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Survival and outcomes for co-infection of chronic hepatitis C with and without cirrhosis and COVID-19: A multicenter retrospective study

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World Journal of Gastroenterology 2021年第42期27卷 7362-7375页

作者： Shimaa Afify basem eysa Fatma Abdel Hamid Omnia M Abo-Elazm Mohamed A Edris Rabab Maher Ahmed Abdelhalim Muhammad Mostafa Abdel Ghaffar Dalia A Omran Hend Ibrahim Shousha Department of Gastroenterology National Hepatology and Tropical Medicine Research InstituteCairo 20222Egypt Department of Endemic Medicine Faculty of MedicineFayoum UniversityEl-Fayoum 13524Egypt Department of Biostatistics and Cancer Epidemiology National Cancer InstituteCairo 20222Egypt Department of Gastroenterology Students HospitalCairo UniversityGiza 12111Egypt The General Organization for Teaching Hospitals and Institutes Cairo 11562Egypt Department of Endemic Medicine Faculty of MedicineCairo UniversityCairo 11562Egypt

BACKGROUND Chronic liver disease,particularly cirrhosis,is associated with worse outcomes in patients infected with coronavirus disease 2019(COVID-19).AIM To assess outcomes of COVID-19 infection among patients with pre-existing hepatitis C with or without liver *** This multicenter,retrospective cohort study included all cases of confirmed coinfection of severe acute respiratory syndrome coronavirus 2 and chronic hepatitis C with or without liver cirrhosis who were admitted to six hospitals(Al-Sahel Hospital,Al-Matareya Hospital,Al-Ahrar Hospital,Ahmed Maher Teaching Hospital,Al-Gomhoreya Hospital,and the National Hepatology and Tropical Medicine Research Institute)affiliated with the General Organization for Teaching Hospitals and Institutes in *** were recruited from May 1,2020,to July 31,***,laboratory,imaging features,and outcomes were *** regression analysis was performed to detect factors affecting *** This retrospective cohort study included 125 patients with chronic hepatitis C and COVID-19 co-infection,of which 64(51.20%)had liver cirrhosis and 40(32.00%)***,cough,dyspnea,and fatigue were the most frequent symptoms in patients with liver ***,sore throat,fatigue,myalgia,and diarrhea were significantly more common in patients with liver cirrhosis than in noncirrhotic *** was no difference between patients with and without cirrhosis regarding *** patients(23.40%)with liver cirrhosis presented with hepatic *** with liver cirrhosis were more likely than non-cirrhotic patients to have combined ground-glass opacities and consolidations in CT chest scans:28(43.75%)vs 4(6.55%),respectively(P value<0.001).These patients also were more likely to have severe COVID-19 infection,compared to patients without liver cirrhosis:29(45.31%)vs 11(18.04%),respectively(P value<0.003).Mortality was higher in patients with liver cirrhosis,compar

关键词： COVID-19 Egypt Outcome Liver cirrhosis Chronic hepatitis C

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