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Combining video and GPS-tracking to study the spatial foraging distribution of a single-prey loading seabird

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Avian Research 2024年第3期15卷 316-325页

作者： Ruben C.Fijn Wouter Courtens bas W.R.Engels Emiel E.van Loon Judy Shamoun-Baranes Waardenburg Ecology Deparonent of Bird EcologyCulemborgthe Netherlands University of Amsterdam Insnitute for Biodiversity and Ecoasystem DymaomicsAmsterdamthe Netherlands Research Insitute for Nature and Forest(INBO) BrusselsBcgium

Seabirds are valuable indicators of marine ecosystem processes and studying seabird diets can shed light on natural or human-induced variability in food-web *** single-prey loading seabird species such as terns have the potential to act as visual sentinels of prey availability ***,obtaining diet information from remote bird colonies is often challenging and time *** this pilot study we present a novel approach to combine two established methods to study seabird foraging ecology,providing a powerful and cost-effective tool to study the distribution of prey items available to *** combined GPS tracking data of Sandwich Terns(Thalasseus sandvicensis)with prey-observations from a hide in 2012 and 2013,and from semicontinuously recorded camera footage in *** doing so,we identified 115 approximate catch locations of prey(86 herring/sprat Clupeidae,29 sandeel Ammodytidae).Combining GPS-data and prey observations yielded detailed knowledge on the movements and chick diets of tracked birds as well as the spatial origin and lengths of captured prey *** catch distances of both Clupeidae and Ammodytidae resulted in deliveries of larger prey items and thus higher energy yield per trip,but also a higher energy expenditure per *** discuss the limitations and potential of our methodological approach to study foraging energetics during chick-provisioning of seabirds that carry prey items visible in their beaks.

关键词： Diet Digitalfilm Geo-referencing Non-invasive monitoring Provisioning Sandwich Tern Thalasseus sandvicensis

Supramolecular Polymerization of Hydrogen-Bonded Trimers in Bulk and Aqueous Medium

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CCS Chemistry 2024年第6期6卷 1458-1465页

作者： Freek V.de Graaf Stef A.H.Jansen Sandra M.C.Schoenmakers bas van Genabeek Marle E.J.Vleugels Bart W.L.van den Bersselaar E.W.Meijer Ghislaine Vantomme Institute for Complex Molecular Systems Laboratory of Macromolecular and Organic ChemistryEindhoven University of Technology5600 MBEindhoven School of Chemistry and RNA Institute University of New South WalesSydneyNew South Wales 2052

Synthetic molecules that form functional noncovalent assemblies in water have received much attention for their potential applications as *** this work,we introduce a novel water-compatible monomer based on the phthalhydrazide moiety that assembles into hydrogen-bonded trimeric *** bulk,the material exhibits a cylindrical nanostructure in the liquid-crystalline phase at elevated temperatures,morphologically distinct from the crystalline lamellar *** water,these molecules effectively form cylinders in a one-dimensional fashion,yielding fibrous *** formation of these supramolecular polymers follows a cooperative mechanism,as evidenced by denaturation *** trimerized pattern represents a new category of aqueous su pramolecular polymers with future prospects for functional complex molecular systems.

关键词： noncovalent chemistry supramolecular polymers hydrogen bonding cooperativity nanostructure

Personalized nutrition to mitigate inflammation in genetically predisposed individuals: a secondary analysis of the Danish PREVENTOMICS intervention

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Food Science and Human Wellness 2024年

作者： Sebastià Galmés Andreu Palou-March Kristina Pigsborg Mona Adnan Aldubayan Sophia M.O.Gormsen Alberto Calleja Joan Trabal Vanesa Martínez Biotza Gutiérrez Josep M.Del bas Faidon Magkos Francisca Serra Eurecat， Centre tecnològic de Catalunya， Biotechnology Area Avd Universitat 1 Laboratory of Molecular Biology， Nutrition and Biotechnology (Nutrigenomics， Biomarkers and Risk Evaluation-NuBE)， University of the Balearic Islands Health Research Institute of the Balearic Islands (IdISBa) CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN)， Carlos III Health Institute (ISCIII) Alimentómica S.L.， Camí de na Pontons.s/n (Pol.11，Parc 3) Department of Nutrition， Exercise and Sports， Faculty of Science， University of Copenhagen Department of Clinical Nutrition， College of Applied Medical Sciences， King Saud bin Abdulaziz University for Health Sciences R&D， Food & Culinary Department Simple Feast Leitat Technological Center C/Innovació 2 Creaciones Aromáticas Industriales SA， Cuatrecasas i Arumí， Sant Quirze del Valles

Deep phenotyping and genetic characterization of individuals are fundamental to assessing the metabolic status and determining nutrition-specific requirements. This study aimed to ascertain the utmost effectiveness of personalized interventions by aligning dietary adjustments with both the genotype and metabolotype of individuals. Therefore， we assessed here the usefulness of a polygenic score (PGS) characterizing a potential pro-inflammatory profile (PGSi) as a nutrigenetic tool to discern individuals from the Danish PREVENTOMICS cohort that could better respond to precision nutrition (PN) plans， specifically targeted at counteracting the low-grade inflammatory profile typically found in obesity. The cohort followed a PN plan to counteract the pro-inflammatory profile (PNi group) or generic dietary recommendations (Control) for 10 weeks. PGSi was applied for genetic stratification (Low/High). The effects of the intervention on anthropometrics and biomarkers related to inflammatory profile and carbohydrate metabolism were assessed. Around 30% of subjects had a high genetic predisposition to pro-inflammatory status (high-PGSi). These individuals demonstrated the most effective response to the dietary plan， experiencing improved body composition， with significant decreases in body weight (△: -4.84%; p=0.039) and body fat (△: -4.86%; p=0.007)， and beneficial changes in pro- and anti-inflammatory biomarkers， with significant increases in IL-10 (△: 71.3%; p=0.025) and decreases in TNF-α (△: -3.0%; p=0.048)， CRP (△: -31.1%)， ICAM1 (△: -5.8%)， and MCP1 (△: -4.2%) circulating levels， compared to low-PGSi individuals. Both phenotypic and genetic stratification contributed to a better understanding of metabolic heterogeneity in response to diet. This approach allows for refinement of the prediction of individual requirements and potentially for better management of obesity.

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Protective Effects of Lycopene on Furan-treated Diabetic and Non-diabetic Rat Lung

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Biomedical and Environmental Sciences 2016年第2期29卷 143-147页

作者： Hatice bas Dilek PANDIR Bozok University Faculty of Arts and Science Department of Biology 66100 Yozgat Turkey

We assessed the effects of furan and lycopene on the histopathological and biochemical changes on lungs, body and lung weights, and food consumption of rats. Furan and diabetes caused histopathological changes, increment in malondialdehyde levels, and decrease in antioxidant enzyme activities. Lycopene showed a protective effect against these damages, except for glutathione-S-transferase and glutathione peroxidase activities. Consequently, furan and diabetes resulted in lung toxicity. Our findings demonstrate that furan treatment resulted in more alterations in histology and biochemical parameters in diabetic rats and lycopene showed protective effects against these alterations.

关键词： Protective Effects Lycopene Furan-treated Diabetic

Current status of esophageal cancer treatment

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Chinese Journal of Cancer Research 2020年第3期32卷 271-286页

作者： Tania Triantafyllou bas P L Wijnhoven Department of Surgery Hippocration General Hospital of AthensNational and Kapodistrian University of AthensAthens 11527Greece Department of Surgery Erasmus University Medical CenterRotterdam 3000the Netherlands

Esophageal cancer(EC) remains one of the most common and aggressive diseases *** review discusses some debates in the modern management of the *** procedures for early cancer(T1a-b) are now embedded in routine care and the challenge will be to more accurately select patients for endoscopic resection with or without adjuvant *** multimodal therapies are associated with improved survival compared to surgery alone for locally advanced esophageal ***, there is no global consensus on the optimal ***, histological subtype(adenocarcinoma *** cell cancer) plays a role in the choice for *** studies are underway to resolve some *** extent of the lymphadenectomy during esophagectomy remains controversial especially after neoadjuvant *** ideal operation balances between limiting surgical trauma and optimizing *** invasive esophagectomy and enhanced recovery pathways are associated with decreased morbidity and faster recovery albeit there is no consensus yet what approach should be ***, immune checkpoint inhibitors present promising preliminary results in the novel treatment of advanced or metastatic EC but their widespread application in clinical practice is still awaited.

关键词： Esophageal cancer endoscopic resection minimally invasive esophagectomy multimodal treatment fast-track protocols

Diagnosis and management of pediatric adrenal insufficiency

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世界儿科杂志:英文版 2016年第3期12卷 261-274页

作者： Ahmet Ucar Firdevs bas Nurcin Saka Growth-Development and Pediatric Endocrine Unit Istanbul School of MedicineIstanbul UniversityTurkey

Background:Adrenal insufficiency(AI)is a wellknown cause of potentially life-threatening *** at each level of the hypothalamic-pituitary-adrenal axis can impair adrenal function,leading to varying degrees of glucocorticoid(GC)*** AI induced by exogenous GCs is the most common cause of *** criteria for the diagnosis and management of iatrogenic AI,neonatal AI,and critical illness-related corticosteroid insuffi ciency(CIRCI)are not *** sources:We reviewed the recent original publications and classical data from the literature,as well as the clinical,diagnostic and management strategies of pediatric ***:Practical points in the diagnosis and management of AI with an emphasis on iatrogenic AI,neonatal AI,and CIRCI are *** the lack of sensitive and practical biochemical tests for diagnosis of subtle AI,GC treatment has to be tailored to highly suggestive clinical symptoms and *** of adrenal crisis is well standardized and patients almost invariably respond well to *** is mainly the delay in treatment that is responsible for mortality in adrenal ***:Education of patients and health care professionals is mandatory for timely interventions for patients with adrenal crisis.

关键词： adrenal insuffi ciency critical illness hypothalamo-pituitary-adrenal axis iatrogenic steroids

Crohn's disease, fatigue, and infiiximab: Is there a role for cytokines in the pathogenesis of fatigue?

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World Journal of Gastroenterology 2007年第14期13卷 2089-2093页

作者： Itta M Minderhoud Melvin Samsom bas Oldenburg Department of Gastroenterology University Medical Centre Utrecht The Netherlands

AIM: To study the effect of infliximab on fatigue in relation to cytokine levels in Crohn's disease (CD) patients. METHODS: Fourteen CD patients were blinded for treatment and received placebo at baseline, and infliximab 2 wk later, with a follow-up of 4 wk. Blood samples were drawn on a regular basis, and questionnaires on fatigue, depression, quality of life, and clinical disease activity were completed at regular intervals. RESULTS: After placebo infusion, fatigue scores decreased within 3 d (3.5 points±1.1, P≤0.01), but returned to baseline values 14 d after this infusion. The drop of fatigue scores following infliximab infusion sustained until the end of the study (3.8 points±1.4, P≤0.05). Quality of life was increased at the end of the study compared to baseline values (138.6±9.4 vs 179.4±6.7; P≤0.005), whereas depression scores were decreased (20.4±9.4 vs 11.3±2.2; P≤0.01). No correlation between the severity of fatigue and the level of cytokines was observed. CONCLUSION: The reduction of fatigue after infliximab infusion is subjective to a placebo effect. The effect of infliximab on fatigue, however, persists while the placebo effect disappears after a short period of time. A clear role of cytokines could not be substantiated.

关键词： Crohn's disease Fatigue Infliximab Cytokines

Evolution of laparoscopic gastrectomy for cancer in the East and West

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Chinese Journal of Cancer Research 2022年第6期34卷 579-586页

作者： Eider Talavera-Urquijo bas P.L.Wijnhoven Department of Surgery University Hospital of DonostiaDonostia-San Sebastian 20014Spain Department of Surgery Erasmus University Medical Centre RotterdamRotterdam 3000the Netherlands

Laparoscopic gastrectomy has evolved differently in Eastern and Western ***,safety and oncological outcomes of laparoscopic gastrectomy were addressed step-by-step by several randomized controlled trials from the *** phase III studies were published from the West that largely did not show a difference between the laparoscopic and open *** this,laparoscopic gastrectomy is seen as the standard for the surgical treatment of early and advanced gastric cancer in many European ***,we review and comment on some important studies on laparoscopic gastrectomy for gastric cancer from Eastern and Western countries and also comment on current and future challenges.

关键词： Laparoscopic gastrectomy minimally invasive surgery gastric cancer

The Japanese Clinical Practice Guidelines for intrahepatic cholangiocarcinoma: a comparison with Western guidelines

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 244-247页

作者： Stefan Buettner bas Groot Koerkamp Department of Surgery Erasmus MC University Medical CenterRotterdamThe Netherlands

The Liver Cancer Study Group of Japan(LCSGJ)recently published the first version of the clinical practice guidelines for intrahepatic cholangiocarcinoma(iCCA)(1).The study group followed the GRADE methodology for evidence-based *** is a world leader in the treatment of cholangiocarcinoma,with Japanese medical centers realizing superior results compared to other developed countries and many landmark articles originating from these *** there are differences between the Japanese iCCA population and patients in other countries,these guidelines contain important lessons for healthcare providers across the world.

关键词： Intrahepatic cholangiocarcinoma treatment guideline