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Multitarget stool DNA for colorectal cancer screening:A review and commentary on the United States Preventive Services Draft Guidelines

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World journal of Gastrointestinal Oncology 2016年第5期8卷 450-458页

作者： barry M Berger Bernard Levin Robert j Hilsden Medical Affairs Exact Sciences Corporation Scientific Advisory Board Exact Sciences Departments of Medicine and Community Health Sciences University of Calgary

Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).The United States Preventive Services Task Force(USPSTF) October 2015 draft recommendation for CRC screening included mt-s DNA as an "alternative" screening test that "may be useful in select clinical circumstances",despite its very high sensitivity for early stage *** evidence supporting mt-s DNA for routine screening use is *** clinical efficacy of mt-s DNA as measured by sensitivity,specificity,life-years gained(LYG),and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document,especially those requiring annual testing *** a population with primarily irregular screening participation,tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual *** paper reviews the evidence supporting mt-s DNA for routine screening and demonstrates,using USPSTF's modeling data,that mt-s DNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing,high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening.

关键词： Colorectal cancer screening Multitarget stool DNA Stool DNA The United States Preventive Services Task Force Cancer Intervention Surveillance Modeling Network Fecal immunological technique Modeling Interval

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Molecular mechanisms of liver ischemia reperfusion injury:Insights from transgenic knockout models

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World journal of Gastroenterology 2013年第11期19卷 1683-1698页

作者： Gourab Datta barry j Fuller Brian R Davidson Liver Transplantation and Hepatobiliary Unit Division of Surgery and Interventional ScienceRoyal Free CampusUniversity College LondonRoyal Free Hampstead NHS Trust HospitalLondon NW 2QGUnited Kingdom

Ischemia reperfusion injury is a major obstacle in liver resection and liver transplantation *** the mechanisms of liver ischemia reperfusion injury(IRI) and developing strategies to counteract this injury will therefore reduce acute complications in hepatic resection and transplantation,as well as expanding the potential pool of usable donor *** initial liver injury is initiated by reactive oxygen species which cause direct cellular injury and also activate a cascade of molecular mediators leading to microvascular changes,increased apoptosis and acute inflammatory changes with increased hepatocyte *** adaptive pathways are activated during reperfusion that reduce the reperfusion *** involves a complex interplay between neutrophils,natural killer T-cells cells,CD4+ T cell subtypes,cytokines,nitric oxide synthases,haem oxygenase-1,survival kinases such as the signal transducer and activator of transcription,Phosphatidylinositol 3-kinases/Akt and nuclear factor κβ *** animals,particularly genetic knockout models,have become a powerful tool at elucidating mechanisms of liver ischaemia reperfusion injury and are complementary to pharmacological *** disruption of the protein at the genetic level is more specific and maintained than pharmacological inhibitors or stimulants of the same *** article reviews the evidence from knockout models of liver IRI about the cellular and molecular mechanisms underlying liver IRI.

关键词： Liver Ischemia/reperfusion Transgenic Knockout Nitric oxide synthase Haem oxygenase Mitogen-activated protein kinase T cell receptor

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Nuclear Cardiology, The Basics 2nd ed. 2008

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丛书名： Contemporary Cardiology

2008年

作者： Frans j Th Wackers Wendy Bruni barry Zaret

ISBN:9781597452625

ISBN: (数字)9781597452625

ISBN: (纸本)9781588299246

ISBN:9781597452625

关键词： Laboratories

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Structural Thermal Stability of Graphene Oxide-Doped Copper–Cobalt Oxide Coatings as a Solar Selective Surface

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journal of Materials Science & Technology 2016年第11期32卷 1179-1191页

作者： M.Mahbubur Rahman Zhong-Tao jiang Chun-Yang Yin Lee Siang Chuah Hooi-Ling Lee Amun Amri Bee-Min Goh barry j.Wood Chris Creagh Nicholas Mondinos Mohmmednoor Altarawneh Bogdan Z.Dlugogorski Surface Analysis and Materials Engineering Research Group School of Engineering & Information Technology Murdoch University Murdoch Western Australia 6150 Australia School of Sdence & Engineering Teesside University Borough Road Middlesbrough TSI 3BA United Kingdom Department of Physics School of Distance Education Universiti Sains Malaysia Minden 11800 Penang Malaysia Department of Chemistry School of Chemical Sciences Universiti Sains Malaysia Minden 11800 Penang Malaysia Department of Chemical Engineering Universitas Riau Pekanharu Indonesia School of Chemistry Bedson Building Newcastle University NE1 7RU United Kingdom School of Chemistry The University of Queensland St. Luda OLD 4072 Australia School of Engineering & Information Technology Murdoch University Murdoch Western Australia 6150 Australia

3d transition metal oxides based thin film coatings such as copper–cobalt oxides exhibit high absorption in the visible region and low emittance in the infrared to far-infrared region of the solar spectrum which is favourable for use as potential selective surface materials in photothermal devices. These materials have the potential to minimize heating while increasing absorption in the operative spectrum range and therefore achieve higher solar selectivity. A series of mixed copper–cobalt metal spinel oxides（Cu_xCo_yO_z）doped with graphene oxide thin films were deposited on commercial grade aluminium substrates using a sol-gel dip-coating technique at an annealing temperature of 500 °C in air for 1 h. Characterizations of the synthesized films were carried out by high temperature synchrotron radiation X-ray Diffraction（SRXRD）, UV–Vis, Fourier Transform infrared spectroscopy（FTIR） and X-ray photoelectron microscopy（XPS）techniques. High thermal stability of coatings with multiple phases, binary and ternary metal oxides, was defined through SR-XRD study. FTIR analysis shows moderate（〈80%） to high（up to 99%） reflectance in the infrared region while the UV–Vis investigations demonstrate that, in the visible region, solar absorption increases gradually（up to 95%） with the addition of graphene oxide to the Cu_x Co_y O_z *** the incorporation of 1.5 wt.% of graphene oxide to the copper–cobalt oxide coatings, a high solar selectivity of 29.01（the ratio of the average solar absorptance in visible and the average thermal emittance in infrared to far infrared region; α/ε） was achieved.

关键词： Coatings Sol-gel method Synchrotron radiation Fourier transform infrared spectroscopy X-ray diffraction X-ray photoelectron spectroscopy

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重症监护:权衡利益和风险,促进明智决策

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英国医学杂志中文版 2019年第13期22卷 198-200页

作者： jamie Gross barry Williams Premila Fade Stephen j Brett 邓璇(译) 莫云凌(校) London North West University Healthcare NHS Trust Watford Road Harrow HA1 3UJ UK Bishops Caundle Dorset Centre for Perioperative Medicine and Critical Care Research Imperial College Healthcare NHS Trust Hammersmith Hospital Du Cane Road London W12 0HS UK 航空医学研究所附属医院

jammie Gross和他的同事们认为:需要做出更多努力,与医疗社区和公众进行更广泛的交流,使人们了解重症监护能够达到什么样的效果,达不到什么样的预期。人口结构的不断改变以及慢性病管理的逐步改善,导致重症监护病房(ICU)收治的患者中,... 详细信息

jammie Gross和他的同事们认为:需要做出更多努力,与医疗社区和公众进行更广泛的交流,使人们了解重症监护能够达到什么样的效果,达不到什么样的预期。人口结构的不断改变以及慢性病管理的逐步改善,导致重症监护病房(ICU)收治的患者中,同时伴有慢性病和虚弱的比例越来越高。这直接造成人们对重症监护服务的需求大幅增加,并以每年大约4%的速度稳步增长。而ICU的病床数量有限,致使紧急手术被取消,一些患者不得不因非临床原因转移到其他医疗单位。鉴于重症监护是一种昂贵的医疗资源,存活者的医疗费用通常远远超出住院费用范围,这种趋势不太可能持续下去。

关键词：重症监护病房慢性病管理风险利益权衡医疗单位人口结构紧急手术

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Predicting an Athlete’s Physiological and Haematological Response to Live High-Train High Altitude Training Using a Hypoxic Sensitivity Test

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journal of Science in Sport and Exercise 2022年第4期4卷 371-385页

作者： Gareth Turner Kate L.Spilsbury David j.Green barry W.Fudge jamie S.M.Pringle Alan j.Richardson Neil S.Maxwell Environmental Extreme Laboratory University of BrightonEastbourneUK English Institute of Sport Bisham AbbeyUK Queensland Academy of Sport BrisbaneAustralia English Institute of Sport LoughboroughUK Aspire Academy DohaQatar University of Birmingham BirminghamUK

Purpose Elite endurance runners frequently utilise live high-train high(LHTH)altitude training to improve endurance per-formance at sea level(SL).Individual variability in response to the hypoxic exposure have resulted in contradictory *** the present case study,changes in total haemoglobin mass(tHbmass)and physiological capacity,in response to 4-weeks of LHTH were *** tested if a hypoxic sensitivity test(HST)could predict altitude-induced adaptations to *** Fifteen elite athletes were selected to complete 4-weeks of LHTH(~2400 m).Athletes visited the laboratory for preliminary testing(PRE),to determine lactate threshold(LT),lactate turn point(LTP),maximal oxygen uptake VO_(2max)and *** LHTH,athletes completed daily physiological measures[arterial oxygen saturation(SpO2)and body mass]and subjective wellbeing *** was repeated,for those who completed the full camp,post-LHTH(POST).Additionally,athletes completed the HST prior to *** A difference(Pjury or *** HST did however,estimate changes in tHbmass and VO_(2max).HST prior to LHTH could allow coaches and practitioners to better inform the acclimatisation strategies and train-ing load application of endurance runners at altitude.

关键词： Altitude training Runners Endurance Haemoglobin mass Performance Hypoxic sensitivity

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新疆鸟类环志与回收

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Zoological Research 2002年第2期23卷 105-105,106,112,135页

作者：马鸣 Pau j.LEADER Geoff j.CAREY barry WILLIAMS 中国科学院新疆生态与地理研究所新疆乌鲁木齐830011 香港观鸟会

20 0 1年 8月 14～ 2 6日在新疆阿勒泰、吐鲁番的 8个环志地点进行了秋季鸟类环志工作。环志鸟类2 33只 ,约 33种 ,多以莺亚科 (Sylviinae)和鸫亚科 (Turdinae)的种类为主。其中的新疆歌鸲 (Lusciniasp )等 17种鸟类均属于中国首次环志... 详细信息

20 0 1年 8月 14～ 2 6日在新疆阿勒泰、吐鲁番的 8个环志地点进行了秋季鸟类环志工作。环志鸟类2 33只 ,约 33种 ,多以莺亚科 (Sylviinae)和鸫亚科 (Turdinae)的种类为主。其中的新疆歌鸲 (Lusciniasp )等 17种鸟类均属于中国首次环志种类 ,占环志种数的 5 3%。

关键词：鸟类环志新疆回收

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肥厚型心肌病心房颤动：决定因素、临床进程与处理

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中华心血管病杂志 2009年第4期37卷 303-307页

作者： Iacopo Olivotto Paolo DiDonna Aurelio Sgalambro Massimo Baldi barry j Maron Franco Cecchi Florence 50132 Referral Center for Myocardial Diseases Careggi University Hospital Division of Cardiology Cardinal Massaia Hospital Hypertrophic Cardiomyopathy Center Minneapolis Heart Institute Foundation

心房颤动（房颤）是一个全球性健康问题，东西方患病率相同，反映人群老化，心血管病负担加重。在肥厚型心肌病（HCM）患者中，房颤是最常见的持续性心律不齐，最常见的并发症之一，对临床病程与预后影响很大。房颤成为HCM治疗的棘手问... 详细信息

心房颤动（房颤）是一个全球性健康问题，东西方患病率相同，反映人群老化，心血管病负担加重。在肥厚型心肌病（HCM）患者中，房颤是最常见的持续性心律不齐，最常见的并发症之一，对临床病程与预后影响很大。房颤成为HCM治疗的棘手问题，特别年轻患者，需要一致的循证治疗策略。尽管HCM房颤的循证依据不多，近期证据提示，新的治疗方法给某些患者带来了希望。

关键词：肥厚型心肌病心房颤动临床病程全球性健康问题循证治疗心血管病心律不齐年轻患者

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Changes in insomnia severity with advanced PAP therapy in patients with posttraumatic stress symptoms and comorbid sleep apnea:A retrospective,nonrandomized controlled study

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Military Medical Research 2019年第4期6卷 308-319页

作者： barry j.Krakow Natalia D.McIver jessica j.Obando Victor A.Ulibarri Sleep&Human Health Institute 6739 Academy Rd NE Ste380AlbuquerqueNM 87109USA Maimonides Sleep Arts&Sciences 6739 Academy Rd NE Ste380AlbuquerqueNM 87109USA Los Alamos Medical Center 3917 W RdLos AlamosNM 87544USA Institution:Mozaik Solutions Solana BeachCA 92075USA

Background:Sleep disorders frequently occur in posttraumatic stress disorder(PTSD)*** insomnia is a common feature of and criteria for the diagnosis of *** sleep disorder,obstructive sleep apnea(OSA),also occurs frequently in PTSD,and emerging research indicates OSA fuels chronic *** research has investigated the impact of OSA treatment on insomnia outcomes(Insomnia Severity Index,ISI)in trauma ***:OSA patients with moderately severe posttraumatic stress symptoms were studied in a retrospective chart ***-six patients who failed CPAP therapy due to expiratory pressure intolerance or complex sleep apnea or both underwent manual titration with advanced PAP modes[autobilevel(ABPAP);adaptive servo-ventilation(ASV)],which were subsequently *** use measured by objective data downloads divided the sample into three groups:compliant regular users(C-RU):n=68;subthreshold users(SC-RU):n=12;and noncompliant users(NC-MU):n=*** average follow-up was 11.89±12.22 *** and posttreatment ISI scores were analyzed to assess residual insomnia symptoms as well as cure ***:The C-RU group showed significant improvements in insomnia with very large effects compared to those in the NC-MU reference group(P=0.019).Insomnia severity significantly decreased in all three groups with large effects(C-RU,P=0.001;SC-RU,P=0.027;NC-MU,P=0.007).Hours of weekly PAP use and insomnia severity were inversely correlated(P=0.001,r=–0.321).However,residual insomnia symptoms based on established ISI cut-offs were quite common,even among the C-RU *** hoc analysis showed that several categories of sedating medications reported at baseline(hypnotics,anti-epileptic,opiates)as well as actual use of any sedating medication(prescription or nonprescription)were associated with smaller insomnia improvements than those in patients not using any sedating ***:In a retrospective,nonrandomized analysis of a selec

关键词： Insomnia Obstructive sleep apnea Complex insomnia CBT-I Posttraumatic stress symptoms CPAP Auto bi-level Adaptive servo-ventilation

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Clinical laboratory and imaging evidence for effectiveness of agarose-agarose macrobeads containing stem-like cells derived from a mouse renal adenocarcinoma cell population (RMBs) in treatment-resistant, advanced metastatic colorectal cancer:Evaluation of

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Chinese journal of Cancer Research 2018年第1期30卷 72-83页

作者： barry H.Smith Lawrence S.Gazda Thomas j.Fahey Angelica Nazarian Melissa A.Laramore Prithy Martis Zoe P.Andrada joanne Thomas Tapan Parikh Sudipta Sureshbabu Nathaniel Berman Allyson j.Ocean Richard D.Hall David j.Wolf The Rogosin Institute New York NY 10021 USA The Rogosin Institute-Xenia Division Xenia OH 45385 USA New York Presbyterian-Weill Cornell Medical Center New York NY 10021 USA Bob Evans Farms Inc. New Albany OH 43054 USA

Objective： The complexity, heterogeneity and capacity of malignant neoplastic cells and tumors for rapid change and evolution suggest that living-cell-based biological-systems approaches to cancer treatment are merited. Testing this hypothesis, the tumor marker, metabolic activity, and overall survival（OS） responses, to the use of one such system, implantable macrobeads [RENCA macrobeads（RMBs）], in phase I and IIa clinical trials in advanced,treatment-resistant metastatic colorectal cancer（m CRC） are described ***： Forty-eight m CRC patients（30 females; 18 males）, who had failed all available, approved treatments,underwent RMB implantation（8 RMB/kg body weight） up to 4 times in phase I and phase IIa open-label ***, labs [tumor and inflammation markers, lactate dehydrogenase（LDH）] and positron emission tomography-computed tomography（PET-CT） imaging to measure number/volume and metabolic activity of the tumors were performed pre-and 3-month-post-implantation to evaluate safety and initial efficacy（as defined by biological responses）. PET-CT maximum standard uptake value（SUVmax）（baseline and d 90; SUVmax ≥2.5）, LDH,and carcinoembryonic antigen（CEA） and/or cancer antigen 19-9（CA 19-9） response（baseline, d 30 and/or d 60）were assessed and compared to ***： Responses after implantation were characterized by an at least 20% decrease in CEA and/or CA 19-9 in75% of patients. Fluorodeoxyglucose（FDG）-positive lesions（phase I, 39; 2 a, 82） were detected in 37/48 evaluable patients, with 35% stable volume and stable or decreased SUV（10） plus four with necrosis; 10, increased tumor volume, SUV. LDH levels remained stable and low in Responders（R）（d 0–60, 290.4–333.9）, but increased steadily in Non-responders（NR）（d 0–60, 382.8–1,278.5）（d 60, P=0.050）. Responders to RMBs, indicated by the changes in the above markers, correlated with OS（R mean OS=10.76 months; NR mean OS=4.9 months; P=0.0006）.Conclusions： The correlations of the tumor marker, tumor volume

关键词： Clinical trial systems-biology RENCA macrobeads metastatic colorectal cancer colon cancer

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