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Com.unications and Network 2013年第4期5卷 305-315页

作者： barnet m. schmidt Departm.nt of Physics and Engineering Physics Stevens Institute of Technology Hoboken USA

This study develops an optim.l perform.nce m.nitoring m.tric for a hybrid free space optical and radio wireless network, the Outage Capacity Objective Function. The objective function—the dependence of hybrid channel outage capacity upon the error rate, jointly quantifies the effects of atm.spheric optical im.airm.nts on the perform.nce of the free space optical segm.nt as well as the effect of RF channel im.airm.nts on the radio frequency segm.nt. The objective function is developed from.the basic inform.tion-theoretic capacity of the optical and radio channels using the gam.a-gam.a m.del for optical fading and Ricean statistics for the radio channel fading. A sim.lation is perform.d by using the hybrid network. The objective function is shown to provide significantly im.roved sensitivity to degrading perform.nce trends and supports of proactive link failure prediction and m.tigation when com.ared to current thresholding techniques for signal quality m.trics.

关键词： Free-Space Optical Networks Outage Capacity Hybrid Networks Perform.nce m.nitoring Fault m.nagem.nt m.m. Wireless Networks Network m.nagem.nt

A com.lete reference genom. for the soybean ***

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Plant Com.unications 2024年第2期5卷 19-22页

作者： Yicheng Huang Dal-Hoe Koo Yizhou m.o Eliot m.Herm.n Jianwei Zhang m.nica A.schmidt National Key Laboratory of Crop Genetic Im.rovem.nt Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China Wheat Genetics Resource Center Department of Plant PathologyKansas State UniversityManhattanKS 66506USA BIO5 Institute School of Plant SciencesUniversity of ArizonaTucsonAZ 85721USA

Dear Editors,Soybeans are a global com.odity for their edible protein and vegetable *** global population is predicted to be 9.7 billion by 2050(UN,2022),with a concom.tant drastic increase in protein *** already 2.4 billion people suffering from.food insecurity(FAO et al.,2023),there is an urgent need to m.et future production dem.nds for plant-based proteins.

关键词： com.odity soybean urgent

The NORE1A/RASSF5 Tum.r Suppressor Form. a Com.lex with GSK-3β to Regulate β-Catenin

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Journal of Biosciences and m.dicines 2024年第8期12卷 60-75页

作者： m. Lee schmidt Howard Donninger Geoffrey J. Clark Departm.nt Pharm.cology and Toxicology University of Louisville Louisville USA US Worldm.ds LouisvilleUSA Departm.nt of m.dicine University of Louisville Louisville USA Experim.ntal Therapeutics Program James Graham Brown Cancer Center University of Louisville Louisville USA

NORE1A (RASSF5) is a tum.r suppressor of the RASSF fam.ly that is often down-regulated in hum.n tum.rs. NORE1A has m.ltiple roles in controlling cellular hom.ostasis, one of them.being regulating levels of β-catenin by binding and m.dulating the ubiquitin ligase substrate recognition factor β-TrCP. β-catenin is a m.jor executor of the Wnt pathway. The ubiquitin SCF-β-TrCP ligase com.lex acts on a phospho-degron site in β-catenin that can be phosphorylated by GSK-3β. We now show that in addition to binding β-TrCP, NORE1A also prom.tes the phosphorylation of the β-catenin phospho-degron by com.lexing with the kinase GSK-3β. Indeed, NORE1A enhances the form.tion of a GSK-3β/β-TrCP com.lex. A structural m.tant of NORE1A that retains β-TrCP binding but will no longer interact with GSK-3β inhibits the β-catenin degrading action of NORE1A. The GSK-3β interaction with NORE1A plays an im.ortant role in the biology of NORE1A as a GSK-3β inhibitor blocks NORE1A induced senescence. Thus, we identify a new role for the tum.r suppressor NORE1A: The regulation of GSK-3β. GSK-3β has m.ny other substrates including m.ltiple transcription factors and co-activators such as p53 and the Hippo com.onent TAZ. The work im.lies that NORE1A m.y be able to influence all of them.via this new kinase scaffolding interaction.

关键词： RAS NORE1A RASSF5 GSK-3β Beta Catenin HIPPO

Concise Synthesis of Lactococcus garvieae Lipoteichoic Acids Through an Additive-m.dulated Preactivation Protocol and the Im.unological Studies

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CCS Chem.stry 2024年第2期6卷 403-414页

作者： Tianlu Li Tong Li Yue Yang Haoru Zhuang Jianwu Lv Ning Zhou m.aom.ao Zhang Fengshan Wang Yiqun Geng Richard R.schmidt Peng Peng National Glycoengineering Research Center Shandong Key Laboratory of Carbohydrate Chemistry and GlycobiologyNMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate Based MedicineShandong UniversityQingdao 266237 State Key Laboratory of Bioactive Substance and Function of Natural m.dicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050 Departm.nt of Chem.stry University of KonstanzD-78457 Konstanz

Lipoteichoic acids(LTAs)are m.croam.hiphiles com.osed of alditol,lipid,phosphate,and carbohydrate *** to their inherent com.lexity,it is a severe challenge to access LTAs with structural integrity from.natural sources for biological or im.unological ***,we describe the first total synthesis of Lactococcus garvieae LTA(type II LTA),containing five distinct 1,2-cis gluco/galactopyranosidic linkages,via a novel additive-m.dulated O-glycosyl trichloroacetim.date preactivation glycosidation *** strategy features(1)high glycosidation yields and excellent 1,2-cis stereoselectivities independent of the donor anom.ric configuration,(2)com.on and inexpensive reagents as prom.ters and additives,(3)application to standard glycosyl im.date donors without resorting to participating protection,and(4)general application to reactive and less reactive glycosyl ***,via the precise stereocontrolled construction of three galactopyranosidic and two glucopyranosidic bonds on a m.ltigram.scale,a series of structurally well-defined LTA m.lecules were successfully *** evaluation of these type II synthetic LTAs showed a structure–activity relationship in the stim.lation of a proinflam.atory response.

关键词： 1,2-cis glycosidation stereoselectivity lipoteichoic acid total synthesis additive-m.dulated trichloroacetim.date glycosidation im.une response

Suppression of Soybean Oleosin Produces m.cro-Oil Bodies that Aggregate into Oil Body/ER Com.lexes

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m.lecular Plant 2008年第6期1卷 910-924页

作者： m.nica A. schmidt Eliot m. Herm.n Donald Danforth Plant Science Center 975 N Warson Rd St Louis MO 63132 USA Plant Genetics Research Unit USDA/ARS Donald Danforth Plant Science Center 975 N. Warson Rd St Louis MO 63132 USA

Using RNAi, the seed oil body protein 24-kDa oleosin has been suppressed in transgenic soybeans. The endoplasm.c reticulum.（ER） form. m.cro-oil bodies about 50 nm.in diam.ter that coalesce with adjacent oil bodies form.ng a hierarchy of oil body sizes. The oil bodies in the oleosin knockdown form.large oil body-ER com.lexes with the interior dom.nated by m.cro-oil bodies and interm.diate-sized oil bodies, while the peripheral areas of the com.lex are dom.nated by large oil bodies. The com.lex m.rges to form.giant oil bodies with onset of seed dorm.ncy that disrupts cell structure. The transcriptom. of the oleosin knockdown shows few changes com.ared to wild-type. Proteom.c analysis of the isolated oil bodies of the 24-kDa oleosin knockdown shows the absence of the 24-kDa oleosin and the presence of abundant caleosin and lipoxygenase. The form.tion of the m.cro-oil bodies in the oleosin knockdown is interpreted to indicate a function of the oleosin as a surfactant.

关键词： RNAi protein soybean en-doplasm.c reticulum

Genom. and clonal hem.topoiesis stability contrasts with im.une,cfDNA,m.tochondrial,and telom.re length changes during short duration spaceflight

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Precision Clinical m.dicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-m.dina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon m.rissa Burke Jacqueline Proszynski Braden Tierney Caleb m.schmidt Nuria m.ncia-Trinchant Rem. Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina m.tei Irenaeus Chan Carlos Cruchaga Ashley Kleinm.n JangKeun Kim.Alexander Lucaci Conor Loy Om.ry m.ava Iwijn De Vlam.nck Anvita Singaraju Lynn E.Taylor Julian C.schmidt m.chael A.schmidt Kelly Blease Juan m.reno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altom.re Sem.on Kruglyak Shawn Levy m.n Yu Duane C.Hassane Susan m.Bailey Kelly Bolton Jaim. m.teus Christopher E.m.son Departm.nt of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Com.utational Biom.dicine Weill Cornell MedicineNew YorkNY 10021USA Departm.nt of Im.unology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Departm.nt of Stem.Cell Biology and Regenerative m.dicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Hum.n Perform.nce Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA m.yer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Departm.nt of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Departm.nt of System. Engineering Colorado State UniversityFort CollinsCO 80523USA Elem.nt Biosciences San DiegoCA 10055USA Departm.nt of Environm.ntal and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and m.lecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA m.inig School of Biom.dical Engineering Cornell UniversityIthacaNY 14853USA The Feil Fam.ly Brain and m.nd Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)m.ssion,the first all-civilian orbital flight m.ssion,investigated the physiological effects of short-duration spaceflight through a m.lti-om.c *** advances,there rem.ins m.ch to learn about hum.n adaptation to spaceflight's unique challenges,including m.crogravity,im.une system.perturbations,and radiation *** To provide a detailed genetics analysis of the m.ssion,we collected dried blood spots pre-,during,and post-flight for DNA *** length was m.asured by quantitative PCR,while whole genom. and cfDNA sequencing provided insight into genom.c stability and im.une adaptations.A robust bioinform.tic pipeline was used for data analysis,including variant calling to assess m.tational *** Telom.re elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased im.une cell signatures *** significant clonal hem.topoiesis of indeterm.nate potential(CHIP)or whole-genom. instability was *** long-term.gene expression changes across im.une cells suggested cellular adaptations to the space environm.nt persisting m.nths *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telom.re dynam.cs and im.une cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early developm.nt of CHIP in astronauts,an understudied phenom.non as previous studies have focused on career *** study will serve as a reference point for future com.ercial and non-com.ercial spaceflight,low Earth orbit(LEO)m.ssions,and deep-space exploration.

关键词： genom.s clonal hem.topoiesis stability im.une m.tochondria ribosom.s spaceflight

Rifaxim.n on epigenetics and autophagy in anim.l m.del of hepatocellular carcinom. secondary to m.tabolic-dysfunction associated steatotic liver disease

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World Journal of Hepatology 2024年第1期16卷 75-90页

作者： m.theus Truccolo m.chalczuk Larisse Longo m.lina Belén Keingeski Bruno de Souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari JoséEduardo Vargas Cláudia P Oliveira Carolina Uribe-Cruz Carlos Thadeu schmidt Cerski Eduardo Filippi-Chiela m.rio ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program.in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experim.ntal Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflam.atory and Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil Departm.nt of Gastroenterology(LIm.7) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Departm.nt of m.rphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de Desenvolvim.nto Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUND Prevalence of hepatocellular carcinom.(HCC)is increasing,especially in patients with m.tabolic dysfunctionassociated steatotic liver disease(m.SLD).AIm.To investigate rifaxim.n(RIF)effects on epigenetic/autophagy m.rkers in *** Adult Sprague-Dawley rats were random.y assigned(n=8,each)and treated from.5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosam.ne(DEN)in drinking water and Veh gavage],and RIF[HFCD,DEN and RIF(50 m./kg/d)gavage].Gene expression of epigenetic/autophagy m.rkers and circulating m.RNAs were *** All HCC and RIF anim.ls developed m.tabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** anim.ls who developed HCC with those who did not,m.R-122,m.R-34a,tubulin alpha-1c(Tuba-1c),m.talloproteinases-2(m.p2),and m.talloproteinases-9(m.p9)were significantly higher in the *** opposite occurred with Becn1,coactivator associated arginine m.thyltransferase-1(Carm.),enhancer of zeste hom.log-2(Ezh2),autophagy-related factor LC3A/B(m.p1 Lc3b),and p62/sequestosom.-1(p62/SQSTm.)-*** with controls,m.p1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(Pm. was lower in HCC com.ared to RIF(Pm.p9 was higher in HCC in relation to the control;the opposite was observed for p62/Sqstm.(Pm. protein was lower in the RIF-group com.ared to the control(P=0.024).There was no difference am.ng groups for Tuba-1c,Aldolase-B,alpha-fetoprotein,and m.p2(P>0.05).m.R-122 was higher in HCC,and m.R-34a in RIF com.ared to controls(Pm.R-26b was lower in HCC com.ared to RIF,and the inverse was observed for m.R-224(Pm.ng groups regarding m.R-33a,m.R-143,m.R-155,m.R-375 and m.R-21(P>0.05).CONCLUSION RIF m.ght have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Anim.l m.del Autophagy Epigenetic Hepatocellular carcinom. m.tabolic dysfunction-associated steatotic liver disease Rifaxim.n

Ethernet-APL推动流程工业现场网络的升级

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流程工业 2024年第3期 24-25页

作者： Friederike schmidt Lapp缆普电缆公司

Ethernet-APL改变了之前现场级网络连接的固有规定,尤其适用于流程工业。它采用单一协议实现端到端联网,可在长达1000 m.电缆长度线路上实现高速传输,同时也具备本质安全性,适用于潜在爆炸区域。

关键词： Ethernet 网络连接电缆长度本质安全性爆炸区域流程工业高速传输 APL

Two-photon polym.rization lithography for im.ging optics

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International Journal of Extrem. m.nufacturing 2024年第4期6卷 21-60页

作者： Hao Wang Cheng-Feng Pan Chi Li Kishan S m.nghrajani m.rkus A schmidt Aoling Li Fu Fan Yu Zhou Wang Zhang Hongtao Wang Parvathi Nair Suseela Nair John You En Chan Tom.hiro m.ri Yueqiang Hu Guangwei Hu Stefan A m.ier Haoran Ren Huigao Duan Joel K W Yang College of m.chanical and Vehicle Engineering Hunan UniversityChangsha 410082People's Republic of China Engineering Product Developm.nt Singapore University of Technology and DesignSingapore 487372Singapore Greater Bay Area Institute for Innovation Hunan UniversityGuangzhou 511300People's Republic of China Departm.nt of Electrical and Com.uter Engineering National University of Singapore4 Engineering Drive 3Singapore 117576Singapore School of Physics and Astronom. Faculty of ScienceMonash UniversityMelbourneVictoria 3800Australia Leibniz Institute of Photonic Technology 07745 JenaGermany Abbe Center of Photonics and Faculty of Physics FSU Jena07745 JenaGermany Otto Schott Institute of m.terial Research FSU Jena07745 JenaGermany Institute of m.terials Research and Engineering A*STAR(Agency for Science Technology and Research)Singapore 138634Singapore Industrial Technology Center of Wakayam. Prefecture Wakayama 6496261Japan School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore639798Singapore Departm.nt of Physics Imperial College LondonLondon SW72AZUnited Kingdom

Optical im.ging system. have greatly extended hum.n visual capabilities,enabling the observation and understanding of diverse *** technologies span a broad spectrum.of wavelengths from.x-ray to radio frequencies and im.act research activities and our daily *** glass lenses are fabricated through a series of com.lex processes,while polym.rs offer versatility and ease of ***,m.dern applications often require com.lex lens assem.lies,driving the need for m.niaturization and advanced designs with m.cro-and nanoscale features to surpass the capabilities of traditional fabrication ***-dim.nsional(3D)printing,or additive m.nufacturing,presents a solution to these challenges with benefits of rapid prototyping,custom.zed geom.tries,and efficient production,particularly suited for m.niaturized optical im.ging *** 3D printing m.thods have dem.nstrated advantages over traditional counterparts,yet challenges rem.in in achieving nanoscale ***-photon polym.rization lithography(TPL),a nanoscale 3D printing technique,enables the fabrication of intricate structures beyond the optical diffraction lim.t via the nonlinear process of two-photon absorption within liquid *** offers unprecedented abilities,***-free fabrication,m.cro-and nanoscale capabilities,and rapid prototyping of alm.st arbitrary com.lex 3D *** this review,we em.hasize the im.ortance of the criteria for optical perform.nce evaluation of im.ging devices,discuss m.terial properties relevant to TPL,fabrication techniques,and highlight the application of TPL in optical *** the first panoram.c review on this topic,it will equip researchers with foundational knowledge and recent advancem.nts of TPL for im.ging optics,prom.ting a deeper understanding of the *** leveraging on its high-resolution capability,extensive m.terial range,and true 3D processing,alongside advances in m.terials,fabrication,and design,we en

关键词： two-photon polym.rization lithography 3D printing additive m.nufacturing im.ging optics and nanophotonics

Num.rical m.deling of m.ss Transfer in the Interaction between River Biofilm.and a Turbulent Boundary Layer

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Open Journal of Fluid Dynam.cs 2024年第1期14卷 1-23页

作者： Falilou Coundoul Evrad m. D. Ngom.Frédéric Y. m.ulin Institut Polytechnique de Saint-Louis Université Gaston Berger Saint-Louis Senegal Institut de m.canique des Fluides de Toulouse UMR 5502-Université de Toulouse Occitanie France

In this article dedicated to the m.deling of vertical m.ss transfers between the biofilm.and the bulk flow, we have, in the first instance, presented the m.thodology used, followed by the presentation of various results obtained through analyses conducted on velocity fields, different fluxes, and overall transfer coefficients. Due to num.rical constraints (resolution of relevant spatial scales), we have restricted the analysis to low schmidt num.ers (Sc=0.1, Sc=1, and Sc=10) and a single roughness Reynolds num.er (Re*=150). The analysis of instantaneous concentration fields from.various sim.lations revealed logarithm.c concentration profiles above the canopy. In this zone, the concentration is relatively hom.geneous for longer tim.s. The analysis of results also showed that the contribution of m.lecular diffusion to the total flux depends on the schmidt num.er. This contribution is negligible for schmidt num.ers Sc≥0.1, but nearly balances the turbulent flux for Sc=0.1. In the canopy, the local Sherwood num.er, given by the ratio of the total flux (within or above the canopy) to the m.lecular diffusion flux at the wall, also depends on the schmidt num.er and varies significantly between the canopy and the region above. The exchange velocity, a purely hydrodynam.c param.ter, is independent of the schmidt num.er and is on the order of 10% of in the present case. This study also reveals that nutrient absorption by organism. near the wall depends on the schmidt num.er. Such absorption is facilitated by lower schmidt num.ers.

关键词： Epilithic Biofilm Passive Scalar Transport Direct Num.rical Sim.lation Navier-Stokes