检索结果-南通市图书馆

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

引用

Neural Regeneration Research 2025年第2期20卷 394-401页

作者： josep.Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Extreme-scale computer architecture

引用

National Science Review 2016年第1期3卷 19-23页

作者： josep.Torrellas Siebel Center for Computer Science University of Illinois at Urbana-Champaign

INTRODUCTION As transistor sizes continue to scale down,we are about to witness extraordinary levels of chip *** early in the next decade,as we reach7 nm,we will be able to integrate,for example,1000 sizable cores and... 详细信息

关键词： Extreme-scale computer architecture than

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Catastrophic climate change and the collapse of human societies

引用

National Science Review 2023年第6期10卷 52-54页

作者： josep.Pe?uelas Sandra Nogué CREAF Cerdanyola del Vallès CSIC Global Ecology Unit CREAF-CSIC-UAB Universitat Autònoma de Barcelona

The scientific community has focused the agenda of studies of climate change on lower-end warming and simple risk analyses,because more realistic complex assessments of risk are more difficult,the benchmark of the international targets is the Paris Agreement goal of limiting warming to <2℃,and the culture of climate science is to try to avoid alarmism[1].Current fires,prolonged droughts,floods and heat waves,together with the consequent food insecurity,civil unrest and migrations,however,are opening the eyes not only of most scientists but also of most people all over the world to the need for considering,at least,the potential catastrophic effects of the collapse of ecosystems and society due to the current emergency of climate change.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Altered histone retention and epigenetic modifications in the sperm of infertile men

引用

Asian Journal of Andrology 2012年第2期14卷 239-240页

作者： Rafael Oliva josep.Luis Ballesca Genetics Unit Department of Physiological Sciences I University of Barcelona Biochemistry and Molecular Genetics Service and Andrology Unit Hospital Clinic 08036 Barcelona Spain

It is well know that the nuclei of spermatogenic cells experience one of the most extremely marked chromatin changes known in cells. At the end of spermatogenesis, the histones are removed in many species and the DNA ... 详细信息

关键词： sperm Genetics Altered histone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combining Solar-Induced Chlorophyll Fluorescence and Optical Vegetation Indices to Better Understand Plant Phenological Responses to Global Change

Journal of Remote Sensing

引用

Journal of Remote Sensing 2023年第1期3卷 334-342页

作者： Yao Zhang josep.Penuelas Sino-French Institute for Earth System Science College of Urban and Environmental SciencesPeking UniversityBeijingChina Institute of Carbon Neutrality Peking UniversityBeijingChina CSIC Global Ecology Unit CREAF-CSIC-UABBarcelonaCataloniaSpain CREAF BarcelonaCataloniaSpain

Recent advances in the satellite retrieval of solar-induced chlorophyll fluorescence(SIF)provide new opportunities for understanding the phenological responses of ecosystems to global climate *** of the strong link between SIF and plant gross photosynthesis,phenological events derived from SIF represent the seasonal variation of ecosystem functioning(photosynthetic phenology)and differ from phenologies derived from traditional vegetation *** provide an overview of recent advances in remotely sensed photosynthetic phenologies,with a focus on their driving factors,their impact on the global carbon cycle,and their relationships with vegetation index-derived land surface phenology *** also discuss future research directions on how to better use various phenological metrics to understand the responses of plants to global change.

关键词： Fluorescence Plant indices

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Human sperm chromatin epigenetic potential： genomics, proteomics, and male infertility

引用

Asian Journal of Andrology 2015年第4期17卷 601-609页

作者： ludit Castillo josep.Maria Estanyol josep.Lluis Ballesca Rafael Oliva Human Genetics Research Group IDIBAPS Faculty of Medicine University of Barcelona Casanova 143 08036 Barcelona Spain Biochemistry and Molecular GeneticsService Biomedical Diagnostic Centre Hospital Clinic Villarroel 170 08036 Barcelona Spain Proteomics Unit Scientific and Technological Centres of the Universityof Barcelona (CCiTUB) Casanova 143 08036 Barcelona Spain Clinic Institute of Gynaecology Obstetrics and Neonatology Hospital Clinic Villarroel 170 08036Barcelona Spain.

The classical idea about the function of the mammalian sperm chromatin is that it serves to transmit a highly protected and transcriptionally inactive paternal genome, largely condensed by protamines, to the next generation. In addition, recent sperm chromatin genome-wide dissection studies indicate the presence of a differential distribution of the genes and repetitive sequences in the protamine-condensed and histone-condensed sperm chromatin domains, which could be potentially involved in regulatory roles after fertilization. Interestingly, recent proteomic studies have shown that sperm chromatin contains many additional proteins, in addition to the abundant histones and protamines, with specific modifications and chromatin affinity features which are also delivered to the oocyte. Both gene and protein signatures seem to be altered in infertile patients and, as such, are consistent with the potential involvement of the sperm chromatin landscape in early embryo development. This present work reviews the available information on the composition of the human sperm chromatin and its epigenetic potential, with a particular focus on recent results derived from high-throughput genomic and proteomic studies. As a complement, we provide experimental evidence for the detection of phosphorylations and acetylations in human protamine 1 using a mass spectrometry approach. The available data indicate that the sperm chromatin is much more complex than what it was previously thought, raising the possibility that it could also serve to transmit crucial paternal epigenetic information to the embryo.

关键词： genomics male infertility proteomics sperm chromatin sperm epigenetics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Abc-frame complex-coefficient filter and controller based current harmonic elimination strategy for three-phase grid connected inverter

引用

Journal of Modern Power Systems and Clean Energy 2016年第1期4卷 87-93页

作者： Xiaoqiang GUO josep.M.GUERRERO Department of Electrical Engineering Yanshan UniversityQinhuangdao 066004China Department of Energy Technology Aalborg University9220 AalborgDenmark

Current quality is one of the most important issues for operating three-phase grid-connected inverter in distributed generation systems. In practice, the grid current quality is degraded in case of non-ideal utility voltage. A new control strategy is proposed for the three-phase gridconnected inverter. Different from the traditional method,our proposal utilizes the unique abc-frame complex-coefficient filter and controller to achieve the balanced, sinusoidal grid current. The main feature of the proposed method is simple and easy to implement without any frame transformation. The theoretical analysis and experimental test are presented. The experimental results verify the effectiveness of the proposed control strategy.

关键词： Grid-connected inverter Current control Complex-coefficient filter Complex-coefficient controller

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Expansion of the hepatocellular carcinoma Milan criteria in liver transplantation: Future directions

引用

World Journal of Gastroenterology 2018年第32期24卷 3626-3636页

作者： Mihai-Calin Pavel josep.Fuster Hepato Bilio Pancreatic Surgery and Transplant Unit Department of Surgery Digestive and Metabolic Diseases Institute Hospital Clínic University of Barcelona Barcelona-Clínic Liver Cancer Group (BCLC) Liver Unit Institut d’Investigacions Biomèdiques August Pii Sunyer (IDIBAPS) CIBEREHD Universitat de Barcelona

Milan criteria are currently the benchmark related to liver transplantation(LT) for hepatocellular carcinoma. However, several groups have proposed different expanded criteria with acceptable results. In this article, we review the current status of LT beyond the Milan criteria in three different scenarios-expanded criteria with cadaveric LT, downstaging to Milan criteria before LT, and expansion in the context of adult living donor LT. The review focuses on three main questions: what would the impact of the expansion beyond Milan criteria be on the patients on the waiting list; whether the dichotomous criteria(yes/no) currently used are appropriate for LT or continuous survival estimations, such as the one of "Metroticket" and whether it should enter into the clinical practice; and, whether the use of living donor LT in the context of expansion beyond Milan criteria is justified.

关键词： Hepatocellular carcinoma Milan criteria Liver transplantation Living donor liver transplantation Expanded criteria Downstaging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modulation of brainstem reflexes induced by non-invasive brain stimulation: is there a future?

引用

Neural Regeneration Research 2021年第10期16卷 2004-2005页

作者： Hatice Kumru Markus Kofler josep.Valls-Sole Institut Guttmann Institut Universitari de Neurorehabilitacióadscrit a la UAB089M6 Badalona–BarcelonaSpain Univ Autonoma de Barcelona 08M93 Bellaterra(Cerdanyola del Vallès)Spain FundacióInstitut d’Investigacióen Ciències de la Salut Germans Trias i Pujol BadalonaBarcelonaSpain Department of Neurology Hochzirl HospitalZirlAustria EMG Unit NeurologyHospital Clinic-IDIBAPSBarcelonaSpain

Kumru et al.(2019)have recently reported significant reduction of the R2 component of the trigeminal blink reflex following highfrequency(20 Hz)repetitive transcranial magnetic stimulation(rTMS)over the vertex in both,healthy subjects and in patients with spinal cord injury(SCI)(Figure 1).The modulatory influence of non-invasive brain stimulation(NIBS)on brainstem reflexes has been only scarcely studied.

关键词： stimulation brainstem al.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ecological stoichiometric comparison of plant-litter-soil system in mixed-species and monoculture plantations of Robinia pseudoacacia,Amygdalus davidiana,and Armeniaca sibirica in the Loess Hilly Region of China

引用

Forest Ecosystems 2023年第3期10卷 411-424页

作者： Senbao Lu Yunming Chen Jordi Sardans josep.Penuelas State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Institute of Soil and Water ConservationChinese Academy of Sciences and Ministry of Water ResourcesYangling712100China University of Chinese Academy of Sciences Beijing100049China Institute of Soil and Water Conservation Northwest A&F UniversityYangling712100China CSIC Global Ecology Unit CREAF-CSIC-UABBellaterra08193CataloniaSpain CREAF Cerdanyola del Vall�es08193CataloniaSpain

We examined how afforestation patterns impact carbon(C),nitrogen(N),and phosphorus(P)stoichiometry in the plant-litter-soil *** leaf,branch,stem,and root,litter,and soil samples were collected from mixedspecies plantations of Robinia pseudoacacia with Amygdalus davidiana(RPAD),*** with Armeniaca sibirica(RPAS),and monocultures of ***(RP),***(AD),and ***(AS)in the Loess Hilly *** results showed that in mixed-species plantations,*** had lower leaf N and P concentrations than in monocultures,while both *** and *** had higher leaf N and P *** P limited tree growth in both afforestation *** *** with *** or *** reduced N-limitation during litter *** soil total N and P concentrations were higher in RPAS than in RPAD,and both were higher than the corresponding *** average soil C:N ratio was the smallest in RPAS,while the average soil C:P ratio was larger in RPAS than in RP.A positive correlation between N and P concentrations,and between C:N and C:P ratios,was found in litter and all plant organs of mono-and ***,for N concentration and C:N ratio,the correlations between plant(i.e.,leaf,branch,root)and litter and between plant and soil were inverse between plantation *** has an increased litter decomposition rate to release N and P,while RPAS has a faster rate of soil N *** was the best plantation(mixed)to improve biogeochemical cycling,as soil nutrient restrictions,particularly for P-limitation,on trees growth were *** study thus provides insights into suitable tree selection and management by revealing C:N:P stoichiometry in the plant-litter-soil system under different afforestation patterns.

关键词： Stoichiometry Plant Litter Soil Tree mixture Loess Plateau

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：