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Journal of Pharmaceutical Analysis 2013年第4期3卷 248-256页

作者： Syed Najmul Hejaz Azmi bashir iqbal Nada Said Hassan Al-Humaimi Iman Rashid Saif Al-Salmani Noora Ali Saad Al-Ghafri Nafisur Rahman Department of Applied Sciences Chemistry SectionHigher College of Technology Department of Chemistry Aligarh Muslim University

An optimized and validated spectrophotometric method has been developed for the determination of cefixime in pharmaceutical formulations. The method is based on the complexa- tion reaction between cefixime and palladium ion in the presence of acidic buffer solution （pH 3） in ethanol-distilled water medium at room temperature. The complex absorbed maximally at 352 nm. Beer＇s law is obeyed in the working concentration range of 2.5-35 μg/mL with apparent molar absorptivity of 1.015×104 L/mol cm and Sandell＇s sensitivity of 0.001 μg/cm2/0.001 absorbance unit. The limits of detection and quantitation for the proposed method are 0.175 and 0.583μg/mL, respectively. The effect of common excipients used as additives has been studied in the determination of cefixime. The proposed method has been successfully applied for the determina- tion of cefixime in pharmaceutical formulations. The results obtained by the proposed method were statistically compared with the reference method using t and F values and found no significant difference between the two methods.

关键词： Spectrophotometry Cefixime Palladium ion Pd(II)-cefixime complex

Decoding molecular mechanisms:brain aging and Alzheimer's disease

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Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay Ali Syed Hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah Mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid bashir Atta-ur-Rahman School of Applied Biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

Comparative study of living donor kidney transplants:Right vs left

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World Journal of Transplantation 2025年第1期15卷 115-123页

作者： Taqi Khan Nadeem Ahmad Qaisar iqbal Muneeb Hassan Lajward Asnath Naveed Khan Sajid Shakeel Kidney Transplant Unit Rehman Medical InstitutePeshawar 25100Khyber PakhtunkhwaPakistan Department of Surgery Princess Noura Binti AbdulRehman UniversityRiyadh 84428Saudi Arabia

BACKGROUND Transplant teams often hesitate to use the right kidney(RK)in living donor(LD)transplants due to the complexities of anastomosing the short,thin-walled right renal veins,which can potentially lead to graft loss or graft ***,circumstances may arise where selecting the RK over the left kidney(LK)is ***,it is crucial to thoroughly examine the implications of such a choice on the overall transplant *** To compare transplant outcomes between recipients of RK and LK while examining the factors that influence these *** We retrospectively analyzed data from adult patients who received LD kidney transplants involving meticulous patient selection and surgical techniques at our center from January 2020 to December *** included all kidney donors who were over 18,fit to donate,and had undergone diethylenetriamine pentaacetic acid split function and/or computed tomography based *** variables examined comprised donor and recipient demographics,and outcome measures included technical graft loss(TGL),delayed or slow graft function(SGF),and post-transplant serum creatinine(SC)*** used a logistic regression model to assess the likelihood of adverse outcomes considering the donor kidney *** Of the 250 transplants performed during the period,56(22%)were *** recipient demographics and transplant factors were comparable for the right and LKs,except that the donor warm and cold ischemia time were shorter for *** and SGF each occurred in 2%(n=1)of RKs and 0.5%(n=1)of LKs,the difference being *** complications,however,were not related to the venous *** RK(2%)developed delayed graft function after 48 hours,which was attributable to postoperative hypoxia rather than the surgical *** post-transplant SC trend and mean SC at the last follow-up were similar across both kidney *** The donor kidney side has little impact on post-transplant

关键词： Living donor Right kidney Right renal vein Venous anastomosis Technical graft loss Early graft function

Clinical and biochemical predictors of intensive care unit admission among patients with diabetic ketoacidosis

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World Journal of Diabetes 2023年第3期14卷 271-278页

作者： Adeel Ahmad Khan Fateen Ata Phool iqbal Mohammed bashir Anand Kartha Department of Endocrinology Hamad Medical CorporationDoha 00000Qatar Department of Medicine Metropolitan Hospital CenterNew YorkNY 10595United States Department of Medicine Hamad Medical CorporationDoha 00000Qatar

BACKGROUND Diabetic ketoacidosis(DKA)contributes to 94%of diabetes-related hospital admissions,and its incidence is *** to the complexity of its management and the need for rigorous monitoring,many DKA patients are managed in the intensive care unit(ICU).However,studies comparing DKA patients managed in ICU to non-ICU settings show an increase in healthcare costs without significantly affecting patient *** is,therefore,essential to identify suitable candidates for ICU care in DKA *** To evaluate factors that predict the requirement for ICU care in DKA *** This retrospective study included consecutive patients with index DKA episodes who presented to the emergency department of four general hospitals of Hamad Medical Corporation,Doha,Qatar,between January 2015 and March *** adult patients(>14 years)fulfilling the American Diabetes Association criteria for DKA diagnosis were *** We included 922 patients with DKA in the final analysis,of which 229(25%)were managed in the *** to non-ICU patients,patients admitted to ICU were older[mean(SD)age of 40.4±13.7 years vs 34.5±14.6 years;P<0.001],had a higher body mass index[median(IQR)of 24.6(21.5-28.4)kg/m2 vs 23.7(20.3-27.9)kg/m2;P<0.030],had T2DM(61.6%)and were predominantly males(69%vs 31%;P<0.020).ICU patients had a higher white blood cell count[median(IQR)of 15.1(10.2-21.2)×103/uL vs 11.2(7.9-15.7)×103/uL,P<0.001],urea[median(IQR)of 6.5(4.6-10.3)mmol/L vs 5.6(4.0-8.0)mmol/L;P<0.001],creatinine[median(IQR)of 99(75-144)mmol/L vs 82(63-144)mmol/L;P<0.001],C-reactive protein[median(IQR)of 27(9-83)mg/L vs 14(5-33)mg/L;P<0.001]and anion gap[median(IQR)of 24.0(19.2-29.0)mEq/L vs 22(17-27)mEq/L;P<0.001];while a lower venous pH[mean(SD)of 7.10±0.15 vs 7.20±0.13;P<0.001]and bicarbonate level[mean(SD)of 9.2±4.1 mmol/L vs 11.6±4.3 mmol/L;P<0.001]at admission than those not requiring ICU management of DKA(P<0.001).Patients in the ICU group had a longer LOS[median(IQR)of

关键词： Diabetic ketoacidosis Type 1 diabetes mellitus Type 2 diabetes mellitus Intensive care unit Critical care outcomes Length of stay

Wernicke's encephalopathy in exclusive breastfed infants

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World Journal of Pediatrics 2017年第5期13卷 485-488页

作者： Javeed iqbal Bhat Qazi iqbal Ahmed Ambreen Ali Ahangar bashir Ahmed Charoo Mushtao Ahmad Sheikh Wajid Ali Syed Department of Pediatrics Sher-I-Kashmir Institute of Medical SciencesSrinagarJammu&KashmirIndia Registrar Department of Anesthesiology and Critical Care GMC SrinagarJammu&KashmirIndia

Background:Kashmir has a population that largely consumes polished rice which is deficient in ***,lactating women in this region are prone to severe thiamine deficiency because of their traditional food avoidance *** beriberi is common in exclusively breastfed infants of thiamine deficient mothers in ***:This was a one year prospective hospitalbased *** included 50 exclusively breastfed infants in our *** patients were evaluated as per unit protocol including complete septic workup and metabolic *** of our patients belonged to low and middle income group families,and mothers were on customary dietary *** and anthropometric data were collected from all the study *** addition,data regarding the treatments received by the study population and overall mortality were ***:The mean age,male:female ratio,and mean weight of the study population were 3.15±0.97 months,1.5∶1,and 5.1±1.1 kg,*** food avoidance practices were followed by 80% of the *** was observed in 40 (80%) *** was observed in 30 (60%).Septic workup including cerebro spinal fluid analysis was normal in all *** magnetic resonance imaging finding was bilateral basal ganglia *** blood thiamine diphosphate levels showed a drastic decrease (10-49 nmol/L).Ten percent of the study infants ***:In exclusively breasffed infants,we observed acute infantile encephalopathy with epidemiological,clinical,biochemical,and radiological features suggestive of infantile Wernicke's encephalopathy and a favourable therapeutic response to thiamine supplementation during the acute stage.

关键词： basal ganglia hyperintensity polished rice Wernicke's encephalopathy

Anthelmintic, antimicrobial, antioxidant and cytotoxic activity of Caltha palustris var. alba Kashmir, India

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Chinese Journal of Natural Medicines 2014年第8期12卷 567-572页

作者： Sofi Mubashir Mohd Yousuf Dar bashir A.Lone M.iqbal Zargar Wajaht A.Shah Department of Chemistry University of Kashmir Centre of Research for Development University of Kashmir Department of Pharmaceutical Sciences University of Kashmir

The methanolic extract obtained from the root portion of Caltha palustris var. alba was evaluated for its anthelmintic efficacy against gastrointestinal nematodes of sheep under both in vitro and in vivo conditions using worm motility inhibition(WMI) assay and fecal egg count reduction(FECR) assay, respectively. The extract was subjected to antimicrobial activity using agar-well diffusion method against different bacterial strains. In addition the extract was evaluated for cytotoxic and antioxidant activity against cultured THP-1(Leukemia), A-549(Lung), HCT-15(Colon), Cervix(HeLa) and PC-3(Prostrate) cell lines by SRB and DPPH radical scavenging assays. The extract used resulted in mean %WMI of 94.44%, as observed when the worms were put in lukewarm buffer for 30 min after exposure to different treatments. The mean mortality index of the sample was 0.95. The lethal concentration(LC50) was 0.11 mg·mL-1. Cell lines were exposed to concentration of 100 μg·mL-1 of extract for 48 h, which reduced the viability of these cell lines. The same plant extract also showed 55.58% DPPH radical scavenging activity.

关键词： Caltha palustris var.alba Anthelmintic activity(in vivo and in vitro) Antimicrobial activity Cytotoxic activity Radical scavenging activity

Detection of Omicron Caused Pneumonia from Radiology Images Using Convolution Neural Network(CNN)

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Computers, Materials & Continua 2023年第2期74卷 3743-3761页

作者： Arfat Ahmad Khan Malik Muhammad Ali Shahid Rab Nawaz bashir Salman iqbal Arshad Shehzad Ahmad Shahid Javeria Maqbool Chitapong Wechtaisong College of Computing Khon Kaen UniverityKhon Kaen40000Thailand Department of Computer Science COMSATS University IslamabadVehari61100Pakistan Department of Petroleum&Gas Engineering University of Engineering&Technology54890Pakistan Electrical Engineering Department SBASSELahore University of Management SciencesLahore54890Pakistan School of Telecommunication Engineering Suranaree University of TechnologyNakhon Ratchasima30000Thailand

COVID-19 disease caused by the SARS-CoV-2 virus has created social and economic disruption across *** ability of the COVID-19 virus to quickly mutate and transfer has created serious concerns across the *** is essential to detectCOVID-19 infection caused by different variants to take preventive measures *** existing method of detection of infections caused by COVID-19 and its variants is costly and *** impacts of theCOVID-19 pandemic in developing countries are very drastic due to the unavailability of medical facilities and infrastructure to handle the *** is the major symptom of COVID-19 *** radiology of the lungs in varies in the case of bacterial pneumonia as compared to COVID-19-caused *** pattern of pneumonia in lungs in radiology images can also be used to identify the cause associated with *** this paper,we propose the methodology of identifying the cause(either due to COVID-19 or other types of infections)of pneumonia from radiology ***,because different variants of COVID-19 lead to different patterns of pneumonia,the proposed methodology identifies pneumonia,the COVID-19 caused pneumonia,and Omicron caused pneumonia from the radiology *** fulfill the above-mentioned tasks,we have used three Convolution Neural Networks(CNNs)at each stage of the proposed *** results unveil that the proposed step-by-step solution enhances the accuracy of pneumonia detection along with finding its cause,despite having a limited dataset.

关键词： COVID-19 pneumonia radiology images omicron convolution neural network(CNN) microscopy

Biosorption characteristics of unicellular green alga Chlorella sorokiniana immobilized in loofa sponge for removal of Cr(Ⅲ)

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Journal of Environmental Sciences 2008年第2期20卷 231-239页

作者： AKHTAR Nasreen iqbal Muhammad ZAFAR Saeed iqbal iqbal Javed Department of Biology Government lslamia College for WomenCooper RoadLahore-54550Pakistan. Environment Biotechnology Group Biotechnology and Food Research CentrePCSIR Laboratories ComplexLahore-54600Pakistan. School of Biological Sciences University of PunjabLahore-54570Pakistan.

Loofa sponge （LS） immobilized biomass of Chlorella sorokiniana （LSIBCS）, isolated from industrial wastewater, was investigated as a new biosorbent for the removal of Cr（Ⅲ） from aqueous solution. A comparison of the biosorption of Cr（Ⅲ） by LSIBCS and free biomass of C. sorokiniana （FBCS） from 10-300 mg Cr（Ⅲ）/L aqueous solutions showed an increase in uptake of 17.79% when the microalgal biomass was immobilized onto loofa sponge. Maximum biosorption capacity for LSIBCS and FBCS was found to be 69.26 and 58.80 mg Cr（Ⅲ）/g biosorbent, respectively, whereas the amount of Cr（Ⅲ） ions adsorbed onto naked LS was 4.97 mg/g. The kinetics of Cr（Ⅲ） biosorption was extremely rapid and equilibrium was established in about 15 and 20 min by LSIBCS and FBCS, respectively. The biosorption equilibrium was well defined by Langmuir adsorption isotherm model. The biosorption kinetics followed the pseudo-second order kinetic model. The biosorption was found to be pH dependent and the maximum sorption occurred at the solution pH 4.0. Desorption studies showed that 98% of the adsorbed Cr（Ⅲ） could be desorbed with 0.1 mol/L HNO3, while other desorbing agents were less effective in the order： EDTA 〉 H2SO4 〉 CH3COOH 〉 HCl. The regenerated LSIBCS retained 92.68% of the initial Cr（Ⅲ） binding capacity up to five cycles of reuse in continuous flow-fixed bed columns. The study revealed that LSIBCS could be used as an effective biosorbent for the removal of Cr（Ⅲ） from wastewater.

关键词： biosorption immobilization loofa sponge Chlorella sorokiniana Cr(Ⅲ) desorption fixed bed column reactor

Graphite versus graphene:plasmonic nanopore DNA sequencing

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Optoelectronics Letters 2023年第6期19卷 353-358页

作者： bashir Fotouhi Faculty of Electrical and Computer Engineering University of KurdistanKurdistanIran

The plasmonic-based graphite-and graphene-nanopores have been investigated by employing the hybrid quantum/classical scheme(HQCS).Transverse,longitudinal,and total absorption spectra obtained from HQCS are analyzed for the graphite and graphene *** were examined for each structure in the presence of deoxyribonucleic acid(DNA) *** simple excitation of the total mode in graphene nanopore shows the best selectivity for DNA sequencing.A novel method based on the transverse and longitudinal modes in a time-series approach has been proposed for selectivity *** the proposed time-series method,the outstanding results show that graphite nanopore is more sensitive than and as selective as graphene *** paper suggests that time-step analysis of the plasmonic absorption in the graphite nanopore is a promising method for DNA sequencing.

关键词： graphene method absorption

Sedimentation retention basin utilization for best management practice

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Journal of Environmental Sciences 2003年第5期15卷 662-668页

作者： Zaheer iqbal CollegeofWaterResourcesandEnvironment

Approaches to the artificial impoundment and theoretical design of sedimentation retention basin are reviewed with particular attention to best management practice(BMP) to control agriculture and surface runoff. Sediments retention basins are the small version of farm pond used where a criteria of farm pond is not met. Such basin traps the pollutants and suspended solids prior to entry into streams and lakes. The study is focused with special reference to the assessment and control of non point source pollution(NPSP) from the sub basin area of Tai Lake in the Xishan County of Wuxi City of China. The author suggested two different approaches to conduct this study including theoretical design for sedimentation retention basin and computation of flow, sediment transport and deposition during the artificial impoundment of retention basin for BMP's utilization. Theoretical design will provide a useful function as a first line defense against the movement of sediments and transport of pollutants into the Tai Lake while the assessment of sediments deposition will help to make its proper use and periodic cleanup.

关键词： agriculture runoff artificial impoundment best management practice sediment retention basin Tai Lake sub basin non point source pollution