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Wernicke's encephalopathy in exclusive breastfed infants

World Journal of Pediatrics 2017年第5期13卷 485-488页

作者： Javeed Iqbal Bhat Qazi Iqbal ahmed Ambreen Ali Ahangar bashir ahmed charoo Mushtao Ahmad Sheikh Wajid Ali Syed Department of Pediatrics Sher-I-Kashmir Institute of Medical SciencesSrinagarJammu&KashmirIndia Registrar Department of Anesthesiology and Critical Care GMC SrinagarJammu&KashmirIndia

Background:Kashmir has a population that largely consumes polished rice which is deficient in ***,lactating women in this region are prone to severe thiamine deficiency because of their traditional food avoidance *** beriberi is common in exclusively breastfed infants of thiamine deficient mothers in ***:This was a one year prospective hospitalbased *** included 50 exclusively breastfed infants in our *** patients were evaluated as per unit protocol including complete septic workup and metabolic *** of our patients belonged to low and middle income group families,and mothers were on customary dietary *** and anthropometric data were collected from all the study *** addition,data regarding the treatments received by the study population and overall mortality were ***:The mean age,male:female ratio,and mean weight of the study population were 3.15±0.97 months,1.5∶1,and 5.1±1.1 kg,*** food avoidance practices were followed by 80% of the *** was observed in 40 (80%) *** was observed in 30 (60%).Septic workup including cerebro spinal fluid analysis was normal in all *** magnetic resonance imaging finding was bilateral basal ganglia *** blood thiamine diphosphate levels showed a drastic decrease (10-49 nmol/L).Ten percent of the study infants ***:In exclusively breasffed infants,we observed acute infantile encephalopathy with epidemiological,clinical,biochemical,and radiological features suggestive of infantile Wernicke's encephalopathy and a favourable therapeutic response to thiamine supplementation during the acute stage.

关键词： basal ganglia hyperintensity polished rice Wernicke's encephalopathy

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