检索结果-南通市图书馆

Analysis of core protein clusters identifies candidate variable sites conferring metronidazole resistance in Helicobacter pylori

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gastroenterology Report 2019年第1期7卷 42-49,I0002页

作者： Eng-Guan Chua Aleksandra W.Debowski KMary Webberley Fanny Peters Binit Lamichhane Mun-Fai Loke jamuna Vadivelu Chin-Yen Tay barry j.marshall Michael j.Wise The marshall Centre for Infectious Diseases Research and Training University of Western AustraliaPerthWestern AustraliaAustralia School of Biomedical Sciences Faculty of Health and Medical SciencesUniversity of Western AustraliaPerthWestern AustraliaAustralia Department of Medical Microbiology University of MalayaKuala LumpurWilayah PersekutuanMalaysia Shenzhen Dapeng New District Kuichong People Hospital ShenzhenGuangdongChina UM marshall Centre University of MalayaKuala LumpurWilayah PersekutuanMalaysia School of Computer Science and Software Engineering University of Western AustraliaPerthWestern AustraliaAustralia

Background:Metronidazole is one of the first-line drugs of choice in the standard triple therapy used to eradicate Helicobacter pylori ***,the global emergence of metronidazole resistance in Hp poses a major challenge to health *** of RdxA is known to be a major mechanism of conferring metronidazole resistance in ***,metronidazole resistance can also arise in *** strains expressing functional RdxA protein,suggesting that there are other mechanisms that may confer resistance to this ***:We performed whole-genome sequencing on 121 *** clinical strains,among which 73 were ***-alignment analysis of core protein clusters derived from clinical strains containing full-length RdxA was *** sites in each alignment were statistically compared between the resistant and susceptible groups to determine candidate genes along with their respective amino-acid changes that may account for the development of metronidazole resistance in ***:Resistance due to RdxA truncation was identified in 34%of metronidazole-resistant *** of core protein clusters derived from the remaining 48 metronidazole-resistant strains and 48 metronidazole-susceptible identified four variable sites significantly associated with metronidazole *** sites included R16H/C in RdxA,D85N in the inner-membrane protein RclC(HP0565),V265I in a biotin carboxylase protein(HP0370)and A51V/T in a putative threonylcarbamoyl–AMP synthase(HP0918).Conclusions:Our approach identified new potential mechanisms for metronidazole resistance in *** that merit further investigation.

关键词： Helicobacter pylori metronidazole antibiotic resistance whole-genome sequencing core protein clusters sequence alignment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Letter to the editor

新发传染病电子杂志 2018年第4期3卷 195-197页

作者： barry marshall 鄭敬 marshall centre uwa university of western australia helicobacter research laboratory marshall centre for infectious diseases research and training

To date,gastric cancer is still in the top 3 most common cancers *** 400 000 gastric cancer cases are reported from China alone *** the incidence and mortality of gastric cancer has been substantially falling,the 5-ye... 详细信息

关键词： cancers Letter

Robustness Assessment and Adaptive FDI for Car Engine

在线全文

学校读者我要写书评

暂无评论

International journal of Automation and computing 2008年第2期5卷 109-118页

作者： Mahavir Singh Sangha j.barry Gomm Control Systems Research Group School of EngineeringLiverpool John Moores University

A new on-line fault detection and isolation （FDI） scheme proposed for engines using an adaptive neural network classifier is evaluated for a wide range of operational modes to check the robustness of the scheme in this paper. The neural classifier is adaptive to cope with the significant parameter uncertainty, disturbances, and environment changes. The developed scheme is capable of diagnosing faults in on-line mode and the FDI for the closed-loop system with can be directly implemented in an on-board crankshaft speed feedback is investigated by diagnosis system （hardware）. The robustness of testing it for a wide range of operational modes including robustness against fixed and sinusoidal throttle angle inputs, change in load, change in an engine parameter, and all these changes occurring at the same time. The evaluations are performed using a mean value engine model （MVEM）, which is a widely used benchmark model for engine control system and FDI system design. The simulation results confirm the robustness of the proposed method for various uncertainties and disturbances.

关键词： On-board fault diagnosis automotive engines adaptive neural networks (ANNs) fault classification robustness assessment

Multitarget stool DNA for colorectal cancer screening:A review and commentary on the United States Preventive Services Draft Guidelines

在线全文

学校读者我要写书评

暂无评论

World journal of Gastrointestinal Oncology 2016年第5期8卷 450-458页

作者： barry M Berger Bernard Levin Robert j Hilsden Medical Affairs Exact Sciences Corporation Scientific Advisory Board Exact Sciences Departments of Medicine and Community Health Sciences University of Calgary

Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).The United States Preventive Services Task Force(USPSTF) October 2015 draft recommendation for CRC screening included mt-s DNA as an "alternative" screening test that "may be useful in select clinical circumstances",despite its very high sensitivity for early stage *** evidence supporting mt-s DNA for routine screening use is *** clinical efficacy of mt-s DNA as measured by sensitivity,specificity,life-years gained(LYG),and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document,especially those requiring annual testing *** a population with primarily irregular screening participation,tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual *** paper reviews the evidence supporting mt-s DNA for routine screening and demonstrates,using USPSTF's modeling data,that mt-s DNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing,high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening.

关键词： Colorectal cancer screening Multitarget stool DNA Stool DNA The United States Preventive Services Task Force Cancer Intervention Surveillance Modeling Network Fecal immunological technique Modeling Interval

Molecular mechanisms of liver ischemia reperfusion injury:Insights from transgenic knockout models

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2013年第11期19卷 1683-1698页

作者： Gourab Datta barry j Fuller Brian R Davidson Liver Transplantation and Hepatobiliary Unit Division of Surgery and Interventional ScienceRoyal Free CampusUniversity College LondonRoyal Free Hampstead NHS Trust HospitalLondon NW 2QGUnited Kingdom

Ischemia reperfusion injury is a major obstacle in liver resection and liver transplantation *** the mechanisms of liver ischemia reperfusion injury(IRI) and developing strategies to counteract this injury will therefore reduce acute complications in hepatic resection and transplantation,as well as expanding the potential pool of usable donor *** initial liver injury is initiated by reactive oxygen species which cause direct cellular injury and also activate a cascade of molecular mediators leading to microvascular changes,increased apoptosis and acute inflammatory changes with increased hepatocyte *** adaptive pathways are activated during reperfusion that reduce the reperfusion *** involves a complex interplay between neutrophils,natural killer T-cells cells,CD4+ T cell subtypes,cytokines,nitric oxide synthases,haem oxygenase-1,survival kinases such as the signal transducer and activator of transcription,Phosphatidylinositol 3-kinases/Akt and nuclear factor κβ *** animals,particularly genetic knockout models,have become a powerful tool at elucidating mechanisms of liver ischaemia reperfusion injury and are complementary to pharmacological *** disruption of the protein at the genetic level is more specific and maintained than pharmacological inhibitors or stimulants of the same *** article reviews the evidence from knockout models of liver IRI about the cellular and molecular mechanisms underlying liver IRI.

关键词： Liver Ischemia/reperfusion Transgenic Knockout Nitric oxide synthase Haem oxygenase Mitogen-activated protein kinase T cell receptor

Escherichia coli-host macrophage interactions in the pathogenesis of inflammatory bowel disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2014年第27期20卷 8751-8763页

作者： Ahmed Tawfik Paul K Flanagan barry j Campbell Department of Gastroenterology Institute of Translational Medicine University of Liverpool

Multiple studies have demonstrated alterations in the intestinal microbial community (termed the microbiome) in Crohn’s disease (CD) and several lines of evidence suggest these changes may have a significant role in disease pathogenesis. In active and quiescent disease, both the faecal and mucosa-associated microbiome are discordant with matched controls with reduced biodiversity, changes in dominant organisms and increased temporal variation described. Mucosa-associated adherent, invasive Escherichia coli (E. coli) (AIEC), pro-inflammatory and resistant to killing by mucosal macrophages, appear to be particularly important. AIEC possess several virulence factors which may confer pathogenic potential in CD. Type-1 pili (FimH) allow adherence to intestinal cells via cell-surface carcinoembryonic antigen-related cell adhesion molecules and possession of long polar fimbrae promotes translocation across the intestinal mucosa via microfold (M)-cells of the follicle-associated epithelium. Resistance to stress genes (htrA, dsbA and hfq) and tolerance of an acidic pH may contribute to survival within the phagolysosomal environment. Here we review the current understanding of the role of mucosa-associated E. coli in Crohn’s pathogenesis, the role of the innate immune system, factors which may contribute to prolonged bacterial survival and therapeutic strategies to target intracellular E. coli.

关键词： Crohn's disease Inflammatory bowel disease Escherichia coli Intra-macrophage survival and replication Phagolysosome Autophagy

C. H. Pander＇s introduction to conodonts, 1856

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Episodes 2008年第4期31卷 429-432页

作者： Sweet, Walter C. Cooper, barry j. School of Earth Sciences The Ohio State University Columbus OH 43210 United States Primary Industries and Resources South Australia Adelaide SA 5001 GPO Box 1671 Australia

It is rare in the annals of science for a single publication to provide a definitive introduction to a previously unknown group of animals. Yet this was the case with the monograph that included the initial descriptions of an important, extinct group of fossil animals： the conodonts. The publication, by Christian Heinrich Pander, appeared in St Petersburg in 1856. The volume of ninety-one pages, written in German and accompanied by seven beautifully executed plates, was issued by the Imperial Academy of Sciences as part of a series entitled Geognostische Beschreibung der Russisch-Baltischen Gouvernements.

关键词：动物科学动物化石牙形石科学研究

Control of the carrier-envelope phases of a synchronously pumped femtosecond optical parametric oscillator and its applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2008年第5期53卷 642-651页

作者： SUN jingHua barry j S Gale Derryck T Reid Ultrafast Optics Group School of Engineering and Physical Sciences Heriot-Watt University Edinburgh EH14 4AS UK Laboratory of Optical Physics Institute of Physics Chinese Academy of Sciences Beijing 100080 China

The intrinsic synchronization, multi-color outputs and related carrier-envelope phases (CEP) among pulses bring advantages to synchronously pumped femtosecond optical parametric oscillators and the pumping sources for broadband frequency comb generation and ultrashort waveform coherent syn-thesis. In this paper, we discuss our latest research results in this field, which cover the following as-pects: the phase relationship and energy conservation law in an OPO and related experimental verifi-cation; control of the pumping Ti:sapphire femtosecond laser's CEP by self-referencing technology, and its repetition-rate locking by piezoelectric transducer (PZT); CEP locking of the pulses from the OPO by beating the non-phase-matched visible outputs against pump supercontinuum to obtain a driving signal for a fast PZT on the OPO end mirror; the generation of a broadband frequency comb spanning from 400 nm to 2.4 μm with 1.2 kHz bandwidth; and the realization of coherent interference between phase controlled pump pulses and signal second harmonic pulses.

关键词：光学参数振荡器载波包络相同步控制超短光脉冲

THIGEMINAL MECHANISMS OF OROFACIAL PAIN

在线全文

学校读者我要写书评

暂无评论

神经解剖学杂志 2001年第B7期17卷 35-36页

作者： barry j. SESSLE Department of Physiology Faculty of Dentistry University of Toronto Canada BDS BSc MDS PhD FRSC

Difficulties with the diagnosis and management of acute and chronic pain conditions stem largely from uncertainties of the aetiology or pathogenesis of the conditions. Recent studies have provided some important new insights into the peripheral and central processes underlying pain, and this presentation will review some of the recent advances in our knowledge of the neural processes involved in pain of the orofacial region.

关键词：口面部疼痛机制三叉神经中枢损伤感受器