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w.AT I LEARNED FROM BRITTON CHANCE

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 223-226页

作者： barry R.MASTERS Department of the History of Science Harvard UniversityCambridgeMA 02138USA Department of Biological Engineering Massachusetts Institute of Technology CambridgeMA 02139USA

In this personal and reflective article,I honor the memory of Britton Chance and explain how.his mentorship during my tenure at the Johnson Research Foundation greatly impacted my scientific career.I emphasize the critical role of mentors on the development of scientists and present some w.nderful and remarkable attributes that characterized Britton Chance's scientific and personal style.

关键词： Britton Chance mentorship scientific attributes and style

Practice of Glycemic Self-Monitoring in Diabetic Patients Follow.d at the Endocrinology Department of Donka University Hospital in Guinea

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Open Journal of Endocrine and Metabolic Diseases 2024年第2期14卷 33-38页

作者： Mamadou Dian Mamoudou Diallo Mamadou Mansour Diallo Mamadou Chérif Diallo Alpha Mamadou Diallo Kadija Dieng Abdoul Mazid Diallo Mody Abdoulaye barry Kadidiatou Bah El’Hadj Zainoul Bah Mamadou Alpha Diallo Ibrahima Condé Ousmane Kourouma Amadou Kaké Diabetology Unit Labe Regional Hospital Labé Guinea Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinea Endocrinology and Diabetology Department of Donka University Hospital Conakry Guinea Pediatrics Department of Donka University Hospital Conakry Guinea

Diabetes is a chronic pathology w.ose evolution is marked by micro and macroangiopathic complications. Optimal management can prevent the onset of complications and improve patients’ quality of life. Objectives: To determine the frequency of self-monitoring of blood glucose and to describe the errors found during self-monitoring in diabetic patients follow.d at the Endocrinology Department of Donka University Hospital in Guinea. Materials and methods: Descriptive cross-sectional study carried out betw.en August and September 2020 involving diabetic patients follow.d up at the Endocrinology and Diabetology Department of the Donka National Hospital, CHU Conakry. Results: A total of 301 patients w.re enrolled, w.th an average age of 44.24 ± 21.01 years. 64.12% w.re female. Type 2 diabetes predominated in 64% of cases. The mean duration of diabetes w.s 6.14 ± 4.67 years, and 75.08% of patients lived in urban areas. Patients w.re on insulin in 36.21% of cases, insulin and biguanides (26.25%), hypoglycemic sulfonamide and biguanides (19.27%) and biguanides in 18.27% of cases. The frequency of self-monitoring of blood glucose w.s 43%, and 38% of patients made errors, notably reusing lancets (60%), not checking the expiration date (55.65%) and not w.shing their hands (48%). Conclusion: This study show. that self-monitoring of blood glucose is not performed by the majority of patients. Numerous errors w.re identified during blood glucose testing. Continued therapeutic education on the use of blood glucose meters w.ll help empow.r patients and improve their quality of life.

关键词： Self-Monitoring of Blood Glucose Diabetes Conakry University Hospital

Functional dyspepsia:Are psychosocial factors of relevance?

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w.rld Journal of Gastroenterology 2006年第17期12卷 2701-2707页

作者： Sandra barry Timothy G Dinan Department of Psychiatry and Alimentary Pharmacobiotic Centre University College Cork CorkIreland

The pathogenesis of Functional Dyspepsia （FD） remains unclear, appears diverse and is thus inadequately understood. Akin to other functional gastrointestinal disorders, research has demonstrated an association betw.en this common diagnosis and psychosocial factors and psychiatric morbidity. Conceptualising the relevance of these factors w.thin the syndrome of FD requires application of the biopsychosocial model of disease. Using this paradigm, dysregulation of the reciprocal communication betw.en the brain and the gut is central to symptom generation, interpretation and exacerbation. Appreciation and understanding of the neurobiological correlates of various psychological states is also relevant. The view.that psychosocial factors exert their influence in FD predominantly through motivation of health care seeking also persists. This appears too one-dimensional an assertion in light of the evidence available supporting a more intdnsic aetiological link. Evolving understanding of pathogenic mechanisms and the heterogeneous nature of the syndrome w.ll facilitate effective management. Co-morbid psychiatric illness w.rrants treatment w.th conventional therapies. Acknow.edging the relevance of psychosocial variables in FD, the degree of w.ich is subject to vadation, has implications for assessment and management. Available evidence suggests psychological therapies may benefit FD patients particularly those w.th chronic symptoms. The rationale for use of psychotropic medications in FD is apparent but the evidence base to support the use of antidepressant pharmacotherapy is to date limited.

关键词： Functional dyspepsia Psychosocial factors Psychiatry Pathophysiology

Application and evaluation of a pattern-based building energy model calibration method using public building datasets

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Building Simulation 2022年第8期15卷 1385-1400页

作者： Kaiyu Sun Tianzhen Hong Janghyun Kim barry Hooper Law.ence Berkeley National Laboratory BerkeleyCAUSA National Renew.ble Energy Laboratory GoldenCOUSA San Francisco Deportment of the Environment San FranciscoCAUSA

Building performance simulation has been adopted to support decision making in the building life *** essential issue is to ensure a building energy simulation model can capture the reality and complexity of buildings and their systems in both the static characteristics and dynamic *** energy model calibration is a technique that takes various types of measured performance data(e.g.,energy use)and tunes key model parameters to match the simulated results w.th the actual *** study performed an application and evaluation of an automated pattern-based calibration method on commercial building models that w.re generated based on characteristics of real buildings.A public building dataset that includes high-level building attributes(e.g.,building type,vintage,total floor area,number of stories,zip code)of 111 buildings in San Francisco,California,USA,w.s used to generate building models in *** level energy use calibrations w.re then conducted by comparing building model results against the actual buildings’monthly electricity and natural gas *** results show.d 57 out of 111 buildings w.re successfully calibrated against actual buildings,w.ile the remaining buildings show.d opportunities for future calibration *** to the pattern-based model calibration method are identified to expand its use for:(1)central heating,ventilation and air conditioning(HVAC)systems w.th chillers,(2)space heating and hot w.ter heating w.th electricity sources,(3)mixed-use building types,and(4)partially occupied buildings.

关键词： model calibration building energy modeling EnergyPlus building performance simulation monthly energy use

Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung

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分子细胞生物学报:英文版 2015年第1期7卷 35-47页

作者： Alexander w.Lange Anusha Sridharan Yan Xu barry R.Stripp Anne-Karina Perl Jeffrey A.w.itsett Division of Pulmonary Biology Cindinnati Children's Hospital Medical Center and the University of Cncinnati Collel ge of MedicineCincinnatiOH 452293039USA Cedars-Sinai Medical Center Los AngelesCA 90048USA

The Hippo/Yap pathw.yis a w.l-conserved signaling cascade that regulates cell proliferation and dfferentiationto control organsize and stem/progenitor cell *** airw.y injury,Yap w.s dynamically regulated in regenerating airw.y epithelial *** *** the role ofHippo signaling in the lung,the mammalian Hippo kinases,Mst1 and Mst2,w.re deleted in epithelial cells ofthe embry-onic and mature mouse ***1/2 deletion in the fetal lung enhanced proliferation and inhibited sacculation and epithelial cell *** transcriptional inhibition of cell proliferation and activation of differentiation during normal perinatal lung maturation w.re inversely regulated follow.ing embryonic Mst1/2 *** of Mst1/2 from bronchiolar epithelial cells in the adult lung caused airw.y hyperplasia and altered *** Yap phosphorylation w.s decreased and Yap nuclear localization and transcriptional targets w.re increased after Mst1/2 deletion,consistent w.th canonical Hippo/Yap *** potentiated cell prolif-eration and inhibited dfferentiation of human bronchial epithelial cells in *** of Mst1/2 and expression ofYAP regulated transcrip-tional targets controlling cell proliferation and diferentiation,including Ajuba LIM *** w.s required forthe effects ofYAP oncell proliferation in ***/Yapsignaling regulates Ajuba and controls proliferation and diferentiation oflung epithelial progenitor cells.

关键词： Hippo/Yap pathw.y lung Ajuba proliferation dfferetiation

Bioinformatics advances in saliva diagnostics

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International Journal of Oral Science 2012年第2期4卷 85-87页

作者： barry Smith David Tw.w.ng University of California at Los Angeles School of Dentistry and Dental Research Institute Center for Health SciencesUniversity of CaliforniaLos AngelesUSA Departmentof Philosophy University at BuffaloBuffaloUSA

There is a need recognized by the National Institute of Dental ＆ Craniofacial Research and the National Cancer Institute to advance basic, translational and clinical saliva research. The goal of the Salivaomics Know.edge Base （SKB） is to create a data management system and w.b resource constructed to support human salivaomics research. To maximize the utility of the SKB for retrieval, integration and analysis of data, w. have developed the Saliva Ontology and SDxMart. This article review. the informatics advances in saliva diagnostics made possible by the Saliva Ontology and SDxMart.

关键词： BioMart database ontology saliva

Isolated Ventricular Septal Defect: Ultrasound, Therapeutic and Evolutionary Aspects of 85 Cases in the Cardiology Department of the Ignace Deen National Hospital in Conakry

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w.rld Journal of Cardiovascular Diseases 2024年第8期14卷 465-479页

作者： Mamadou Bassirou Bah Amadou Diouldé Doumbouya Elhdj Yaya Balde Mamadou Aliou Balde Alpha Kone Ibrahima Sory Sylla Mamadou Dian Bah Aboulaye Bah Mamadou Diallo Thierno Siradjo Balde Abdoulaye Camara Morlaye Soumaoro Ibrahima Sory barry Souleymane Diakité Mamadou Dadhi Balde Cardiology Department of the Ignace Deen Hospital Conakry Guinea Cardiology Department Donka Hospital Conakry Guinea

Introduction: Ventricular septal defect (VSD) is the most common congenital heart disease of all congenital heart defects. The aim of this study w.s to investigate the echographic, therapeutic and evolutionary aspects of ventricular septal defects (VSD) in the general cardiology department of the Hôpital National Ignace Deen. Methods: A retrospective data collection w.s carried out from January 2018 to December 2023 including 85 cases of isolated IVC w.s performed. The variables studied w.re epidemiological, clinical, paraclinical, therapeutic and evolutionary. Results: Of the 320 patients seen during the study period for congenital heart disease, 85 (26.556%) w.re isolated IVCs. Age at diagnosis ranged from 3 months to 16 years, w.th an average age of 3.59 years. The most represented ethnic group w.s the Fulani (50.58%). The 8.24% came from consanguineous marriage versus 22.35%. 91.76% of children had a history of bronchitis. The most common clinical signs found w.re systolic murmur (90.58%), grow.h retardation (51.76%). Only 4 cases (4.70%) had a malformation associated w.th IVC represented by DiGeorges disease (2.35%) and trisomy 21 (2.35%). Nearly half the patients had type IIb VIC (44.71%). The other half w.re represented by type 1 (18.82%), type IIa (20%), type III (10.59%) and type IV (5.88%). According to site more than tw.-thirds of VICs (71.64%) w.re perimembranous in location, follow.d by infundibular (16.47%) and muscular (11.76%) VICs. In our study 55.29% presented an indication for both surgical intervention and medical treatment, w.ile 16.47% required only medical treatment. In contrast, 28.23% w.re placed under exclusive surveillance. Of the 47 patients for w.om surgery w.s indicated, 29 (61.17%) underw.nt surgical repair, w.ile 18 (38.83%) w.re aw.iting confirmation for surgery. Conclusion: VIC is the most common congenital heart disease. An early detection strategy and the establishment of specialized centers could improve the outcome of these chil

关键词： Ventricular Septal Defect Congenital Heart Disease Ignace Deen

Coronaviruses in pregnant w.men in Saudi Arabia:A systematic comparative review.of MERS-CoV and SARS-CoV-2

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Asian pacific Journal of Reproduction 2021年第3期10卷 97-101页

作者： Mazin barry Magdoleen A.barry Division of Infectious Diseases Department of MedicineCollege of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Obstetrics and Gynecology King Salman HospitalMinistry of HealthRiyadhSaudi Arabia

Objective:To compare the effects of coronaviruses,such as Middle East respiratory syndrome coronavirus(MERS-CoV)or coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),on pregnant w.men in Saudi Arabia,and to understand the disease dynamics of these coronaviruses so as to konw.how.to provide care and management of infected pregnant w.men and ***:w. conducted a systematic review.of all published papers on MERS-CoV and SARS-CoV-2 infections in pregnant w.men in Saudi Arabia to identify know.edge *** and exclusion criteria w.re based on the PRISMA *** search included all papers w.ich w.re published betw.en September 1,2012 and November 29,2020 on pregnant w.men w.th MERS-CoV and/or COVID-19 in Saudi *** 26 papers screened,five w.re included in the ***:A total of 11 pregnant w.men w.th MERS-CoV and four w.th COVID-19 w.re reported in Saudi Arabia in the medical literature during the review.*** mean ages of the w.men w.re 33 and 31 years old for MERS-CoV and COVID-19,*** and fetal mortality in cases of MERSCoV w.re 35%and 30%,respectively,w.ile no maternal or fetal mortalities w.re reported in COVID-19 ***:Very limited data has emerged from Saudi Arabia on pregnant w.men MERS-CoV and *** such high mortality observed w.th MERS-CoV compared to COVID-19,there is a need for greater reporting of cases to truly grasp the extent of these infections in pregnant w.men in a country w.ere both coronaviruses are circulating.

关键词： MERS-CoV SARS-CoV-2 COVID-19 Pregnant w.men

POLICING CORRUPTION AND ECONOMIC CRIME -- How.CAN w. DO IT BETTER？

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Frontiers of Law.in China-Selected Publications from Chinese Universities 2015年第4期10卷 625-656页

作者： barry Rider Univ Cambridge Ctr Dev Studies Cambridge CB2 1TN England BPP Univ Law London England Renmin Univ China Comparat Law Beijing Peoples R China Univ Free State Mercantile Law Bloemfontein South Africa Univ London Inst Adv Legal Studies London WC1E 7HU England

w.ile history records that economically motivated crime and misconduct in its various forms has existed since the earliest civilizations and has alw.ys raised issues of fairness and integrity, in recent years addition...

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