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Model of Mediating Determinants of Time Differences in INDYCAR

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Journalism and Mass Communication 2024年第4期14卷 232-240页

作者： Wilfrido Isidro Aldana Balderas Héctor Daniel Molina Ruiz Enrique Martínez Muñoz Eleazar Villegas González Tirso Javier Hernández Gracia Arturo Sánchez Sánchez Cruz García Lirios Alfredo barrera Escobar University of México HuehuetocaMèxico University of Hidalgo PachucaMèxico University of Tlaxcala Mèxico University of CDMX Mexico University of FV Mexico

The IndyCar series distinguishes itself by providing the same design and operation of the single-seater to its *** difference in times is then attributable to the skills of the drivers,but considering the data from the races could test this *** objective of this work was to establish a trajectory model to predict race times.A cross-sectional,correlational,and explanatory work was carried out with a sample of 18,474 records in the period from 2020 to 2023 of the IndyCar *** results show that the time span predicts the time *** relation to the studies of acceptance of the technology,the adjustment of this to human capacities to explain the time differences in the series of racing cars is discussed.

关键词： time differences ranking differences ranking race time laps completed

Influence of microbial priming and seeding depth on germination and growth of native wildflowers

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Ecological Processes 2021年第1期10卷 266-273页

作者： Daniela barrera Juan Luera Kaitlynn Lavallee Pushpa Soti Mathematics and Science Academy University of Texas-Rio Grande ValleyEdinburg 78539USA Sharyland Pioneer High School MissionTX 78573USA. Department of Biology University of Texas-Rio Grande ValleyEdinburgTX 78539USA. School of Earth Environmentand Marine SciencesUniversity of Texas-Rio Grande ValleyEdinburgTX 78539USA.

Background:Using native wildflowers for restoring marginal lands has gained considerable *** of wildflowers can be challenging due to several environmental *** the microbial community in degraded habitats can potentially result in the native plant performance and habitat *** study was conducted to investigate the impact of native soil microbes and seeding depth on germination of south Texas native *** wildflower species,Ratibida columnifera(Nutt.)(Mexican Hat)and Verbesina encelioides(Cav.)(cowpen daisy),were treated with microbial wash extracted from native soils,and germination rate was recorded for 14-day *** further analyzed the growth,biomass allocation,and root colonization by mycorrhizal fungi in these two plants growing them in a plant growth chamber for 6 *** determine the impact of seeding depth,we planted the seeds of the two plant species at 2-cm,6-cm,and 12-cm depth and monitored germination and plant ***:The two species responded differently to the seeding depth and microbial wash *** wash treatment resulted in higher germination rate in *** compared to control,while it did not have any impact on *** seed *** microbial treatment did not influence the total biomass,it had a significant impact on the biomass allocation in both the plant *** seeds germinated at both 2-cm and 6-cm depth and did not germinate at 12 cm,while the *** seeds germinated only at 2 cm and did not germinate at 6-cm or 12-cm seeding ***:While our results are species specific,our results indicate that native soil microbes can potentially improve the seed germination and growth of *** results also indicate the importance of specific seeding depth when sowing wildflower seeds for habitat restoration.

关键词： Habitat restoration Soil microbes Seeding depth Wildflowers Root endophytes

A regularization scheme for explicit level-set XFEM topology optimization

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Frontiers of Mechanical Engineering 2019年第2期14卷 153-170页

作者： Markus J.GEISS Jorge L.barrera Narasimha BODDETI Kurt MAUTE Ann and H.J.Smead Department of Aerospace Engineering Sciences University of Colorado at BoulderBoulderCO 80309-0429USA Singapore University of Technology and Design SUTD Digital Manufacturing and Design CentreSingapore 487372Singapore

Regularization of the level-set(LS)field is a critical part of LS-based topology optimization(TO)*** this is achieved by advancing the LS field through the solution of a Hamilton-Jacobi equation combined with a reinitialization *** approach,however,may limit the maximum step size and introduces discontinuities in the design ***,energy functionals and intermediate LS value penalizations have been *** paper introduces a novel LS regularization approach based on a signed distance field(SDF)which is applicable to explicit LSbased *** SDF is obtained using the heat method(HM)and is reconstructed for every design in the optimization *** governing equations of the HM,as well as the ones describing the physical response of the system of interest,are discretized by the extended finite element method(XFEM).Numerical examples for pro?blems modeled by linear elasticity,nonlinear hyperelasticity and the incompressible Navier-Stokes equations in two and three dimensions are presented to show the applicability of the proposed scheme to a broad range of design optimization problems.

关键词： level-set regularization explicit level-sets XFEM CutFEM topology optimization heat method signed distance field nonlinear structural mechanics fluid mechanics

Gourds and Tendrils of Cucurbitaceae: How Their Shape Diversity, Molecular and Morphological Novelties Evolved via Whole-Genome Duplications

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Molecular Plant 2020年第8期13卷 1108-1110页

作者： Josuébarrera-Redondo Rafael Lira-Saade Luis E.Eguiarte Departamento de Ecología Evolutiva Instituto de EcologíaUniversidad Nacional Autónoma de MéxicoCircuito Exterior s/n Anexo al Jardín BotánicoCiudad de México 04510Mexico UBIPRO Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoAvenido de los Barrios#1Col.Los Reyes IztacalaTlalnepantlaEstado de México 54090Mexico

Whole-genome duplications(WGDs)are regarded as important drivers of macroevolution in plants(Clark and Donoghue,2018).However,there are few studies that test a connection between WGDs and evolutionary *** proper study of evolutionary patterns related to WGDs needs a well-resolved phylogeny,accurate dates of the WGD events,and historical reconstructions of the evolutionary novelties(Clark and Donoghue,2018).The advent of exhaustive phylogenomic studies is becoming a promising way to solve these issues,as wholegenome data can help clarify obscure phylogenetic relationships,evaluate patterns associated with WGDs,and track down the evolution of life-history traits that shaped plant lineages(Bellot et al.,2020).

关键词： Whole phylogeny traits

Influence of local and landscape environmental factors on alpha and beta diversity of macroinvertebrates in Andean rivers

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Journal of Mountain Science 2023年第9期20卷 2487-2501页

作者： DIAZ-ROJAS Camila A PEDROZA-RAMOS Adriana X barrera-HERRERA July A ROA-FUENTES Camilo A Ecology Unit in Aquatic Systems Research Group Pedagogical and Technological University of ColombiaUPTCAvenida Central del Norte 39-115TunjaBoyacáColombia

Research on macroinvertebrate community structure in Andean rivers has been oriented towards describing patterns of alpha and gamma diversity by taking into account environmental predictors at local spatial scales(e.g.,micro-and mesohabitats).However,the patterns of beta diversity and the importance of landscape-scale variables have been evaluated to a lesser *** objective of this study was to describe the patterns of alpha and beta diversity of benthic macroinvertebrates in the Andean rivers of the Orinoco basin and their relationship with local and landscape environmental variation.A stratified random sampling of macroinvertebrates was carried out at 40 sites(comprising an altitudinal range of between 500 and 2900 m.a.s.l.),local and landscape variables were *** results showed that the variation of alpha diversity was influenced by local and landscape variables,which are directly and indirectly related to the contribution of sediments,substrate composition and flow velocity,providing a heterogeneity of *** beta diversity was explained by the combined effect of local and landscape *** the beta diversity phenomena,turnover was predominant while nestedness presented a minor contribution and both were explained in greater proportion by local descriptors and some landscape variables,specifically those of a geomorphological *** results concur with the view of an environmental and spatial hierarchy within the river habitat and highlight the influence of multiple scales on macroinvertebrate *** above suggests that both local and landscape scales must necessarily be considered for environmental management and the conservation of Andean lotic ecosystems.

关键词： Andean lotic systems Andean agroecosystems Instream habitat Landcover Turnover Nestedness

Abiotic stress-associated microRNAs in plants： discovery, expression analysis, and evolution

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Frontiers in Biology 2013年第2期8卷 189-197页

作者： Blanca E. barrera-FIGUEROA Zhigang WU Renyi LIU Departamento de Biotecnologia Universidad del Papaloapan Tuxtepec Oaxaca 68301 Mexico Department of Botany and Plant Sciences University of California Riverside CA 92521 USA

Abiotic stresses such as drought, cold, and high salinity are among the most adverse factors that affect plant growth and yield in the field. MicroRNAs are small RNA molecules that regulate gene expression in a sequence-specific manner and play an important role in plant stress response. Identifying abiotic stress-associated microRNAs and understanding their function will help develop new strategies for improvement of plant stress tolerance. Here we highlight recent advances in our understanding of abiotic stress-associated miRNAs in various plants, with focus on their discovery, expression analysis, and evolution.

关键词： microRNA abiotic stress epigenetics gene expression evolution

A narrative review of the success of intramuscular gluteal injections and its impact in psychiatry

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Bio-Design and Manufacturing 2018年第3期1卷 161-170页

作者： Erfan Soliman Sarujan Ranjan Tianyou Xu Carol Gee Aidan Harker Alvaro barrera John Geddes Department of Engineering Sciences Institute of BiomedicalEngineering Old Road Campus Research BuildingUniversity of Oxford Oxford OX3 7DQ UK Warneford Hospital Oxford Health NHS Foundation Trust Warneford Ln Oxford OX3 7JX UK Department of Psychiatry University of Oxford Warneford Hospital Warneford Ln Oxford OX3 7JX UK

There are 12 billion injections given worldwide every year. For many injections, the intramuscular route is favoured over the subcutaneous route due to the increased vascularity of muscle tissue and the corresponding increase in the bioavailability of drugs when administered intramuscularly. This paper is a review of the variables that affect the success of intramuscular injections and the implications that these success rates have in psychiatry and general medicine. Studies have shown that the success rates of intended intramuscular injections vary between 32 and 52%, with the rest potentially resulting in inadvertent subcutaneous drug deposition. These rates are found to be even lower for certain at-risk populations, such as obese patients and those on antipsychotic medications. The variables associated with an increased risk of injection failure include female sex, obesity, site of injection, and subcutaneous fat depth. New guidelines and methods are needed in order to address this challenge and ensure that patients receive optimum care. Looking forward, the best way to improve the delivery of intramuscular injections worldwide is to develop uniform algorithms or innovative medical devices to confirm or guarantee successful delivery at the bedside.

关键词： Intramuscular injection Gluteal Subcutaneous Ultrasound Computed tomography Antipsychotic

Kinetic study of austenite formation during continuous heating of unalloyed ductile iron

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International Journal of Minerals,Metallurgy and Materials 2015年第1期22卷 27-31页

作者： Octvio Vazquez-Gómez Jos Antonio barrera-Godínez Hctor Javier Vergara-Hernndez Faculty of Chemistry Metallurgical Engineering DepartmentAutonomous National University of Mexico Metallurgy Science Postgraduate Programme Morelia Institute of Technology

The austenite formation kinetics in unalloyed cast ductile iron was studied on the basis of dilatometry measurements, and Avrami＇s equation was used to estimate the material＇s kinetic parameters. A continuous heating transformation diagram was constructed us-ing heating rates in the range of 0.06 to 0.83℃·s^-1. As the heating rate was augmented, the critical temperatures, c1A and Aα, as well as the intercritical range, which was evaluated as the difference between the critical temperatures, α c1Δ T =A_a- A_c1 , increased. At a low heating rate, the kinetics of austenite formation was slow as a consequence of the iron＇s silicon content. The effect of heating rate on k and n, the kinetic parameters of Avrami＇s equation, was also determined. Parameter n, which is associated with nucleation sites and growth geometry, de-creased with an increase in heating rate. In addition, parameter k increased with the increase of heating rate, suggesting that the nucleation and growth rates are carbon-and silicon-diffusion controlled during austenite formation under continuous heating.

关键词： ductile iron austenite continuous heating heating rate kinetics dilatometry

Is the combination of immunotherapy with conventional chemotherapy the key to increase the efficacy of colorectal cancer treatment?

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World Journal of Gastrointestinal Oncology 2023年第2期15卷 251-267页

作者： Jonadab E Olguin Monica G Mendoza-Rodriguez C Angel Sanchez-barrera Luis I Terrazas Laboratorio Nacional en Salud Diagnóstico Molecular y Efecto Ambiental en Enfermedades Crónico-degenerativasFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico Unidad de Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC) is among the most prevalent and deadly neoplasms worldwide. According to GLOBOCAN predictions, its incidence will increase from 1.15 million CRC cases in 2020 to 1.92 million cases in 2040. Therefore, a better understanding of the mechanisms involved in CRC development is necessary to improve strategies focused on reducing the incidence, prevalence,and mortality of this oncological pathology. Surgery, chemotherapy, and radiotherapy are the main strategies for treating CRC. The conventional chemotherapeutic agent utilized throughout the last four decades is 5-fluorouracil, notwithstanding its low efficiency as a single therapy. In contrast, combining 5-fluorouracil therapy with leucovorin and oxaliplatin or irinotecan increases its efficiency. However, these treatments have limited and temporary solutions and aggressive side effects. Additionally, most patients treated with these regimens develop drug resistance, which leads to disease progression. The immune response is considered a hallmark of cancer;thus, the use of new strategies and methodologies involving immune molecules, cells, and transcription factors has been suggested for CRC patients diagnosed in stages Ⅲ and Ⅳ. Despite the critical advances in immunotherapy, the development and impact of immune checkpoint inhibitors on CRC is still under investigation because less than 25% of CRC patients display an increased 5-year survival. The causes of CRC are diverse and include modifiable environmental factors(smoking, diet, obesity, and alcoholism), individual genetic mutations, and inflammation-associated bowel diseases. Due to these diverse causes, the solutions likely cannot be generalized. Interestingly, new strategies, such as single-cell multiomics, proteomics, genomics, flow cytometry, and massive sequencing for tumor microenvironment analysis, are beginning to clarify the way forward. Thus,the individual mechanisms involved in developing the CRC microenvironment, their causes, and t

关键词： Colorectal cancer Immunotherapy checkpoint inhibitors Chemotherapy Immunotherapy Immune response