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Pancreatic cancer serum biomarker PC-594:Diagnostic performance and comparison to CA19-9

World Journal of Gastroenterology 2015年第21期21卷 6604-6612页

作者： Shawn A Ritchie bassirou chitou Qingan Zheng Dushmanthi Jayasinghe Wei Jin Asuka Mochizuki Dayan B Goodenowe Department of Biomarker Discovery and Validation Phenome- nome DiscoveriesSaskatoonSK S7N 4L8Canada Department of Manufacturing Phenomenome DiscoveriesSaskatoonSK S7N 4L8Canada Phenomenome Laboratory Services Phenomenome Discoveries

AIM:To investigate serum PC-594 fatty acid levels as a potential biomarker in North American pancreatic cancer(PaC) patients,and to compare its performance to ***:Using tandem mass spectrometry,we evaluated serum PC-594 levels from 84 North American patients with confirmed PaC and 99 cancer-free control *** determined CA19-9 levels by *** between Pa C patients and controls,and association with clinical variables was determined by analysis of variance and *** performance was evaluated by receiver-operator characteristic(ROC)curve analysis,and PC-594 correlation with age and CA19-9 determined by regression ***:Mean PC-594 levels were 3.7 times lower in Pa C patients compared to controls(P 0.05).Using 1.25 μmol/L as a PC-594 threshold produced a relative risk(RR) of 9.4(P < 0.0001,95%CI:5.0-17.7).The area under the receiver-operator characteristic curve(ROCAUC) was 0.93(95%CI:0.91-0.95) for PC-594 and 0.85(95%CI:0.82-0.88) for *** at 90% specificity was 87% for PC-594 and 71% for *** Pa C patients with CA19-9 above 35 U/m L showed normal PC-594 levels,while 24 Pa C patients with normal CA19-9 showed low PC-594 ***-five of the 99 control subjects(86%) showed normal levels of both ***:PC-594 biomarker levels are significantly reduced in North American Pa C patients,and showed superior diagnostic performance compared to CA19-9.

关键词： Pancreatic cancer Risk Screening Blood Fatty acid Biomarker Metabolite PC-594

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Physico-Chemical Characterization of Waters and Sediments of Basins in the Cotton Area in Benin: Case of the Alibori Basin in the Commune of Banikoara North of Benin

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Journal of Environmental Protection 2019年第11期10卷 1436-1449页

作者： Nafiou Egbéola chitou Waris Kéwouyémi Chouti Jacques Kouazounde Daouda Mama Laboratoire de Chimie Inorganique et de l’Environnement Faculté des Sciences et Techniques (FAST) Université d’Abomey-Calavi Cotonou Bénin Laboratoire d’Hydrologie Appliquée Faculté des Sciences et Techniques (FAST) Université d’Abomey-Calavi Cotonou Bénin

The Alibori Basin, with an area of 13,400 km2, is a tributary of the Niger River in Benin. It is a river that passes through the potentially agricultural area of Benin. The waters of the river are useful for wildlife and are used for various purposes (drinking water, laundry, domestic activities). They regularly receive the discharges and drainage of the residues of the chemical fertilizers and pesticides not used by crops during the cultivation of the river and watershed bank. This study aims to assess the impact of the agricultural inputs on the quality of the waters from Alibori river on the basis of its physico-chemical characteristics and concentrations in Trace Metal Elements such as Zn, Pb, Cd and Cu. Seven (7) sites were selected along the river. Concentrations of , , , ?, Cu2+ and Zn2+ were measured using a spectrophotometer DR 1800 and that of Pb and Cd by Metalyse. The Metal Trace Elements were measured in the Alibori river sediments after being treated and mineralized using aqua regia. The results revealed that Alibori river characteristics varied with seasons and its waters and sediments were polluted by metals, phosphates and nitrites. The pollution of waters of the Alibori River was due to the intensive use of the chemical fertilizers and pesticides for agricultural purposes.

关键词： Alibori River Fertilizers Pesticides

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Assessment of the Risk of Toxicity of Fish in the River So by Contamination in Heavy Metals(Southern Benin,West Africa)

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Journal of Geoscience and Environment Protection 2018年第12期6卷 202-215页

作者： Florence Tohozin Waris Kéwouyèmi Chouti Nafiou chitou Ringo Fernand Avahounlin Carine Nelly Kélomè Vissin W.Expédit Chaire Internationale de Physique Mathématique et Applications(CIPMA CHAIRE-UNESCO FASTUAC)CotonouBenin Laboratory of Inorganic Chemistry and Environment(LAICE) Faculty of Science and Technology(FAST)University of Abomey-CalaviAbomey-CalaviBenin Laboratory of Applied Hydrology(LAH) National Institute of Water(NIW)University of Abomey-CalaviAbomey-CalaviBenin Département des Sciences de la Terre Universitéd’Abomey-CalaviAbomey-CalaviBenin Institut de Géographie de l’Aménagement du Territoire et de l’Environnement(IGATEUAC)Abomey-CalaviBenin

The purpose of this study is to assess the state of contamination of fish in the S? River by trace metal elements including Zinc, Lead, Cadmium, Copper and Arsenic. Water samples and four species of both sexes (Clarias anguillaris, Kribia kribensis, Tilapia guineensis and Eleotris vittata) were collected and analyzed. The pH, temperature and values of the chemical species present in the water of the S? River characterize an ecosystem favorable to the growth of aquatic species. The Metallic Traces Elements (MTE) concentrations vary from one fish species to another and depend on the sex and age of the animal. Zinc and copper are more concentrated in males than females with the exception of copper in Tilapia. The Pb concentration is higher in young Kribia and Clarias as well as Zn and Cd in young Tilapia. The concentrations in Cd and Pb are well above the European standards and those in the Republic of Benin, worrying results that express a health toxicity risk related to the consumption of fish of the river S?.

关键词： Health Toxicity Risk So River Metallic Traces Elements Fish

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鼻内镜下综合治疗慢性泪囊炎

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北方药学 2014年第10期11卷 76-78页

作者：石尧机庞永明李辉赵杰 S.ALHOUDA chitou ALLASSANE MAAZOU HALIDOU ISSA ANGO 中华人民共和国援非尼日尔医疗队广西北海市人民医院耳鼻咽喉科北海536000 非洲尼日尔共和国马拉迪医院

目的:观察鼻内镜下三种不同方法治疗慢性泪囊炎所需的手术时间、出血量及效果。方法:98例慢性泪囊炎分为三组,A组28例(31眼)在鼻内镜下应用膨胀海绵行鼻腔泪囊吻合造口术(置管),B组33例(35眼)鼻内镜下应用银夹、膨胀海绵行鼻腔泪囊造口... 详细信息

目的:观察鼻内镜下三种不同方法治疗慢性泪囊炎所需的手术时间、出血量及效果。方法:98例慢性泪囊炎分为三组,A组28例(31眼)在鼻内镜下应用膨胀海绵行鼻腔泪囊吻合造口术(置管),B组33例(35眼)鼻内镜下应用银夹、膨胀海绵行鼻腔泪囊造口术(不置管),C组37例(40眼)在鼻内镜下联合应用眼光导纤维、电刀、丝裂霉素C(mitomycin C,MMC)、耳脑胶及明胶海绵行鼻腔泪囊造口术(不置管),三组所需的手术时间、出血量及疗效进行对比分析。结果:平均手术时间、平均出血量及有效率(6个月、12个月)分别是A组、B组、C组。结论:鼻内镜下联合应用内光导纤维引导,电刀、丝裂霉素c和耳脑胶及明胶海绵行鼻腔泪囊造口术,能减少手术时间,出血少,疗效好、复发率低,是一种操作简单、安全可靠、经济、快速、实用、疗效好的方法。

关键词：鼻内窥镜慢性泪囊炎泪囊鼻腔造口术光导纤维耳脑胶

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西部非洲巨大甲状腺肿的诊治研究

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中外医学研究 2012年第14期10卷 13-16页

作者：石尧机赵杰叶小武 S.ALHOUDA chitou ALLASSANE MAAZOU HALIDOU ISSA ANGO 彭定军姚立平吴海峰肖静中华人民共和国援非尼日尔医疗队非洲尼日尔共和国马拉迪医院北海市人民医院广西北海536000

目的:探讨简陋条件下西非巨大甲状腺肿诊断、手术麻醉、解剖方法、手术技巧,减少出血、术后颈部不适和瘢痕。预防和减少喉上神经、喉返神经和甲状旁腺的损伤及术后呼吸困难。方法:回顾性分析2008年11月-2011年11月75例巨大甲状腺肿手术... 详细信息

目的:探讨简陋条件下西非巨大甲状腺肿诊断、手术麻醉、解剖方法、手术技巧,减少出血、术后颈部不适和瘢痕。预防和减少喉上神经、喉返神经和甲状旁腺的损伤及术后呼吸困难。方法:回顾性分析2008年11月-2011年11月75例巨大甲状腺肿手术切除患者的临床资料。结果:3年来共治疗巨大甲状腺肿75例,74例治愈,死亡1例。住院5～14d,切口Ⅰ/甲71例,Ⅰ/乙4例,无一例出现术后出血需再手术。抽搐、甲亢危象4例,呼吸困难4例,声嘶4例,呛咳2例。3例发生术后暂时性声嘶,术后1～3个月恢复正常。结论:西非巨大甲状腺肿物采用手术治疗可行。详细询问病史、细致的体格检查及常规的超声检查对巨大甲状腺肿物的性质鉴别仍是简单可行的诊断措施。全麻加气管插管、不断颈前肌群、先摘除瘤体、囊内切除腺体、靠下极结扎甲状腺上动脉、不解剖喉返神经、囊内结扎甲状腺下血管等方法在西非是治疗巨大甲状腺肿较好的方式,具有损伤率低、并发症少、出血少、手术时间短及住院天数少等优点。

关键词：巨大甲状腺肿手术治疗

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