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Identification of potential P. falciparum transketolase inhibitors: pharmacophore design, in silico screening and docking studies

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Journal of Biophysical Chemistry（生物物理化学） 2010年第2期

作者： Shweta Joshi Alok ranjan Singh Uzma Saqib Prakash Chandra Misra Mohammad Imran Siddiqi Jitendra Kumar Saxena

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Integrated physiological and molecular approaches to improvement of abiotic stress tolerance in two pulse crops of the semi‐arid tropics

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The Crop Journal 2018年第2期 99-114页

作者： Arbind K. Choudhary Rafat Sultana M. Isabel Vales Kul Bhushan Saxenad Ravi ranjan Kumar Pasala Ratnakumar ICAR Research Complex for Eastern Region Bihar Agricultural University Texas A&M University， College Station International Crops Research Institute for the Semi-Arid Tropics National Institute of Abiotic Stress Management

Chickpea(Cicer arietinum L.) and pigeonpea [Cajanus cajan L.(Millsp.)] play an important role in mitigating protein malnutrition for millions of poor vegetarians living in regions of the semi-arid tropics. Abiotic stresses such as excess and limited soil moisture(water-logging and drought), heat and chilling(high and low temperature stresses), soil salinity, and acidity are major yield constraints, as these two crops are grown mostly under rainfed conditions in risk-prone marginal and degraded lands with few or no inputs. Losses due to such stresses vary from 30% to 100% depending on their severity. The literature abounds in basic information concerning screening techniques, physiological mechanisms, and genetics of traits associated with resistance/tolerance to abiotic stresses in these two crops. However, the final outcome in terms of resistant/tolerant varieties has been far from satisfactory. This situation calls for improving selection efficiency through precise phenotyping and genotyping under high-throughput controlled conditions using modern tools of genomics. In this review, we suggest that an integrated approach combining advances from genetics, physiology, and biotechnology needs to be used for higher precision and efficiency of breeding programs aimed at improving abiotic stress tolerance in both chickpea and pigeonpea.

关键词： ABIOTIC stresses CHICKPEA GENOMICS GENOTYPING INTEGRATED approach Pigeonpea

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Improvement of Dissolution Rate of Gliclazide Using Solid Dispersions with Aerosil 380 and Its Effect on Alloxan Induced Diabetic Rats

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Pharmacology & Pharmacy（药理与制药） 2019年第8期

作者： Subrata Paul Md. Nur Islam Md. Ashraf Ali ranjan Kumar Barman Mir Imam Ibne Wahed Bytul M. Rahman

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Role of Polyethylene Glycol and Silica for Dissolution Enhancement of Cefuroxime Axetil: In-Vitro Performance Evaluation and Characterization

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Pharmacology & Pharmacy（药理与制药） 2023年第5期

作者： Mst. Boby Aktar Bithy Milon Kumar Ghosh Ashim Kumar Md. Rafiqul Islam Khan Mir Imam Ibne Wahed ranjan Kumar Barman

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Development and Evaluation of Stable Paracetamol Loaded Solid Dispersion with Enhanced Analgesic and Hepatoprotective Property

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Pharmacology & Pharmacy（药理与制药） 2023年第4期

作者： Ashim Kumar Milon Kumar Ghosh Mst. Boby Aktar Bithy Md. Rafiqul Islam Khan Md. Monimul Huq Mir Imam Ibne Wahed ranjan Kumar Barman

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Plant Biosystems Design Research Roadmap 1.0

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BioDesign Research 2020年第1期2020卷 53-90页

作者： Xiaohan Yang June I.Medford Kasey Markel Patrick M.Shih Henrique C.De Paoli Cong T.Trinh Alistair J.McCormick Raphael Ployet Steven G.Hussey Alexander A.Myburg Poul Erik Jensen Md Mahmudul Hassan Jin Zhang Wellington Muchero Udaya C.Kalluri Hengfu Yin Renying Zhuo Paul E.Abraham Jin-Gui Chen David J.Weston Yinong Yang Degao Liu Yi Li Jessy Labbe Bing Yang Jun Hyung Lee Robert W.Cottingham Stanton Martin Mengzhu Lu Timothy J.Tschaplinski Guoliang Yuan Haiwei Lu Priya ranjan Julie C.Mitchell Stan D.Wullschleger Gerald A.Tuskan Biosciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA The Center for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTN 37831USA Department of Biology Colorado State UniversityFort CollinsCO 80523USA Department of Plant Biology University of CaliforniaDavisDavisCAUSA Feedstocks Division Joint BioEnergy InstituteEmeryvilleCAUSA Department of Biodesign Biological Systems and Engineering DivisionLawrence Berkeley National LaboratoryBerkeleyCAUSA Department of Chemical and Biomolecular Engineering University of TennesseeKnoxvilleTN 37996USA SynthSys and Institute of Molecular Plant Sciences School of Biological SciencesUniversity of EdinburghEdinburgh EH93BFUK Department of Biochemistry Genetics and MicrobiologyForestry and Agricultural Biotechnology Institute(FABI)University of PretoriaPretoria 0002South Africa Department of Food Science University of CopenhagenRolighedsvej 26DK-1858FrederiksbergCopenhagenDenmark State Key Laboratory of Subtropical Silviculture School of Forestry and BiotechnologyZhejiang A&F UniversityHangzhouZhejiang 311300China State Key Laboratory of Tree Genetics and Breeding Research Institute of Subtropical ForestryChinese Academy of ForestryHangzhouZhejiang 311400China Department of Plant Pathology and Environmental Microbiology and the Huck Institute of the Life Sciences The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Genetics Cell Biology and DevelopmentCenter for Precision Plant Genomics and Center for Genome EngineeringUniversity of MinnesotaSaint PaulMN 55108USA Department of Plant Science and Landscape Architecture University of ConnecticutStorrsCT 06269USA Division of Plant Sciences Bond Life Sciences CenterUniversity of MissouriColumbiaMOUSA Donald Danforth Plant Science Center St.LouisMOUSA Environmental Sciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA

Human life intimately depends on plants for food,biomaterials,health,energy,and a sustainable *** plants have been genetically improved mostly through breeding,along with limited modification via genetic engineering,yet they are still not able to meet the ever-increasing needs,in terms of both quantity and quality,resulting from the rapid increase in world population and expected standards of living.A step change that may address these challenges would be to expand the potential of plants using biosystems design *** represents a shift in plant science research from relatively simple trial-and-error approaches to innovative strategies based on predictive models of biological *** biosystems design seeks to accelerate plant genetic improvement using genome editing and genetic circuit engineering or create novel plant systems through de novo synthesis of plant *** this perspective,we present a comprehensive roadmap of plant biosystems design covering theories,principles,and technical methods,along with potential applications in basic and applied plant biology *** highlight current challenges,future opportunities,and research priorities,along with a framework for international collaboration,towards rapid advancement of this emerging interdisciplinary area of ***,we discuss the importance of social responsibility in utilizing plant biosystems design and suggest strategies for improving public perception,trust,and acceptance.

关键词： Plant utilizing breeding

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