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The industrial dynamics of water innovation:A comparison between China and Europe

International Journal of Innovation Studies 2018年第1期2卷 14-32页

作者： MariúAbritta Moro Ursula S.McKnight barth f.smets Yang Min Maj Munch Andersen Department of Environmental Engineering Technical University of DenmarkBygningstorvet 1152800 Kgs.LyngbyDenmark Sino-Danish Center for Education and Research(SDC) Niels Jensens Vej 28000 Aarhus CDenmark Research Center for Eco-Environmental Science.Chinese Academy of Science 18 Shuangqing RoadHaidian DistrictBeijingChina Department of Management Engineering Technical University of DenmarkDiplomvej Building 3722800 Kgs.LyngbyDenmark

The expansion of the green economy agenda has increased the attention on ecoinnovations globally,with issues related to water stress identified as one of the major bottlenecks for sustainable economic *** evolutionary economic theory,this study investigates the industrial dynamics of the water sector,comparing China and Europe using patent *** comparison feeds into the“catching up”literature,addressing the challenges of the“green economy”agenda in different regions in various stages of *** highlight the neglected micro-dynamics of water innovation,investigating the roles of different innovators in the development of water technological trajectories,with a special focus on water innovations closely related to climate change adaptation and mitigation *** water innovators(universities)were found to be more important in China than in *** were also identified between Europe and China;big companies were found to be the main innovative leaders with no substantial changes documented over the timeframe ***,the finding implies a rapid Chinese technological catching up of water technologies in the last three decades,where our research has pointed towards the role of redirection of Chinese policies with a stronger focus on sustainable *** analysis,overall,sheds light on the state and nature of the globalizing green growth agenda.

关键词： Water innovation Eco-innovation Evolutionary economics Knowledge institutions Business demography

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Evaluation of sodium borocaptate(BSH)and boronophenylalanine(BPA)as boron delivery agents for neutron capture therapy(NCT)of cancer:an update and a guide for the future clinical evaluation of new boron delivery agents for NCT

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Cancer Communications 2024年第8期44卷 893-909页

作者： Rolf f.barth Nilendu Gupta Shinji Kawabata Department of Pathology The Ohio State UniversityColumbusOhioUSA Department of Radiation Oncology The Ohio State UniversityColumbusOhioUSA Department of Neurosurgery Osaka Medical and Pharmaceutical UniversityTakatsukiOsakaJapan

Boron neutron capture therapy(BNCT)is a cancer treatment modality based on the nuclear capture and fission reactions that occur when boron-10,a stable isotope,is irradiated with neutrons of the appropriate energy to produce boron-11 in an unstable form,which undergoes instantaneous nuclear fission to produce high-energy,tumoricidal alpha *** primary purpose of this review is to provide an update on the first drug used clinically,sodium borocaptate(BSH),by the Japanese neurosurgeon Hiroshi Hatanaka to treat patients with brain tumors and the second drug,boronophenylalanine(BPA),which first was used clinically by the Japanese dermatologist Yutaka Mishima to treat patients with cutaneous ***,BPA has become the primary drug used as a boron delivery agent to treat patients with several types of cancers,specifically brain tumors and recurrent tumors of the head and neck *** focus of this review will be on the initial studies that were carried out to define the pharmacokinetics and pharmacodynamics of BSH and BPA and their biodistribution in tumor and normal tissues following administration to patients with high-grade gliomas and their subsequent clinical use to treat patients with highgrade ***,wewill summarize the studies thatwere carried out in Japan with BSH and subsequently at our own institution,The Ohio State University,and those of several other ***,we will describe studies carried out in Japan with BPA and then in the United States that have led to its use as the primary drug that is being used clinically for ***,although there have been intense efforts to develop new and better boron delivery agents for BNCT,none of these have yet been evaluated *** present reportwill provide a guide to the future clinical evaluation of new boron delivery agents prior to their clinical use for BNCT.

关键词： Boron neutron capture therapy(BNCT) boronophenylalanine(BPA) brain tumors head and neck cancer sodium borocaptate(BSH)

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Boron neutron capture therapy of cancer:where do we stand now?

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Cancer Communications 2024年第8期44卷 889-892页

作者： Rolf f.barth Gong Wu Maria da Graca H.Vicente John C Grecula Nilendu Gupta Department of Pathology The Ohio State UniversityColumbusOhioUSA Mass Spectrometry and Proteomics facility The Ohio State UniversityColumbusOhioUSA Department of Chemistry Louisiana State UniversityBaton RougeLouisianaUSA Department of Radiation Oncology The Ohio State UniversityColumbusOhioUSA

1 INTRODUCTION,This is the third Editorial/Commentary that one of us(***)has written relating to boron neutron capture therapy(BNCT)[1,2].for those readers who are unfamiliar with BNCT we would refer them to several recent comprehensive reviews[3–5].The second Editorial ended on a hopeful note that with the introduction of acceleratorbased neutron sources(ABNSs),BNCT would enter into the mainstream of radiation therapy[2].

关键词： boron 1,2 neutron

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Impact of Plastic Waste on the Human Health in Low-Income Countries: A Systematic Review

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Journal of Environmental Protection 2024年第5期15卷 572-595页

作者： Ramde Wendkoaghenda Sophie Gbandama Koffi Kouame Pacome Gansore Aminata Camara Kelety Tolno barthélemy Assogba Ange Wenceslas Vinciale Niare Boubacar Patrice Ngangue Institute for Interdisciplinary Training and Research in Health Sciences and Education Ouagadougou Burkina Faso Regional Directorate of Health and Public Hygiene of South-Central Burkina faso Ministry of Health Ouagadougou Burkina Faso Department of Health Promotion and Education Ministry of Health and Public Hygi&#232ne Ouagadougou Burkina Faso Department of Dermatology-Venorology Treichville University Hospital F&#233lix Houphou&#235t-Boigny University Abidjan C&#244te d&#8217Ivoire Department of Infectious and Tropical Diseases Donka National Hospital Faculty of Health Sciences and Techniques Bamako Mali National AIDS Control Program PNLS Ministry of Health and Public Hygiene Abidjan C&#244te d&#8217Ivoire Marketing and Consumer Welfare Research Laboratory Abomey-Calavi University Cotonou Benin Regional Health Directorate of the District of Bamako Ministry of Health and Social Development Bamako Mali Department of family Medicine Faculty of Medicine and Odonto Stomatology University of Sciences Techniques and Technologies of Bamako Bamako Mali faculty of Nursing Sciences Laval University Quebec Canada

Background: Plastic pollution is the accumulation of waste composed of plastic and its derivatives all over the environment. Whether in the form of visible garbage or microparticles, as it slowly degrades, plastic pollution poses significant threats to terrestrial and aquatic habitats and the wildlife that call them home, whether through ingestion, entanglement or exposure to the chemicals contained in the material. Unfortunately, there is a lack of documentation on the impact of plastic waste on human health in low- and middle-income countries (LMICs). Methods: We searched five electronic databases (PubMed, Embase, Global Health, CINAHL and Web of Science) and gray literature, following the preferred reporting elements for systematic reviews and meta-analyses (PRISMA), for the impact of plastic waste on human health in developing countries. We included quantitative and qualitative studies written in English and french. We assessed the quality of the included articles using the Mixed Methods Appraisal tool (MMAT). Results: A total of 3779 articles were initially identified by searching electronic databases. After eliminating duplicates, 3167 articles were reviewed based on title and abstract, and 26 were selected for full-text review. Only three articles were retained. The three articles dealt with practices likely to lead to oral exposure to plastic chemicals in human health, as well as the level of awareness of participants concerning the possible impact of plastic on human health, namely, the use of plastic baby bottles, the use of microwaves to cook food and reheat precooked food, the use of plastic bottles to store water in the refrigerator, water purifier containers with plastic bodies and plastic lunch boxes, the reuse of plastic bags and the inadequacy of treatment facilities. Conclusion: Plastic waste poses different risks to human health at every stage of its life cycle. Hence, strategies must be adopted to raise public awareness of the dangers of plastic

关键词： Human Population Plastic Waste Health Impact Low-Income-Countries (Humans Iatrogenic Disease Plastics Policy Recycling Waste Management)

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What did Sun Yat-sen really die of?A re-assessment of his illness and the cause of his death

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Chinese Journal of Cancer 2016年第9期35卷 485-489页

作者： Rolf f.barth Jie Chen Department of Pathology The Ohio State UniversityColumbusOH 43210USA. Department of Pathology Peking Union Medical College HospitalBeijing 100730P.R.China.

This year is the 150 th anniversary of the birth of Sun Yat-sen(November 12, 1866) and the 91 st year following his death(March 12, 1925). It generally has been believed that the cause of his death was "liver cancer." However, as indicated in the oicial autopsy report, dated March 13, 1925, of the Peking Union Medical College Hospital(PUMCH) in Beijing, the cause of his death in reality was an adenocarcinoma of the gallbladder with direct extension to the liver and diaphragm as well as widespread metastases to the peritoneal cavity. This important piece of information seems to have never been reported in the English language literature, and it was only in 2013 that the true cause of his death was stated in a one-line sentence in a non-medical Chinese online source. It had been mistakenly believed that the cause of Dr. Sun's death was liver cancer, based on the observations made following an exploratory laparotomy, which had been performed at PUMCH on January 26, 1925. The purpose of this short report is to provide more details relating to his terminal illness and to correct the historical record for a medical audience as to the cause of the death of Sun Yat-sen, a very important igure in the history of 20 th century China.

关键词： Sun 死因病情评估中国历史历史记录 sen 肺腺癌

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Common-path interferometric label-free protein sensing with resonant dielectric nanostructures

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Light(Science & Applications) 2020年第1期9卷 1086-1094页

作者： Isabel barth Donato Conteduca Christopher Reardon Steven Johnson Thomas f.Krauss Department of Physics University of YorkYO105DD YorkUK Department of Electronic Engineering University of YorkYO105DD YorkUK

Research toward photonic biosensors for point-of-care applications and personalized medicine is driven by the need for high-sensitivity,low-cost,and reliable *** the most sensitive modalities,interferometry offers particularly high performance,but typically lacks the required operational simplicity and ***,we introduce a common-path interferometric sensor based on guided-mode resonances to combine high performance with inherent *** sensor exploits the simultaneous excitation of two orthogonally polarized modes,and detects the relative phase change caused by biomolecular binding on the sensor *** wide dynamic range of the sensor,which is essential for fabrication and angle tolerance,as well as versatility,is controlled by integrating multiple,tuned structures in the field of *** approach circumvents the trade-off between sensitivity and dynamic range,typical of other phase-sensitive modalities,without increasing *** sensor enables the challenging label-free detection of procalcitonin,a small protein(13 kDa)and biomarker for infection,at the clinically relevant concentration of 1 pg mL^(−1),with a signal-to-noise ratio of *** result indicates the utility for an exemplary application in antibiotic guidance,and opens possibilities for detecting further clinically or environmentally relevant small molecules with an intrinsically simple and robust sensing modality.

关键词： dielectric integrating simplicity

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Boron delivery agents for neutron capture therapy of cancer

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Cancer Communications 2018年第1期38卷 371-385页

作者： Rolf f.barth Peng Mi Weilian Yang Department of Pathology The Ohio State University4132 Graves Hall333 W.10th AveColumbusOH 43210USA Department of Radiology Center for Medical ImagingState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center for BiotherapyChengduSichuan 610041P.R.China Present Address:Neurosurgery and Brain and Nerve Research Laboratory The First Affiliated Hospital of Suzhou UniversitySuzhouJiangsu 215004P.R.China

Boron neutron capture therapy(BNCT)is a binary radiotherapeutic modality based on the nuclear capture and fission reactions that occur when the stable isotope,boron-10,is irradiated with neutrons to produce high energy alpha *** review will focus on tumor-targeting boron delivery agents that are an essential component of this binary *** low molecular weight boron-containing drugs currently are being used clinically,boronopheny-lalanine(BPA)and sodium borocaptate(BSH).Although they are far from being ideal,their therapeutic efficacy has been demonstrated in patients with high grade gliomas,recurrent tumors of the head and neck region,and a much smaller number with cutaneous and extra-cutaneous *** of their limitations,great effort has been expended over the past 40 years to develop new boron delivery agents that have more favorable biodistribution and uptake for clinical *** include boron-containing porphyrins,amino acids,polyamines,nucleosides,peptides,monoclonal antibodies,liposomes,nanoparticles of various types,boron cluster compounds and ***-rently,however,none of these have reached the stage where there is enough convincing data to warrant clinical biodistribution ***,at present the best way to further improve the clinical efficacy of BNCT would be to optimize the dosing paradigms and delivery of BPA and BSH,either alone or in combination,with the hope that future research will identify new and better boron delivery agents for clinical use.

关键词： Boron delivery agents Neutron capture therapy Brain tumors Head and neck cancer Melanoma

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Optimizing Nitrogen Use Efficiency for No-Till Corn Production by Improving Root Growth and Capturing NO_(3)-N in Subsoil

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Pedosphere 2016年第4期26卷 474-485页

作者： Eduardo f. CAIRES Renato ZARDO fILHO Gabriel barth Helio A. W. JORIS Department of Soil Science and Agricultural Engineering State University of Ponta Grossa Ponta Grossa 84030-900 Green Circle Growers 51051 US FIighway 20 Oberlin OH 44074 ABC foundation Research and Agricultural Development Castro 84165-700

Subsoil acidity restricts root growth and reduces crop yields in many parts of the world. More than half of the fertilizer nitrogen(N) applied in crop production is currently lost to the environment. This study aimed to investigate the effect of gypsum application on the efficiency of N fertilizer in no-till corn(Zea mays L.) production in southern Brazil. A field experiment examined the effects of surface-applied gypsum(0, 5, 10, and 15 Mg ha^(-1)) and top-dressed ammonium nitrate(NH_4NO_3)(60, 120, and 180 kg N ha^(-1)) on corn root length, N uptake, and grain yield. A greenhouse experiment was conducted using undisturbed soil columns collected from the field experiment site to evaluate NO_3-N leaching, N uptake, and root length with surface-applied gypsum(0 and 10 Mg ha^(-1)) and top-dressed NH_4NO_3(0 and 180 kg N ha^(-1)). Amelioration of subsoil acidity due to gypsum application increased corn root growth,N uptake, grain yield, and N use efficiency. Applying gypsum to the soil surface increased corn grain yield by 19%–38% and partial factor productivity of N(PfPN) by 27%–38%, depending on the N application rate. Results of the undisturbed soil column greenhouse experiment showed that improvement of N use efficiency by gypsum application was due to the higher N uptake from NO_3-N in the subsoil as a result of increased corn root length. Our results suggest that ameliorating subsoil acidity with gypsum in a no-till corn system could increase N use efficiency, improve grain yield, and reduce environmental risks due to NO_3-N leaching.

关键词： ammonium nitrate grain yield N uptake nitrate leaching partial factor productivity of nitrogen soil acidity

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Neutralizing antibodies in hepatitis C virus infection

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World Journal of Gastroenterology 2007年第36期13卷 4824-4830页

作者： Mirjam B Zeisel Samira fafi-Kremer Isabel fofana Heidi barth franoise Stoll-Keller Michel Doffo■l Thomas f Baumert Inserm U748Strasbourg France Université Louis Pasteur Strasbourg France Liver Diseases Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutesof Health Bethesda MD United States Universitaires de Strasbourg Strasbourg France Service d'Hépatogastro-entérologie Hpitaux Universitaires de Strasbourg

Hepatitis C virus (HCV) is a major cause of hepatitis world-wide. The majority of infected individuals develop chronic hepatitis which can then progress to liver cirrhosis and hepatocellular carcinoma. Spontaneous viral clearance occurs in about 20%-30% of acutely infected individuals and results in resolution of infection without sequaelae. Both viral and host factors appear to play an important role for resolution of acute infection. A large body of evidence suggests that a strong, multispecific and long-lasting cellular immune response appears to be important for control of viral infection in acute hepatitis C. Due too the lack of convenient neutralization assays, the impact of neutralizing responses for control of viral infection had been less defined. In recent years, the development of robust tissue culture model systems for HCV entry and infection has finally allowed study of antibody-mediated neutralization and to gain further insights into viral targets of host neutralizing responses. In addition, detailed analysis of antibody-mediated neutralization in individual patients as well as cohorts with well defined viral isolates has enabled the study of neutralizing responses in the course of HCV infection and characterization of the impact of neutralizing antibodiesfor control of viral infection. This review will summarize recent progress in the understanding of the molecular mechanisms of antibody-mediated neutralization and its impact for HCV pathogenesis.

关键词： Hepatitis C virus Virus-host cell interaction Viral entry Neutralizing antibodies

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Boron neutron capture therapy for vulvar melanoma and genital extramammary Paget’s disease with curative responses

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Cancer Communications 2018年第1期38卷 400-409页

作者： Junichi Hiratsuka Nobuhiko Kamitani Ryo Tanaka Eisaku Yoden Ryuji Tokiya Minoru Suzuki Rolf f.barth Koji Ono Department of Radiation Oncology Kawasaki Medical School577MatsushimaKurashikiOkayama 701-0192Japan Department of Dermatology Kawasaki Medical SchoolKurashikiOkayama 701-0192Japan Particle Radiation Oncology Kyoto University Research Reactor InstituteOsaka 590-0494Japan Department of Pathology The Ohio State UniversityColumbusOH 43210USA

Background:Although the most commonly recommended treatment for melanoma and extramammary Paget’s disease(EMPD)of the genital region is wide surgical excision of the lesion,the procedure is highly invasive and can lead to functional and sexual *** treatments have been used for local control when wide local exci-sion was not ***,we describe four patients with genital malignancies who were treated with boron neutron capture therapy(BNCT).Methods:The four patients included one patient with vulvar melanoma(VM)and three with genital *** underwent BNCT at the Kyoto University Research Reactor between 2005 and 2014 using para-boronophenylalanine as the boron delivery *** were irradiated with an epithermal neutron beam between the curative tumor dose and the tolerable skin/mucosal ***:All patients showed similar tumor and normal tissue responses following BNCT and achieved complete responses within 6 *** most severe normal tissue response was moderate skin erosion during the first 2 months,which diminished gradually *** or contact pain persisted for 2 months and resolved com-pletely by 4 ***:Treating VM and EMPD with BNCT resulted in complete local tumor *** on our clinical expe-rience,we conclude that BNCT is a promising treatment for primary VM and EMPD of the genital region.

关键词： Boron neutron capture therapy Vulvar melanoma Extramammary Paget’s disease Penis Vulva

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