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Microcomputed Tomography Applications in Bone and Mineral Research

1998年

作者： bart A. Weitz Stephen B. Castleberry John F. Tanner Jr

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Advances in Computed Tomography 2013年第3期2卷 121-127页

作者： Zachary Ryan bart Joseph Michael Wallace 1Biomedical Engineering Indiana University-Purdue University Indianapolis Indianapolis USA 2Orthopeadic Surgery Indiana University School of Medicine Indianapolis USA Biomedical Engineering Indiana University-Purdue University Indianapolis Indianapolis USA

Microcomputed tomography (μCT) has evolved as a development of simple X-ray imaging into an indispensable technique used in both laboratory research and clinical diagnostics. Commercially available systems are capable of creating images at sub-micrometer resolutions to map out the complex web of trabecular bone in small animals, and offer an accurate measurement of bone mineral density for patients at risk of osteoporotic fractures. This review describes the development of μCT, its ability to analyze bone, and how it can be used alongside other clinical and laboratory techniques. μCT offers a non-destructive alternative for imaging mineralized tissues with no required preparation and can also be utilized with living specimen to track skeletal development.

关键词： Bone CT Mineralization Vascularization BMD Modeling

Characterization of acquired nutlin-3 resistant non-small cell lung cancer cells

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Cancer Drug Resistance 2021年第1期4卷 233-243页

作者： Christophe Deben Laurie Freire Boullosa Andreas Domen An Wouters bart Cuypers Kris Laukens Filip Lardon Patrick Pauwels Center for Oncological Research(CORE) Integrated Personalized&Precision Oncology Network(IPPON)University of AntwerpWilrijk 2610Belgium Adrem Data Lab Department of Computer ScienceUniversity of AntwerpAntwerp 2020Belgium Molecular Parasitology Unit Department of Biomedical SciencesInstitute of Tropical MedicineAntwerp 2000Belgium Department of Pathology Antwerp University HospitalEdegem 2650Belgium

Aim:The purpose of this manuscript is to study the potential characteristics of acquired nutlin-3 resistant non-small cell lung cancer cells(NSCLC).Nutlin-3 is an inhibitor of the murine-double minute 2 protein,the main negative regulator of wild type p53,of which several derivatives are currently in clinical ***:A549 NSCLC cells were exposed to increasing concentrations of nutlin-3 for a period of 18 *** derivates were cultured,and the most resistance subclone was selected for whole transcriptome *** set enrichment analysis was performed on differentially expressed genes between A549 nutlin-3 resistant cancer cells and the parental A549 p53 wild type cancer *** findings were validated at the gene,protein and/or functional ***:All nutlin-3 resistant subclones acquired mutations in the TP53 gene,resulting in overexpression of the mutant p53 *** most resistant subclone was enriched for genes related to epithelial to mesenchymal transition(EMT),resulting in increased migratory and invasive ***,these cells were enriched in genes related to inflammation,tissue remodelling,and ***,expression of several immune checkpoints,including PD-L1 and PD-L2,was significantly upregulated,and cisplatin-induced cell death was ***:Transcriptome analysis of a highly nutlin-3 resistant A549 subclone shows the relevance of studying(1)resistance to standard of care chemotherapy;(2)secretion of immunomodulating chemo-and cytokines;(3)immune checkpoint expression;and(4)EMT and invasion in nutlin-3 resistant cancer cells in addition to acquired mutations in the TP53 gene.

关键词： p53 murine-double minute 2 non-small cell lung cancer acquired resistance nutlin-3

^(99m)TC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice

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Bone Research 2015年第2期3卷 92-99页

作者： Zhendong A Zhong Anderson Peck Shihong Li Jeff Van Oss John Snider Casey J Droscha Tingtung A Chang bart O Williams Center for Skeletal Disease Research Van Andel Research Institute Department of Internal Medicine Center for Musculoskeletal Health UC Davis Medical Center Small Animal Imaging Facility Van Andel Research Institute

99mTc-Methylene diphosphonate （99mTc-MDP） is widely used in clinical settings to detect bone abnormalities. However, the mechanism of 99mTc-MDP uptake in bone is not well elucidated. In this study, we utilized a mouse tibia injury model, single-photon emission computed tomography （gamma scintigraphy or SPECT）, ex vivo micro-computed tomography, and histology to monitor 99mTc-MDP uptake in injury sites during skeletal healing. In an ex vivo culture system, calvarial cells were differentiated into osteoblasts with osteogenic medium, pulsed with 99mTc-MDP at different time points, and quantitated for 99mTc-MDP uptake with a gamma counter. We demonstrated that 99mTc-MDP uptake in the injury sites corresponded to osteoblast generation in those sites throughout the healing process. The 99mTc-MDP uptake within the injury sites peaked on day 7 post-injury, while the injury sites were occupied by mature osteoblasts also starting from day 7. ~mTc-MDP uptake started to decrease 14 days post-surgery, when we observed the highest level of bony tissue in the injury sites. We also found that 99mTc-MDP uptake was associated with osteoblast maturation and mineralization in vitro. This study provides direct and biological evidence for 99mTc-MDP uptake in osteoblasts during bone healing in vivo and in vitro.

关键词： MDP bone TC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice SPECT

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大数据分析

Can liver stiffness measurement accurately predict disease progression and clinical outcome in patients with metabolic dysfunction-associated steatotic liver disease and bridging fibrosis or cirrhosis?

作者： (英)bart Baesens

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 912-915页

作者： Diederick J.van Doorn Adriaan G.Holleboom R.bart Takkenberg Joanne Verheij Marten A.Lantinga Department of Gastroenterology and Hepatology Amsterdam UMCUniversity of AmsterdamAmsterdam Gastroenterology Endocrinology MetabolismAmsterdamThe Netherlands Department of Vascular Medicine Internal MedicineAmsterdam UMCUniversity of AmsterdamAmsterdam Gastroenterology Endocrinology MetabolismAmsterdamThe Netherlands Department of Hepatopancreatobiliary Pathology Amsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands

Diederick *** Doorn1,Adriaan ***2,*** Takkenberg1,Joanne Verheij3,Marten ***11Department of Gastroenterology and Hepatology,Amsterdam UMC,University of Amsterdam,Amsterdam Gastroenterology Endocrinology Metabolism,Amsterdam,The Netherlands;2Department of Vascular Medicine,Internal Medicine,Amsterdam UMC,University of Amsterdam,Amsterdam Gastroenterology Endocrinology Metabolism,Amsterdam,The Netherlands;3Department of Hepatopanc Metabolic dysfunction-associated steatotic liver disease(MASLD)-until recently termed non-alcoholic fatty liver disease(NAFLD)-is a rising cause of chronic liver disease with an estimated global prevalence of 30%(1).

关键词： Cirrhosis liver stiffness steatotic liver disease

Lithological indicators of discontinuities in mountain soils rich in calcium carbonate in the Polish Carpathians

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Journal of Mountain Science 2020年第5期17卷 1058-1083页

作者： Joanna Beata KOWALSKA bartlomiej KAJDAS Tomasz ZALESKI Depatment of Soil Science and Agrophysics University of AgricultureAl.Mickiewicza 2131-120 KrakowPoland Natural Science Education Centre Jagiellonian UniversityGronostajowa 530-387 KrakowPoland

Six soils located within the Polish Carpathians,developed on calcium carbonate–rich sedimentary parent materials and representing various reference groups,were investigated in order to detect the lithic *** propose using a multidirectional approach to assess the lithic discontinuity in these soils,one that includes grain size distribution,geochemical composition,heavy mineral content and micromorphology,supported by a traditional soil survey.A further aim of this process was to identify the possible admixture of allochthonous material of aeolian *** studied soils presented lithic discontinuities mostly at the contact of underlying calcium carbonate–rich coarsegrained slope deposits with the overlaying colluvium layer having a lower content of rock *** significant changes in grain size distribution,especially in the silt and sand content,as well as high Uniformity Values and partially,high Lithological Discontinuity Index values,confirmed the occurrence of a lithic discontinuity in all studied *** heterogeneity in the soil profiles was also confirmed by the distribution of the major oxides;however,their distribution did not clearly indicate the lithic *** most visible distinctions were noted from CaO content,which resulted from the deposition of carbonate-free materials(aeolian silts)and their mixing with the calcium carbonate–rich parent ***,the analysis of heavy mineral content confirmed the allochthonous origin of the upper(and in some cases also the middle)parts of all profiles,which was manifested by the presence of highly weathering-resistant minerals such as zircon,epidote and various types of *** micromorphological features of some of the studied soils showed distinctiveness within the soil profile,manifested by changes in b-fabric pattern,the occurrence and distribution of secondary carbonate and the coarse and fine coarse and fine *** on the high content of silt within the u

关键词： Lithic discontinuities Heavy minerals Geochemistry Slope processes Micromorphology Uniformity Values

Simulating Spiraling Bubble Movement in the EL Approach

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Open Journal of Fluid Dynamics 2017年第3期7卷 288-309页

作者： Andreas Weber Hans-Jorg bart Axel Klar Department of Separation Science and Technology TU KaiserslauternKaiserslauternGermany Department of Technomathematics TU KaiserslauternKaiserslauternGermany

Simulating the detailed movement of a rising bubble can be challenging, especially when it comes to bubble path instabilities. A solution based on the Euler Lagrange (EL) approach is presented, where the bubbles show oscillating shape and/or instable paths while computational cost are at a far lower level than in DNS. The model calculates direction, shape and rotation of the bubbles. A lateral force based on rotation and direction is modeled to finally create typical instable path lines. This is embedded in an EL simulation, which can resolve bubble size distribution, mass transfer and chemical reactions. A parameter study was used to choose appropriate model constants for a mean bubble size of 3 mm. To ensure realistic solution, validation against experimental data of single rising bubbles and bubble swarms are presented. References with 2D and also 3D analysis are taken into account to compare simulative data in terms of typical geometrical parameters and average field values.

关键词： Euler Lagrange Bubble Column Bubble Path Instability Ellipsoidal Bubble Bubble Shape Zigzag Path

The differential genetic signatures related to climatic landscapes for jaguars and pumas on a continental scale

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Integrative Zoology 2021年第1期16卷 2-18页

作者： Marina ZANIN Noa GONZALEZ-BORRAJO Cuauhtémoc CHÁVEZ Yamel RUBIO bart HARMSEN Claudia KELLER Pablo VILLALVA Ana Carolina SRBEK-ARAUJO Leonora Pires COSTA Francisco PALOMARES Biology Department Federal University of MaranhãoSão LuísBrazil Departamento de Biologia de la Conservación Estación Biológica de DoñanaSevillaSpain Departamento de Ciencias Ambientales Universidad Autónoma MetropolitanaMexico CityMexico Escuela de Biologia Universidad Autónoma de SinaloaCuliacánMexico Panthera New YorkUSA Biodiversity Coordination Amazon Research InstituteManausBrazil Biology Department Vila Velha UniversityVila VelhaBrazil Biological Sciences Department Federal University of Espírito SantoVitóriaBrazil

Modern and paleoclimate changes may have altered species dynamics by shifting species’niche suitability over space and *** analyze whether the current genetic structure and isolation of the two large American felids,jaguar(Panthera onca)and puma(Puma concolor),are mediated by changes in climatic suitability and connection routes over modern and paleoclimatic *** estimate species distribution under 5 climatic landscapes(modern,Holocene,last maximum glaciations[LMG],average suitability,and climatic instability)and correlate them with individuals’genetic isolation through causal modeling on a resemblance *** species exhibit genetic isolation patterns correlated with LMG climatic suitability,suggesting that these areas may have worked as“allele refuges.”However,the jaguar showed higher vulnerability to climate changes,responding to modern climatic suitability and connection routes,whereas the puma showed a continuous and gradual transition of genetic *** differential responsiveness to climate change,both species are subjected to the climatic effects on genetic configuration,which may make them susceptible to future climatic changes,since these are progressing faster and with higher intensity than changes in the ***,the effects of climatic changes should be considered in the design of conservation strategies to ensure evolutionary and demographic processes mediated by gene flow for both species.

关键词： causal modeling climatic landscape ecological niche modeling gene flow linear mixed model

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欧盟植物新品种权利保护运作机制

中国种业 2008年第12期 10-13页

作者：杨志祥 bart Kiewiet 长沙学院法学与公共管理系湖南长沙410003

欧盟植物新品种权利可以通过向欧盟的单个成员国家(总共25个国家中的21个)申请获得,也可以向覆盖所有25个成员国的欧盟获得。本文阐述了欧盟植物新品种办事处(CPVO)的组成、DUS条件(特异性、一致性和稳定性)、新颖性、新品种命名、强制... 详细信息

欧盟植物新品种权利可以通过向欧盟的单个成员国家(总共25个国家中的21个)申请获得,也可以向覆盖所有25个成员国的欧盟获得。本文阐述了欧盟植物新品种办事处(CPVO)的组成、DUS条件(特异性、一致性和稳定性)、新颖性、新品种命名、强制性许可、强制执行、技术审查和行业现状信息等。

关键词：植物新品种保护欧盟成员国 DUS条件强削性许可技术审查行业现状信息