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Clinical laboratory and imaging evidence for effectiveness of agarose-agarose macrobeads containing stem-like cells derived from a mouse renal adenocarcinoma cell population (RMBs) in treatment-resistant, advanced metastatic colorectal cancer:Evaluation of

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Chinese Journal of Cancer Research 2018年第1期30卷 72-83页

作者： barry H.smith Lawrence s.Gazda Thomas J.Fahey Angelica Nazarian Melissa A.Laramore Prithy Martis Zoe P.Andrada Joanne Thomas Tapan Parikh sudipta sureshbabu Nathaniel Berman Allyson J.Ocean Richard D.Hall David J.Wolf The Rogosin Institute New York NY 10021 USA The Rogosin Institute-Xenia Division Xenia OH 45385 USA New York Presbyterian-Weill Cornell Medical Center New York NY 10021 USA Bob Evans Farms Inc. New Albany OH 43054 USA

Objective： The complexity, heterogeneity and capacity of malignant neoplastic cells and tumors for rapid change and evolution suggest that living-cell-based biological-systems approaches to cancer treatment are merited. Testing this hypothesis, the tumor marker, metabolic activity, and overall survival（Os） responses, to the use of one such system, implantable macrobeads [RENCA macrobeads（RMBs）], in phase I and IIa clinical trials in advanced,treatment-resistant metastatic colorectal cancer（m CRC） are described ***： Forty-eight m CRC patients（30 females; 18 males）, who had failed all available, approved treatments,underwent RMB implantation（8 RMB/kg body weight） up to 4 times in phase I and phase IIa open-label ***, labs [tumor and inflammation markers, lactate dehydrogenase（LDH）] and positron emission tomography-computed tomography（PET-CT） imaging to measure number/volume and metabolic activity of the tumors were performed pre-and 3-month-post-implantation to evaluate safety and initial efficacy（as defined by biological responses）. PET-CT maximum standard uptake value（sUVmax）（baseline and d 90; sUVmax ≥2.5）, LDH,and carcinoembryonic antigen（CEA） and/or cancer antigen 19-9（CA 19-9） response（baseline, d 30 and/or d 60）were assessed and compared to ***： Responses after implantation were characterized by an at least 20% decrease in CEA and/or CA 19-9 in75% of patients. Fluorodeoxyglucose（FDG）-positive lesions（phase I, 39; 2 a, 82） were detected in 37/48 evaluable patients, with 35% stable volume and stable or decreased sUV（10） plus four with necrosis; 10, increased tumor volume, sUV. LDH levels remained stable and low in Responders（R）（d 0–60, 290.4–333.9）, but increased steadily in Non-responders（NR）（d 0–60, 382.8–1,278.5）（d 60, P=0.050）. Responders to RMBs, indicated by the changes in the above markers, correlated with Os（R mean Os=10.76 months; NR mean Os=4.9 months; P=0.0006）.Conclusions： The correlations of the tumor marker, tumor volume

关键词： Clinical trial systems-biology RENCA macrobeads metastatic colorectal cancer colon cancer

Acute Alithiasis Cholecystitis in Children: Diagnostic and Therapeutic Approach in the Pediatric surgery Department of the CHU of Conakry

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Open Journal of Pediatrics 2023年第1期13卷 86-91页

作者： Balla Keita Mamadou Alpha Toure Mohamed Lamine sadou sacko Thierno saidou barry Mohamed Lamine Diallo Mamadou Madiou barry Daniel Agbo-Panzo Department of Pediatric surgery National Hospital of Donka/CHU Conakry Guinea Faculty of science and Technology University Gamal Abdel Nasser of Conakry Conakry Guinea

Acute alithiasic cholecystitis (AAC) is the inflammatory disease of the gallbladder in the absence of gallstones. It is a rare pathology in children. The aim was to describe the clinical, diagnostic and therapeutic characteristics of this disease. Materials and Method: This was a 3-year retrospective study (January 2008 to December 2010) including 66 patient records collected for CAA. Results: The frequency of AAC was 3.57%, the mean age of the patients was 8 ± 3.52 years, and there were 36 boys and 30 girls. The main clinical features were right hypochondrial pain (66 cases), positive Murphy’s (66 cases), fever (53 cases) and jaundice or sub-jaundice (51 cases). The main ultrasound signs were thickened vesicular wall 50 cas (75.76%), vesicular distension 50cas (75.76%) and positive ultrasound Murphy 47 cas (71.21%). Medical treatment was exclusive in 64 patients (96.97%) and surgical treatment in 2 patients (3.03%). Conclusion: Acute alithiasic cholecystitis is a rare pathology in children, the clinical picture is not very specific and abdominal ultrasound is the key to early diagnosis. Conservative treatment is the first choice in the absence of any complications.

关键词： Acute Alithiasic Cholecystitis Children Medical Treatment

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可编程逻辑器件可重配置性的应用

电子设计技术 2000年第9期 68-68,70+72页

作者： barry FLANNAGHAN MARTIN s. WON sNELL & WILCOX公司 ALTERA公司技术总监

低成本的可编程逻辑器件和現场可编程门阵列,用起来可能真的得心应手,但说不定也会得不偿失。对于“低成本”和“多优点”,业内并没有标准的界定,所以务请仔细研究靖楚:一个厂家的说法,不一定放诸四海而皆准。

关键词：可编程逻辑器件重配置画面可重配置性配置方案微处理器 PLD 定位器视频处理器逻辑单元

Acute Thoracic syndrome in sickle Cell Children at the Pediatrics Department of Donka National Hospital

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Open Journal of Pediatrics 2020年第4期10卷 688-694页

作者： M. M. Diop A. barry M. L. Diallo E. Camara I. K. barry M. A. Doukoure M. C. barry s. B. Diallo N. V. Gateu Tadjom H. Dia M. P. Diallo Departement of Pediatric Donka National Hospital Conakry Guinea University Gamal Abdel Nasser of Conakry Conakry Guinea Pediatric Emergency Department Donka National Hospital Conakry Guinea Ignace Deen Department of Pediatrics Conakry Guinea

Introduction: Acute thoracic syndrome is the appearance of a new pulmonary infiltrate on radiology associated with fever, desaturation or respiratory signs. It is the second leading cause of hospitalization andspan> the first cause of death in sickle cell patients. It is an acute pulmonary complication whose pathophysiological mechanisms are still poorly understood. This study aims to study the epidemiological, clinical, therapeutic and evolutionary aspespan>cts of Acute Chest Syndrome in children at the Pediatrics Department of Donka National Hospital. Method: This is a prospective study of descriptive type for a period of 6 months from February 19 to August 19, 2019 on patients with sickle cell disease who developed an ATS in the pediatrics department of Donka National Hospital. Epidemiological, clinical, therapeutic and evolutionary data were studied and proportionate data were calculated. Results: The frequency of ATS was 39%. The mean age of our patients was 9.83 years with the extremes ofspan> 4 and 16 years. The age group from 6 to 10 years with a frequency of 66.7% was the most affected. Fever was the main clinical manifestation, followed by hepatomespan>span style="font-family:Verdana;">galy. All our patients were homozygous ss and

关键词： sickle Cell Disease Acute Thoracic syndrome Pediatrics Donka

Multitarget stool DNA for colorectal cancer screening:A review and commentary on the United states Preventive services Draft Guidelines

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World Journal of Gastrointestinal Oncology 2016年第5期8卷 450-458页

作者： barry M Berger Bernard Levin Robert J Hilsden Medical Affairs Exact Sciences Corporation scientific Advisory Board Exact Sciences Departments of Medicine and Community Health sciences University of Calgary

Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United states Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).The United states Preventive services Task Force(UsPsTF) October 2015 draft recommendation for CRC screening included mt-s DNA as an "alternative" screening test that "may be useful in select clinical circumstances",despite its very high sensitivity for early stage *** evidence supporting mt-s DNA for routine screening use is *** clinical efficacy of mt-s DNA as measured by sensitivity,specificity,life-years gained(LYG),and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document,especially those requiring annual testing *** a population with primarily irregular screening participation,tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual *** paper reviews the evidence supporting mt-s DNA for routine screening and demonstrates,using UsPsTF's modeling data,that mt-s DNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing,high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening.

关键词： Colorectal cancer screening Multitarget stool DNA stool DNA The United states Preventive services Task Force Cancer Intervention surveillance Modeling Network Fecal immunological technique Modeling Interval

sUsTAINABLE AGRICULTURE: ITs sTATUs QUO AND TREND IN CHINA

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Journal of Geographical sciences 1996年第3期6卷 1-12页

作者： Cai Yunlong(Department of Geography, Peking University, Beijing 100871People’s Republic of China)barry smit(Department of Geography, University of Guelph)Guelph, Ontario, N1G2W1, Canada)

Agriculture is a complex of processes that takes place within a threefold (that is, bio-physical, socio-political and techno-economic) environmatal framework. The sustainability of agriculturral systems can also be assessed within this framework. sustainable agnculture has different meanings at various spatial scales At local and regional scales, it is just ecological farming. At national and global scales, however, the emphasis is put on the issues of food production and distribution. Based upon the framework, this paper discusses the current situation and future trend of Chinese agriculture in relation to sustainability.

关键词： sustainable agriculture food supply issue ecological farming China

PHREEQC在地下水溶质反应运移模拟中的应用

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水文地质工程地质 2004年第2期31卷 20-24页

作者：毛晓敏刘翔 barry D A 英国爱丁堡大学土木与环境研究所清华大学环境科学与工程系北京100084

由于地下水污染的加剧,对地下水中污染物运移规律的研究日益受到重视。地下水中的溶质在运移过程中伴随着溶质组分间的化学反应,因此需要建立地下水溶质运移与化学反应的耦合模型。PHREEQC是近年来发展起来的描述局部平衡反应、动态生... 详细信息

由于地下水污染的加剧,对地下水中污染物运移规律的研究日益受到重视。地下水中的溶质在运移过程中伴随着溶质组分间的化学反应,因此需要建立地下水溶质运移与化学反应的耦合模型。PHREEQC是近年来发展起来的描述局部平衡反应、动态生物化学反应的水文地球化学模拟软件。本文利用该模拟软件对一维地下水流动过程中溶质离子交换反应和动态氧化还原反应进行了模拟。结果表明,PHREEQC能够成功地进行溶质运移情况下复杂水化学反应模拟,但对于复杂地下水流和溶质运动的情况,有必要耦合其它的地下水流动和溶质运移软件来共同完成。

关键词：地下水污染化学反应耦合模型溶质离子交换动态氧化还原

罗非鱼池塘环境因子对叶绿素a影响的通径分析

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环境科学与技术 2015年第12期38卷 110-116页

作者：李志波宋超季丽 Kamira barry 陈家长南京农业大学无锡渔业学院江苏无锡214081 中国水产科学研究院淡水渔业研究中心中国水产科学研究院内陆渔业生态环境和资源重点开放实验室江苏无锡214081

叶绿素a(Chl.a)是各类水体浮游植物生长状况的表征,其含量体现出水体生态系统的初级生产能力和水质环境状况。Chl.a含量的高低与诸多环境因子的变化密切相关,以通径分析的方法来研究水体环境因子变化对Chl.a的影响,能够剖分Chl.a受各环... 详细信息

叶绿素a(Chl.a)是各类水体浮游植物生长状况的表征,其含量体现出水体生态系统的初级生产能力和水质环境状况。Chl.a含量的高低与诸多环境因子的变化密切相关,以通径分析的方法来研究水体环境因子变化对Chl.a的影响,能够剖分Chl.a受各环境因子的影响为直接和间接作用,解析出各因子对浮游植物生长效应的决定比例,使复杂的水体环境因子关系明了清晰化。该实验主要研究罗非鱼(Oreochromis niloticus)养殖池塘水体营养因子TN、TP、NH_4^+-N、NO_3^--N、NO_2^--N及pH变化对Chl.a的影响,通过相关性分析和多元回归分析剔除了对Chl.a影响不大的TN和NO_2^--N,并在此基础上根据偏回归系数建立罗非鱼养殖池塘Chl.a与环境因子的多元回归方程。重点进行了通径分析,计算得出pH、TP、NH_4^+-N和NO_3--N变化对叶绿素a影响的直接通径系数分别为0.416、0.325、0.404和-0.223,间接通径系数总和分别为-0.276、0.198、0.072和-0.163。分析表明,环境因子的变化其自身可以以直接敏感的方式较大比例地影响浮游植物的生长和繁殖,而通过作用其他因子间接对浮游植物的生长和繁殖产生影响的路径也十分重要,前后两者的绝对作用值和的比例分别约为65.9%和34.1%。决定系数显示TP和NH_4^+-N是对Chl.a影响最大的因子,其决定值分别达到了0.235和0.221。研究表明,通径分析能够更科学地为了解罗非鱼等养殖池塘水体系统的营养结构、更合理地为水体环境的控制和改善及健康养殖模式的寻求提供科学依据。

关键词：罗非鱼池塘通径分析环境因子叶绿素a

Ostrich Antibody and Its Application to skin Diseases, a Review and Case Report

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Health 2018年第10期10卷 1357-1370页

作者： Yasuhiro Tsukamoto Osamu Maeda Genshi shigekawa stuart Greenberg barry Hendler Department of Animal sciences Graduate School of Environmental & Biological Sciences Kyoto Prefecture University Kyoto Japan Clinical studies Zeal Cosmetics Osaka Japan Bioresearch section Maz World Hong Kong Science Park Hong Kong S.A.R. China Clinical studies Ostri Gen Holdings West Newton MA USA Microfollicular Hair Transplantation Ambler PA USA

Antibodies are immunoglobulins produced by B cells when antigens such as allergens or pathogens invade an animal’s body. The antibodies remove and inactivate antigens. Antibodies are distributed in internal body and mucosal membrane to protect living animals, but they are excellent proteins that can exert their functions, “antigen-antibody reactions,” even when removed from the body. For that reason, antibodies are being put to practical use in diagnostic kits for conditions such as pregnancy and influenza infection, and as anticancer drugs targeting specific tumor markers. The result has been an increasing use of antibodies for research, diagnosis, and therapeutic purposes. Unfortunately, antibodies from experimental mammals such as mice, rats, and rabbits, are not suited to industrial use because of their high production cost. Moreover, handling of these antibodies is difficult due to their vulnerability to heat, acids and alkalis. Accordingly, there is no adaptability to mass production. Recently, we developed a convenient method for the low-cost, mass-production of antibodies using egg-laying hen ostriches. The ostrich egg is an excellent source of antibodies for industrial purposes. The present report shows that the ostrich antibodies have therapeutic effects in ailments such as atopic dermatitis, acne, pyoderma, and pollen allergies. We have successfully produced and purified ostrich immunoglobulin yolk (IgY) against pollen allergens (Cryj1, Cryj2, Chao1, Chao2) and found that allergic reactions were alleviated in skin patch tests of allergic patients by using the ostrich IgY. In addition, we produced ostrich IgY against the homogenates of staphylococcus aureus and Propionibacterium acnes, and applied to dermal lesions of atopic dermatitis and acne patients, and then observed the therapeutic effects on the dermatitis of volunteer subjects. Antibody against s. aureus also had the therapeutic effect on canine pyoderma caused by MRsA. A particular advantage in us

关键词： Ostrich Antibody Cosmetics Atopic Dermatitis Acne Pollen Allergy Pyoderma