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Inhibition of Biofilms by Non-Thermal Plasma Treated Novel Solutions

Advances in Microbiology 2014年第16期4卷 1188-1196页

作者： Utku K. ercan Siddharth S. Joshi Adam Yost Natalie Gogotsi Sean O’Toole Michelle Paff Eric Melchior Suresh G. Joshi Department of Surgery Drexel University College of Medicine Philadelphia Pennsylvania USA Department of Microbiology and Immunology Drexel University College of Medicine Philadelphia Pennsylvania USA

Biofilms act as a reservoir of infection, and periodically release cells in vicinity that are capable of developing new biofilm colonies and disseminate infection. Many chronic bacterial infections are serious that are associated with biofilms and have high morbidity and mortality, partly due to their higher resistance to antimicrobial agents, and partly due to lack of strong biocides which can efficiently treat and inhibit biofilm formation. We recently demonstrated that nonequilibrium non-thermal dielectric-barrier discharge plasma (Plasma) can also be applied to control pathogens via applying treated-liquids, and these liquids acquire broad-spectrum antimicrobial properties. In present studies we demonstrated a range of plasma-activated simple chemical solutions which significantly inhibited biofilm formation by multidrug-resistant bacterial pathogens. Plasma-activated methionine solution exhibited strong inhibitory activity against the biofilms of car-bapenem-resistant Acinetobacter baumannii, methicillin-resistant Staphylococcus aureus, metal-lo-β-lactamase (NDM1)-positive Klebsiella pneumoniae, and Enterococcus faecalis, and prevented the formation of biofilms by about 70% as compared to untreated controls in single exposure. In addition to inhibition of biofilm formation, a complete inactivation of biofilm-embedded bacterial cells was observed in less than 30 minute’s exposure to candidate plasma-activated methionine solution. These findings suggest that plasma-activated solutions have a potential to prevent biofilm formation, and as biofilm inhibitor.

关键词： Acinetobacter baumannii Antibacterial Solution Antibiofilm Agent Biofilm MRSA Nonthermal Plasma

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土耳其总统埃尔多安的反政变法宝

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商业周刊（中文版） 2016年第18期 16-18页

作者： Donna Abu-Nasr Onur Ant ercan Ersoy 永年

这位土耳其领导人对伊斯坦布尔宗教界和政界的影响得到了进一步巩固，

关键词：土耳其埃尔多安变法总统伊斯坦布尔宗教界领导人

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Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue

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World Journal of Gastroenterology 2017年第6期23卷 1018-1029页

作者： Sanne van Erp Ece ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong Department of Gastroenterology and Hepatology Leiden University Medical Center C.J.Gorter Center Leiden University Medical Center Department of Radiology Leiden University Medical Center Department of Medical Statistics Leiden University Medical Center Center for Inflammatory Bowel Diseases University of California Los Angeles Department of Gastroenterology and Hepatology University Medical Center Utrecht Department of Psychiatry Leiden University Medical Center Department of Rheumatology Leiden University Medical Center Department of Neuropsychology Leiden University Medical Center Department of Radiology Leiden University Medical CenterLeiden

To evaluate brain involvement in quiescent Crohn’s disease (CD) patients with fatigue using quantitative magnetic resonance imaging (MRI).METHODSMultiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue (defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study *** glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine (P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow (P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P 1-weighted analysis. In addition, no correlation was found between mental status and MRI *** work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls.

关键词： Magnetic resonance imaging Systemic inflammation Fatigue Crohn’s disease Cognition

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氧化应激酶在开角型青光眼患者中的作用

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世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 36-37页

作者： Yildirim o. Ates? N.A. ercan B. 张少娟 Mersin universitesi Tip Fakültesi Hastanesi Zeytinlibahc?e Cad. 33079 Mersin Turkey

Purpose: To investigate the role of oxidative stress and lipid peroxidation in the pathogenesis of primary open-angle glaucoma (POAG). Materials and methods: The activities of myeloperoxidase (MPO), catalase (CAT), and the levels of plasma malondialdehyde (MDA) were measured in 40 (15 men and 25 women) patients with POAG and 60 (30 men and 30 women)-healthy controls. Results: Therewas no significant difference in the activities of CAT andMPO between the POAG patients and the controls. However, the plasmaMDA level was significantly higher in patients than the controls. Conclusion: The results of this preliminary study suggest that the possible alterations of plasmaMDA levels may be associated with the pathogenesis of POAG, but further research is needed to understand the role of oxidative damage in this important disorder of aging.

关键词：开角型青光眼氧化应激脂质过氧化反应过氧化氢酶血浆丙二醛髓过氧化物酶致病过程增龄性

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信息安全环境的构建与保护

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河南图书馆学刊 2006年第3期26卷 28-31页

作者：刘二灿河南财经学院图书馆河南郑州450002

在这个科技大革命的时代里,黑客、噪音、污染、垃圾、入侵等虽然改头换面了,却一样没少,从经济的角度思维,它们占用了人们的有效经济运行时间,大大影响了人们的工作效率,构成了物质和精神的双重污染。促进信息化健康发展,构建安全的信... 详细信息

在这个科技大革命的时代里,黑客、噪音、污染、垃圾、入侵等虽然改头换面了,却一样没少,从经济的角度思维,它们占用了人们的有效经济运行时间,大大影响了人们的工作效率,构成了物质和精神的双重污染。促进信息化健康发展,构建安全的信息环境,30%依靠安全技术,而70%依赖于切实有效的安全管理。

关键词：信息安全环境保护管理

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Synapsin Polymorphisms Could Be Correlated with Stroop Simple Reaction Time Scores

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American Journal of Molecular Biology 2016年第1期6卷 25-32页

作者： Ahmet Buber Burge Kabukcu Basay Omer Basay Onder Ozturk Huseyin Alacam Kemal Utku Yazici Ali Bacanli Mustafa Ertan Ay Mehmet Emin Erdal Hasan Herken Eyup Sabri ercan Child and Adolescent Psychiatry Department Pamukkale University Medical Faculty Denizli Turkey Psychiatry Department Pamukkale University Medical Faculty Denizli Turkey Child and Adolescent Psychiatry Department Firat University Medical Faculty Elazig Turkey Child and Adolescent Psychiatry Department Gaziantep Children Hospital Gaziantep Turkey Medical Biology and Genetics Department Mersin University Medical Faculty Mersin Turkey Child and Adolescent Psychiatry Department Ege University Medical Faculty Izmir Turkey

Objective: The aim of this study was to research the relationship between Attention Deficit Hyperactivity Disorder (ADHD) and the synapsin III -196G>A and -631C>G polymorphisms and study their impact on neurocognition and behavior in Turkish children and adolescents. Methods: A total of 201 ADHD-diagnosed children and 100 control subjects aged between 8 and 15 years were recruited, and genetic material was obtained from saliva. In the diagnostic assessments, the KSADS- PL semi-structured interview was applied. Children with any comorbid psychiatric diagnosis (with the exclusion of oppositional defiant disorder (ODD)), medical conditions, prior psychotropic drug use history or IQ score below 80 were excluded. For the behavioral and ADHD symptom assessments, the Turgay DSM-IV Disruptive Behaviors Rating Scale, Teacher Report Form (TRF) and Child Behavior Checklist (CBCL) were completed by the parents and teachers. Neurocognitive profiles were evaluated with the CNS-Vital Signs computerized neurocognitive test battery. Results: No significant difference in ADHD prevalence was observed between subjects with the synapsin III gene -196G>A polymorphism and -631C>G polymorphisms. These polymorphisms were also not associated with subtypes of ADHD. We found a relationship between both polymorphisms and Stroop simple reaction time. Conclusion: Synapsin’s effect could be limited during childhood, but synapsin polymorphisms could be associated with Stroop simple reaction time.

关键词： Attention Deficit Hyperactivity Disorder Synapsin III Association Cognitive Function

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大学语文教学中优秀传统文化教育的创新研究

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科教文汇 2020年第25期 63-64页

作者：郭二灿郑州工业应用技术学院河南郑州451150

语文是学生从小学到大学都需要学习的一门学科。学生最开始接触语文这一学科时,主要学习一些简单的字、词、拼音等,了解不同词句的具体意思。而到了大学语文阶段,学生需要接触更多具有难度的内容。在传统的大学语文教学阶段,教师在开展... 详细信息

语文是学生从小学到大学都需要学习的一门学科。学生最开始接触语文这一学科时,主要学习一些简单的字、词、拼音等,了解不同词句的具体意思。而到了大学语文阶段,学生需要接触更多具有难度的内容。在传统的大学语文教学阶段,教师在开展语文教学时采用的方式相对陈旧。因此,在新时代背景下,当前的大学语文教师必须不断地开拓创新,所以我们就以大学语文教学中的传统文化教育作为研究方向,来看看如何针对这一内容展开创新。

关键词：大学语文传统文化教育创新

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白癜风及其眼部发现:一项相关性研究

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世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 24-25页

作者： Bulbul Baskan E. Baykara M. ercan I. 党倩丽 Uludag University Medical Faculty Dermatology Department Gorukle16059 Bursa Turkey

Objective: In this study, we aimed to evaluate the ocular findings in vitiligo patients and reveal any clinical feature that might suggest an association or a risk factor. Background: Very few reports in the literature are available about the ocular findings in vitiligo and the possible associations of the ocular findings in vitiligo patients have not been studied so far. Methods: A total of 45 patients with previously documented cutaneous vitiligo were examined for ocular findings. Demographic features including age, gender, duration of vitiligo, presence of associated autoimmune diseases, type of vitiligo and the anatomical distributions of vitiligo were recorded to evaluate a possible relationship with the ocular findings. Univariate and multivariate analyses as well as cluster analysis were performed. After description of the clusters, the Mann-Whitney U-test and Fisher’s exact test were used to determine the variables. Concordance among the variables in each group was evaluated with the McNemar test. Results: Ten patients had ocular findings that included anterior segment (iris) involvement, ring-like peripapillary atrophy around the optic nerve, atrophy of pigment epithelium, focal hypopigmented spots and diffuse hypopigmentation. The presence of periorbital vitiligo was significantly related to the ocular findings. Cluster analysis revealed concordances between periorbital and genitalial localizations of vitiligo and ocular findings. Conclusion: The number of patients and the range of ocular findings in our study are insufficient to make definite conclusions but anatomical localizations, primarily periorbital and to a lesser extent genitalial vitiligo, seem to be the most probably alerting features for ocular findings.

关键词：聚类分析色素减退斑生殖器部位自身免疫疾病色素上皮秩和检验眼部检查统计学特征单变量多

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PLAU和AKT1在口腔鳞癌中的表达

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安徽医科大学学报 2022年第11期57卷 1821-1825页

作者：孙二灿肖巧玲夏飞飞刘喆徐江黎昌学石河子大学医学院石河子832000 石河子大学医学院第一附属医院口腔科石河子832000

目的探讨激酶纤溶酶原激活剂(PLAU)和蛋白激酶B1(AKT1)在口腔鳞癌(OSCC)及正常组织中的表达、预后和两分子在OSCC组织中的相关性。方法采用免疫组化法检测70例OSCC及50例正常组织中PLAU和AKT1的表达水平,分析PLAU和AKT1表达与临床病理... 详细信息

目的探讨激酶纤溶酶原激活剂(PLAU)和蛋白激酶B1(AKT1)在口腔鳞癌(OSCC)及正常组织中的表达、预后和两分子在OSCC组织中的相关性。方法采用免疫组化法检测70例OSCC及50例正常组织中PLAU和AKT1的表达水平,分析PLAU和AKT1表达与临床病理特征、预后和两分子在OSCC组织中的相关性,并使用生物信息学数据库进一步验证实验结果。结果PLAU和AKT1在OSCC组织中的表达高于正常组织(P<0.05);Kaplan-Meier分析显示,PLAU和AKT1低表达患者的生存时间长于高表达患者(P<0.05);Spearman秩和相关检验显示,在OSCC组织中,PLAU和AKT1表达有着较强的相关性(r=0.357,P<0.05);GEPIA生物信息学数据库分析结果与实验结果一致。结论PLAU和AKT1在OSCC组织中高表达,且与患者不良预后相关,在OSCC组织中PLAU和AKT1存在相关性。

关键词：口腔鳞癌 PLAU AKT1 免疫组化预后

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超声灰度直方图对多形性腺瘤与腺淋巴瘤鉴别诊断效能的初步研究

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国际口腔医学杂志 2022年第1期49卷 60-65页

作者：夏飞飞秦文娟冯佳周旭阳孙二灿黎昌学石河子大学医学院第一附属医院口腔科石河子832008

目的探讨超声灰度直方图对腮腺多形性腺瘤与腺淋巴瘤的鉴别诊断价值。方法对18例多形性腺瘤(PA)与13例腺淋巴瘤(AL)患者的术前超声图像进行灰度直方图分析,比较PA与AL组患者直方图的均值、方差、偏度、峰度及第1、10、50、90、99百分位... 详细信息

目的探讨超声灰度直方图对腮腺多形性腺瘤与腺淋巴瘤的鉴别诊断价值。方法对18例多形性腺瘤(PA)与13例腺淋巴瘤(AL)患者的术前超声图像进行灰度直方图分析,比较PA与AL组患者直方图的均值、方差、偏度、峰度及第1、10、50、90、99百分位数的差异。应用受试者工作特征(ROC)曲线计算各参数的鉴别诊断效能。结果 PA组的方差高于AL组,偏度和峰度值低于AL组,其差异具有统计学意义(P0.05)。ROC曲线分析显示,峰度值最具鉴别诊断效能,曲线下面积(AUC)为0.744 (P=0.022),最佳临界值为1.71,敏感度为76.9%,特异度为61.1%,约登指数为0.380。方差的鉴别诊断效能、最佳临界值、敏感度、特异度及约登指数分别为0.735 (P=0.028)、864.94、72.2%、76.9%及0.491。结论超声灰度直方图对PA与AL具有一定的鉴别诊断价值。

关键词：多形性腺瘤腺淋巴瘤直方图超声灰度超声检查

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