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Histone Acetylation, VERNALIZATION INSENSITIVE 3, FLOWERING LOCUS C, and the Vernalization Response

Molecular Plant 2009年第4期2卷 724-737页

作者： Donna M. Bond Elizabeth S. Dennis barry j. pogson E. j.an Finnegan CSIRO Plant Industry Canberra Australia ARC Centre of Excellence in Plant Energy Biology School of Biochemistry and Molecular Biology Australian National University Canberra Australia

The quantitative induction of VIN3 by low temperatures is required for PRC2 repression of FLC and promotion of flowering （vernalization） in Arabidopsis. Histone acetylation, a chromatin modification commonly associated with gene transcription, increased on VIN3 chromatin in two spatially and temporally distinct phases in response to low temperatures. During short-term cold exposure, histone H3 acetylation at the transcription start site rapidly increased, implying that it is required for VlN3 induction. Subsequent changes in histone H3 and H4 acetylation occurred following continued VIN3 transcription during prolonged cold exposure. Members of the SAGA-like transcriptional adaptor complex, including the histone acetyltransferase GCNS, which induces expression of the cold acclimation pathway genes, do not regulate VlN3 induction during cold exposure, indicating that the cold acclimation pathway and the cold-induction of VlN3 are regulated by different transcriptional mechanisms. Mutations in the other 11 histone acetyltransferase genes did not affect VlN3 induction. However, nicotinamide, a histone deacetyiase inhibitor, induced VIN3 and altered histone acetylation at the VIN3 locus. VIN3 induction was proportional to the length of nicotinamide treatment, which was associated with an early-flowering phenotype and repression of FLC. However, unlike vernalization, the repression of FLC was independent of VIN3 activity. Nicotinamide treatment did not cause a change in the expression of any genes in the autonomous pathway or members of the PRC2 complex, the well characterized repressors of FLC. Our data suggest that FLC is repressed via a novel pathway involving the SIR2 class of histone deacetylases.

关键词： Cold acclimation histone acetyltransferase histone deacetylase SIR2 nicotinamide.

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Transcriptional Control of SET DOMAIN GROUP 8 and CAROTENOID ISOMERASE during Arabidopsis Development

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Molecular Plant 2010年第1期3卷 174-191页

作者： Christopher I. Cazzonelli Andrea C. Roberts Melanie E. Carmody barry j. pogson Australian Research Council Centre of Excellence in Plant Energy Biology Research School of Biology The Australian National University Canberra ACT0200 Australia

Carotenoids are pigments required for photosynthesis, photoprotection and the production of carotenoid- derived hormones such as ABA and strigolactones. The carotenoid biosynthetic pathway bifurcates after lycopene to produce epsilon- and beta-carotenoids and this branch is critical for determining carotenoid composition. Here, we show how the branch point can be regulated by the chromatin-modifying histone methyltransferase, Set Domain Group 8 （SDG8） targeting the carotenoid isomerase （CRTISO）. SDG8 is required to maintain permissive expression of CRTISO during seedling development, in leaves, shoot apex, and some floral organs. The CRTISO and SDG8 promoters show overlapping tissue-specific patterns of reporter gene activity. Interestingly, CRTISO showed atypical reporter gene expression in terms of greater variability between different lines compared to the Cauliflower Mosaic Virus 35S promoter （CaMV35s） and ~LCY promoters, potentially due to chromosomal position effects. Regulation of the CRTISO promoter was dependent in part upon the presence or absence of SDG8. Knockouts of SDG8 （carotenoid and chloroplast regulation （ccrl）） and CRTISO （ccr2） result in altered carotenoid composition and this could be restored in ccr2 using the CaMV35s or CRTISO promoters. In contrast, varying degrees of GUS expression and carotenoid complementation by CRTISO overexpression using CaMV35S or CRTISO promoters in the ccrl background demonstrated that both the CRTISO promoter and open reading frame are necessary for SDG8-mediated expression of CRTISO.

关键词： Photosynthesis secondary metabolism--terpenoids, isoprenoids, and carotenoids chloroplast biology epigenetics gene expression gene regulation.

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C. H. Pander＇s introduction to conodonts, 1856

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Episodes 2008年第4期31卷 429-432页

作者： Sweet, Walter C. Cooper, barry j. School of Earth Sciences The Ohio State University Columbus OH 43210 United States Primary Industries and Resources South Australia Adelaide SA 5001 GPO Box 1671 Australia

It is rare in the annals of science for a single publication to provide a definitive introduction to a previously unknown group of animals. Yet this was the case with the monograph that included the initial descriptions of an important, extinct group of fossil animals： the conodonts. The publication, by Christian Heinrich Pander, appeared in St Petersburg in 1856. The volume of ninety-one pages, written in German and accompanied by seven beautifully executed plates, was issued by the Imperial Academy of Sciences as part of a series entitled Geognostische Beschreibung der Russisch-Baltischen Gouvernements.

关键词：动物科学动物化石牙形石科学研究

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THIGEMINAL MECHANISMS OF OROFACIAL PAIN

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神经解剖学杂志 2001年第B7期17卷 35-36页

作者： barry j. SESSLE Department of Physiology Faculty of Dentistry University of Toronto Canada BDS BSc MDS PhD FRSC

Difficulties with the diagnosis and management of acute and chronic pain conditions stem largely from uncertainties of the aetiology or pathogenesis of the conditions. Recent studies have provided some important new insights into the peripheral and central processes underlying pain, and this presentation will review some of the recent advances in our knowledge of the neural processes involved in pain of the orofacial region.

关键词：口面部疼痛机制三叉神经中枢损伤感受器

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A History of Fischer-Tropsch Wax Upgrading at BP-from Catalyst Screening Studies to Full Scale Demonstration in Alaska

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j.urnal of Natural Gas Chemistry 2006年第1期15卷 1-10页

作者： j.hn P. Collins j.ep j. H. M. Font Freide barry Nay BP Exploration America Inc. BP Exploration Operating Company

Conversion of Fischer-Tropsch wax into high quality synthetic crude or finished transportation fuels such as premium diesel has been studied over the past 15 years within BP. Catalyst screening and selection was carried out in dedicated micro-reactors and pilot plants, whose designs are critical to the performance selection. Variation in catalyst composition and defining the gas to oil feed ratios with the operating temperature are a few of the parameters studied. Product selection and maximizing diesel yield combined with stability （catalyst life） were the ultimate drivers. The selected catalyst was then tested under commercial conditions in a dedicated 300 barrel per day demonstration plant. The products were also tested in engines to assess their combustion characteristics.

关键词： Fischer-Tropsch wax upgrading hydrocracking synthetic crude diesel naphtha engine emission

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Unifying the Software Process Spectrum

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软件学报 2006年第4期17卷 649-657页

作者： Mingshu Li barry W. Boehm Leon j. Osterweil State Key Lab of Computer Science and Lab. for Internet Software Technologies Institute of Software at Chinese Academy of Sciences Beijing 100080 China University of Southern California CA 90089-0781 USA University of Massachusetts Amherst Amherst MA 01003 USA

Software Process Workshop (SPW 2005) was held in Beij.ng on May 25-27, 2005. This paper introduces the motivation of organizing such a workshop, as well as its theme and paper gathering and review; and summarizes the main content and insights of 11 keynote speeches, 30 regular papers in five sessions of “Process Content”, “Process Tools and Metrics”, “Process Management”, “Process Representation and Analysis”, and “Experience Reports”, 8 software development support tools demonstration, and the ending panel “Where Are We Now? Where Should We Go Next?”.

关键词：软件处理微处理宏处理过程表征

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Robustness Assessment and Adaptive FDI for Car Engine

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International j.urnal of Automation and computing 2008年第2期5卷 109-118页

作者： Mahavir Singh Sangha j.barry Gomm Control Systems Research Group School of EngineeringLiverpool John Moores University

A new on-line fault detection and isolation （FDI） scheme proposed for engines using an adaptive neural network classifier is evaluated for a wide range of operational modes to check the robustness of the scheme in this paper. The neural classifier is adaptive to cope with the significant parameter uncertainty, disturbances, and environment changes. The developed scheme is capable of diagnosing faults in on-line mode and the FDI for the closed-loop system with can be directly implemented in an on-board crankshaft speed feedback is investigated by diagnosis system （hardware）. The robustness of testing it for a wide range of operational modes including robustness against fixed and sinusoidal throttle angle inputs, change in load, change in an engine parameter, and all these changes occurring at the same time. The evaluations are performed using a mean value engine model （MVEM）, which is a widely used benchmark model for engine control system and FDI system design. The simulation results confirm the robustness of the proposed method for various uncertainties and disturbances.

关键词： On-board fault diagnosis automotive engines adaptive neural networks (ANNs) fault classification robustness assessment

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Multitarget stool DNA for colorectal cancer screening:A review and commentary on the United States Preventive Services Draft Guidelines

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World j.urnal of Gastrointestinal Oncology 2016年第5期8卷 450-458页

作者： barry M Berger Bernard Levin Robert j.Hilsden Medical Affairs Exact Sciences Corporation Scientific Advisory Board Exact Sciences Departments of Medicine and Community Health Sciences University of Calgary

Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).The United States Preventive Services Task Force(USPSTF) October 2015 draft recommendation for CRC screening included mt-s DNA as an "alternative" screening test that "may be useful in select clinical circumstances",despite its very high sensitivity for early stage *** evidence supporting mt-s DNA for routine screening use is *** clinical efficacy of mt-s DNA as measured by sensitivity,specificity,life-years gained(LYG),and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document,especially those requiring annual testing *** a population with primarily irregular screening participation,tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual *** paper reviews the evidence supporting mt-s DNA for routine screening and demonstrates,using USPSTF's modeling data,that mt-s DNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing,high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening.

关键词： Colorectal cancer screening Multitarget stool DNA Stool DNA The United States Preventive Services Task Force Cancer Intervention Surveillance Modeling Network Fecal immunological technique Modeling Interval

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Molecular mechanisms of liver ischemia reperfusion inj.ry:Insights from transgenic knockout models

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World j.urnal of Gastroenterology 2013年第11期19卷 1683-1698页

作者： Gourab Datta barry j.Fuller Brian R Davidson Liver Transplantation and Hepatobiliary Unit Division of Surgery and Interventional ScienceRoyal Free CampusUniversity College LondonRoyal Free Hampstead NHS Trust HospitalLondon NW 2QGUnited Kingdom

Ischemia reperfusion inj.ry is a maj.r obstacle in liver resection and liver transplantation *** the mechanisms of liver ischemia reperfusion inj.ry(IRI) and developing strategies to counteract this inj.ry will therefore reduce acute complications in hepatic resection and transplantation,as well as expanding the potential pool of usable donor *** initial liver inj.ry is initiated by reactive oxygen species which cause direct cellular inj.ry and also activate a cascade of molecular mediators leading to microvascular changes,increased apoptosis and acute inflammatory changes with increased hepatocyte *** adaptive pathways are activated during reperfusion that reduce the reperfusion *** involves a complex interplay between neutrophils,natural killer T-cells cells,CD4+ T cell subtypes,cytokines,nitric oxide synthases,haem oxygenase-1,survival kinases such as the signal transducer and activator of transcription,Phosphatidylinositol 3-kinases/Akt and nuclear factor κβ *** animals,particularly genetic knockout models,have become a powerful tool at elucidating mechanisms of liver ischaemia reperfusion inj.ry and are complementary to pharmacological *** disruption of the protein at the genetic level is more specific and maintained than pharmacological inhibitors or stimulants of the same *** article reviews the evidence from knockout models of liver IRI about the cellular and molecular mechanisms underlying liver IRI.

关键词： Liver Ischemia/reperfusion Transgenic Knockout Nitric oxide synthase Haem oxygenase Mitogen-activated protein kinase T cell receptor

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Escherichia coli-host macrophage interactions in the pathogenesis of inflammatory bowel disease

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World j.urnal of Gastroenterology 2014年第27期20卷 8751-8763页

作者： Ahmed Tawfik Paul K Flanagan barry j.Campbell Department of Gastroenterology Institute of Translational Medicine University of Liverpool

Multiple studies have demonstrated alterations in the intestinal microbial community (termed the microbiome) in Crohn’s disease (CD) and several lines of evidence suggest these changes may have a significant role in disease pathogenesis. In active and quiescent disease, both the faecal and mucosa-associated microbiome are discordant with matched controls with reduced biodiversity, changes in dominant organisms and increased temporal variation described. Mucosa-associated adherent, invasive Escherichia coli (E. coli) (AIEC), pro-inflammatory and resistant to killing by mucosal macrophages, appear to be particularly important. AIEC possess several virulence factors which may confer pathogenic potential in CD. Type-1 pili (FimH) allow adherence to intestinal cells via cell-surface carcinoembryonic antigen-related cell adhesion molecules and possession of long polar fimbrae promotes translocation across the intestinal mucosa via microfold (M)-cells of the follicle-associated epithelium. Resistance to stress genes (htrA, dsbA and hfq) and tolerance of an acidic pH may contribute to survival within the phagolysosomal environment. Here we review the current understanding of the role of mucosa-associated E. coli in Crohn’s pathogenesis, the role of the innate immune system, factors which may contribute to prolonged bacterial survival and therapeutic strategies to target intracellular E. coli.

关键词： Crohn's disease Inflammatory bowel disease Escherichia coli Intra-macrophage survival and replication Phagolysosome Autophagy

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