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世界核心医学期刊文摘（皮肤病学分册） 2005年第11期1卷 35-35页

作者： Ho S.G.Y. basketter d.a. Jefferies d. J.P. Mcfadden 刘艳 dr. Contact dermatitis Clinic St. John's Institute of Dermatology St. Thomas'Hospital Lambeth Palace Rd London SE1 7EH United Kingdom

Background: despite having a positive patch test reaction to para-phenylened.a.ine (PPd), some patients continue to dye their hair, while others are forced to give up or abandon this practice. This difference in patient behaviour could be due to the degree of sensitization. Objectives: To establish whether the ability to continue dyeing hair in PPd.a.lergic patients is related to the strength of patch test reaction. To note differences in other clinical features in relation to the strength of patch test reaction. Methods We analysed retrospectively the patch test records of 400 sequential PPd-positive patients for the strength of patch test reaction (+, ++, +++) and different clinical features. data were analysed using Cochran-Mantel-Haenszel χ2 tests. Results: There was a strong linear relationship between the strength of patch test reaction and continuation with hair dyeing. Patients were more likely to report a history of hair dye reaction with increasing strength of patch test reaction. There was no difference in strength of patch test reaction in relation to age, site of rash, occupation (hairdressing) or history of atopic eczema. Overall concomitant reactivity with related.a.omatic amine allergens (benzocaine,N-isopropyl-Nphenyl-para-phenylened.a.ine, para-aminobenzoic acid) was infrequent. Conclusions: Patients with stronger patch test reactions (++, +++) are more likely to have a clear history of reacting to hair dye and.a.e less likely to still be dyeing their hair.

关键词：斑贴试验过敏患者苯二胺反应强度特应性皮炎发疹苯佐卡因 Cochran 线性关系数据分析

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