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Working with adolescents with mental disorders: the efficacy of a multiprofessional intervention

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In Vivo Toxicity Assessment of Gold Nanoparticles in Drosophila melanogaster

Health（健康） 2010年第7期

作者： Gatta Michela Pertile Riccardo Testa Costantino Paolo Tomadini Paola Perakis Ecaterini battistella pier antonio

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Nano Research 2011年第4期4卷 405-413页

作者： pier Paolo Pompa Giuseppe Vecchio antonio Galeone Virgilio Brunetti Stefania Sabella Gabriele Maiorano Andrea Falqui GiovanniBertoni Roberto Cingolani Italian Institute of Technology Center for Bio-Molecular Nanotechnology Via Barsanti 1-73010 Arnesano （Lecce） Italy Italian Institute of Technology Central Research Laboratories Via Morego 30-16136 Genova Italy

The growing use of nanomaterials in commercial goods and novel technologies is generating increasing questions about possible risks for human health and environment, due to the lack of an in-depth assessment of their potential toxicity. In this context, we investigated the effects of citrate-capped gold nanoparticles （AuNPs） on the model system Drosophila melanogaster upon ingestion. We observed a significant in vivo toxicity of AuNPs, which elicited clear adverse effects in treated organisms, such as a strong reduction of their life span and fertility, presence of DNA fragmentation, as well as a significant overexpression of the stress proteins. Transmission electron microscopy demonstrated the localization of the nanoparticles in tissues of Drosophila. The experimental evidence of high in vivo toxicity of a nanoscale material, which is widely considered to be safe and biocompatible in its bulk form, opens up important questions in many fields, including nanomedicine, material science, health, drug delivery and risk assessment.

关键词： Nanoparticles nanotoxicology gold in vivo studies

Special features of SARS-CoV-2 in daily practice

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World Journal of Clinical Cases 2020年第18期8卷 3920-3933页

作者： Ioannis A Charitos Andrea Ballini Lucrezia Bottalico Stefania Cantore pier Carmine Passarelli Francesco Inchingolo antonio D'Addona Luigi Santacroce Department of Emergency and Urgency National Poisoning CentreRiuniti University Hospital of FoggiaFoggia 71122Italy Department of Biosciences Biotechnologies and BiopharmaceuticsUniversity Campus"E.Quagliariello"University of Bari“Aldo Moro”Bari 70125Italy Department of Precision Medicine University of Campania“Luigi Vanvitelli”Naples 80138Italy Interdepartmental Research Center for Pre-Latin Latin and Oriental Rights and Culture Studies(CEDICLO)University of BariBari 70121Italy Department of Interdisciplinary Medicine University of Bari“Aldo Moro”Bari 70124Italy Sorriso&Benessere-Ricerca e Clinica S.R.L Bari 70129Italy Department of Head Neck and Sense OrgansDivision of Oral Surgery and ImplantologyFondazione Policlinico Universitario A.Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Department of Interdisciplinary Medicine Section of Dental MedicineUniversity of Bari“Aldo Moro”Bari 70124Italy Department of Head and Neck and Sensory Organs Division of Oral Surgery and ImplantologyFondazione Policlinico Universitario A.Gemelli IRCCS—UniversitàCattolica del Sacro CuoreRoma 00168Italy Ionian Department Microbiology and Virology LaboratoryPoliclinico University HospitalUniversity of Bari“Aldo Moro”Bari 70124Italy

The severe acute respiratory syndrome-coronavirus-2(commonly known as SARS-CoV-2)is a novel coronavirus(designated as 2019-nCoV),which was isolated for the first time after the Chinese health authorities reported a cluster of pneumonia cases in Wuhan,China in December *** management of the Coronavirus Disease-2019 disease is evolving quickly and treatment guidelines,based on scientific evidence and experts’opinions with clinical experience,are constantly being *** January 30,2020,the World Health Organization declared the SARS-CoV-2 outbreak as a"Public Health Emergency of International Concern".The total lack of immune protection brought about a severe spread of the contagion all over the *** this reason,diagnostic tools,patient management and therapeutic approaches have been tested along the way,in the desperate race to break free from the widespread infection and its fatal respiratory *** medical knowledge and research on severe and critical patients’management and experimental treatments are still evolving,but several protocols on minimizing risk of infection among the general population,patients and healthcare workers have been approved and diffused by International Health Authorities.

关键词： Pandemics Viruses SARS-CoV-2/COVID-19 Sepsis Acute respiratory distress syndrome Acute respiratory distress syndrome Translational medicine Clinical microbiology Clinical biochemistry Antivirals Emergency and critical care medicine

Use of biological meshes for abdominal wall reconstruction in highly contaminated fields

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World Journal of Gastroenterology 2010年第15期16卷 1928-1933页

作者： Andrea Cavallaro Emanuele Lo Menzo Maria Di Vita antonio Zanghì Vincenzo Cavallaro pier Francesco Veroux Alessandro Cappellani General Surgery and Senology Department of Surgery "Policlinico - Vittorio Emanuele" Hospital University of Catania Medical School Via S. Sofi a 78 95123 Catania Italy Department of Surgery University of Maryland School of Medicine Baltimore MD 21201 United States Department of Surgical Sciences Organs Trasplants Advanced Technologies Medical University of Catania "Policlinico - Vittorio Emanue-le" Hospital Via S. Sofi a 78 95123 Catania Italy

Abdominal wall defects and incisional hernias represent a challenging problem. In particular, when a synthetic mesh is applied to contaminated wounds, its removal is required in 50%-90% of cases. Biosynthetic meshes are the newest tool available to surgeons and they could have a role in ventral hernia repair in a potential-ly contaminated field. We describe the use of a sheet of bovine pericardium graft in the reconstruction of abdominal wall defect in two patients. Bovine pericardium graft was placed in the retrorectus space and secured to the anterior abdominal wall using polypropylene sutures in a tension-free manner. We experienced no evidence of recurrence at 4 and 5 years follow-up.

关键词： Biological meshes Bovine Pericardium Infection Hernia

Intestinal amyloidosis:Two cases with different patterns of clinical and imaging presentation

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World Journal of Gastroenterology 2010年第20期16卷 2566-2570页

作者： pier Paolo Mainenti Sabrina Segreto Marcello Mancini antonio Rispo Immacolata Cozzolino Stefania Masone Ciro Roberto Rinaldi Gerardo Nardone Marco Salvatore IBB CNR NaplesVia Pansini 580131NaplesItaly Department of Biomorphological and Functional Sciences Section of RadiologyUniversity of Naples"Federico II"Via Pansini 580131NaplesItaly Department of Gastro-enterology University of Naples"Federico II"Via Pansini 580131NaplesItaly Department of Biomorphological and Functional Sciences Section of PathologyUniversity of Naples "Federico II"Via Pansini 580131NaplesItaly Department of General Surgery Geriatry and EndoscopyUniversity of Naples"Federico II"Via Pansini 580131NaplesItaly Department of Biotechnology Haema-tology UnitUniversity of Naples"Federico II"Via Pansini 580131NaplesItaly

The involvement of the small bowel in systemic forms of amyloidosis may be diffuse or very rarely *** cases of focal amyloidomas of the duodenum and jejunum without extraintestinal manifestations have been *** focal amyloidomas consisted of extensive amyloid infiltration of the entire intestinal wall *** barium studies,ultrasound and computed tomography(CT)patterns of diffuse small bowel amyloidosis have been described:the signs are non-specific and may include small-bowel dilatation,symmetric bowel wall thickening,mesenteric infiltration,and mesenteric *** data are available about the positron emission tomography (PET)/CT and magnetic resonance imaging(MRI)patterns of intestinal *** report two cases of small bowel amyloidosis:the former characterized by focal deposition of amyloid proteins exclusively within blood vessel walls of the terminal ileum,the latter characterized by diffuse intestinal involvement observed on MRI and PET/CT studies.

关键词： Amyloidosis Small bowel Positron emission tomography/computed tomography Magnetic resonance imaging Computed tomography

Novel Engineered Human Fluorescent Osteoblasts for Scaffolds Bioassays

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Journal of Biomaterials and Nanobiotechnology 2010年第1期1卷 1-6页

作者： Katia Campioni Cristina Morelli antonio D. Agostino Lorenzo Trevisiol pier Francesco Nocini Marco Manfrini Mauro Tognon Department of Odontostomatology and Maxillo-Facial Surgery School of Medicine and School of Dentistry University of Verona Verona Italy Section of Cell Biology and Molecular Genetics School of Medicine and Centre of Biotechnology University of Ferrara Ferrara Italy

Many cellular models have been used to investigate bone substitutes including coralderived hydroxylapatite (HA). The aim of this study was to verify whether a new cellular model represented by Saos-eGFP cells can be used to test biomaterials by in vitro assays. SaoseGFP cells which express the enhanced Green Fluorescent Protein (eGFP), were derived from the osteoblast-like cell line Saos-2. To this purpose Saos-eGFP cells were employed to investigate the in-vitro bioactivity of a well characterized coral-derived HA biomaterial, in block and granule forms. This engineered cell line, by evaluating the emitted fluorescence, allowed us to assay (i) cell adhesion, (ii) cell proliferation and (iii) colony capability. Electron microscopy analysis was employed to evaluate the (iv) morphology of cells seeded on the biomaterial surface. (v) Histological analysis of the bone grown after scaffold implantation was carried out in specimens from two clinical cases. Saos-eGFP cells indicate, as established before, that the coralline-HA biomaterials has a good in vitro cytocompatibility when tested with human osteoblast-like cells. Some differences in proliferation activity was detected for the two different forms assayed. Cytocompatibility data from in vitro analyses were confirmed by in vivo behaviour of biomaterials. Our tests suggest that the engineered cell line Saos-eGFP represents a suitable in vitro mode for studying the biocompatibility, the cell adhesion, spreading and proliferation on biomaterials developed for clinical applications. The main advantages of this cellular model are (i) less time consuming and (ii) a reduced cost of the experiments.

关键词： Fluorescence Osteoblast Biomaterial

Multi-objective optimization design of bridge piers with hybrid heuristic algorithms

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第6期13卷 420-432页

作者： Francisco J. MARTINEZ-MARTIN Fernando GONZALEZ-VIDOSA antonio HOSPITALER Víctor YEPES Department of Geotechnical Engineering Universitat Politècnica de València 46022 Valencia Spain Department of Construction Engineering ICITECH Universitat Politècnica de València 46022 Valencia Spain

This paper describes one approach to the design of reinforced concrete (RC) bridge piers, using a three-hybrid multi- objective simulated annealing (SA) algorithm with a neighborhood move based on the mutation operator from the genetic algorithms (GAs), namely MOSAMO1, MOSAMO2 and MOSAMO3. The procedure is applied to three objective functions: the economic cost, the reinforcing steel congestion and the embedded CO 2 emissions. Additional results for a random walk and a descent local search multi-objective algorithm are presented. The evaluation of solutions follows the Spanish Code for structural concrete. The methodology was applied to a typical bridge pier of 23.97 m in height. This example involved 110 design variables. Results indicate that algorithm MOSAMO2 outperforms other algorithms regarding the definition of Pareto fronts. Further, the proposed procedure will help structural engineers to enhance their bridge pier designs.

关键词： Bridge piers Concrete structures Multi-objective optimization Simulated annealing (SA) Structural design

The Italian ZECOMIX Platform: CO<sub>2</sub>Capture on Calcined Dolomite in Fluidized Bed Carbonator Unit

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Natural Resources 2014年第9期5卷 433-441页

作者： Silvera Scaccia Stefano Stendardo Giuseppina Vanga Leandro Pagliari Stefano Cassani Mirko Nobili Giuseppe Messina Andrea Assettati Giuliano Guidarelli Salvatore Attanasi Caterino Stringola Andrea Grasso Ivano Cassani antonio Calabró pier Ugo Foscolo Department of Chemistry Chemical Engineering and Materials University of L’Aquila L’Aquila Italy Energy Efficiency UTEE-GRT ENEA-CCEI UMBRIA Perugia Italy Sustainable Combustion Laboratory (UTTEI-COMSO) C.R. ENEA Rome Italy

The Italian Zecomix platform is a gasification pilot-scale plant integrated CCS technology, whose flexibility allows operating each unit alone. For quantitative analysis of the gaseous species an analytical system based on commercially available instruments and sampling lines at various points of plant was properly designed. A Fourier Transform Infrared Spectrometric (FTIR) with portable low resolution and gas chromatographic tools were used. The fluidized bed calciner/ carbonator unit was fed with naturally occurring dolomite (about 300 kg) from quarry of Biella (Italy) and tested for CO2 capture. Carbonation reaction was conducted at around 700°C under simulated reformed synthesis gas containing 30% of CO2. Based on GC and FTIR results a CO2 retention better than 70% was achieved. The application of grain model establishing the carbonation reaction was kinetically controlled within 50 seconds and the reaction rate constant was comparable to that obtained at laboratory-scale level by thermogravimetric analyzer.

关键词： ZECOMIX Experimental Platform Dolomite CO2 Capture Fluidized Bed GC and FTIR Kinetics