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A network-based cognitive training induces cognitive improvements and neuroplastic changes in patients with relapsing-remitting multiple sclerosis:an exploratory case-control study

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Neural Regeneration Research 2021年第6期16卷 1111-1120页

作者： Riccardo Manca Micaela Mitolo Iain D.Wilkinson David Paling basil sharrack Annalena Venneri Department of Neuroscience University of SheffieldSheffieldUK Istituto di Ricovero e Cura a Carattere Scientifico Istituto delle Scienze Neurologiche di Bologna Diagnostica Funzionale NeuroradiologicaBolognaItaly Academic Unit of Radiology University of SheffieldSheffieldUK Academic Department of Neuroscience Sheffield Teaching HospitalNational Health Service Foundation TrustSheffieldUK

Cognitive impairments are commonly observed in patients with multiple sclerosis and are associated with lower levels of quality of *** consensus has been reached on how to tackle effectively cognitive decline in this clinical population *** exploratory case-control study aims to investigate the effectiveness of a hypothesis-based cognitive training designed to target multiple domains by promoting the synchronous co-activation of different brain areas and thereby improve cognition and induce changes in functional connectivity in patients with relapsing-remitting multiple ***-five patients(36 females and 9 males,mean age 44.62±8.80 years)with clinically stable relapsing-remitting multiple sclerosis were assigned to either a standard cognitive training or to control groups(sham training and nonactive control).The standard training included twenty sessions of computerized exercises involving various cognitive functions supported by distinct brain *** sham training was a modified version of the standard training that comprised the same exercises and number of sessions but with increased processing speed *** non-active control group received no cognitive *** patients underwent comprehensive neuropsychological and magnetic resonance imaging assessments at baseline and after 5 *** and resting-state magnetic resonance imaging data were analyzed using repeated measures *** reassessment,the standard training group showed significant cognitive improvements compared to both control groups in memory tasks not specifically targeted by the training:the Buschke Selective Reminding Test and the Semantic Fluency *** standard training group showed reductions in functional connectivity of the salience network,in the anterior cingulate cortex,associated with improvements on the Buschke Selective Reminding *** changes were observed in the sham training *** findings suggest that multi-domain tr

关键词： cognitive training magnetic resonance imaging multiple sclerosis neuroplasticity neuropsychology rehabilitation salience network

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