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Real-world evidence on adjuvant chemotherapy.in older adults with stage II/III colon cancer

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World Journal of Gastrointestinal Oncology 2020年第6期12卷 604-618页

作者： Atul batra Rodrigo Rigo Dropen Sheka Winson y.Cheung Department of Medicine Tom Baker Cancer CentreCalgaryAlberta T2N 1N4Canada Department of Oncology University of CalgaryCalgaryAlberta T 2N 4N2Canada

Colon cancer represents one of the most common cancers diagnosed in older adults *** standard of care in resected stage II and stage III colon cancer continues to *** there is unequivocal evidence to suggest both disease free and overall survival benefits with the use of combination chemotherapy.in patients with stage III colon cancer,data regarding its use in patients with stage II colon cancer are less ***,although colon cancer is a disease that affects older adults,there is considerable debate on the value of adjuvant chemotherapy.in the aging *** particular,many.older patients are undertreated when compared to their y.unger *** this review,we will describe the clinical trials that contributed to the current adjuvant chemotherapy.approach in colon cancer,discuss representation of older adults in trials and the specific challenges associated with the management of this subpopulation,and highlight the role of comprehensive geriatric *** will also review how real-world evidence complements the data gaps from clinical trials of early.stage colon cancer.

关键词： Colon cancer Older adults Adjuvant chemotherapy Real-world evidence

Evaluation of corrosion resistance, mechanical integrity.loss and biocompatibility.of PCL/HA/TiO_(2) hy.rid coated biodegradable ZM21 Mg alloy

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Journal of Magnesium and Alloy. 2022年第11期10卷 3179-3204页

作者： Navdeep Singh Uma batra Kamal Kumar Anil Mahapatro Department of Metallurgical and Materials Engineering Punjab Engineering CollegeChandigarh 160012India Department of Mechanical Engineering Punjab Engineering CollegeChandigarh 160012India Department of Biomedical Engineering Wichita State UniversityWichitaKS 67260United States

A novel PCL/HA/TiO_(2)hy.rid coating on ZM21 Mg alloy.substrate has been investigated for corrosion resistance, biocompatibility.and mechanical integrity.loss in terms of bending, compressive and tensile strength in phy.iological media. The prepared hy.rid coating was dip coated over ZM21 from HA/TiO_(2)and PCL solutions followed by.creating a microporous PCL lay.r by.utilizing Non-solvent Induced Phase Separation(NIPS) technique. The electrochemical measurement and in-vitro degradation study.in SBF after 28 day. showed that the PCL/HA/TiO_(2) hy.rid coating reduced H2 evolution rate, weight loss, and corrosion rate by.64, 116 and 118 times respectively. as compared to uncoated ZM21 samples. The surface studies carried out using SEM-EDX, FTIR and XRD revealed formation of highly.stable 3d flower-like HA cry.tals with Ca/P ratio of 1.60 in the PCL micropores. This dense apatite growth effectively.protected the PCL/HA/TiO_(2)hy.rid coated samples to maintain the good mechanical integrity.even after 28 day. of immersion as compared to HA/TiO_(2)composite coated, As-polished(A/P) and As-machined(A/M) samples. The failure analy.is of samples under mechanical loading were performed using *** in-vitro cellular viability.of L929 fibroblast cells on PCL/HA/TiO_(2)hy.rid coating was found 50.47% higher with respect to control group,whereas bacterial viability.was supressed by.57.15 and 62.35% against gram-positive Staphy.ococcus aureus and gram-negative Escherichia coli bacterial models. The comprehensive assessment indicates PCL/HA/TiO_(2)hy.rid coating as a suitable candidate to delay.early.degradation and mechanical integrity.loss of Mg-based alloy. for devising biodegradable orthopaedic implant.

关键词： Magnesium alloy Surface modification Hy.rid coating Mechanical integrity.loss Degradation rate Biocompatibility

Investigating TiO_(2)-HA-PCL hy.rid coating as an efficient corrosion resistant barrier of ZM21 Mg alloy

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Journal of Magnesium and Alloy. 2021年第2期9卷 627-646页

Surface modification for improving corrosion resistance of Mg alloy. is highly.demanded for degradable orthopedic and cardiovascular *** research reports the design and development of TiO_(2)–HA composite and novel TiO_(2)–HA–PCL hy.rid coating belonging to the unique class of inorganic organic hy.rid with striking features that are explored for the first time in the corrosion resistance of Mg ***–gel dip coating combined with non-solvent induced phase separation is used to create the hy.rid ***_(2)–HA–PCL hy.rid coating introduces strong hy.rogen bonding between TiO_(2)–HA inorganic matrix and PCL organic lay.r in addition to the Vander wall electrostatic interaction of the later with the Mg substrate which in turn enhance adhesion strength to about 1.5 times of TiO_(2)–HA *** corrosion potentials for TiO_(2)–HA–PCL and TiO_(2)–HA were found to be-0.407 V and-1.017 V(vs Ag/Ag Cl),*** current densities of TiO_(2)–HA–PCL and TiO_(2)–HA were found to be 7.31×10^(-8)A/cm^(2)and 4.03×10^(-4)A/cm^(2)*** corrosion resistance of coatings was confirmed by.immersion testing by.weight loss,pH changes and H_(2)evolution measurements at interval of 7 day. till 28 *** present TiO_(2)–HA–PCL coating in comparison to TiO_(2)–HA coating demonstrate nearly.6%less weight *** outcome of the present work was compared with the similar coatings in recent *** work done ingresses enhancing the corrosion resistance of Mg alloy.,which fulfill the dreams of future degradable orthopedic and cardiovascular devices.

关键词： Corrosion resistance TiO_(2)-HA-PCL Contact angle Adhesion strength

An optimized ion trap geometry.to measure quadrupole shifts of ^(171)y.~＋ clocks

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Chinese Phy.ics B 2016年第11期25卷 230-237页

作者： N batra B K Sahoo S De Academy.of Scientific and Innovative Research CSIR-NPL Campus New Delhi India CSIR-National Phy.ical Laboratory Dr. K. S. Krishnan Marg New Delhi 110012 India Theoretical Phy.ics Division Physical Research Laboratory Navrangpura Ahmedabad 380009 India

We propose a new ion-trap geometry.to carry.out accurate measurements of the quadrupole shifts in the （171）y. *** trap will minimize the quadrupole shift due to the harmonic component of the confining potential by.an order of *** will be useful to reduce the uncertainties in the clock frequency.measurements of the 6s 2S（1/2）→4f（13）6s2 2F（7/2）and 6s 2S（1/2）→5d2D（3/2） transitions,from which we can deduce the precise values of the quadrupole moments（0s） of the 4f（13）6s2 2F（7/2） and 5d2D（3/2） ***,it may.be able to affirm the validity.of the measured 0 value of the4f（13）6s22F（7/2） state,for which three independent theoretical studies defer almost by.one order of magnitude from the *** also calculate 0s using the relativistic coupled-cluster（RCC） *** use these 0 values to estimate the quadrupole shift that can be measured in our proposed ion trap experiment.

关键词： validity.minimize carry.clock relativistic precise deduce magnitude expectation spatially

Novel PA encapsulated PCL hy.rid coating for corrosion inhibition of biodegradable Mg alloy.:A triple triggered self-healing response for sy.ergistic multiple protection

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Journal of Magnesium and Alloy. 2023年第4期11卷 1440-1460页

作者： Navdeep Singh Grewal Uma batra Kamal Kumar Anil Mahapatro Department of Metallurgical and Materials Engineering Punjab Engineering CollegeChandigarh 160012India Department of Mechanical Engineering Punjab Engineering CollegeChandigarh 160012India Department of Biomedical Engineering Wichita State UniversityWichitaKS 67260USA

Surface coatings have been extensively.used to control the degradation rate of Mg alloy. for bioimplant ***,these coatings only.act as passive *** corrosive media,structural damage impairs their barrier properties,resulting in rapid degradation of Mg *** present study.incorporates phy.ic acid(PA)as a healing agent in poly.aprolactone(PCL)microcapsules with a unique honey.omb core matrix to obtain a self-healing PA-PCLcaps *** contact between simulated body.fluid(SBF)and PA-PCLcaps coated ZM21 exhibited Cassie-Baxter interfacial states,resulting in significant hy.rophobicity.with a contact angle(CA)of *** corrosion potential(Ecorr)and current density.Icorr)were found to be-0.28 V and 1.1×10^(-9)A/cm^(2),respectively.for PA-PCLcaps coating,resulting in biosafe corrosion rate of 2.5×10^(-4)mm/*** mechanical scratching,rapid HA mineralization at scratched regions recovered the hy.rogen evolution rate(HER,0.36 mL/cm^(2)/day.and pH change(pH 7.10)of scratched PA-PCLcaps coated ZM21 samples to corresponding unscratched samples within one day.of *** coating’s self-healing ability.could be attributed to PA released from punctured microcapsules,which facilitates HA *** pH-triggered(pH 10)and Mg(II)-triggered(5 mM)conditions enhanced PA release from PA-PCLcaps coating by.2.5 and 3.1 times,*** a result,dense HA mineralization occurred,which protects the coating from structural defects and ensures its durability.in stimulating *** findings of present study.provide new insight for design of multiple stimuli-feedback based self-healing coatings on biodegradable Mg alloy..

关键词： Self-healing coating Corrosion resistance Magnesium alloy Phy.ic acid Poly.aprolactone microcapsules

Structure of Comparative Advantage of China and India： Global and Regional Dy.amics

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China & World Economy 2007年第6期15卷 69-86页

作者： Amita batra Senior Fellow Indian Council for Research on International Economic Relations New Delhi India.

This paper investigates the extent of competition between China and lndia in the world and ASEAN markets. The analy.is is undertaken using the concept of revealed comparative advantage, relative market shares, long-term trend analy.is and statistical tests of convergence. In the context of the ASEAN market the evaluation of competition between India and China has been undertaken with special reference to the prior implementation of the ASEAN-China Free Trade Area relative to the ASEAN-India Free Trade Area. The results suggest that threat perceptions at the product level might currently.prevail for both economies from each other across all sectors in both markets even though the intensity.of the competitive threat varies across products. However, long-term trend analy.is shows that the patterns of comparative advantage of India and China are evolving along divergent paths and, therefore, competition between the two economies might not be a major issue.

关键词： Asian economic integration competitive threat market share revealed comparative advantage

Development of multi-functional nano-paint for energy.harvesting applications

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Progress in Natural Science:Materials International 2018年第1期28卷 1-6页

作者： Bir B.Bohara Ashok K.batra Department of Phy.ics Chemistry and Mathematics (Materials Science Group) College of Engineering Technology and Physical Sciences Alabama A&M University

The multi-functionality.of lead magnesium niobate-lead titanate/paint（PMN-PT/paint） nanocomposite films for energy.harvesting via piezoelectric and py.oelectric effects is described. PMN-PT/paint films have been fabricated by.a conventional paint-brushing technique to provide a low-cost, low-temperature and low–energy.route to create multi-functional films. The properties investigated included dielectric constants, ε' and ε'', as a function of temperature, frequency.and composition. From these parameters, it is indicated that the dielectric constants and AC conductivity.σAC) increase with an increase of filler content and temperature, imply.ng an improvement of the functionality.of the films. The results revealed that σACobey.d the relation σAC=Aωs, and exponents, was found to decrease by.increasing the temperature. The correlated barrier hopping was the dominant conduction mechanism in the nanocomposite films. The efforts were made to investigate the performance of nanocomposite films to mechanical vibrations and thermal variations. A cantilever sy.tem was designed and examined to assess its performance as energy.harvesters. The highest output voltage and power for a PMN-PT/paint based harvester with a broad frequency.response operating in the-31-piezoelectric mode were 65 mV and 1 nW, *** and power were shown to be enhanced by.application of thermal variations. Thus, films could be utilized for combined energy.harvesting via piezoelectric and py.oelectric characteristics.

关键词： Dielectric Py.oelectricity Piezoelectricity Nanocomposites PMN-PT Energy.harvesting

In vivo antianxiety.and antidepressant activity.of Murray. paniculata leaf extracts

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Journal of Integrative Medicine 2017年第4期15卷 320-325页

作者： Pragy. Sharma Sonali batra Ashwani Kumar Anupam Sharma University.Institute of Pharmaceutical Sciences Panjab University

OBJECTIVE： Different parts of Murray. paniculata have been used traditionally.for treating several ailments including mental disorders. The present study.was designed to evaluate the antianxiety.and antidepressant potential of M. paniculata leaves using elevated plus maze model and forced swim test, respectively. METHODS： Extracts of M. panicu/ata made with petroleum ether （60-80 ℃）, chloroform, ethanol and water were evaluated for antianxiety.and antidepressant activity. The anxioly.ic chloroform extract was subjected to column chromatography. y.elding five fractions （F1-F5）. Fraction F5 （100 mg/kg）, which showed notable anxioly.ic activity. was further chromatographed to get four subfractions （F5.1-F5.4）. Simultaneously. the ethano extract was partitioned with ethy. acetate to obtain ethy. acetate soluble fraction （EASF） and ethy. acetate insoluble fraction. Phy.ochemical screening of bioactive extracts/fractions and detection of mahanimbine in M paniculata leaf extract by.thin-lay.r chromatography.was also carried out. RESULTS： Fraction F5.3 （25 mg/kg） and EASF （20 mg/kg） showed significant anxioly.ic and antidepressant activity. respectively. Thin-lay.r chromatography.and phy.ochemical screening demonstrated the absence of mahanimbine in M. paniculata leaves. Coumarins were observed to be responsible for the anxioly.ic activity. CONCLUSION： The results validate the traditional use of M. paniculata leaves in the treatment of menta disorders.

关键词： Murray. paniculata anxiety depressant coumarins mahanimbine plants, medicinal

Gallbladder cancer with tumor thrombus in the superior vena cava

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Hepatobiliary.& Pancreatic Diseases International 2010年第3期9卷 325-328页

作者： Sandeep batra Dinesh Chandra Doval Ullas batra Pandalanghat Suresh Amit Dhiman Vineet Talwar Department of Medical Oncology Rajiv Gandhi Cancer Hospital Sector 5

BACKGROUND:Gastrointestinal cancers,especially.pancreatobiliary.cancers,are frequently.associated with or are complicated by.thromboembolic phenomena due to hy.ercoagulability.and/or altered venous drainage,especially.of the abdomen and lower *** report describes an unusual and interesting case of gallbladder carcinoma developing a viable tumor thrombus in the superior vena cava(SVC)with resultant SVC obstruction,while on gefitinibbased anti-epidermal growth factor receptor(EGFR)***:A 60-y.ar-old woman was incidentally.diagnosed to have gallbladder cancer on *** had disease recurrence and received sy.temic chemotherapy.followed by.gefitinib-based anti-EGFR ***,while on gefitinib-based therapy.she presented with clinical signs and sy.ptoms suggestive of SVC ***:A whole body.PET scan revealed a metabolically.active tumor thrombus in the SVC,besides other sites of metabolically.active disease inclusive of the lung parenchy.a, ly.ph nodes and *** was treated with antithrombotics and external beam radiotherapy.directed to the SVC thrombus leading to sy.ptomatic *** continues to survive on the day.of writing this ***:This rare complication,though theoretically.possible,is unreported because of the short overall survival of advanced gallbladder cancer *** highlights that with the availability.of better chemotherapeutic/biotherapeutic agents for increasing in the lifespan of cancer patients,we may.come across such cases more frequently.in the future.

关键词： gallbladder carcinoma superior vena cava tumor thrombus epidermal growth factor receptor