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Predicting an Athlete’s Physiological and Haematological Response to Live High-Train High Altitude Training Using a Hypoxic sensitivity Test

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Journal of science in sport and Exercise 2022年第4期4卷 371-385页

作者： Gareth Turner Kate L.spilsbury David J.Green barry W.Fudge Jamie s.M.Pringle Alan J.Richardson Neil s.Maxwell Environmental Extreme Laboratory University of BrightonEastbourneUK English Institute of sport Bisham AbbeyUK Queensland Academy of sport BrisbaneAustralia English Institute of sport LoughboroughUK Aspire Academy DohaQatar University of Birmingham BirminghamUK

Purpose Elite endurance runners frequently utilise live high-train high(LHTH)altitude training to improve endurance per-formance at sea level(sL).Individual variability in response to the hypoxic exposure have resulted in contradictory *** the present case study,changes in total haemoglobin mass(tHbmass)and physiological capacity,in response to 4-weeks of LHTH were *** tested if a hypoxic sensitivity test(HsT)could predict altitude-induced adaptations to *** Fifteen elite athletes were selected to complete 4-weeks of LHTH(~2400 m).Athletes visited the laboratory for preliminary testing(PRE),to determine lactate threshold(LT),lactate turn point(LTP),maximal oxygen uptake VO_(2max)and *** LHTH,athletes completed daily physiological measures[arterial oxygen saturation(spO2)and body mass]and subjective wellbeing *** was repeated,for those who completed the full camp,post-LHTH(POsT).Additionally,athletes completed the HsT prior to *** A difference(Ps found from PRE to POsT in average tHbmass(1.8%±3.4%),VO_(2max)(2.7%±3.4%),LT(6.1%±4.6%)and LTP(5.4%±3.8%),after 4-weeks *** revealed a decrease in oxygen saturation at rest(Δsp_(r))and higher hypoxic ventilatory response at rest(HVRr)predicted individual changes *** hypoxic cardiac response at rest(HCRr)and higher HVRr predicted individual changes VO_(2max).Conclusion Four weeks of LHTH at~2400 m increased tHbmass and enhanced physiological capacity in elite endurance *** was no observed relationship between these changes and baseline characteristics,pre-LHTH serum ferritin levels,or reported incidents of musculoskeletal injury or *** HsT did however,estimate changes in tHbmass and VO_(2max).HsT prior to LHTH could allow coaches and practitioners to better inform the acclimatisation strategies and train-ing load application of endurance runners at altitude.

关键词： Altitude training Runners Endurance Haemoglobin mass Performance Hypoxic sensitivity

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Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung

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分子细胞生物学报:英文版 2015年第1期7卷 35-47页

作者： Alexander W.Lange Anusha sridharan Yan Xu barry R.stripp Anne-Karina Perl Jeffrey A.Whitsett Division of Pulmonary Biology Cindinnati Children's Hospital Medical Center and the University of Cncinnati Collel ge of MedicineCincinnatiOH 452293039USA Cedars-sinai Medical Center Los AngelesCA 90048USA

The Hippo/Yap pathwayis a wll-conserved signaling cascade that regulates cell proliferation and dfferentiationto control organsize and stem/progenitor cell *** airway injury,Yap was dynamically regulated in regenerating airway epithelial *** *** the role ofHippo signaling in the lung,the mammalian Hippo kinases,Mst1 and Mst2,were deleted in epithelial cells ofthe embry-onic and mature mouse ***1/2 deletion in the fetal lung enhanced proliferation and inhibited sacculation and epithelial cell *** transcriptional inhibition of cell proliferation and activation of differentiation during normal perinatal lung maturation were inversely regulated followving embryonic Mst1/2 *** of Mst1/2 from bronchiolar epithelial cells in the adult lung caused airway hyperplasia and altered *** Yap phosphorylation was decreased and Yap nuclear localization and transcriptional targets were increased after Mst1/2 deletion,consistent with canonical Hippo/Yap *** potentiated cell prolif-eration and inhibited dfferentiation of human bronchial epithelial cells in *** of Mst1/2 and expression ofYAP regulated transcrip-tional targets controlling cell proliferation and diferentiation,including Ajuba LIM *** was required forthe effects ofYAP oncell proliferation in ***/Yapsignaling regulates Ajuba and controls proliferation and diferentiation oflung epithelial progenitor cells.

关键词： Hippo/Yap pathway lung Ajuba proliferation dfferetiation

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Nonlinear Integrated Optical Waveguides in Chalcogenide Glasses

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光学学报 2003年第S1期23卷 363-364页

作者： Yinlan Ruan barry Luther-Davies Weitang Li Andrei Rode Marek samoc The Australian Photonics Cooperative Research Center Laser Physics Centre The Australian National University Canberra ACT 0200 Australia

This paper reports on the study and measurement of the third order optical nonlinearity in bulk sulfide-based chalcogenide glasses; The fabrication process of the ultrafast laser deposited As-s-(se)-based chalcogenide... 详细信息

关键词： Chalcogenide Glasses optical nonlinearity chalcogenide glasses optical waveguides plasma etching

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The Firebrand Behind the Tire Branc

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成功营销 2008年第12期 56-57页

作者： barry Janoff

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The Application of the LDL Principle

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World Journal of Cardiovascular Diseases 2016年第5期6卷 109-125页

作者： David s. schade Brendan Cavanaugh barry Ramo R. Philip Eaton Division of Endocrinology DoIM School of Medicine University of New Mexico Albuquerque NM USA New Mexico Heart Institute Albuquerque NM USA

The LDL Principle has recently been invoked to describe the observation that lowering the LDL cholesterol (by whatever means) results in a lowering of atherosclerotic cardiovascular events. The scientific basis of the LDL Principle dates back to the discovery that the LDL receptor is the prime determinant of the circulating LDL-c concentration. since that time, major advances have been made at both the basic and clinical science level in our understanding of the pathogenesis and reversal of atherosclerosis. The incorporation of atherogenic lipoproteins plus inflammatory mediators into plaque formation permits the targeted intervention into preventing plaque rupture. In addition, genetic studies identifying individuals with unique phenotypes of either abnormally high or low LDL-c concentrations have provided insight into possible therapeutic modalities that have recently provided the physician with the tools necessary to apply the LDL Principle to achieve reversal of atherosclerosis. The epidemic of atherosclerotic cardiovascular disease has resulted in numerous randomized controlled intervention trials in an attempt to identify approaches to reduce AsCD morbidity and mortality. Recently published data indicate that circulating LDL-c levels of 50 mg/dl or less are not only physiologic at birth but also effective in greatly reducing cardiovascular disease. In addition, the recent availability of two PCsK9 inhibitors provides the primary care physician with the possibility of achieving this low level of LDL-c even in statin intolerant patients. The widespread availability of the coronary artery calcium scan plus the inclusion of traditional cardiovascular risk factors in risk assessment has enabled the physician to readily identify asymptomatic individuals at high risk for cardiovascular events. Aggressively applying the LDL Principle to these individuals has the potential of greatly reducing cardiovascular mortality. This review will document the scientific basis for

关键词： LDL Principle Atherosclerosis Myocardial Infarction Atherosclerosis Reversal LDL Cholesterol

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Chinese Mining Enterprises in Zambia "Bad Employers"?

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China Today 2012年第6期61卷 44-46页

作者： barry sAUTMAN the Division of social science Hong Kong University of Science and Technology

ANovember 2Oll Human Rights Watch report on alleged labor abuses in four mining firms in ,Zambia parented by state-owned enterprise China Non-ferrous Metal Min- ing Co. （CNMC） has predictably become a media sensation. Countless news outlets and blogs have reported that the Chinese firms are ＂bad employers＂ compared to the five Western-based major foreign in- vestors in Zambia＇s copper mining indus- try, as regards safety, pay, work hours and union fights.

关键词：中国企业赞比亚矿业企业雇主新闻媒体矿业公司观察报告有色金属

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正电子发射断层成像术在肥厚型心肌病中的应用：发现微血管功能异常所致的心肌低灌注

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中华心血管病杂志 2009年第12期37卷 1069-1073页

作者： Franco Cecchi Iacopo Olivotto Massimo Baldi Martin s. Maron barry J. Maron Florence 50129 Dipartimento cuore e vasi-S. Lucavecchio Azienda Ospedaliera Universitaria Careggi Division of Cardiology Tufts-New England Medical Center Hypertrophic Cardiomyopathy Center Minneapolis Heart Institute Foundation

肥厚型心肌病是最常见的遗传性心脏疾病，其在人群中患病率约为2／1000，以表型表达和临床表现差异极大为特点——从完全无症状到猝死、疾病进展和心力衰竭相关并发症等。微血管水平的心肌缺血与疾病表达和临床后果密切相关，是一些致... 详细信息

肥厚型心肌病是最常见的遗传性心脏疾病，其在人群中患病率约为2／1000，以表型表达和临床表现差异极大为特点——从完全无症状到猝死、疾病进展和心力衰竭相关并发症等。微血管水平的心肌缺血与疾病表达和临床后果密切相关，是一些致命性并发症，如室性心律失常、猝死、左心室重构和收缩功能障碍的直接原因。至今，肥厚型心肌病患者心肌缺血的评估还存在一定技术和实际的困难，尚没有纳入到规范的临床实践中，亦没有列入肥厚型心肌病的诊疗指南。

关键词：肥厚型心肌病正电子发射断层成像术微血管功能异常遗传性心脏疾病低灌注相关并发症室性心律失常

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Does Ethanol Play a Pro-Oxidant Role during Oxidative stress in the Liver?

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Journal of Biosciences and Medicines 2015年第8期3卷 1-9页

作者： Patience O. Obih Joseph s. soblosky barry J. Potter College of Pharmacy Xavier University of Louisiana New Orleans USA The Alcohol Research Center LSU Health New Orleans USA The Department of Physiology at LsU Health New Orleans USA

Oxidative stress has been implicated in the pathophysiology of liver injury during xenobiotic and alcohol metabolism, ischemia/reperfusion injury. In this study we examined if ethanol acted as a pro-oxidant making cells become more sensitive to tert-butylhydroperoxide (tBH) killing. Cell viability was determined in a rat hepatoma cell line (FTO2B) and rat primary hepatocytes in culture in the presence or absence of ethanol pretreatment. To elucidate the contribution of labile iron, deferoxamine (DF, an iron chelator) or lipid free radicals, N,N-diphenyl-p-phenylenediamine (DPPD, a lipid scavenger) were added to the ethanol tBH co-treatment. The levels of glutathione (GsH) and glutathione disulfide (GssG) in the hepatocytes were also measured. Ethanol treatment (both pretreatment and co-treatment during the 3-hr tBH exposure) increased cell killing dramatically in both FTO2B cells and primary rat hepatocytes. Both DF and DPPD decreased ethanol-enhanced tBH cell killing in hepatocytes. These results demonstrated that co-treatment of FTO2B cells and primary rat hepatocytes with ethanol and tBH increased cell killing. The GsH level was dramatically reduced while GssG level rose. Both DFP and DPPD reversed or protected the cells from this insult, indicating that ethanol was a pro-oxidant.

关键词： Ethanol Liver Hepatocytes FTO2B Cells t-Butyl Hydroperoxide

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Effect of pre-stretching on microstructure of aged 2524 aluminium alloy

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Transactions of Nonferrous Metals society of China 2011年第9期21卷 1957-1962页

作者：权力伟赵刚 sam GAO barry.C.MUDDLE 东北大学材料与冶金学院沈阳110004 ARC Centre of Excellence for Design in Light Metals Monash University

The effects of pre-stretching following solution treatment on the hardness and microstructures of aged 2524 aluminium alloy at 170 ℃ were *** hardness values under different pre-stretching conditions were measured,and the corresponding microstructures were characterized by transmission electron microscopy（TEM）.The results show that compared with unstretched samples,the peak hardness is increased and the time to reach the peak hardness is reduced with the increase of pre-strain;the number density of s（Al2CuMg） phases is increased and the length is shortened in pre-stretched ***,the number density of GPB zones is decreased with the increase of pre-strain in peak-aged *** the pre-strain is up to 5%,s phases play the predominant contribution to the peak *** and uniformly distributed s phases lead to a higher hardness than GPB zones together with s phases existing in conventionally aged 2524 alloy.

关键词： 2524 aluminium alloy pre-stretch s phase GPB zone

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Climate change,thermal niches,extinction risk and maternal-effect rescue of toad-headed lizards,Phrynocephalus,in thermal extremes of the Arabian Peninsula to the Qinghai-Tibetan Plateau

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Integrative Zoology 2018年第4期13卷 450-470页

作者： barry sINERVO Donald B.MILEs Yayong WU Fausto R.MÉNDEZ-DE LA CRUZ sebastian KIRCHHOF Yin QI The Institute for the study of the Ecological and Evolutionary Climate Impacts University of Californiaand Department of Ecology and Evolutionary BiologyUniversity of CaliforniaSanta CruzCaliforniaUSA Department of Biological sciences Ohio UniversityAthensOhioUSA Chengdu Institute of Biology Chinese Academy of SciencesChengduSichuanChina Laboratory of Herpetology Institute of BiologyUniversidad Nacional Autónoma de MéxicoMexico CityMexico Museum of Natural History Leibniz-Institute for Evolution and Biodiversity Scienceand Berlin-Brandenburg Institute of Advanced Biodiversity Research(BBIB)BerlinGermany

Determining the susceptibility of species to changing thermal niches is a major goal for *** this paper we develop an eco-physiological model of extinction risk under climate change premised on behavioral *** method downscales operative environmental temperatures,which restrict hours of activity of lizards,hr,for present-day climate(1975)and future climate scenarios(2070).We apply our model using occurrence records of 20 Phrynocephalus lizards(or taxa in species complexes)drawn from literature and museum *** analysis is phylogenetically informed,because some clades may be more sensitive to rising *** limits for computed hr predict local extirpations among Phrynocephalus lizards at continental scales and delineate upper boundaries of thermal niches as defined by Extreme Value *** the 8.5 Representative Concentration Pathway scenario,we predict extirpation of 64%of local populations by 2070 across 20 Phrynocephalus species,and 12 are at high risk of total extinction due to thermal limits being *** tandem with global strategies of lower CO_(2) emissions,we propose regional strategies for establishing new national parks to protect extinction-prone taxa by preserving high-elevation climate refugia within existing sites of species *** propose that evolved acclimatization–maternal plasticity–may ameliorate risk,but is poorly *** studies revealed that adaptive maternal plasticity by thermoregulating gravid females alter progeny thermal preferences by±1℃.We describe plasticity studies for extinction-prone species that could assess whether they might be buffered from climate warming–a *** discuss an epigenetic framework for studying such maternal-effect evolution.

关键词： climate change eco-physiology extinction model maternal effect lizards

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