolism(APPM).AIM To understand the prevalence,burden and progression of liver disease in patients with APPM including alpha-1 antitrypsin *** We conducted a retrospective analysis of anonymized patient-level claims data from a german health insurance provider(AOK PLUS).The APPM cohort comprised patients with APPM(identified using the german Modification of the International Classification of Diseases-10th revision[ICD-10-gM]code E88.0 between 01/01/2010-30/09/2020)and incident liver disease(ICD-10-gM codes K74,K70.2-3 and K71.7 between 01/01/2012-30/09/2020).The control cohort comprised patients without APPM but with incident liver *** were incidence/prevalence of liver disease in patients with APPM,demographics/baseline characteristics,diagnostic procedures,progression-free survival(PFS),disease progression and *** Overall,2680 and 26299 patients were included in the APPM(fibrosis,96;cirrhosis,2584)and control(fibrosis,1444;cirrhosis,24855)cohorts,*** 100000 individuals,annual incidence and prevalence of APPM and liver disease was 10-15 and 36-51,*** the APPM cohort,median survival was 4.7 years[95%confidence interval(CI):3.5-7.0]and 2.5 years(95%CI:2.3-2.8)in patients with fibrosis and cirrhosis,respectively.A higher proportion of patients in the APPM cohort experienced disease progression(92.0%)compared with the control cohort(67.2%).Median PFS was shorter in the APPM cohort(0.9 years,95%CI:0.7-1.1)compared with the control cohort(3.7 years,95%CI:3.6-3.8;Prrhosis in the control cohort had longer event-free survival for ascites,hepatic encephalopathy,hepatic failure and esophageal/gastric varices than patients with cirrhosis in the APPM cohort(Prosis in the control cohort had longer event-free survival for ascites,cir

关键词： Alpha-1 antitrypsin deficiency Epidemiology germany Liver diseases retrospective study

HPC-oriented Canonical Workflows for Machine Learning Applications in Climate and Weather Prediction

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Data Intelligence 2022年第2期4卷 271-285页

作者： Amirpasha Mozaffari Michael Langguth Bing gong Jessica Ahring Adrian rojas Campos Pascal Nieters Otoniel Jose Campos Escobar Martin Wittenbrink Peter baumann Martin g.Schultz Forschungszentrum Julich gmbH 52425 JulichGermany Osnabruick University 49074O snabrickGermany Jacobs University Bremen 28759 BremenGermany Deutscher Wetterdienst 63067 Offenbach am MainGermany

Machine learning(ML)applications in weather and climate are gaining momentum as big data and the immense increase in High-performance computing(HPC)power are paving the *** FAIr data and reproducible ML practices are significant challenges for Earth system *** though the FAIr principle is well known to many scientists,research communities are slow to adopt *** Workflow Framework for research(CWFr)provides a platform to ensure the FAIrness and reproducibility of these practices without overwhelming *** conceptual paper envisions a holistic CWFr approach towards ML applications in weather and climate,focusing on HPC and big ***,we discuss Fair Digital Object(FDO)and research Object(rO)in the Deeprain project to achieve granular *** is a project that aims to improve precipitation forecast in germany by using *** concept envisages the raster datacube to provide data harmonization and fast and scalable data *** suggest the Juypter notebook as a single reproducible *** addition,we envision JuypterHub as a scalable and distributed central platform that connects all these elements and the HPC resources to the researchers via an easy-to-use graphical interface.

关键词： FAIr reproducibility Machine learning Earth system sciences Workflow