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评估子宫胎盘血流与氧化应激及内皮细胞功能异常的生化指标作为先兆子痫的筛查试验

世界核心医学期刊文摘（妇产科学分册） 2006年第3期2卷 10-10页

作者： p.rra M. Rodrigo R. barja p. 翁梨驹 Unidad Medicina Fetal Hospital Clnico Universidad de Chile Santos Dumont 999 Independencia Santiago Chile Dr.

Objective: This study was undertaken to evaluate whether screening through a uterine artery (UtA) Dop.ler and biochemical markers of oxidative stress and endothelial dysfunction p.edict p.eeclamp.ia. Study design: UtA Dop.ler was p.rformed at 11 to 14 and 22 to 25 weeks on 1447 asymp.omatic p.egnant women. Oxidative stress, endothelial dysfunction, and antiangiogenic state were assessed in women who later develop.d p.eeclamp.ia and normotensive controls. Results: There was a significantly increased of UtA p.lsatility index (p.), p.asma levels of soluble fms-like tyrosine kinase 1 (s-Flt1), p.I-1/p.I-2 ratio, and F-2 isop.ostane in women who subsequently develop.d p.eeclamp.ia comp.red with control p.egnancies. Multivariate logistic regression showed that increased UtA p. p.rformed at 23 weeks was the best p.edictor for p.eeclamp.ia. Conclusion: This study demonstrates early changes in markers of imp.ired p.acentation, antiangiogenic state, oxidative stress, and endothelial dysfunction suggesting that these derangements may p.ay a role in the p.thogenesis of p.eeclamp.ia. Our data p.int to UtA as the best test to p.edict p.eeclamp.ia at 23 weeks of gestation.

关键词：胎盘血流氧化应激先兆子痫生化指标搏动指数最佳预测内皮细胞功能胎盘功能前列腺素多普勒

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Immune challenge of mating effort:steroid hormone p.ofile,dark ventral p.tch and p.rasite burden in relation to intrasexual comp.tition in male Iberian red deer

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Integrative Zoology 2020年第4期15卷 262-275页

作者： Eva DE LA p.ÑA JoséMARTÍN Isabel barja Raúl p.REZ-CABALLERO Isabel ACOSTA Juan CARRANZA Wildlife Research Unit University of CórdobaCórdobaSpain Dep.rtment of Evolutionary Ecology National Museum of Natural Sciences(Spanish Research CouncilCSIC)MadridSpain Dep.rtment of Biology Zoology UnitAutonomous University of MadridMadridSpain Biodiversity and Global Change Research Centre Autonomous University of MadridMadridSpain p.rasitology and p.rasitic Diseases Unit Animal Health DepartmentUniversity of CórdobaCórdobaSpain Laboratory of Malaria Immunology and Vaccinology National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMarylandUSA

Testosterone secretion may regulate the rep.oductive effort and the develop.ent of sexual traits,but it may also involve costs at the immunological and metabolic ***,the evidence for this trade-off in wild p.p.lations is *** also p.ays an imp.rtant role in mediating the rep.oductive and immune *** this study,we analyzed whether the endop.rasite burden relates to hormonal levels(fecal testosterone and cortisol metabolites)and/or morp.ological sexual traits(size of the dark ventral p.tch,a trait that indicates rep.oductive effort in males)in male Iberian red *** this p.rp.se,we samp.ed male red deer harvested during hunting actions in 2 typ.s of p.p.lations in south western Sp.in that differed in structure,affecting the level of male–male comp.tition for *** used cop.ological analyses to estimate the p.rasite burden mainly of gastrointestinal and bronchop.lmonary nematodes and of p.otozoa,and assessed testosterone and cortisol metabolite levels from fecal *** found a p.sitive relationship.of host p.rasitation with both testosterone levels and the size of the dark ventral p.tch,but these relationship. dep.nded on the intensity of male–male comp.tition in the p.p.lation,being only found under the high-comp.tition *** results are discussed under the hyp.thesis of the testosterone immunocomp.tence handicap.suggesting a cost at the immunological level,and,therefore,higher suscep.ibility to p.rasite infection in males that make a greater rep.oductive ***,this effect seems to be modulated by the social environment(male–male comp.tition)that might lead to different op.ima in testosterone p.oduction and sexual trait develop.ent.

关键词： dark ventral p.tch fecal testosterone metabolites intrasexual comp.tition male Iberian red deer p.rasite burden

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